Modulation of notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 8046-8054

  Li, Kang ^a,c   Li, Yucheng ^a   Wu, Wenjuan ^a   Gordon, Wendy R ^b   Chang, David W ^a   Lu, Mason ^a   Scoggin, Shane ^a   Fu, Tihui ^a   Vien, Long ^a   Histen, Gavin ^b   Zheng, Ji ^a   Martin Hollister, Rachel ^a   Duensing, Thomas ^a   Singh, Sanjaya ^a   Blacklow, Stephen C ^b   Yao, Zhengbin ^a   Aster, Jon C ^b   Zhou, Bin Bing S ^a,d  

^a Tanox Biosystems Inc   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c PFIZER INC   (United States)

^d WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CHEMICAL ACTIVATION; MODULATION; MONOCLONAL ANTIBODIES;

ANTIBODY MIMICS; CELL TYPES; CELLULAR PROLIFERATIONS; EXTRACELLULAR; FUNCTIONAL SCREENINGS; HUMAN DISEASES; JUXTAMEMBRANE; NOTCH RECEPTORS; NOTCH SIGNALING; POTENT INHIBITORS; POTENTIAL THERAPEUTIC TARGETS; PROTEOLYTIC CLEAVAGES; REGULATORY REGIONS; T CELLS;

ANTIBODIES;

EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A13; MONOCLONAL ANTIBODY A2; MONOCLONAL ANTIBODY A4; MONOCLONAL ANTIBODY A8; MONOCLONAL ANTIBODY G3; NOTCH3 RECEPTOR; UNCLASSIFIED DRUG; NOTCH RECEPTOR; NOTCH3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANTIBODY SCREENING; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CELL DIVISION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; HUMAN; HUMAN CELL; MALE; MODULATION; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; CELL MOTION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; EPITOPES; HUMANS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 43149113910     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800170200     Document Type: Article

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