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Volumn 46, Issue 3, 2017, Pages 364-378

Successful and Maladaptive T Cell Aging

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

EID: 85015727612     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.03.010     Document Type: Review
Times cited : (234)

References (164)
  • 1
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal, A., Agrawal, S., Cao, J.N., Su, H., Osann, K., Gupta, S., Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 178 (2007), 6912–6922.
    • (2007) J. Immunol. , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.N.3    Su, H.4    Osann, K.5    Gupta, S.6
  • 2
    • 79953159005 scopus 로고    scopus 로고
    • Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
    • Akbar, A.N., Henson, S.M., Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?. Nat. Rev. Immunol. 11 (2011), 289–295.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 289-295
    • Akbar, A.N.1    Henson, S.M.2
  • 3
    • 84999766469 scopus 로고    scopus 로고
    • Senescence of T lymphocytes: implications for enhancing human immunity
    • Akbar, A.N., Henson, S.M., Lanna, A., Senescence of T lymphocytes: implications for enhancing human immunity. Trends Immunol. 37 (2016), 866–876.
    • (2016) Trends Immunol. , vol.37 , pp. 866-876
    • Akbar, A.N.1    Henson, S.M.2    Lanna, A.3
  • 5
    • 84946780490 scopus 로고    scopus 로고
    • NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine
    • Bai, A., Moss, A., Rothweiler, S., Longhi, M.S., Wu, Y., Junger, W.G., Robson, S.C., NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat. Commun., 6, 2015, 8819.
    • (2015) Nat. Commun. , vol.6 , pp. 8819
    • Bai, A.1    Moss, A.2    Rothweiler, S.3    Longhi, M.S.4    Wu, Y.5    Junger, W.G.6    Robson, S.C.7
  • 6
    • 67049167214 scopus 로고    scopus 로고
    • Quantifying the development of the peripheral naive CD4+ T-cell pool in humans
    • Bains, I., Antia, R., Callard, R., Yates, A.J., Quantifying the development of the peripheral naive CD4+ T-cell pool in humans. Blood 113 (2009), 5480–5487.
    • (2009) Blood , vol.113 , pp. 5480-5487
    • Bains, I.1    Antia, R.2    Callard, R.3    Yates, A.J.4
  • 7
    • 70449721165 scopus 로고    scopus 로고
    • Quantifying thymic export: combining models of naive T cell proliferation and TCR excision circle dynamics gives an explicit measure of thymic output
    • Bains, I., Thiébaut, R., Yates, A.J., Callard, R., Quantifying thymic export: combining models of naive T cell proliferation and TCR excision circle dynamics gives an explicit measure of thymic output. J. Immunol. 183 (2009), 4329–4336.
    • (2009) J. Immunol. , vol.183 , pp. 4329-4336
    • Bains, I.1    Thiébaut, R.2    Yates, A.J.3    Callard, R.4
  • 8
    • 84898662234 scopus 로고    scopus 로고
    • B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation
    • Barnett, L.G., Simkins, H.M., Barnett, B.E., Korn, L.L., Johnson, A.L., Wherry, E.J., Wu, G.F., Laufer, T.M., B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation. J. Immunol. 192 (2014), 3607–3617.
    • (2014) J. Immunol. , vol.192 , pp. 3607-3617
    • Barnett, L.G.1    Simkins, H.M.2    Barnett, B.E.3    Korn, L.L.4    Johnson, A.L.5    Wherry, E.J.6    Wu, G.F.7    Laufer, T.M.8
  • 18
    • 0035884911 scopus 로고    scopus 로고
    • Down-regulation of CD28 expression by TNF-alpha
    • Bryl, E., Vallejo, A.N., Weyand, C.M., Goronzy, J.J., Down-regulation of CD28 expression by TNF-alpha. J. Immunol. 167 (2001), 3231–3238.
    • (2001) J. Immunol. , vol.167 , pp. 3231-3238
    • Bryl, E.1    Vallejo, A.N.2    Weyand, C.M.3    Goronzy, J.J.4
  • 19
    • 26844513278 scopus 로고    scopus 로고
    • Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis
    • Bryl, E., Vallejo, A.N., Matteson, E.L., Witkowski, J.M., Weyand, C.M., Goronzy, J.J., Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Arthritis Rheum. 52 (2005), 2996–3003.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2996-3003
    • Bryl, E.1    Vallejo, A.N.2    Matteson, E.L.3    Witkowski, J.M.4    Weyand, C.M.5    Goronzy, J.J.6
  • 20
    • 76249100899 scopus 로고    scopus 로고
    • Age-related alterations of gene expression patterns in human CD8+ T cells
    • Cao, J.N., Gollapudi, S., Sharman, E.H., Jia, Z., Gupta, S., Age-related alterations of gene expression patterns in human CD8+ T cells. Aging Cell 9 (2010), 19–31.
    • (2010) Aging Cell , vol.9 , pp. 19-31
    • Cao, J.N.1    Gollapudi, S.2    Sharman, E.H.3    Jia, Z.4    Gupta, S.5
  • 21
    • 84862901641 scopus 로고    scopus 로고
    • Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95
    • Carney, E.F., Srinivasan, V., Moss, P.A., Taylor, A.M., Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95. J. Immunol. 189 (2012), 261–268.
    • (2012) J. Immunol. , vol.189 , pp. 261-268
    • Carney, E.F.1    Srinivasan, V.2    Moss, P.A.3    Taylor, A.M.4
  • 22
    • 84959559428 scopus 로고    scopus 로고
    • Purinergic regulation of the immune system
    • Cekic, C., Linden, J., Purinergic regulation of the immune system. Nat. Rev. Immunol. 16 (2016), 177–192.
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 177-192
    • Cekic, C.1    Linden, J.2
  • 23
    • 84883826522 scopus 로고    scopus 로고
    • T cell aging: a review of the transcriptional changes determined from genome-wide analysis
    • Chen, G., Lustig, A., Weng, N.P., T cell aging: a review of the transcriptional changes determined from genome-wide analysis. Front. Immunol., 4, 2013, 121.
    • (2013) Front. Immunol. , vol.4 , pp. 121
    • Chen, G.1    Lustig, A.2    Weng, N.P.3
  • 26
    • 0242495755 scopus 로고    scopus 로고
    • Cutting edge: long-term B cell memory in humans after smallpox vaccination
    • Crotty, S., Felgner, P., Davies, H., Glidewell, J., Villarreal, L., Ahmed, R., Cutting edge: long-term B cell memory in humans after smallpox vaccination. J. Immunol. 171 (2003), 4969–4973.
    • (2003) J. Immunol. , vol.171 , pp. 4969-4973
    • Crotty, S.1    Felgner, P.2    Davies, H.3    Glidewell, J.4    Villarreal, L.5    Ahmed, R.6
  • 31
    • 84907223820 scopus 로고    scopus 로고
    • Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly
    • Derhovanessian, E., Maier, A.B., Hähnel, K., McElhaney, J.E., Slagboom, E.P., Pawelec, G., Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly. J. Immunol. 193 (2014), 3624–3631.
    • (2014) J. Immunol. , vol.193 , pp. 3624-3631
    • Derhovanessian, E.1    Maier, A.B.2    Hähnel, K.3    McElhaney, J.E.4    Slagboom, E.P.5    Pawelec, G.6
  • 32
    • 84937437691 scopus 로고    scopus 로고
    • Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice
    • Deshpande, N.R., Parrish, H.L., Kuhns, M.S., Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice. eLife, 4, 2015, e05949.
    • (2015) eLife , vol.4 , pp. e05949
    • Deshpande, N.R.1    Parrish, H.L.2    Kuhns, M.S.3
  • 33
    • 84954529730 scopus 로고    scopus 로고
    • Fluctuating fitness shapes the clone-size distribution of immune repertoires
    • Desponds, J., Mora, T., Walczak, A.M., Fluctuating fitness shapes the clone-size distribution of immune repertoires. Proc. Natl. Acad. Sci. USA 113 (2016), 274–279.
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. 274-279
    • Desponds, J.1    Mora, T.2    Walczak, A.M.3
  • 36
    • 85009260860 scopus 로고    scopus 로고
    • Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis
    • Domnich, A., Arata, L., Amicizia, D., Puig-Barberà, J., Gasparini, R., Panatto, D., Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis. Vaccine 35 (2017), 513–520.
    • (2017) Vaccine , vol.35 , pp. 513-520
    • Domnich, A.1    Arata, L.2    Amicizia, D.3    Puig-Barberà, J.4    Gasparini, R.5    Panatto, D.6
  • 38
    • 84893710050 scopus 로고    scopus 로고
    • Human memory T cells: generation, compartmentalization and homeostasis
    • Farber, D.L., Yudanin, N.A., Restifo, N.P., Human memory T cells: generation, compartmentalization and homeostasis. Nat. Rev. Immunol. 14 (2014), 24–35.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 24-35
    • Farber, D.L.1    Yudanin, N.A.2    Restifo, N.P.3
  • 45
    • 84925428013 scopus 로고    scopus 로고
    • Narrowing of human influenza A virus-specific T cell receptor α and β repertoires with increasing age
    • Gil, A., Yassai, M.B., Naumov, Y.N., Selin, L.K., Narrowing of human influenza A virus-specific T cell receptor α and β repertoires with increasing age. J. Virol. 89 (2015), 4102–4116.
    • (2015) J. Virol. , vol.89 , pp. 4102-4116
    • Gil, A.1    Yassai, M.B.2    Naumov, Y.N.3    Selin, L.K.4
  • 46
    • 1642462959 scopus 로고    scopus 로고
    • T cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cells
    • Gomez, I., Marx, F., Gould, E.A., Grubeck-Loebenstein, B., T cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cells. Exp. Gerontol. 39 (2004), 597–605.
    • (2004) Exp. Gerontol. , vol.39 , pp. 597-605
    • Gomez, I.1    Marx, F.2    Gould, E.A.3    Grubeck-Loebenstein, B.4
  • 48
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • Goronzy, J.J., Weyand, C.M., Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 14 (2013), 428–436.
    • (2013) Nat. Immunol. , vol.14 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2
  • 49
    • 0035202615 scopus 로고    scopus 로고
    • Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    • Goronzy, J.J., Fulbright, J.W., Crowson, C.S., Poland, G.A., O'Fallon, W.M., Weyand, C.M., Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J. Virol. 75 (2001), 12182–12187.
    • (2001) J. Virol. , vol.75 , pp. 12182-12187
    • Goronzy, J.J.1    Fulbright, J.W.2    Crowson, C.S.3    Poland, G.A.4    O'Fallon, W.M.5    Weyand, C.M.6
  • 50
    • 84947738985 scopus 로고    scopus 로고
    • High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
    • Goronzy, J.J., Qi, Q., Olshen, R.A., Weyand, C.M., High-throughput sequencing insights into T-cell receptor repertoire diversity in aging. Genome Med., 7, 2015, 117.
    • (2015) Genome Med. , vol.7 , pp. 117
    • Goronzy, J.J.1    Qi, Q.2    Olshen, R.A.3    Weyand, C.M.4
  • 51
    • 0029128905 scopus 로고
    • The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature
    • Gross, P.A., Hermogenes, A.W., Sacks, H.S., Lau, J., Levandowski, R.A., The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature. Ann. Intern. Med. 123 (1995), 518–527.
    • (1995) Ann. Intern. Med. , vol.123 , pp. 518-527
    • Gross, P.A.1    Hermogenes, A.W.2    Sacks, H.S.3    Lau, J.4    Levandowski, R.A.5
  • 52
    • 84898775328 scopus 로고    scopus 로고
    • Role of dendritic cells in innate and adaptive immune response in human aging
    • Gupta, S., Role of dendritic cells in innate and adaptive immune response in human aging. Exp. Gerontol. 54 (2014), 47–52.
    • (2014) Exp. Gerontol. , vol.54 , pp. 47-52
    • Gupta, S.1
  • 54
    • 63049130261 scopus 로고    scopus 로고
    • Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
    • Haines, C.J., Giffon, T.D., Lu, L.S., Lu, X., Tessier-Lavigne, M., Ross, D.T., Lewis, D.B., Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J. Exp. Med. 206 (2009), 275–285.
    • (2009) J. Exp. Med. , vol.206 , pp. 275-285
    • Haines, C.J.1    Giffon, T.D.2    Lu, L.S.3    Lu, X.4    Tessier-Lavigne, M.5    Ross, D.T.6    Lewis, D.B.7
  • 58
    • 33744484987 scopus 로고    scopus 로고
    • Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors
    • Henel, G., Singh, K., Cui, D., Pryshchep, S., Lee, W.W., Weyand, C.M., Goronzy, J.J., Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors. Blood 107 (2006), 4449–4457.
    • (2006) Blood , vol.107 , pp. 4449-4457
    • Henel, G.1    Singh, K.2    Cui, D.3    Pryshchep, S.4    Lee, W.W.5    Weyand, C.M.6    Goronzy, J.J.7
  • 59
    • 84865306843 scopus 로고    scopus 로고
    • Properties of end-stage human T cells defined by CD45RA re-expression
    • Henson, S.M., Riddell, N.E., Akbar, A.N., Properties of end-stage human T cells defined by CD45RA re-expression. Curr. Opin. Immunol. 24 (2012), 476–481.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 476-481
    • Henson, S.M.1    Riddell, N.E.2    Akbar, A.N.3
  • 61
    • 84929659679 scopus 로고    scopus 로고
    • Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways
    • Henson, S.M., Macaulay, R., Riddell, N.E., Nunn, C.J., Akbar, A.N., Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways. Eur. J. Immunol. 45 (2015), 1441–1451.
    • (2015) Eur. J. Immunol. , vol.45 , pp. 1441-1451
    • Henson, S.M.1    Macaulay, R.2    Riddell, N.E.3    Nunn, C.J.4    Akbar, A.N.5
  • 64
    • 25844467829 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review
    • Jefferson, T., Rivetti, D., Rivetti, A., Rudin, M., Di Pietrantonj, C., Demicheli, V., Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet 366 (2005), 1165–1174.
    • (2005) Lancet , vol.366 , pp. 1165-1174
    • Jefferson, T.1    Rivetti, D.2    Rivetti, A.3    Rudin, M.4    Di Pietrantonj, C.5    Demicheli, V.6
  • 65
    • 84871835297 scopus 로고    scopus 로고
    • Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age
    • Johnson, P.L., Yates, A.J., Goronzy, J.J., Antia, R., Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age. Proc. Natl. Acad. Sci. USA 109 (2012), 21432–21437.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 21432-21437
    • Johnson, P.L.1    Yates, A.J.2    Goronzy, J.J.3    Antia, R.4
  • 66
    • 0037103256 scopus 로고    scopus 로고
    • Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
    • Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J.A., Sinclair, A.J., Nayak, L., Moss, P.A., Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169 (2002), 1984–1992.
    • (2002) J. Immunol. , vol.169 , pp. 1984-1992
    • Khan, N.1    Shariff, N.2    Cobbold, M.3    Bruton, R.4    Ainsworth, J.A.5    Sinclair, A.J.6    Nayak, L.7    Moss, P.A.8
  • 68
    • 0037128660 scopus 로고    scopus 로고
    • Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    • Kimmig, S., Przybylski, G.K., Schmidt, C.A., Laurisch, K., Möwes, B., Radbruch, A., Thiel, A., Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195 (2002), 789–794.
    • (2002) J. Exp. Med. , vol.195 , pp. 789-794
    • Kimmig, S.1    Przybylski, G.K.2    Schmidt, C.A.3    Laurisch, K.4    Möwes, B.5    Radbruch, A.6    Thiel, A.7
  • 69
    • 84857777282 scopus 로고    scopus 로고
    • Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates
    • Kwissa, M., Nakaya, H.I., Oluoch, H., Pulendran, B., Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. Blood 119 (2012), 2044–2055.
    • (2012) Blood , vol.119 , pp. 2044-2055
    • Kwissa, M.1    Nakaya, H.I.2    Oluoch, H.3    Pulendran, B.4
  • 70
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages, C.S., Suffia, I., Velilla, P.A., Huang, B., Warshaw, G., Hildeman, D.A., Belkaid, Y., Chougnet, C., Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 181 (2008), 1835–1848.
    • (2008) J. Immunol. , vol.181 , pp. 1835-1848
    • Lages, C.S.1    Suffia, I.2    Velilla, P.A.3    Huang, B.4    Warshaw, G.5    Hildeman, D.A.6    Belkaid, Y.7    Chougnet, C.8
  • 71
    • 77951473037 scopus 로고    scopus 로고
    • Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages
    • Lamar, D.L., Weyand, C.M., Goronzy, J.J., Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages. Blood 115 (2010), 3278–3286.
    • (2010) Blood , vol.115 , pp. 3278-3286
    • Lamar, D.L.1    Weyand, C.M.2    Goronzy, J.J.3
  • 72
    • 84922056020 scopus 로고    scopus 로고
    • The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
    • Lanna, A., Henson, S.M., Escors, D., Akbar, A.N., The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat. Immunol. 15 (2014), 965–972.
    • (2014) Nat. Immunol. , vol.15 , pp. 965-972
    • Lanna, A.1    Henson, S.M.2    Escors, D.3    Akbar, A.N.4
  • 73
    • 84936980441 scopus 로고    scopus 로고
    • Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach
    • Laydon, D.J., Bangham, C.R., Asquith, B., Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach. Philos. Trans. R. Soc. Lond. B Biol. Sci., 370, 2015, 370.
    • (2015) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.370 , pp. 370
    • Laydon, D.J.1    Bangham, C.R.2    Asquith, B.3
  • 75
    • 84892818946 scopus 로고    scopus 로고
    • Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
    • Le Page, A., Fortin, C., Garneau, H., Allard, N., Tsvetkova, K., Tan, C.T., Larbi, A., Dupuis, G., Fülöp, T., Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly. Cell Commun. Signal., 12, 2014, 2.
    • (2014) Cell Commun. Signal. , vol.12 , pp. 2
    • Le Page, A.1    Fortin, C.2    Garneau, H.3    Allard, N.4    Tsvetkova, K.5    Tan, C.T.6    Larbi, A.7    Dupuis, G.8    Fülöp, T.9
  • 78
    • 84865296093 scopus 로고    scopus 로고
    • Immune senescence and vaccines to prevent herpes zoster in older persons
    • Levin, M.J., Immune senescence and vaccines to prevent herpes zoster in older persons. Curr. Opin. Immunol. 24 (2012), 494–500.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 494-500
    • Levin, M.J.1
  • 79
    • 0242552003 scopus 로고    scopus 로고
    • Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine
    • Levin, M.J., Smith, J.G., Kaufhold, R.M., Barber, D., Hayward, A.R., Chan, C.Y., Chan, I.S., Li, D.J., Wang, W., Keller, P.M., et al. Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine. J. Infect. Dis. 188 (2003), 1336–1344.
    • (2003) J. Infect. Dis. , vol.188 , pp. 1336-1344
    • Levin, M.J.1    Smith, J.G.2    Kaufhold, R.M.3    Barber, D.4    Hayward, A.R.5    Chan, C.Y.6    Chan, I.S.7    Li, D.J.8    Wang, W.9    Keller, P.M.10
  • 81
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li, G., Yu, M., Lee, W.W., Tsang, M., Krishnan, E., Weyand, C.M., Goronzy, J.J., Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat. Med. 18 (2012), 1518–1524.
    • (2012) Nat. Med. , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3    Tsang, M.4    Krishnan, E.5    Weyand, C.M.6    Goronzy, J.J.7
  • 82
    • 84937680792 scopus 로고    scopus 로고
    • Age-associated failure to adjust type I IFN receptor signaling thresholds after T cell activation
    • Li, G., Ju, J., Weyand, C.M., Goronzy, J.J., Age-associated failure to adjust type I IFN receptor signaling thresholds after T cell activation. J. Immunol. 195 (2015), 865–874.
    • (2015) J. Immunol. , vol.195 , pp. 865-874
    • Li, G.1    Ju, J.2    Weyand, C.M.3    Goronzy, J.J.4
  • 83
    • 84961254556 scopus 로고    scopus 로고
    • TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition
    • Li, H.M., Hiroi, T., Zhang, Y., Shi, A., Chen, G., De, S., Metter, E.J., Wood, W.H. 3rd, Sharov, A., Milner, J.D., et al. TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J. Leukoc. Biol. 99 (2016), 505–513.
    • (2016) J. Leukoc. Biol. , vol.99 , pp. 505-513
    • Li, H.M.1    Hiroi, T.2    Zhang, Y.3    Shi, A.4    Chen, G.5    De, S.6    Metter, E.J.7    Wood, W.H.8    Sharov, A.9    Milner, J.D.10
  • 84
    • 84994890342 scopus 로고    scopus 로고
    • Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis
    • Li, Y., Shen, Y., Hohensinner, P., Ju, J., Wen, Z., Goodman, S.B., Zhang, H., Goronzy, J.J., Weyand, C.M., Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis. Immunity 45 (2016), 903–916.
    • (2016) Immunity , vol.45 , pp. 903-916
    • Li, Y.1    Shen, Y.2    Hohensinner, P.3    Ju, J.4    Wen, Z.5    Goodman, S.B.6    Zhang, H.7    Goronzy, J.J.8    Weyand, C.M.9
  • 85
    • 84924925651 scopus 로고    scopus 로고
    • Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions
    • Lin, Y., Damjanovic, A., Metter, E.J., Nguyen, H., Truong, T., Najarro, K., Morris, C., Longo, D.L., Zhan, M., Ferrucci, L., et al. Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin. Sci. 128 (2015), 367–377.
    • (2015) Clin. Sci. , vol.128 , pp. 367-377
    • Lin, Y.1    Damjanovic, A.2    Metter, E.J.3    Nguyen, H.4    Truong, T.5    Najarro, K.6    Morris, C.7    Longo, D.L.8    Zhan, M.9    Ferrucci, L.10
  • 86
    • 84891760313 scopus 로고    scopus 로고
    • How T follicular helper cells and the germinal centre response change with age
    • Linterman, M.A., How T follicular helper cells and the germinal centre response change with age. Immunol. Cell Biol. 92 (2014), 72–79.
    • (2014) Immunol. Cell Biol. , vol.92 , pp. 72-79
    • Linterman, M.A.1
  • 92
    • 84927750142 scopus 로고    scopus 로고
    • Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults
    • Mohanty, S., Joshi, S.R., Ueda, I., Wilson, J., Blevins, T.P., Siconolfi, B., Meng, H., Devine, L., Raddassi, K., Tsang, S., et al. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J. Infect. Dis. 211 (2015), 1174–1184.
    • (2015) J. Infect. Dis. , vol.211 , pp. 1174-1184
    • Mohanty, S.1    Joshi, S.R.2    Ueda, I.3    Wilson, J.4    Blevins, T.P.5    Siconolfi, B.6    Meng, H.7    Devine, L.8    Raddassi, K.9    Tsang, S.10
  • 96
    • 84963631903 scopus 로고    scopus 로고
    • Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures
    • Nakaya, H.I., Hagan, T., Duraisingham, S.S., Lee, E.K., Kwissa, M., Rouphael, N., Frasca, D., Gersten, M., Mehta, A.K., Gaujoux, R., et al. Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures. Immunity 43 (2015), 1186–1198.
    • (2015) Immunity , vol.43 , pp. 1186-1198
    • Nakaya, H.I.1    Hagan, T.2    Duraisingham, S.S.3    Lee, E.K.4    Kwissa, M.5    Rouphael, N.6    Frasca, D.7    Gersten, M.8    Mehta, A.K.9    Gaujoux, R.10
  • 98
    • 84974815462 scopus 로고    scopus 로고
    • The Hayflick limit may determine the effective clonal diversity of naive T cells
    • Ndifon, W., Dushoff, J., The Hayflick limit may determine the effective clonal diversity of naive T cells. J. Immunol. 196 (2016), 4999–5004.
    • (2016) J. Immunol. , vol.196 , pp. 4999-5004
    • Ndifon, W.1    Dushoff, J.2
  • 99
    • 84856278095 scopus 로고    scopus 로고
    • Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
    • Newell, E.W., Sigal, N., Bendall, S.C., Nolan, G.P., Davis, M.M., Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity 36 (2012), 142–152.
    • (2012) Immunity , vol.36 , pp. 142-152
    • Newell, E.W.1    Sigal, N.2    Bendall, S.C.3    Nolan, G.P.4    Davis, M.M.5
  • 100
    • 84921634186 scopus 로고    scopus 로고
    • Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories
    • Nikolich-Žugich, J., Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J. Immunol. 193 (2014), 2622–2629.
    • (2014) J. Immunol. , vol.193 , pp. 2622-2629
    • Nikolich-Žugich, J.1
  • 101
    • 84959346767 scopus 로고    scopus 로고
    • Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: A systematic review and meta-analysis
    • Nishijima, T.F., Muss, H.B., Shachar, S.S., Moschos, S.J., Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: A systematic review and meta-analysis. Cancer Treat. Rev. 45 (2016), 30–37.
    • (2016) Cancer Treat. Rev. , vol.45 , pp. 30-37
    • Nishijima, T.F.1    Muss, H.B.2    Shachar, S.S.3    Moschos, S.J.4
  • 102
    • 3142546949 scopus 로고    scopus 로고
    • De novo T-cell generation in patients at different ages and stages of HIV-1 disease
    • Nobile, M., Correa, R., Borghans, J.A., D'Agostino, C., Schneider, P., De Boer, R.J., Pantaleo, G., Swiss HIV Cohort Study. De novo T-cell generation in patients at different ages and stages of HIV-1 disease. Blood 104 (2004), 470–477.
    • (2004) Blood , vol.104 , pp. 470-477
    • Nobile, M.1    Correa, R.2    Borghans, J.A.3    D'Agostino, C.4    Schneider, P.5    De Boer, R.J.6    Pantaleo, G.7
  • 103
    • 44649127931 scopus 로고    scopus 로고
    • Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection
    • Obar, J.J., Khanna, K.M., Lefrançois, L., Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity 28 (2008), 859–869.
    • (2008) Immunity , vol.28 , pp. 859-869
    • Obar, J.J.1    Khanna, K.M.2    Lefrançois, L.3
  • 104
    • 84885402793 scopus 로고    scopus 로고
    • The effect of age on thymic function
    • Palmer, D.B., The effect of age on thymic function. Front. Immunol., 4, 2013, 316.
    • (2013) Front. Immunol. , vol.4 , pp. 316
    • Palmer, D.B.1
  • 107
    • 85006160492 scopus 로고    scopus 로고
    • Convergence of innate and adaptive immunity during human aging
    • Pereira, B.I., Akbar, A.N., Convergence of innate and adaptive immunity during human aging. Front. Immunol., 7, 2016, 445.
    • (2016) Front. Immunol. , vol.7 , pp. 445
    • Pereira, B.I.1    Akbar, A.N.2
  • 110
    • 34447260501 scopus 로고    scopus 로고
    • The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire
    • Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., Moss, P.A., The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire. J. Virol. 81 (2007), 7759–7765.
    • (2007) J. Virol. , vol.81 , pp. 7759-7765
    • Pourgheysari, B.1    Khan, N.2    Best, D.3    Bruton, R.4    Nayak, L.5    Moss, P.A.6
  • 116
    • 84891060089 scopus 로고    scopus 로고
    • Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging
    • Renkema, K.R., Li, G., Wu, A., Smithey, M.J., Nikolich-Žugich, J., Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J. Immunol. 192 (2014), 151–159.
    • (2014) J. Immunol. , vol.192 , pp. 151-159
    • Renkema, K.R.1    Li, G.2    Wu, A.3    Smithey, M.J.4    Nikolich-Žugich, J.5
  • 117
    • 0036216138 scopus 로고    scopus 로고
    • Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons
    • Reuben, D.B., Cheh, A.I., Harris, T.B., Ferrucci, L., Rowe, J.W., Tracy, R.P., Seeman, T.E., Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J. Am. Geriatr. Soc. 50 (2002), 638–644.
    • (2002) J. Am. Geriatr. Soc. , vol.50 , pp. 638-644
    • Reuben, D.B.1    Cheh, A.I.2    Harris, T.B.3    Ferrucci, L.4    Rowe, J.W.5    Tracy, R.P.6    Seeman, T.E.7
  • 121
    • 14044278803 scopus 로고    scopus 로고
    • Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients
    • Rowshani, A.T., Bemelman, F.J., van Leeuwen, E.M., van Lier, R.A., ten Berge, I.J., Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation 79 (2005), 381–386.
    • (2005) Transplantation , vol.79 , pp. 381-386
    • Rowshani, A.T.1    Bemelman, F.J.2    van Leeuwen, E.M.3    van Lier, R.A.4    ten Berge, I.J.5
  • 125
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl, M., Lung, T.L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., Grubeck-Loebenstein, B., Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 168 (2002), 5893–5899.
    • (2002) J. Immunol. , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3    Gschösser, C.4    Asch, E.5    Blasko, I.6    Parson, W.7    Böck, G.8    Schönitzer, D.9    Trannoy, E.10    Grubeck-Loebenstein, B.11
  • 132
    • 79952115866 scopus 로고    scopus 로고
    • DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis
    • Shao, L., Goronzy, J.J., Weyand, C.M., DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol. Med. 2 (2010), 415–427.
    • (2010) EMBO Mol. Med. , vol.2 , pp. 415-427
    • Shao, L.1    Goronzy, J.J.2    Weyand, C.M.3
  • 134
    • 0012950854 scopus 로고    scopus 로고
    • Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
    • Son, N.H., Murray, S., Yanovski, J., Hodes, R.J., Weng, N., Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J. Immunol. 165 (2000), 1191–1196.
    • (2000) J. Immunol. , vol.165 , pp. 1191-1196
    • Son, N.H.1    Murray, S.2    Yanovski, J.3    Hodes, R.J.4    Weng, N.5
  • 135
    • 0037338890 scopus 로고    scopus 로고
    • TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
    • Stefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W.E., Germain, R.N., TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat. Immunol. 4 (2003), 248–254.
    • (2003) Nat. Immunol. , vol.4 , pp. 248-254
    • Stefanová, I.1    Hemmer, B.2    Vergelli, M.3    Martin, R.4    Biddison, W.E.5    Germain, R.N.6
  • 136
    • 84884169197 scopus 로고    scopus 로고
    • Immunosenescence: a product of the environment?
    • Su, D.M., Aw, D., Palmer, D.B., Immunosenescence: a product of the environment?. Curr. Opin. Immunol. 25 (2013), 498–503.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 498-503
    • Su, D.M.1    Aw, D.2    Palmer, D.B.3
  • 137
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    • Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., Kirkland, J.L., Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J. Clin. Invest. 123 (2013), 966–972.
    • (2013) J. Clin. Invest. , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 140
    • 70849110194 scopus 로고    scopus 로고
    • Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
    • Tsukamoto, H., Clise-Dwyer, K., Huston, G.E., Duso, D.K., Buck, A.L., Johnson, L.L., Haynes, L., Swain, S.L., Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. USA 106 (2009), 18333–18338.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 18333-18338
    • Tsukamoto, H.1    Clise-Dwyer, K.2    Huston, G.E.3    Duso, D.K.4    Buck, A.L.5    Johnson, L.L.6    Haynes, L.7    Swain, S.L.8
  • 144
    • 33749513413 scopus 로고    scopus 로고
    • Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virus-specific CD8+ T cells
    • van Leeuwen, E.M., Koning, J.J., Remmerswaal, E.B., van Baarle, D., van Lier, R.A., ten Berge, I.J., Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virus-specific CD8+ T cells. J. Immunol. 177 (2006), 4998–5005.
    • (2006) J. Immunol. , vol.177 , pp. 4998-5005
    • van Leeuwen, E.M.1    Koning, J.J.2    Remmerswaal, E.B.3    van Baarle, D.4    van Lier, R.A.5    ten Berge, I.J.6
  • 149
    • 84859485913 scopus 로고    scopus 로고
    • T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection
    • Wang, G.C., Dash, P., McCullers, J.A., Doherty, P.C., Thomas, P.G., T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection. Sci. Transl. Med., 4, 2012, 128ra42.
    • (2012) Sci. Transl. Med. , vol.4 , pp. 128ra42
    • Wang, G.C.1    Dash, P.2    McCullers, J.A.3    Doherty, P.C.4    Thomas, P.G.5
  • 150
    • 0035147101 scopus 로고    scopus 로고
    • CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems
    • Warrington, K.J., Takemura, S., Goronzy, J.J., Weyand, C.M., CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum. 44 (2001), 13–20.
    • (2001) Arthritis Rheum. , vol.44 , pp. 13-20
    • Warrington, K.J.1    Takemura, S.2    Goronzy, J.J.3    Weyand, C.M.4
  • 156
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry, E.J., T cell exhaustion. Nat. Immunol. 12 (2011), 492–499.
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 158
    • 84884148864 scopus 로고    scopus 로고
    • Impact of aging on antigen presentation cell function of dendritic cells
    • Wong, C., Goldstein, D.R., Impact of aging on antigen presentation cell function of dendritic cells. Curr. Opin. Immunol. 25 (2013), 535–541.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 535-541
    • Wong, C.1    Goldstein, D.R.2
  • 159
    • 84893386522 scopus 로고    scopus 로고
    • Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection
    • Wu, T., Hu, Y., Lee, Y.T., Bouchard, K.R., Benechet, A., Khanna, K., Cauley, L.S., Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection. J. Leukoc. Biol. 95 (2014), 215–224.
    • (2014) J. Leukoc. Biol. , vol.95 , pp. 215-224
    • Wu, T.1    Hu, Y.2    Lee, Y.T.3    Bouchard, K.R.4    Benechet, A.5    Khanna, K.6    Cauley, L.S.7
  • 160
    • 41149170727 scopus 로고    scopus 로고
    • Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
    • Yager, E.J., Ahmed, M., Lanzer, K., Randall, T.D., Woodland, D.L., Blackman, M.A., Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 205 (2008), 711–723.
    • (2008) J. Exp. Med. , vol.205 , pp. 711-723
    • Yager, E.J.1    Ahmed, M.2    Lanzer, K.3    Randall, T.D.4    Woodland, D.L.5    Blackman, M.A.6
  • 161
    • 84885448124 scopus 로고    scopus 로고
    • Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
    • Yang, Z., Fujii, H., Mohan, S.V., Goronzy, J.J., Weyand, C.M., Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J. Exp. Med. 210 (2013), 2119–2134.
    • (2013) J. Exp. Med. , vol.210 , pp. 2119-2134
    • Yang, Z.1    Fujii, H.2    Mohan, S.V.3    Goronzy, J.J.4    Weyand, C.M.5
  • 162
    • 84961841635 scopus 로고    scopus 로고
    • Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis
    • Yang, Z., Shen, Y., Oishi, H., Matteson, E.L., Tian, L., Goronzy, J.J., Weyand, C.M., Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci. Transl. Med., 8, 2016, 331ra38.
    • (2016) Sci. Transl. Med. , vol.8 , pp. 331ra38
    • Yang, Z.1    Shen, Y.2    Oishi, H.3    Matteson, E.L.4    Tian, L.5    Goronzy, J.J.6    Weyand, C.M.7
  • 163
    • 84859574715 scopus 로고    scopus 로고
    • Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
    • Yu, M., Li, G., Lee, W.W., Yuan, M., Cui, D., Weyand, C.M., Goronzy, J.J., Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc. Natl. Acad. Sci. USA 109 (2012), E879–E888.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E879-E888
    • Yu, M.1    Li, G.2    Lee, W.W.3    Yuan, M.4    Cui, D.5    Weyand, C.M.6    Goronzy, J.J.7
  • 164
    • 84973557311 scopus 로고    scopus 로고
    • Mathematical model reveals the role of memory CD8 T cell populations in recall responses to influenza
    • Zarnitsyna, V.I., Handel, A., McMaster, S.R., Hayward, S.L., Kohlmeier, J.E., Antia, R., Mathematical model reveals the role of memory CD8 T cell populations in recall responses to influenza. Front. Immunol., 7, 2016, 165.
    • (2016) Front. Immunol. , vol.7 , pp. 165
    • Zarnitsyna, V.I.1    Handel, A.2    McMaster, S.R.3    Hayward, S.L.4    Kohlmeier, J.E.5    Antia, R.6


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