Homeostasis of the naive CD4+ T cell compartment during aging

Journal of Immunology

Volumn 180, Issue 3, 2008, Pages 1499-1507

  Kilpatrick, Ryan D ^a,b   Rickabaugh, Tammy ^a   Hultin, Lance E ^a   Hultin, Patricia ^a   Hausner, Mary Ann ^a   Detels, Roger ^b   Phair, John ^c   Jamieson, Beth D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD45RA ANTIGEN; CD45 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGING; ARTICLE; CD4+ T LYMPHOCYTE; CELL AGING; CELL EXPANSION; CELL LOSS; CELL PROLIFERATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HOMEOSTASIS; HUMAN; LONGITUDINAL STUDY; MALE; PRIORITY JOURNAL; AGED; IMMUNOLOGY; METABOLISM; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION; TELOMERE; THYMUS;

ADULT; AGED; AGING; ANTIGENS, CD31; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HOMEOSTASIS; HUMANS; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TELOMERE; THYMUS GLAND;

EID: 40749132135     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.3.1499     Document Type: Article

References (52)

1. Aspinall, R., and D. Andrew. 2000. Thymic involution in aging. J. Clin. Immunol. 20: 250-256.
2. Flores, K. G., J. Li, G. D. Sempowski, B. F. Haynes, and L. P. Hale. 1999. Analysis of the human thymic perivascular space during aging. J. Clin. Invest. 104: 1031-1039.
3. Douek, D. C., R. D. McFarland, P. H. Keiser, E. A. Gage, J. M. Massey, B. F. Haynes, M. A. Polis, A. T. Haase, M. B. Feinberg, J. L. Sullivan, et al. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396: 690-695.
4. Jamieson, B. D., D. C. Douek, S. Killian, L. E. Hultin, D. D. Scripture-Adams, J. V. Giorgi, D. Marelli, R. A. Koup, and J. A. Zack. 1999. Generation of functional thymocytes in the human adult. Immunity 10: 569-575.
5. Bertho, J. M., C. Demarquay, N. Moulian, M. A. Van Der, S. Berrih-Aknin, and P. Gourmelon. 1997. Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life. Cell. Immunol. 179: 30-40.
6. Poulin, J. F., M. N. Viswanathan, J. M. Harris, K. V. Komanduri, E. Wieder, N. Ringuette, M. Jenkins, J. M. McCune, and R. P. Sekaly. 1999. Direct evidence for thymic function in adult humans. J. Exp. Med. 190: 479-486.
7. Al Harthi, L., G. Marchetti, C. M. Steffens, J. Poulin, R. Sekaly, and A. Landay. 2000. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). J. Immunol. Methods 237: 187-197.
8. Haynes, B. F., M. L. Markert, G. D. Sempowski, D. D. Patel, and L. P. Hale. 2000. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18: 529-560.
9. Nobile, M., R. Correa, J. A. Borghans, C. D'Agostino, P. Schneider, R. J. de Boer, and G. Pantaleo. 2004. De novo T-cell generation in patients at different ages and stages of HIV-1 disease. Blood 104: 470-477.
10. Steffens, C. M., K. Y. Smith, A. Landay, S. Shott, A. Truckenbrod, M. Russert, and L. Al Harthi. 2001. T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals. AIDS 15: 1881-1882.
11. Ye, P., A. P. Kourtis, and D. E. Kirschner. 2003. Reconstitution of thymic function in HIV-1 patients treated with highly active antiretroviral therapy. Clin. Immunol. 106: 95-105.
12. Zhang, L., S. R. Lewin, M. Markowitz, H. H. Lin, E. Skulsky, R. Karanicolas, Y. He, X. Jin, S. Tuttleton, M. Vesanen, et al. 1999. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J. Exp. Med. 190: 725-732.
13. Naylor, K., G. Li, A. N. Vallejo, W. W. Lee, K. Koetz, E. Bryl, J. Witkowski, J. Fulbright, C. M. Weyand, and J. J. Goronzy. 2005. The influence of age on T cell generation and TCR diversity. J. Immunol. 174: 7446-7452.
14. Kieper, W. C., J. T. Burghardt, and C. D. Surh. 2004. A role for TCR affinity in regulating naive T cell homeostasis. J. Immunol. 172: 40-44.
15. Kieper, W. C., A. Troy, J. T. Burghardt, C. Ramsey, J. Y. Lee, H. Q. Jiang, W. Dummer, H. Shen, J. J. Cebra, and C. D. Surh. 2005. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol. 174: 3158-3163.
16. Seddon, B., and R. Zamoyska. 2003. Regulation of peripheral T-cell homeostasis by receptor signalling. Curr. Opin. Immunol. 15: 321-324.
17. O'Neill, R. M., J. Hassan, and D. J. Reen. 2003. IL-7-regulated homeostatic maintenance of recent thymic emigrants in association with caspase-mediated cell proliferation and apoptotic cell death. J. Immunol. 170: 4524-4531.
18. + T cells enables preservation of a naive repertoire. J. Immunol. 161: 5909-5917.
19. Tan, J. T., E. Dudl, E. LeRoy, R. Murray, J. Sprent, K. I. Weinberg, and C. D. Surh. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. USA 98: 8732-8737.
20. Aggarwal, S., and S. Gupta. 1998. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J. Immunol. 160: 1627-1637.
21. Donnini, A., F. Re, M. Bollettini, R. Moresi, S. Tesei, G. Bernardini, and M. Provinciali. 2005. Age-related susceptibility of naive and memory CD4 T cells to apoptosis induced by IL-2 deprivation or PHA addition. Biogerontology 6: 193-204.
22. Haynes, L. 2005. The effect of aging on cognate function and development of immune memory. Curr. Opin. Immunol. 17: 476-479.
23. Linton, P. J., and K. Dorshkind. 2004. Age-related changes in lymphocyte development and function. Nat. Immunol. 5: 133-139.
24. Linton, P. J., L. Haynes, N. R. Klinman, and S. L. Swain. 1996. Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 184: 1891-1900.
25. Miller, R. A. 2000. Effect of aging on T lymphocyte activation. Vaccine 18: 1654-1660.
26. + subsets. Mech. Ageing Dev. 123: 375-390.
27. Swain, S., K. Clise-Dwyer, and L. Haynes. 2005. Homeostasis and the age-associated defect of CD4 T cells. Semin. Immunol. 17: 370-377.
28. Stockinger, H., W. Schreiber, O. Majdic, W. Holter, D. Maurer, and W. Knapp. 1992. Phenotype of human T cells expressing CD31, a molecule of the immunoglobulin supergene family. Immunology 75: 53-58.
29. Torimoto, Y., D. M. Rothstein, N. H. Dang, S. F. Schlossman, and C. Morimoto. 1992. CD31, a novel cell surface marker for CD4 cells of suppressor lineage, unaltered by state of activation. J. Immunol. 148: 388-396.
30. + T-cell subsets characterized by coexpression of CD45RA and CD45RO isoforms. Blood 88: 3513-3521.
31. Thiel, A., J. Schmitz, S. Miltenyi, and A. Radbruch. 1997. CD45RA-expressing memory/effector Th cells committed to production of interferon-γ lack expression of CD31. Immunol. Lett. 57: 189-192.
32. Kimmig, S., G. K. Przybylski, C. A. Schmidt, K. Laurisch, B. Mowes, A. Radbruch, and A. Thiel. 2002. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195: 789-794.
33. Detels, R., A. Munoz, G. McFarlane, L. A. Kingsley, J. B. Margolick, J. Giorgi, L. K. Schrager, and J. P. Phair. 1998. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration: Multicenter AIDS Cohort Study Investigators. J. Am. Med. Assoc. 280: 1497-1503.
34. Killian, M. S., J. Monteiro, J. Matud, L. E. Hultin, M. A. Hausner, O. O. Yang, P. K. Gregersen, R. Detels, J. V. Giorgi, and B. D. Jamieson. 2004. Persistent alterations in the T-cell repertoires of HIV-1-infected and at-risk uninfected men. AIDS 18: 161-170.
35. Hultin, L., and P. Hultin. 2006. Flow cytometry-based immunophenotyping method and applications. In Manual of Molecular and Clinical Laboratory Immunology. B. Detrick, R. Hamilton, and J. Folds, eds. ASM Press, Washington, D.C., pp. 147-157.
36. Cawthon, R. M. 2002. Telomere measurement by quantitative PCR. Nucleic Acids Res. 30: e47.
37. Hultdin, M., E. Gronlund, K. Norrback, E. Eriksson-Lindstrom, T. Just, and G. Roos. 1998. Telomere analysis by fluorescence in situ hybridization and flow cytometry. Nucleic Acids Res. 26: 3651-3656.
38. Killian, M. S., J. Matud, R. Detels, J. V. Giorgi, and B. D. Jamieson. 2002. MaGiK method of T-cell receptor repertoire analysis. Clin. Diagn. Lab. Immunol. 9: 858-863.
39. Pham, T., M. Belzer, J. A. Church, C. Kitchen, C. M. Wilson, S. D. Douglas, Y. Geng, M. Silva, R. M. Mitchell, and P. Krogstad. 2003. Assessment of thymic activity in human immunodeficiency virus-negative and -positive adolescents by real-time PCR quantitation of T-cell receptor rearrangement excision circles. Clin. Diagn. Lab. Immunol. 10: 323-328.
40. + naive T cells in elderly persons. Mech. Ageing Dev. 124: 395-402.
41. Messele, T., M. Abdulkadir, A. L. Fontanet, B. Petros, D. Hamann, M. Koot, M. T. Roos, P. T. Schellekens, F. Miedema, and T. F. Rinke de Wit. 1999. Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin. Exp. Immunol. 115: 443-450.
42. + T cell subsets in adult allogeneic haematopoietic cell transplant recipients. Bone Marrow Transplant. 32: 609-616.
43. + T cells constrains the TCR repertoire in healthy human adults. Eur. J. Immunol. 35: 1987-1994.
44. Effros, R. B. 2000. Long-term immunological memory against viruses. Mech. Ageing Dev. 121: 161-171.
45. Webster, R. G. 2000. Immunity to influenza in the elderly. Vaccine 18: 1686-1689.
46. Herndler-Brandstetter, D., D. P. Cioca, and B. Grubeck-Loebenstein. 2006. Immunizations in the elderly: do they live up to their promise? Wien. Med. Wochenschr. 156: 130-141.
47. Globerson, A., and R. B. Effros. 2000. Ageing of lymphocytes and lymphocytes in the aged. Immunol. Today 21: 515-521.
48. Roth, A., H. Yssel, J. Pene, E. A. Chavez, M. Schertzer, P. M. Lansdorp, H. Spits, and R. M. Luiten. 2003. Telomerase levels control the lifespan of human T lymphocytes. Blood 102: 849-857.
49. Effros, R. B. 1998. Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly. Am. J. Hum. Genet. 62: 1003-1007.
50. Pfister, G., D. Weiskopf, L. Lazurdi, R. D. Kovaiou, D. P. Cioca, M. Keller, B. Lorbeg, W. Parson, and B. Grubeck-Loebenstein. 2006. Naive T cells in the elderly: are they still there? Ann. NY Acad. Sci. 1067: 152-157.
51. Weng, N., B. L. Levine, C. H. June, and R. J. Hodes. 1997. Regulation of telomerase RNA template expression in human T lymphocyte development and activation. J. Immunol. 158: 3215-3220.
52. Pawelec, G., S. Koch, C. Franceschi, and A. Wikby. 2006. Human immunosenescence: does it have an infectious component? Ann. NY Acad. Sci. 1067: 56-65.