Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

Cell Communication and Signaling

Volumn 12, Issue 1, 2014, Pages

  Le Page, Aurélie ^a   Fortin, Carl ^a,b   Garneau, Hugo ^a   Allard, Nancy ^a   Tsvetkova, Krassimira ^a   Tan, Crystal Tze Ying ^c   Larbi, Anis ^c   Dupuis, Gilles ^a   Fülöp, Tamas ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c AGENCY FOR SCIENCE   (Singapore)

Author keywords

Aging; Confocal microscopy; Lck; Lipid rafts; Protein tyrosine kinases; Protein tyrosine phosphatases; SHP 1; T cells; TCR CD28 signaling

Indexed keywords

CD28 ANTIGEN; CD45 ANTIGEN; INTERLEUKIN 2; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; REGULATOR PROTEIN; 2 AMINO 5H PYRIDO(3',2';5,6)THIOPYRANO(4,3 D)PYRIMIDINE; 2-AMINO-5H-PYRIDO(3',2';5,6)THIOPYRANO(4,3-D)PYRIMIDINE; ENZYME INHIBITOR; PTPN6 PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE;

AGED; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEREGULATION; DOWN REGULATION; ENZYMATIC ASSAY; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; LIPID RAFT; LYMPHOCYTE PROLIFERATION; NEGATIVE FEEDBACK; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SRC HOMOLOGY DOMAIN; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; WESTERN BLOTTING; ADULT; AGE; CELL MEMBRANE; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MUTATION;

MAMMALIA;

ADULT; AGE FACTORS; AGED; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MEMBRANE MICRODOMAINS; MUTATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PYRIMIDINES; T-LYMPHOCYTES;

EID: 84892818946     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-12-2     Document Type: Article

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