메뉴 건너뛰기




Volumn 29, Issue 1, 2014, Pages 105-111

Cellular signaling in the aging immune system

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 5; FREE RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; JANUS KINASE; LAT PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NFAT;

EID: 84902273600     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2014.05.007     Document Type: Review
Times cited : (123)

References (82)
  • 2
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
    • Solana R., Tarazona R., Inmaculada G., Lesur O., Dupuis G., Fülöp T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Sem Immunol 2012, 24:331-341.
    • (2012) Sem Immunol , vol.24 , pp. 331-341
    • Solana, R.1    Tarazona, R.2    Inmaculada, G.3    Lesur, O.4    Dupuis, G.5    Fülöp, T.6
  • 3
    • 84886033654 scopus 로고    scopus 로고
    • Human T cell aging and the impact of persistent viral infections
    • Fülöp T., Larbi A., Pawelec G. Human T cell aging and the impact of persistent viral infections. Front Immunol 2013, 4:271.
    • (2013) Front Immunol , vol.4 , pp. 271
    • Fülöp, T.1    Larbi, A.2    Pawelec, G.3
  • 5
    • 79955955068 scopus 로고    scopus 로고
    • Impact of age on T cell signaling: a general defect or specific alterations?
    • Larbi A., Pawelec G., Wong S.C., Goldeck D., Tai J.J., Fülöp T. Impact of age on T cell signaling: a general defect or specific alterations?. Ageing Res Rev 2011, 10:370-378.
    • (2011) Ageing Res Rev , vol.10 , pp. 370-378
    • Larbi, A.1    Pawelec, G.2    Wong, S.C.3    Goldeck, D.4    Tai, J.J.5    Fülöp, T.6
  • 6
    • 84892818946 scopus 로고    scopus 로고
    • Modulation of signaling in lymphocytes from elderly donors. Inhibition of SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
    • Le Page A., Fortin C., Garneau H., Allard N., Tsvetkova K., Larbi A., Dupuis G., Fülöp T. Modulation of signaling in lymphocytes from elderly donors. Inhibition of SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly. Cell Commun Signal 2014, 12:2.
    • (2014) Cell Commun Signal , vol.12 , pp. 2
    • Le Page, A.1    Fortin, C.2    Garneau, H.3    Allard, N.4    Tsvetkova, K.5    Larbi, A.6    Dupuis, G.7    Fülöp, T.8
  • 7
    • 84868208626 scopus 로고    scopus 로고
    • Signaling pathways in aged T cells-a reflection of T cell differentiation, cell senescence and host environment
    • Goronzy J.J., Li G., Yu M., Weyand C.M. Signaling pathways in aged T cells-a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol 2012, 24:365-372.
    • (2012) Semin Immunol , vol.24 , pp. 365-372
    • Goronzy, J.J.1    Li, G.2    Yu, M.3    Weyand, C.M.4
  • 8
    • 68549094231 scopus 로고    scopus 로고
    • Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells
    • Garcia G.G., Miller R.A. Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells. Cell Immunol 2009, 259:100-104.
    • (2009) Cell Immunol , vol.259 , pp. 100-104
    • Garcia, G.G.1    Miller, R.A.2
  • 10
    • 84892640743 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
    • Sapey E., Greenwood H., Walton G., Mann E., Love A., Aaronson N., Insall R.H., Stockley R.A., Lord J.M. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 2014, 123:239-248.
    • (2014) Blood , vol.123 , pp. 239-248
    • Sapey, E.1    Greenwood, H.2    Walton, G.3    Mann, E.4    Love, A.5    Aaronson, N.6    Insall, R.H.7    Stockley, R.A.8    Lord, J.M.9
  • 11
    • 84902283443 scopus 로고    scopus 로고
    • Aging of cell communication: loss of receptor function
    • Interdiscipl Top Gerontol Basel, Karger
    • Robert L., Fulop T. Aging of cell communication: loss of receptor function. Aging: Facts and Theories 2014, Vol. 39:142-162. Interdiscipl Top Gerontol Basel, Karger.
    • (2014) Aging: Facts and Theories , vol.39 , pp. 142-162
    • Robert, L.1    Fulop, T.2
  • 12
    • 84897531380 scopus 로고    scopus 로고
    • Neutrophil extracellular traps as innate immune reaction against the emerging Apicomplexan parasite Besnoitia besnoiti
    • Muñoz Caro T., Hermosilla C., Silva L.M.R., Cortes H., Taubert A. Neutrophil extracellular traps as innate immune reaction against the emerging Apicomplexan parasite Besnoitia besnoiti. PLoS One 2014, 9:e91415.
    • (2014) PLoS One , vol.9
    • Muñoz Caro, T.1    Hermosilla, C.2    Silva, L.M.R.3    Cortes, H.4    Taubert, A.5
  • 14
    • 84870239678 scopus 로고    scopus 로고
    • Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress
    • Riyad Khanfer R., Carroll D., Lord J.M., Phillips A.C. Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress. Int J Psychophysiol 2012, 86:238-244.
    • (2012) Int J Psychophysiol , vol.86 , pp. 238-244
    • Riyad Khanfer, R.1    Carroll, D.2    Lord, J.M.3    Phillips, A.C.4
  • 15
    • 84883199752 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in innate immunity
    • Arthur J.S.C., Ley S.C. Mitogen-activated protein kinases in innate immunity. Nature Rev Immunol 2013, 13:679-692.
    • (2013) Nature Rev Immunol , vol.13 , pp. 679-692
    • Arthur, J.S.C.1    Ley, S.C.2
  • 16
    • 0021628850 scopus 로고
    • Age-related changes in cAMP and cGMP levels during phagocytosis in human polymorphonuclear leukocytes
    • Fülöp T., Fóris G., Leövey A. Age-related changes in cAMP and cGMP levels during phagocytosis in human polymorphonuclear leukocytes. Mech Ageing Dev 1984, 27:233-237.
    • (1984) Mech Ageing Dev , vol.27 , pp. 233-237
    • Fülöp, T.1    Fóris, G.2    Leövey, A.3
  • 17
    • 31044435260 scopus 로고    scopus 로고
    • The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging
    • Larbi A., Douziech N., Fortin C., Linteau A., Dupuis G., Fulop T. The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun Ageing 2005, 2:6.
    • (2005) Immun Ageing , vol.2 , pp. 6
    • Larbi, A.1    Douziech, N.2    Fortin, C.3    Linteau, A.4    Dupuis, G.5    Fulop, T.6
  • 20
    • 84857546470 scopus 로고    scopus 로고
    • Beyond pattern recognition: five immune checkpoints for scaling the microbial threat
    • Blander J.M., Sander L.E. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nature Rev Immunol 2012, 12:215-225.
    • (2012) Nature Rev Immunol , vol.12 , pp. 215-225
    • Blander, J.M.1    Sander, L.E.2
  • 21
    • 84880788557 scopus 로고    scopus 로고
    • Pattern recognition receptor function in neutrophils
    • Thomas C.J., Schroder K. Pattern recognition receptor function in neutrophils. Trends Immunol 2013, 34:317-328.
    • (2013) Trends Immunol , vol.34 , pp. 317-328
    • Thomas, C.J.1    Schroder, K.2
  • 22
    • 84884332722 scopus 로고    scopus 로고
    • Immunity, mechanisms of NOD-like receptor-associated inflammasome activation
    • Wen H., Miao E.A., Ting J.P.Y. Immunity, mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 2013, 39:432-441.
    • (2013) Immunity , vol.39 , pp. 432-441
    • Wen, H.1    Miao, E.A.2    Ting, J.P.Y.3
  • 24
    • 84875419278 scopus 로고    scopus 로고
    • T cell receptor signalling networks: branched, diversified and bounded
    • Brownlie R.J., Zamoyska R. T cell receptor signalling networks: branched, diversified and bounded. Nature Rev immunol 2013, 13:257-269.
    • (2013) Nature Rev immunol , vol.13 , pp. 257-269
    • Brownlie, R.J.1    Zamoyska, R.2
  • 25
    • 84881529180 scopus 로고    scopus 로고
    • The role of membrane rafts in Lck transport, regulation and signalling in T cells
    • Ventimiglia L.N., Alonso M.A. The role of membrane rafts in Lck transport, regulation and signalling in T cells. Biochem J 2013, 454:169-179.
    • (2013) Biochem J , vol.454 , pp. 169-179
    • Ventimiglia, L.N.1    Alonso, M.A.2
  • 26
    • 79959906941 scopus 로고    scopus 로고
    • The immunological synapse: a cause or consequence of T-cell receptor triggering?
    • Alarcón B., Mestre D., Martínez-Martín N. The immunological synapse: a cause or consequence of T-cell receptor triggering?. Immunology 2011, 133:420-425.
    • (2011) Immunology , vol.133 , pp. 420-425
    • Alarcón, B.1    Mestre, D.2    Martínez-Martín, N.3
  • 27
    • 80052946904 scopus 로고    scopus 로고
    • Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling
    • Schoenborn J.R., Tan Y.X., Zhang C., Shokat K.M., Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal 2011, 4:ra59.
    • (2011) Sci Signal , vol.4
    • Schoenborn, J.R.1    Tan, Y.X.2    Zhang, C.3    Shokat, K.M.4    Weiss, A.5
  • 29
    • 84857192210 scopus 로고    scopus 로고
    • A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts
    • Ballek O., Broučková A., Manning J., Filipp D. A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts. Immunol Lett 2012, 142:64-74.
    • (2012) Immunol Lett , vol.142 , pp. 64-74
    • Ballek, O.1    Broučková, A.2    Manning, J.3    Filipp, D.4
  • 30
    • 84655163826 scopus 로고    scopus 로고
    • Vitamin E, signalosome and gene expression in T cells
    • Molano A., Meydani S.N. Vitamin E, signalosome and gene expression in T cells. Mol Aspects Med 2012, 33:55-62.
    • (2012) Mol Aspects Med , vol.33 , pp. 55-62
    • Molano, A.1    Meydani, S.N.2
  • 31
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen L., Flies D.B. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Rev Immunol 2013, 13:227-242.
    • (2013) Nature Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 33
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Ray P.D., Huang B.W., Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012, 24:981-990.
    • (2012) Cell Signal , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.W.2    Tsuji, Y.3
  • 34
    • 34547954316 scopus 로고    scopus 로고
    • Oxidative stress modulation and T cell activation
    • Larbi A., Kempf J., Pawelec G. Oxidative stress modulation and T cell activation. Exp Gerontol 2007, 42:852-858.
    • (2007) Exp Gerontol , vol.42 , pp. 852-858
    • Larbi, A.1    Kempf, J.2    Pawelec, G.3
  • 35
    • 84870199516 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the aging of the T cell immune response
    • Moro-Garcia M.A., Alonso-Arias R., Lopez-Larrea C. Molecular mechanisms involved in the aging of the T cell immune response. Curr Genomics 2012, 13:589-602.
    • (2012) Curr Genomics , vol.13 , pp. 589-602
    • Moro-Garcia, M.A.1    Alonso-Arias, R.2    Lopez-Larrea, C.3
  • 36
    • 84865306843 scopus 로고    scopus 로고
    • Properties of end-stage human T cells defined by CD45RA re-expression
    • Henson S.M., Riddell N.E., Akbar A.N. Properties of end-stage human T cells defined by CD45RA re-expression. Curr Opin Immunol 2012, 24:476-481.
    • (2012) Curr Opin Immunol , vol.24 , pp. 476-481
    • Henson, S.M.1    Riddell, N.E.2    Akbar, A.N.3
  • 37
    • 79251641161 scopus 로고    scopus 로고
    • Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process
    • Libri V., Azevedo R.I., Jackson S.E., Di Mitri D., Lachmann R., Fuhrmann S., Vukmanovic-Stejic M., Yong K., Battistini L., Kern F., et al. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology 2011, 132:326-339.
    • (2011) Immunology , vol.132 , pp. 326-339
    • Libri, V.1    Azevedo, R.I.2    Jackson, S.E.3    Di Mitri, D.4    Lachmann, R.5    Fuhrmann, S.6    Vukmanovic-Stejic, M.7    Yong, K.8    Battistini, L.9    Kern, F.10
  • 40
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: how much can the adaptive immune system adapt?
    • Weng N.P. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006, 24:495-499.
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.P.1
  • 41
    • 50249105938 scopus 로고    scopus 로고
    • Tailoring T-cell receptor signals by proximal negative feedback mechanisms
    • Acuto O., Di Bartolo V., Michel F. Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nature Rev Immunol 2008, 8:699-712.
    • (2008) Nature Rev Immunol , vol.8 , pp. 699-712
    • Acuto, O.1    Di Bartolo, V.2    Michel, F.3
  • 42
    • 0037105622 scopus 로고    scopus 로고
    • Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells
    • Yasuda K., Nagafuku M., Shima T., Okada M., Yagi T., Yamada T., Minaki Y., Kato A., Tani-Ichi S., Hamaoka T., Kosugi A. Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol 2002, 169:2813-2817.
    • (2002) J Immunol , vol.169 , pp. 2813-2817
    • Yasuda, K.1    Nagafuku, M.2    Shima, T.3    Okada, M.4    Yagi, T.5    Yamada, T.6    Minaki, Y.7    Kato, A.8    Tani-Ichi, S.9    Hamaoka, T.10    Kosugi, A.11
  • 43
    • 33746114879 scopus 로고    scopus 로고
    • The kinetic-segregation model: TCR triggering and beyond
    • Davis S.J., van der Merwe P.A. The kinetic-segregation model: TCR triggering and beyond. Nature Immunol 2006, 7:803-809.
    • (2006) Nature Immunol , vol.7 , pp. 803-809
    • Davis, S.J.1    van der Merwe, P.A.2
  • 44
    • 84890333698 scopus 로고    scopus 로고
    • Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor
    • Chapman N.M., Connolly S.F., Reinl E.L., Houtman J.C.D. Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor. J Immunol 2013, 191:6208-6221.
    • (2013) J Immunol , vol.191 , pp. 6208-6221
    • Chapman, N.M.1    Connolly, S.F.2    Reinl, E.L.3    Houtman, J.C.D.4
  • 45
    • 84864762292 scopus 로고    scopus 로고
    • Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity
    • Stanford S.M., Rapini M., Bottini M. Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology 2012, 137:1-19.
    • (2012) Immunology , vol.137 , pp. 1-19
    • Stanford, S.M.1    Rapini, M.2    Bottini, M.3
  • 46
    • 84872784967 scopus 로고    scopus 로고
    • Regulating naïve and memory CD8 T cell homeostasis-a role for protein tyrosine phosphatases
    • Pike K.A., Tremblay M.L. Regulating naïve and memory CD8 T cell homeostasis-a role for protein tyrosine phosphatases. FEBS J 2012, 280:432-444.
    • (2012) FEBS J , vol.280 , pp. 432-444
    • Pike, K.A.1    Tremblay, M.L.2
  • 47
    • 84859891065 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
    • Rhee I., Veillette A. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nature Immunol 2012, 18:439-447.
    • (2012) Nature Immunol , vol.18 , pp. 439-447
    • Rhee, I.1    Veillette, A.2
  • 48
    • 61849153316 scopus 로고    scopus 로고
    • SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels
    • Lorenz U. SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev 2009, 228:342-359.
    • (2009) Immunol Rev , vol.228 , pp. 342-359
    • Lorenz, U.1
  • 49
    • 17644386593 scopus 로고    scopus 로고
    • Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation
    • Barrett D.M., Black S.M., Todor H., Schmidt-Ullrich R.K., Dawson K.S., Mikkelsen R.B. Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J Biol Chem 2005, 280:14453-14461.
    • (2005) J Biol Chem , vol.280 , pp. 14453-14461
    • Barrett, D.M.1    Black, S.M.2    Todor, H.3    Schmidt-Ullrich, R.K.4    Dawson, K.S.5    Mikkelsen, R.B.6
  • 50
    • 0037338890 scopus 로고    scopus 로고
    • TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
    • Stefanová I., Hemmer B., Vergelli M., Martin R., Biddison W.E., Germain R.N. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunol 2003, 4:248-254.
    • (2003) Nature Immunol , vol.4 , pp. 248-254
    • Stefanová, I.1    Hemmer, B.2    Vergelli, M.3    Martin, R.4    Biddison, W.E.5    Germain, R.N.6
  • 51
    • 0034948374 scopus 로고    scopus 로고
    • Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts
    • Kosugi A., Sakakura J., Yasuda K., Ogata M., Hamaoka T. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 2001, 4:669-680.
    • (2001) Immunity , vol.4 , pp. 669-680
    • Kosugi, A.1    Sakakura, J.2    Yasuda, K.3    Ogata, M.4    Hamaoka, T.5
  • 52
    • 78649869141 scopus 로고    scopus 로고
    • SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells
    • Fowler C.C., Pao L.I., Blattman J.N., Greenberg P.D. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol 2010, 185:3256-3267.
    • (2010) J Immunol , vol.185 , pp. 3256-3267
    • Fowler, C.C.1    Pao, L.I.2    Blattman, J.N.3    Greenberg, P.D.4
  • 53
    • 84859574715 scopus 로고    scopus 로고
    • Signal inhibition by the dual-specific phosphatase 4 impairs T cell dependent B-cell responses with age
    • Yu M., Li G., Lee W.W., Yuan M., Cui D., Weyand C.M., Goronzy J.J. Signal inhibition by the dual-specific phosphatase 4 impairs T cell dependent B-cell responses with age. Proc Natl Acad Sci USA 2012, 109:E879-E888.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Yu, M.1    Li, G.2    Lee, W.W.3    Yuan, M.4    Cui, D.5    Weyand, C.M.6    Goronzy, J.J.7
  • 54
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li G., Yu M., Lee W.W., Tsang M., Krishnan E., Weyand C.M., Goronzy J.J. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nature Med 2012, 18:1518-1524.
    • (2012) Nature Med , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3    Tsang, M.4    Krishnan, E.5    Weyand, C.M.6    Goronzy, J.J.7
  • 55
    • 84857727992 scopus 로고    scopus 로고
    • Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
    • Henson S.M., Macaulay R., Franzese O., Akbar A.N. Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade. Immunology 2011, 135:355-363.
    • (2011) Immunology , vol.135 , pp. 355-363
    • Henson, S.M.1    Macaulay, R.2    Franzese, O.3    Akbar, A.N.4
  • 56
    • 1242342002 scopus 로고    scopus 로고
    • Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases
    • Persson C., Sjöblom T., Groen A., Kappert K., Engström U., Hellman U., Heldin C.H., den Hertog J., Ostman A. Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci U S A 2004, 101:1886-1891.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1886-1891
    • Persson, C.1    Sjöblom, T.2    Groen, A.3    Kappert, K.4    Engström, U.5    Hellman, U.6    Heldin, C.H.7    den Hertog, J.8    Ostman, A.9
  • 57
    • 79960843915 scopus 로고    scopus 로고
    • Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation
    • Kim H.K., Jhon T.H., Lee G.J.S.Y. Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation. Cell Signal 2011, 23:1633-1639.
    • (2011) Cell Signal , vol.23 , pp. 1633-1639
    • Kim, H.K.1    Jhon, T.H.2    Lee, G.J.S.Y.3
  • 59
    • 33744478401 scopus 로고    scopus 로고
    • Free radical theory of aging: an update: increasing the functional life span
    • Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 2006, 1067:10-21.
    • (2006) Ann N Y Acad Sci , vol.1067 , pp. 10-21
    • Harman, D.1
  • 60
    • 0034100421 scopus 로고    scopus 로고
    • Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes
    • Lenton K.J., Therriault H., Cantin A.M., Fülöp T., Payette H., Wagner J.R. Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes. Am J Clin Nutr 2000, 71:1194-2000.
    • (2000) Am J Clin Nutr , vol.71 , pp. 1194-2000
    • Lenton, K.J.1    Therriault, H.2    Cantin, A.M.3    Fülöp, T.4    Payette, H.5    Wagner, J.R.6
  • 61
    • 84883271387 scopus 로고    scopus 로고
    • Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?
    • Bocci V., Valacchi G. Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?. Curr Med Chem 2013, 20:3397-3415.
    • (2013) Curr Med Chem , vol.20 , pp. 3397-3415
    • Bocci, V.1    Valacchi, G.2
  • 63
    • 80053513183 scopus 로고    scopus 로고
    • Regulation of protein tyrosine phosphatases by reversible oxidation
    • Ostman A., Frijhoff J., Sandin A., Böhmer F.D. Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem 2011, 150:345-356.
    • (2011) J Biochem , vol.150 , pp. 345-356
    • Ostman, A.1    Frijhoff, J.2    Sandin, A.3    Böhmer, F.D.4
  • 65
    • 84885670616 scopus 로고    scopus 로고
    • Fuelling immunity: insights into metabolism and lymphocyte finction
    • Pearce E.L. Fuelling immunity: insights into metabolism and lymphocyte finction. Science 2013, 342:1242454.
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1
  • 67
    • 84885994719 scopus 로고    scopus 로고
    • Increased mammalian target of rapamycin complex 2 signalling promotes age-related decline in CD4 T cell signaling and function
    • Perkey E., Fingar D., Miller R.A., Garcia G.G. Increased mammalian target of rapamycin complex 2 signalling promotes age-related decline in CD4 T cell signaling and function. J Immunol 2013, 191:4648-4655.
    • (2013) J Immunol , vol.191 , pp. 4648-4655
    • Perkey, E.1    Fingar, D.2    Miller, R.A.3    Garcia, G.G.4
  • 68
    • 84875529784 scopus 로고    scopus 로고
    • Immunosenescence in vertebrates and invertebrates
    • Müller L., Fülöp T., Pawelec G. Immunosenescence in vertebrates and invertebrates. Immun Aging 2013, 10:12.
    • (2013) Immun Aging , vol.10 , pp. 12
    • Müller, L.1    Fülöp, T.2    Pawelec, G.3
  • 74
    • 15044354122 scopus 로고    scopus 로고
    • Low-grade inflammation with aging has consequences for T-lymphocyte signaling
    • Larbi A., Dupuis G., Douziech N., Khalil A., Fülöp T. Low-grade inflammation with aging has consequences for T-lymphocyte signaling. Ann N Y Acad Sci 2004, 1030:125-133.
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 125-133
    • Larbi, A.1    Dupuis, G.2    Douziech, N.3    Khalil, A.4    Fülöp, T.5
  • 75
    • 74149086692 scopus 로고    scopus 로고
    • Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation
    • Larbi A., Cabreiro F., Zelba H., Marthandan S., Combet E., Friguet B., Petropoulos I., Barnett Y., Pawelec G. Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radic Biol Med 2010, 48:26-34.
    • (2010) Free Radic Biol Med , vol.48 , pp. 26-34
    • Larbi, A.1    Cabreiro, F.2    Zelba, H.3    Marthandan, S.4    Combet, E.5    Friguet, B.6    Petropoulos, I.7    Barnett, Y.8    Pawelec, G.9
  • 76
    • 84880571356 scopus 로고    scopus 로고
    • The role of the T cell in age-related inflammation
    • Macauulay R., Akbar A.N., Henson S.M. The role of the T cell in age-related inflammation. Age 2013, 35:563-572.
    • (2013) Age , vol.35 , pp. 563-572
    • Macauulay, R.1    Akbar, A.N.2    Henson, S.M.3
  • 77
    • 2442713628 scopus 로고    scopus 로고
    • Lipid rafts in lymphocyte activation
    • Pizzo P., Viola A. Lipid rafts in lymphocyte activation. Microbes Infect 2004, 6:686-692.
    • (2004) Microbes Infect , vol.6 , pp. 686-692
    • Pizzo, P.1    Viola, A.2
  • 78
    • 4444236958 scopus 로고    scopus 로고
    • Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse
    • Taner S.B., Onfelt B., Pirinen N.J., McCann F.E., Magee A.I., Davis D.M. Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse. Traffic 2004, 5:651-661.
    • (2004) Traffic , vol.5 , pp. 651-661
    • Taner, S.B.1    Onfelt, B.2    Pirinen, N.J.3    McCann, F.E.4    Magee, A.I.5    Davis, D.M.6
  • 80
    • 0842309906 scopus 로고    scopus 로고
    • Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes
    • Larbi A., Douziech N., Dupuis G., Khalil A., Pelletier H., Guerard K.P., Fülöp T. Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. J Leukoc Biol 2004, 75:373-381.
    • (2004) J Leukoc Biol , vol.75 , pp. 373-381
    • Larbi, A.1    Douziech, N.2    Dupuis, G.3    Khalil, A.4    Pelletier, H.5    Guerard, K.P.6    Fülöp, T.7
  • 81
    • 33646580485 scopus 로고    scopus 로고
    • Impairment of SHP-1 down regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    • Fortin C.F., Larbi A., Lesur O., Douziech N., Fulop T. Impairment of SHP-1 down regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J Leukoc Biol 2006, 79:1061-1072.
    • (2006) J Leukoc Biol , vol.79 , pp. 1061-1072
    • Fortin, C.F.1    Larbi, A.2    Lesur, O.3    Douziech, N.4    Fulop, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.