-
1
-
-
84878864199
-
Hallmarks of aging
-
Lopez-Otin C., Blasco M.A., Partridge L., Serrano M., Kroemer G. Hallmarks of aging. Cell 2013, 153:1194-1217.
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
Lopez-Otin, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
2
-
-
84868193217
-
Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
-
Solana R., Tarazona R., Inmaculada G., Lesur O., Dupuis G., Fülöp T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Sem Immunol 2012, 24:331-341.
-
(2012)
Sem Immunol
, vol.24
, pp. 331-341
-
-
Solana, R.1
Tarazona, R.2
Inmaculada, G.3
Lesur, O.4
Dupuis, G.5
Fülöp, T.6
-
3
-
-
84886033654
-
Human T cell aging and the impact of persistent viral infections
-
Fülöp T., Larbi A., Pawelec G. Human T cell aging and the impact of persistent viral infections. Front Immunol 2013, 4:271.
-
(2013)
Front Immunol
, vol.4
, pp. 271
-
-
Fülöp, T.1
Larbi, A.2
Pawelec, G.3
-
4
-
-
84873322444
-
The immune system in the elderly: a fair fight against diseases?
-
Larbi A., Rymkiewicz P., Vasudez A., Low I., Binte Shadan N., Mustafah S., Ayyadhury S., Fülöp T. The immune system in the elderly: a fair fight against diseases?. Aging Health 2013, 9:1.
-
(2013)
Aging Health
, vol.9
, pp. 1
-
-
Larbi, A.1
Rymkiewicz, P.2
Vasudez, A.3
Low, I.4
Binte Shadan, N.5
Mustafah, S.6
Ayyadhury, S.7
Fülöp, T.8
-
5
-
-
79955955068
-
Impact of age on T cell signaling: a general defect or specific alterations?
-
Larbi A., Pawelec G., Wong S.C., Goldeck D., Tai J.J., Fülöp T. Impact of age on T cell signaling: a general defect or specific alterations?. Ageing Res Rev 2011, 10:370-378.
-
(2011)
Ageing Res Rev
, vol.10
, pp. 370-378
-
-
Larbi, A.1
Pawelec, G.2
Wong, S.C.3
Goldeck, D.4
Tai, J.J.5
Fülöp, T.6
-
6
-
-
84892818946
-
Modulation of signaling in lymphocytes from elderly donors. Inhibition of SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
-
Le Page A., Fortin C., Garneau H., Allard N., Tsvetkova K., Larbi A., Dupuis G., Fülöp T. Modulation of signaling in lymphocytes from elderly donors. Inhibition of SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly. Cell Commun Signal 2014, 12:2.
-
(2014)
Cell Commun Signal
, vol.12
, pp. 2
-
-
Le Page, A.1
Fortin, C.2
Garneau, H.3
Allard, N.4
Tsvetkova, K.5
Larbi, A.6
Dupuis, G.7
Fülöp, T.8
-
7
-
-
84868208626
-
Signaling pathways in aged T cells-a reflection of T cell differentiation, cell senescence and host environment
-
Goronzy J.J., Li G., Yu M., Weyand C.M. Signaling pathways in aged T cells-a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol 2012, 24:365-372.
-
(2012)
Semin Immunol
, vol.24
, pp. 365-372
-
-
Goronzy, J.J.1
Li, G.2
Yu, M.3
Weyand, C.M.4
-
8
-
-
68549094231
-
Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells
-
Garcia G.G., Miller R.A. Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells. Cell Immunol 2009, 259:100-104.
-
(2009)
Cell Immunol
, vol.259
, pp. 100-104
-
-
Garcia, G.G.1
Miller, R.A.2
-
10
-
-
84892640743
-
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
-
Sapey E., Greenwood H., Walton G., Mann E., Love A., Aaronson N., Insall R.H., Stockley R.A., Lord J.M. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 2014, 123:239-248.
-
(2014)
Blood
, vol.123
, pp. 239-248
-
-
Sapey, E.1
Greenwood, H.2
Walton, G.3
Mann, E.4
Love, A.5
Aaronson, N.6
Insall, R.H.7
Stockley, R.A.8
Lord, J.M.9
-
11
-
-
84902283443
-
Aging of cell communication: loss of receptor function
-
Interdiscipl Top Gerontol Basel, Karger
-
Robert L., Fulop T. Aging of cell communication: loss of receptor function. Aging: Facts and Theories 2014, Vol. 39:142-162. Interdiscipl Top Gerontol Basel, Karger.
-
(2014)
Aging: Facts and Theories
, vol.39
, pp. 142-162
-
-
Robert, L.1
Fulop, T.2
-
12
-
-
84897531380
-
Neutrophil extracellular traps as innate immune reaction against the emerging Apicomplexan parasite Besnoitia besnoiti
-
Muñoz Caro T., Hermosilla C., Silva L.M.R., Cortes H., Taubert A. Neutrophil extracellular traps as innate immune reaction against the emerging Apicomplexan parasite Besnoitia besnoiti. PLoS One 2014, 9:e91415.
-
(2014)
PLoS One
, vol.9
-
-
Muñoz Caro, T.1
Hermosilla, C.2
Silva, L.M.R.3
Cortes, H.4
Taubert, A.5
-
13
-
-
54249156556
-
Aging and neutrophils: there is still much to do
-
Fortin C.F., McDonald P.P., Lesur O., Fülöp T. Aging and neutrophils: there is still much to do. Rejuven Res 2008, 11:873-882.
-
(2008)
Rejuven Res
, vol.11
, pp. 873-882
-
-
Fortin, C.F.1
McDonald, P.P.2
Lesur, O.3
Fülöp, T.4
-
14
-
-
84870239678
-
Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress
-
Riyad Khanfer R., Carroll D., Lord J.M., Phillips A.C. Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress. Int J Psychophysiol 2012, 86:238-244.
-
(2012)
Int J Psychophysiol
, vol.86
, pp. 238-244
-
-
Riyad Khanfer, R.1
Carroll, D.2
Lord, J.M.3
Phillips, A.C.4
-
15
-
-
84883199752
-
Mitogen-activated protein kinases in innate immunity
-
Arthur J.S.C., Ley S.C. Mitogen-activated protein kinases in innate immunity. Nature Rev Immunol 2013, 13:679-692.
-
(2013)
Nature Rev Immunol
, vol.13
, pp. 679-692
-
-
Arthur, J.S.C.1
Ley, S.C.2
-
16
-
-
0021628850
-
Age-related changes in cAMP and cGMP levels during phagocytosis in human polymorphonuclear leukocytes
-
Fülöp T., Fóris G., Leövey A. Age-related changes in cAMP and cGMP levels during phagocytosis in human polymorphonuclear leukocytes. Mech Ageing Dev 1984, 27:233-237.
-
(1984)
Mech Ageing Dev
, vol.27
, pp. 233-237
-
-
Fülöp, T.1
Fóris, G.2
Leövey, A.3
-
17
-
-
31044435260
-
The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging
-
Larbi A., Douziech N., Fortin C., Linteau A., Dupuis G., Fulop T. The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun Ageing 2005, 2:6.
-
(2005)
Immun Ageing
, vol.2
, pp. 6
-
-
Larbi, A.1
Douziech, N.2
Fortin, C.3
Linteau, A.4
Dupuis, G.5
Fulop, T.6
-
18
-
-
79955947701
-
Dysregulation of human Toll-like receptor function in aging
-
Shaw A.C., Panda A., Joshi S.R., Qian F., Allore H.G., Montgomery R.R. Dysregulation of human Toll-like receptor function in aging. Ageing Res Rev 2011, 10:346-353.
-
(2011)
Ageing Res Rev
, vol.10
, pp. 346-353
-
-
Shaw, A.C.1
Panda, A.2
Joshi, S.R.3
Qian, F.4
Allore, H.G.5
Montgomery, R.R.6
-
19
-
-
5644265023
-
Signal transduction and functional changes in neutrophils with aging
-
Fulop T., Larbi A., Douziech N., Fortin C., Guérard K.P., Lesur O., Khalil A., Dupuis G. Signal transduction and functional changes in neutrophils with aging. Aging Cell 2004, 3:217-226.
-
(2004)
Aging Cell
, vol.3
, pp. 217-226
-
-
Fulop, T.1
Larbi, A.2
Douziech, N.3
Fortin, C.4
Guérard, K.P.5
Lesur, O.6
Khalil, A.7
Dupuis, G.8
-
20
-
-
84857546470
-
Beyond pattern recognition: five immune checkpoints for scaling the microbial threat
-
Blander J.M., Sander L.E. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nature Rev Immunol 2012, 12:215-225.
-
(2012)
Nature Rev Immunol
, vol.12
, pp. 215-225
-
-
Blander, J.M.1
Sander, L.E.2
-
21
-
-
84880788557
-
Pattern recognition receptor function in neutrophils
-
Thomas C.J., Schroder K. Pattern recognition receptor function in neutrophils. Trends Immunol 2013, 34:317-328.
-
(2013)
Trends Immunol
, vol.34
, pp. 317-328
-
-
Thomas, C.J.1
Schroder, K.2
-
22
-
-
84884332722
-
Immunity, mechanisms of NOD-like receptor-associated inflammasome activation
-
Wen H., Miao E.A., Ting J.P.Y. Immunity, mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 2013, 39:432-441.
-
(2013)
Immunity
, vol.39
, pp. 432-441
-
-
Wen, H.1
Miao, E.A.2
Ting, J.P.Y.3
-
23
-
-
77950892491
-
APC, T cells, and the immune synapse
-
Reichardt P., Dornbach B., Gunzer M. APC, T cells, and the immune synapse. Curr Top Microbiol Immunol 2010, 340:229-249.
-
(2010)
Curr Top Microbiol Immunol
, vol.340
, pp. 229-249
-
-
Reichardt, P.1
Dornbach, B.2
Gunzer, M.3
-
24
-
-
84875419278
-
T cell receptor signalling networks: branched, diversified and bounded
-
Brownlie R.J., Zamoyska R. T cell receptor signalling networks: branched, diversified and bounded. Nature Rev immunol 2013, 13:257-269.
-
(2013)
Nature Rev immunol
, vol.13
, pp. 257-269
-
-
Brownlie, R.J.1
Zamoyska, R.2
-
25
-
-
84881529180
-
The role of membrane rafts in Lck transport, regulation and signalling in T cells
-
Ventimiglia L.N., Alonso M.A. The role of membrane rafts in Lck transport, regulation and signalling in T cells. Biochem J 2013, 454:169-179.
-
(2013)
Biochem J
, vol.454
, pp. 169-179
-
-
Ventimiglia, L.N.1
Alonso, M.A.2
-
26
-
-
79959906941
-
The immunological synapse: a cause or consequence of T-cell receptor triggering?
-
Alarcón B., Mestre D., Martínez-Martín N. The immunological synapse: a cause or consequence of T-cell receptor triggering?. Immunology 2011, 133:420-425.
-
(2011)
Immunology
, vol.133
, pp. 420-425
-
-
Alarcón, B.1
Mestre, D.2
Martínez-Martín, N.3
-
27
-
-
80052946904
-
Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling
-
Schoenborn J.R., Tan Y.X., Zhang C., Shokat K.M., Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal 2011, 4:ra59.
-
(2011)
Sci Signal
, vol.4
-
-
Schoenborn, J.R.1
Tan, Y.X.2
Zhang, C.3
Shokat, K.M.4
Weiss, A.5
-
28
-
-
84886910386
-
Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells
-
Coussens N.P., Hayashi R., Brown P.H., Balagopalan L., Balbo A., Akpan I., Houtman J.C.D., Barr V.A., Schuck P., Appella E., Samelson L.E. Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells. Mol Cell Biol 2013, 33:4140-4151.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4140-4151
-
-
Coussens, N.P.1
Hayashi, R.2
Brown, P.H.3
Balagopalan, L.4
Balbo, A.5
Akpan, I.6
Houtman, J.C.D.7
Barr, V.A.8
Schuck, P.9
Appella, E.10
Samelson, L.E.11
-
29
-
-
84857192210
-
A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts
-
Ballek O., Broučková A., Manning J., Filipp D. A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts. Immunol Lett 2012, 142:64-74.
-
(2012)
Immunol Lett
, vol.142
, pp. 64-74
-
-
Ballek, O.1
Broučková, A.2
Manning, J.3
Filipp, D.4
-
30
-
-
84655163826
-
Vitamin E, signalosome and gene expression in T cells
-
Molano A., Meydani S.N. Vitamin E, signalosome and gene expression in T cells. Mol Aspects Med 2012, 33:55-62.
-
(2012)
Mol Aspects Med
, vol.33
, pp. 55-62
-
-
Molano, A.1
Meydani, S.N.2
-
31
-
-
84875463042
-
Molecular mechanisms of T cell co-stimulation and co-inhibition
-
Chen L., Flies D.B. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Rev Immunol 2013, 13:227-242.
-
(2013)
Nature Rev Immunol
, vol.13
, pp. 227-242
-
-
Chen, L.1
Flies, D.B.2
-
33
-
-
84857116578
-
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
-
Ray P.D., Huang B.W., Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012, 24:981-990.
-
(2012)
Cell Signal
, vol.24
, pp. 981-990
-
-
Ray, P.D.1
Huang, B.W.2
Tsuji, Y.3
-
34
-
-
34547954316
-
Oxidative stress modulation and T cell activation
-
Larbi A., Kempf J., Pawelec G. Oxidative stress modulation and T cell activation. Exp Gerontol 2007, 42:852-858.
-
(2007)
Exp Gerontol
, vol.42
, pp. 852-858
-
-
Larbi, A.1
Kempf, J.2
Pawelec, G.3
-
35
-
-
84870199516
-
Molecular mechanisms involved in the aging of the T cell immune response
-
Moro-Garcia M.A., Alonso-Arias R., Lopez-Larrea C. Molecular mechanisms involved in the aging of the T cell immune response. Curr Genomics 2012, 13:589-602.
-
(2012)
Curr Genomics
, vol.13
, pp. 589-602
-
-
Moro-Garcia, M.A.1
Alonso-Arias, R.2
Lopez-Larrea, C.3
-
36
-
-
84865306843
-
Properties of end-stage human T cells defined by CD45RA re-expression
-
Henson S.M., Riddell N.E., Akbar A.N. Properties of end-stage human T cells defined by CD45RA re-expression. Curr Opin Immunol 2012, 24:476-481.
-
(2012)
Curr Opin Immunol
, vol.24
, pp. 476-481
-
-
Henson, S.M.1
Riddell, N.E.2
Akbar, A.N.3
-
37
-
-
79251641161
-
Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process
-
Libri V., Azevedo R.I., Jackson S.E., Di Mitri D., Lachmann R., Fuhrmann S., Vukmanovic-Stejic M., Yong K., Battistini L., Kern F., et al. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology 2011, 132:326-339.
-
(2011)
Immunology
, vol.132
, pp. 326-339
-
-
Libri, V.1
Azevedo, R.I.2
Jackson, S.E.3
Di Mitri, D.4
Lachmann, R.5
Fuhrmann, S.6
Vukmanovic-Stejic, M.7
Yong, K.8
Battistini, L.9
Kern, F.10
-
38
-
-
80053363591
-
Free radicals and redox signalling in T-cells during chronic inflammation and ageing
-
Griffiths H.R., Dunston C.R., Bennett S.J., Grant M.M., Phillips D.C., Kitas G.D. Free radicals and redox signalling in T-cells during chronic inflammation and ageing. Biochem Soc Trans 2011, 39:1273-1278.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1273-1278
-
-
Griffiths, H.R.1
Dunston, C.R.2
Bennett, S.J.3
Grant, M.M.4
Phillips, D.C.5
Kitas, G.D.6
-
40
-
-
33646546302
-
Aging of the immune system: how much can the adaptive immune system adapt?
-
Weng N.P. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006, 24:495-499.
-
(2006)
Immunity
, vol.24
, pp. 495-499
-
-
Weng, N.P.1
-
41
-
-
50249105938
-
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
-
Acuto O., Di Bartolo V., Michel F. Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nature Rev Immunol 2008, 8:699-712.
-
(2008)
Nature Rev Immunol
, vol.8
, pp. 699-712
-
-
Acuto, O.1
Di Bartolo, V.2
Michel, F.3
-
42
-
-
0037105622
-
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells
-
Yasuda K., Nagafuku M., Shima T., Okada M., Yagi T., Yamada T., Minaki Y., Kato A., Tani-Ichi S., Hamaoka T., Kosugi A. Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol 2002, 169:2813-2817.
-
(2002)
J Immunol
, vol.169
, pp. 2813-2817
-
-
Yasuda, K.1
Nagafuku, M.2
Shima, T.3
Okada, M.4
Yagi, T.5
Yamada, T.6
Minaki, Y.7
Kato, A.8
Tani-Ichi, S.9
Hamaoka, T.10
Kosugi, A.11
-
43
-
-
33746114879
-
The kinetic-segregation model: TCR triggering and beyond
-
Davis S.J., van der Merwe P.A. The kinetic-segregation model: TCR triggering and beyond. Nature Immunol 2006, 7:803-809.
-
(2006)
Nature Immunol
, vol.7
, pp. 803-809
-
-
Davis, S.J.1
van der Merwe, P.A.2
-
44
-
-
84890333698
-
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor
-
Chapman N.M., Connolly S.F., Reinl E.L., Houtman J.C.D. Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor. J Immunol 2013, 191:6208-6221.
-
(2013)
J Immunol
, vol.191
, pp. 6208-6221
-
-
Chapman, N.M.1
Connolly, S.F.2
Reinl, E.L.3
Houtman, J.C.D.4
-
45
-
-
84864762292
-
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity
-
Stanford S.M., Rapini M., Bottini M. Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology 2012, 137:1-19.
-
(2012)
Immunology
, vol.137
, pp. 1-19
-
-
Stanford, S.M.1
Rapini, M.2
Bottini, M.3
-
46
-
-
84872784967
-
Regulating naïve and memory CD8 T cell homeostasis-a role for protein tyrosine phosphatases
-
Pike K.A., Tremblay M.L. Regulating naïve and memory CD8 T cell homeostasis-a role for protein tyrosine phosphatases. FEBS J 2012, 280:432-444.
-
(2012)
FEBS J
, vol.280
, pp. 432-444
-
-
Pike, K.A.1
Tremblay, M.L.2
-
47
-
-
84859891065
-
Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
-
Rhee I., Veillette A. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nature Immunol 2012, 18:439-447.
-
(2012)
Nature Immunol
, vol.18
, pp. 439-447
-
-
Rhee, I.1
Veillette, A.2
-
48
-
-
61849153316
-
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels
-
Lorenz U. SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev 2009, 228:342-359.
-
(2009)
Immunol Rev
, vol.228
, pp. 342-359
-
-
Lorenz, U.1
-
49
-
-
17644386593
-
Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation
-
Barrett D.M., Black S.M., Todor H., Schmidt-Ullrich R.K., Dawson K.S., Mikkelsen R.B. Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J Biol Chem 2005, 280:14453-14461.
-
(2005)
J Biol Chem
, vol.280
, pp. 14453-14461
-
-
Barrett, D.M.1
Black, S.M.2
Todor, H.3
Schmidt-Ullrich, R.K.4
Dawson, K.S.5
Mikkelsen, R.B.6
-
50
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
-
Stefanová I., Hemmer B., Vergelli M., Martin R., Biddison W.E., Germain R.N. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunol 2003, 4:248-254.
-
(2003)
Nature Immunol
, vol.4
, pp. 248-254
-
-
Stefanová, I.1
Hemmer, B.2
Vergelli, M.3
Martin, R.4
Biddison, W.E.5
Germain, R.N.6
-
51
-
-
0034948374
-
Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts
-
Kosugi A., Sakakura J., Yasuda K., Ogata M., Hamaoka T. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 2001, 4:669-680.
-
(2001)
Immunity
, vol.4
, pp. 669-680
-
-
Kosugi, A.1
Sakakura, J.2
Yasuda, K.3
Ogata, M.4
Hamaoka, T.5
-
52
-
-
78649869141
-
SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells
-
Fowler C.C., Pao L.I., Blattman J.N., Greenberg P.D. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol 2010, 185:3256-3267.
-
(2010)
J Immunol
, vol.185
, pp. 3256-3267
-
-
Fowler, C.C.1
Pao, L.I.2
Blattman, J.N.3
Greenberg, P.D.4
-
53
-
-
84859574715
-
Signal inhibition by the dual-specific phosphatase 4 impairs T cell dependent B-cell responses with age
-
Yu M., Li G., Lee W.W., Yuan M., Cui D., Weyand C.M., Goronzy J.J. Signal inhibition by the dual-specific phosphatase 4 impairs T cell dependent B-cell responses with age. Proc Natl Acad Sci USA 2012, 109:E879-E888.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Yu, M.1
Li, G.2
Lee, W.W.3
Yuan, M.4
Cui, D.5
Weyand, C.M.6
Goronzy, J.J.7
-
54
-
-
84870293512
-
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
-
Li G., Yu M., Lee W.W., Tsang M., Krishnan E., Weyand C.M., Goronzy J.J. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nature Med 2012, 18:1518-1524.
-
(2012)
Nature Med
, vol.18
, pp. 1518-1524
-
-
Li, G.1
Yu, M.2
Lee, W.W.3
Tsang, M.4
Krishnan, E.5
Weyand, C.M.6
Goronzy, J.J.7
-
55
-
-
84857727992
-
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
-
Henson S.M., Macaulay R., Franzese O., Akbar A.N. Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade. Immunology 2011, 135:355-363.
-
(2011)
Immunology
, vol.135
, pp. 355-363
-
-
Henson, S.M.1
Macaulay, R.2
Franzese, O.3
Akbar, A.N.4
-
56
-
-
1242342002
-
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases
-
Persson C., Sjöblom T., Groen A., Kappert K., Engström U., Hellman U., Heldin C.H., den Hertog J., Ostman A. Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci U S A 2004, 101:1886-1891.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 1886-1891
-
-
Persson, C.1
Sjöblom, T.2
Groen, A.3
Kappert, K.4
Engström, U.5
Hellman, U.6
Heldin, C.H.7
den Hertog, J.8
Ostman, A.9
-
57
-
-
79960843915
-
Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation
-
Kim H.K., Jhon T.H., Lee G.J.S.Y. Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation. Cell Signal 2011, 23:1633-1639.
-
(2011)
Cell Signal
, vol.23
, pp. 1633-1639
-
-
Kim, H.K.1
Jhon, T.H.2
Lee, G.J.S.Y.3
-
58
-
-
77956635663
-
The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling
-
Kwon J., Shatynski K.E., Chen H., Morand S., de Deken X., Miot F., Leto T.L., Williams M.S. The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling. Sci Signal 2010, 3:ra59.
-
(2010)
Sci Signal
, vol.3
-
-
Kwon, J.1
Shatynski, K.E.2
Chen, H.3
Morand, S.4
de Deken, X.5
Miot, F.6
Leto, T.L.7
Williams, M.S.8
-
59
-
-
33744478401
-
Free radical theory of aging: an update: increasing the functional life span
-
Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 2006, 1067:10-21.
-
(2006)
Ann N Y Acad Sci
, vol.1067
, pp. 10-21
-
-
Harman, D.1
-
60
-
-
0034100421
-
Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes
-
Lenton K.J., Therriault H., Cantin A.M., Fülöp T., Payette H., Wagner J.R. Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes. Am J Clin Nutr 2000, 71:1194-2000.
-
(2000)
Am J Clin Nutr
, vol.71
, pp. 1194-2000
-
-
Lenton, K.J.1
Therriault, H.2
Cantin, A.M.3
Fülöp, T.4
Payette, H.5
Wagner, J.R.6
-
61
-
-
84883271387
-
Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?
-
Bocci V., Valacchi G. Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?. Curr Med Chem 2013, 20:3397-3415.
-
(2013)
Curr Med Chem
, vol.20
, pp. 3397-3415
-
-
Bocci, V.1
Valacchi, G.2
-
62
-
-
84055191068
-
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
-
Wiede F., Shields B.J., Chew S.H., Kyparissoudis K., van Vliet C., Galic S., Tremblay M.L., Russell S.M., Godfrey D.I., Tiganis T. T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest 2011, 121:4758-4774.
-
(2011)
J Clin Invest
, vol.121
, pp. 4758-4774
-
-
Wiede, F.1
Shields, B.J.2
Chew, S.H.3
Kyparissoudis, K.4
van Vliet, C.5
Galic, S.6
Tremblay, M.L.7
Russell, S.M.8
Godfrey, D.I.9
Tiganis, T.10
-
63
-
-
80053513183
-
Regulation of protein tyrosine phosphatases by reversible oxidation
-
Ostman A., Frijhoff J., Sandin A., Böhmer F.D. Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem 2011, 150:345-356.
-
(2011)
J Biochem
, vol.150
, pp. 345-356
-
-
Ostman, A.1
Frijhoff, J.2
Sandin, A.3
Böhmer, F.D.4
-
64
-
-
34249728740
-
Do membrane rafts contribute to human immunosenescence?
-
Tomoiu A., Larbi A., Fortin C., Dupuis G., Fulop T. Do membrane rafts contribute to human immunosenescence?. Ann N Y Acad Sci 2007, 1100:98-110.
-
(2007)
Ann N Y Acad Sci
, vol.1100
, pp. 98-110
-
-
Tomoiu, A.1
Larbi, A.2
Fortin, C.3
Dupuis, G.4
Fulop, T.5
-
65
-
-
84885670616
-
Fuelling immunity: insights into metabolism and lymphocyte finction
-
Pearce E.L. Fuelling immunity: insights into metabolism and lymphocyte finction. Science 2013, 342:1242454.
-
(2013)
Science
, vol.342
, pp. 1242454
-
-
Pearce, E.L.1
-
67
-
-
84885994719
-
Increased mammalian target of rapamycin complex 2 signalling promotes age-related decline in CD4 T cell signaling and function
-
Perkey E., Fingar D., Miller R.A., Garcia G.G. Increased mammalian target of rapamycin complex 2 signalling promotes age-related decline in CD4 T cell signaling and function. J Immunol 2013, 191:4648-4655.
-
(2013)
J Immunol
, vol.191
, pp. 4648-4655
-
-
Perkey, E.1
Fingar, D.2
Miller, R.A.3
Garcia, G.G.4
-
68
-
-
84875529784
-
Immunosenescence in vertebrates and invertebrates
-
Müller L., Fülöp T., Pawelec G. Immunosenescence in vertebrates and invertebrates. Immun Aging 2013, 10:12.
-
(2013)
Immun Aging
, vol.10
, pp. 12
-
-
Müller, L.1
Fülöp, T.2
Pawelec, G.3
-
69
-
-
78049232743
-
Aging, frailty and age-related diseases
-
Fülöp T., Larbi A., Witkowski J.M., McElhaney J., Loeb M., Mitnitski A., Pawelec G. Aging, frailty and age-related diseases. Biogerontology 2010, 11:547-563.
-
(2010)
Biogerontology
, vol.11
, pp. 547-563
-
-
Fülöp, T.1
Larbi, A.2
Witkowski, J.M.3
McElhaney, J.4
Loeb, M.5
Mitnitski, A.6
Pawelec, G.7
-
70
-
-
84885982251
-
Aging, immunosenescence and membrane rafts: the lipid connection
-
Fülöp T., Le Page A., Garneau H., Azimi N., Baehl S., Dupuis G., Pawelec G., Larbi A. Aging, immunosenescence and membrane rafts: the lipid connection. Longevity Healthspan 2012, 1:6.
-
(2012)
Longevity Healthspan
, vol.1
, pp. 6
-
-
Fülöp, T.1
Le Page, A.2
Garneau, H.3
Azimi, N.4
Baehl, S.5
Dupuis, G.6
Pawelec, G.7
Larbi, A.8
-
71
-
-
80052682032
-
Reversible senescence in human CD4+CD45RA+CD27-memory T cells
-
Di Mitri D., Azevedo R.I., Henson S.M., Libri V., Riddell N.E., Macaulay R., Kipling D., Soares M.V., Battistini L., Akbar A.N. Reversible senescence in human CD4+CD45RA+CD27-memory T cells. J Immunol 2011, 187:2093-2100.
-
(2011)
J Immunol
, vol.187
, pp. 2093-2100
-
-
Di Mitri, D.1
Azevedo, R.I.2
Henson, S.M.3
Libri, V.4
Riddell, N.E.5
Macaulay, R.6
Kipling, D.7
Soares, M.V.8
Battistini, L.9
Akbar, A.N.10
-
72
-
-
84885167222
-
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
-
Youm Y.H., Grant R.W., McCabe L.R., Albarado D.C., Nguyen K.Y., Ravussin A., Pistell P., Newman S., Carter R., Laque A., et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 2013, 18:519-532.
-
(2013)
Cell Metab
, vol.18
, pp. 519-532
-
-
Youm, Y.H.1
Grant, R.W.2
McCabe, L.R.3
Albarado, D.C.4
Nguyen, K.Y.5
Ravussin, A.6
Pistell, P.7
Newman, S.8
Carter, R.9
Laque, A.10
-
73
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi C., Bonafè M., Valensin S., Olivieri F., De Luca M., Ottaviani E., De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:244-254.
-
(2000)
Ann N Y Acad Sci
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafè, M.2
Valensin, S.3
Olivieri, F.4
De Luca, M.5
Ottaviani, E.6
De Benedictis, G.7
-
74
-
-
15044354122
-
Low-grade inflammation with aging has consequences for T-lymphocyte signaling
-
Larbi A., Dupuis G., Douziech N., Khalil A., Fülöp T. Low-grade inflammation with aging has consequences for T-lymphocyte signaling. Ann N Y Acad Sci 2004, 1030:125-133.
-
(2004)
Ann N Y Acad Sci
, vol.1030
, pp. 125-133
-
-
Larbi, A.1
Dupuis, G.2
Douziech, N.3
Khalil, A.4
Fülöp, T.5
-
75
-
-
74149086692
-
Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation
-
Larbi A., Cabreiro F., Zelba H., Marthandan S., Combet E., Friguet B., Petropoulos I., Barnett Y., Pawelec G. Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radic Biol Med 2010, 48:26-34.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 26-34
-
-
Larbi, A.1
Cabreiro, F.2
Zelba, H.3
Marthandan, S.4
Combet, E.5
Friguet, B.6
Petropoulos, I.7
Barnett, Y.8
Pawelec, G.9
-
76
-
-
84880571356
-
The role of the T cell in age-related inflammation
-
Macauulay R., Akbar A.N., Henson S.M. The role of the T cell in age-related inflammation. Age 2013, 35:563-572.
-
(2013)
Age
, vol.35
, pp. 563-572
-
-
Macauulay, R.1
Akbar, A.N.2
Henson, S.M.3
-
77
-
-
2442713628
-
Lipid rafts in lymphocyte activation
-
Pizzo P., Viola A. Lipid rafts in lymphocyte activation. Microbes Infect 2004, 6:686-692.
-
(2004)
Microbes Infect
, vol.6
, pp. 686-692
-
-
Pizzo, P.1
Viola, A.2
-
78
-
-
4444236958
-
Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse
-
Taner S.B., Onfelt B., Pirinen N.J., McCann F.E., Magee A.I., Davis D.M. Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse. Traffic 2004, 5:651-661.
-
(2004)
Traffic
, vol.5
, pp. 651-661
-
-
Taner, S.B.1
Onfelt, B.2
Pirinen, N.J.3
McCann, F.E.4
Magee, A.I.5
Davis, D.M.6
-
79
-
-
77954672564
-
Plasma membrane microdomains in aging and disease
-
Ohno-Iwashita Y., Shimada Y., Hayashi M., Inomata M. Plasma membrane microdomains in aging and disease. Geriatr Gerontol Int 2010, 10(Suppl. 1):S41-S52.
-
(2010)
Geriatr Gerontol Int
, vol.10
, Issue.Suppl. 1
-
-
Ohno-Iwashita, Y.1
Shimada, Y.2
Hayashi, M.3
Inomata, M.4
-
80
-
-
0842309906
-
Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes
-
Larbi A., Douziech N., Dupuis G., Khalil A., Pelletier H., Guerard K.P., Fülöp T. Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. J Leukoc Biol 2004, 75:373-381.
-
(2004)
J Leukoc Biol
, vol.75
, pp. 373-381
-
-
Larbi, A.1
Douziech, N.2
Dupuis, G.3
Khalil, A.4
Pelletier, H.5
Guerard, K.P.6
Fülöp, T.7
-
81
-
-
33646580485
-
Impairment of SHP-1 down regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
-
Fortin C.F., Larbi A., Lesur O., Douziech N., Fulop T. Impairment of SHP-1 down regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J Leukoc Biol 2006, 79:1061-1072.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 1061-1072
-
-
Fortin, C.F.1
Larbi, A.2
Lesur, O.3
Douziech, N.4
Fulop, T.5
-
82
-
-
84874612342
-
Causes, consequences and reversal of immune system aging
-
Montecino-Rodrigez E., Berent-Maoz B., Dorschkind K. Causes, consequences and reversal of immune system aging. J Clin Invest 2013, 123:958-965.
-
(2013)
J Clin Invest
, vol.123
, pp. 958-965
-
-
Montecino-Rodrigez, E.1
Berent-Maoz, B.2
Dorschkind, K.3
|