The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

Nature Immunology

Volumn 15, Issue 10, 2014, Pages 965-972

  Lanna, Alessio ^a   Henson, Sian M ^a   Escors, David ^a,b   Akbar, Arne N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Atención Primaria Y Promoción de La Salud   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TAB1; SCAFFOLD PROTEIN; TELOMERASE; UNCLASSIFIED DRUG; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAB1 PROTEIN, HUMAN; TERT PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL AGING; CELL CULTURE; CELL PROLIFERATION; GENE EXPRESSION; GENETICS; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AMP-ACTIVATED PROTEIN KINASES; CD4-POSITIVE T-LYMPHOCYTES; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TELOMERASE;

EID: 84922056020     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2981     Document Type: Article

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