Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+ T-cell proliferation by distinct pathways

European Journal of Immunology

Volumn 45, Issue 5, 2015, Pages 1441-1451

  Henson, Sian M ^a   Macaulay, Richard ^a   Riddell, Natalie E ^a   Nunn, Craig J ^a   Akbar, Arne N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; Inhibitory receptors; T cells

Indexed keywords

CD27 ANTIGEN; CD45RA ANTIGEN; GAMMA INTERFERON; GRANZYME B; MITOGEN ACTIVATED PROTEIN KINASE P38; PERFORIN; PROGRAMMED DEATH 1 LIGAND 1; TELOMERASE; TUMOR NECROSIS FACTOR ALPHA; CD45 ANTIGEN; CYTOKINE; H2AFX PROTEIN, HUMAN; HISTONE; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; AGING; ANTAGONISTS AND INHIBITORS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PATHOLOGY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD45; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOKINES; HISTONES; HUMANS; IMMUNOLOGIC MEMORY; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTE SUBSETS; TELOMERASE; YOUNG ADULT;

EID: 84929659679     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445312     Document Type: Article

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