Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Nature Immunology

Volumn 17, Issue 8, 2016, Pages 966-975

  Pulko, Vesna ^a   Davies, John S ^a   Martinez, Carmine ^a   Lanteri, Marion C ^b   Busch, Michael P ^b   Diamond, Michael S ^c,d   Knox, Kenneth ^a   Bush, Erin C ^e   Sims, Peter A ^e,f   Sinari, Shripad ^g   Billheimer, Dean ^g   Haddad, Elias K ^h   Murray, Kristy O ^i,j   Wertheimer, Anne M ^a   Nikolich Žugich, Janko ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NewYork Presbyterian Hospital   (United States)

^f Baylor College of Medicine ^*  (United States)

^g UNIVERSITY OF ARIZONA   (United States)

^h DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j TEXAS CHILDREN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; CD28 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; CXCL3 CHEMOKINE; FAS ANTIGEN; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 1BETA; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MATRIX METALLOPROTEINASE 19; PROTEIN KINASE B; VIRUS ANTIGEN; TRANSCRIPTOME;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CELL AGING; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EFFECTOR CELL; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; FEMALE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOTHERAPY; INFLUENZA A; INFLUENZA A VIRUS; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERSISTENT INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TELOMERE HOMEOSTASIS; ACUTE DISEASE; AGING; CELL CULTURE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; IMMUNOSENESCENCE; LYMPHOCYTE ACTIVATION; MIDDLE AGED; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; VERY ELDERLY; VIRUS INFECTION; YOUNG ADULT;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; AGING; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; IMMUNOSENESCENCE; LYMPHOCYTE ACTIVATION; MIDDLE AGED; PHENOTYPE; T-LYMPHOCYTE SUBSETS; TRANSCRIPTOME; VIRUS DISEASES; YOUNG ADULT;

EID: 84976298029     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3483     Document Type: Article

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