T cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cells

Experimental Gerontology

Volumn 39, Issue 4, 2004, Pages 597-605

  Gomez, I ^a   Marx, F ^b   Gould, E A ^c   Grubeck Loebenstein, B ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

Author keywords

Aging; Dendritic cells; ELISPOT; Na ve T cells; Rabies virus; T cell response; Tick borne encephalitis virus

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; RECOMBINANT PROTEIN;

AGED; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; CELL ISOLATION; CELL SIZE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GROUPS BY AGE; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MALE; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; RABIES VIRUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TICK BORNE ENCEPHALITIS FLAVIVIRUS;

ADULT; AGED; AGING; ANTIGEN PRESENTATION; ANTIGENS, CD45; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; ENCEPHALITIS VIRUSES, TICK-BORNE; FEMALE; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RABIES VIRUS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

ACARI; RABIES VIRUS; TICK-BORNE ENCEPHALITIS VIRUS;

EID: 1642462959     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2003.11.018     Document Type: Conference Paper

References (35)

1. Burns E.A., Lum L.G., L'Hommedieu G., Goodwin J.S. Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. J Gerontol. 48:1993;B231-B236.
2. Chang M.P., Utsuyama M., Hirokawa K., Makinodan T. Decline in the production of interleukin-3 with age in mice. Cell Immunol. 115:1988;1-12.
3. Cipres A., Gala S., Martinez A.C., Merida I., Williamson P. An IL-2 receptor beta subdomain that controls Bcl-X(L) expression and cell survival. Eur J Immunol. 29:1999;1158-1167.
4. Fagnoni F.F., Vescovini R., Passeri G., Bologna G., Pedrazzoni M., Lavagetto G., Casti A., Franceschi C., Passeri M., Sansoni P. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood. 95:2000;2860-2868.
5. Fossum S. Dendritic leukocytes: features of their in vivo physiology. Res Immunol. 140:1989;883-891. (discussion 918-26).
6. George A.J., Ritter M.A. Thymic involution with ageing: obsolescence or good housekeeping? Immunol Today. 17:1996;267-272.
7. Ghaffari G., Passalacqua D.J., Bender B.S., Briggs D.J., Goodenow M.M., Sleasman J.W. Human lymphocyte proliferation responses following primary immunization with rabies vaccine as neoantigen. Clin Diagn Lab Immunol. 8:2001;880-883.
8. Gomez I., Hainz U., Jenewein B., Schwaiger S., Wolf A.M., Grubeck-Loebenstein B. Changes in the expression of CD31 and CXCR3 in CD4(+) naïve T cells in elderly persons. Mech Ageing Dev. 124:2003;395-402.
9. Gomez I., Marx F., Saurwein-Teissl M., Gould E.A., Grubeck-Loebenstein B. Characterization of tick-borne encephalitis virus specific human T lymphocyte responses by stimulation with structural TBEV proteins expressed in a recombinant Baculovirus. Viral Immunol. 16 (3):2003b;407-414.
10. Grubeck-Loebenstein B., Berger P., Saurwein-Teissl M., Zisterer K., Wick G. No immunity for the elderly. Nat Med. 4:1998;870.
11. Grubeck-Loebenstein B., Wick G. The aging of the immune system. Adv Immunol. 80:2002;243-284.
12. Gschoesser C., Almanzar G., Hainz U., Ortin J., Schonitzer D., Schild H., Saurwein-Teissl M., Grubeck-Loebenstein B. CD4+ and CD8+ mediated cellular immune response to recombinant influenza nucleoprotein. Vaccine. 20:2002;3731-3738.
13. Kelly E., Won A., Refaeli Y., Van Parijs L. IL-2 and related cytokines can promote T cell survival by activating AKT. J Immunol. 168:2002;597-603.
14. Kimmig S., Przybylski G.K., Schmidt C.A., Laurisch K., Mowes B., Radbruch A., Thiel A. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med. 195:2002;789-794.
15. King L.A., Possee R.D. The baculovirus expression system: a laboratory guide, London. 1992.
16. Kirberg J., Berns A., von Boehmer H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med. 186:1997;1269-1275.
17. Linton P.J., Haynes L., Klinman N.R., Swain S.L. Antigen-independent changes in naive CD4 T cells with aging. J Exp Med. 184:1996;1891-1900.
18. Marx F., Gritsun T.S., Grubeck-Loebenstein B., Gould E.A. Diagnostic immunoassays for tick-borne encephalitis virus based on recombinant baculovirus protein expression. J Virol Methods. 91:2001;75-84.
19. Nagelkerken L., Hertogh-Huijbregts A., Dobber R., Drager A. Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells. Eur J Immunol. 21:1991;273-281.
20. Negoro S., Hara H., Miyata S., Saiki O., Tanaka T., Yoshizaki K., Igarashi T., Kishimoto S. Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified Tac-positive T cells. Mech Ageing Dev. 36:1986;223-241.
21. Negoro S., Hara H., Miyata S., Saiki O., Tanaka T., Yoshizaki K., Nishimoto N., Kishimoto S. Age-related changes of the function of T cell subsets: predominant defect of the proliferative response in CD8 positive T cell subset in aged persons. Mech Ageing Dev. 39:1987;263-279.
22. Nordin A.A., Collins G.D. Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice. J Immunol. 131:1983;2215-2218.
23. Osugi Y., Vuckovic S., Hart D.N. Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes. Blood. 100:2002;2858-2866.
24. Ouyang Q., Cicek G., Westendorp R.G., Cools H.J., van der Klis R.J., Remarque E.J. Reduced IFN-gamma production in elderly people following in vitro stimulation with influenza vaccine and endotoxin. Mech Ageing Dev. 121:2000;131-137.
25. Prager E., Staffler G., Majdic O., Saemann M., Godar S., Zlabinger G., Stockinger H. Induction of hyporesponsiveness and impaired T lymphocyte activation by the CD31 receptor:ligand pathway in T cells. J Immunol. 166:2001;2364-2371.
26. Saurwein-Teissl M., Schonitzer D., Grubeck-Loebenstein B. Dendritic cell responsiveness to stimulation with influenza vaccine is unimpaired in old age. Exp Gerontol. 33:1998;625-631.
27. Scheibenbogen C., Lee K.H., Mayer S., Stevanovic S., Moebius U., Herr W., Rammensee H.G., Keilholz U. A sensitive ELISPOT assay for detection of CD8+ T lymphocytes specific for HLA class I-binding peptide epitopes derived from influenza proteins in the blood of healthy donors and melanoma patients. Clin Cancer Res. 3:1997;221-226.
28. Schlienger K., Craighead N., Lee K.P., Levine B.L., June C.H. Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells. Blood. 96:2000;3490-3498.
29. Steger M.M., Maczek C., Grubeck-Loebenstein B. Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin Exp Immunol. 105:1996;544-550.
30. Steger M.M., Maczek C., Grubeck-Loebenstein B. Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations. Mech Ageing Dev. 93:1997;125-130.
31. Steinman R.M. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol. 9:1991;271-296.
32. Takeda S., Rodewald H.R., Arakawa H., Bluethmann H., Shimizu T. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity. 5:1996;217-228.
33. Utsuyama M., Hirokawa K., Kurashima C., Fukayama M., Inamatsu T., Suzuki K., Hashimoto W., Sato K. Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood. Mech Ageing Dev. 63:1992;57-68.
34. Vissinga C., Hertogh-Huijbregts A., Rozing J., Nagelkerken L. Analysis of the age-related decline in alloreactivity of CD4+ and CD8+ T cells in CBA/ RIJ mice. Mech Ageing Dev. 51:1990;179-194.
35. Young J.L., Ramage J.M., Gaston J.S., Beverley P.C. In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells. Eur J Immunol. 27:1997;2383-2390.