Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

Immunity

Volumn 45, Issue 4, 2016, Pages 903-916

  Li, Yinyin ^a   Shen, Yi ^a   Hohensinner, Philipp ^a,b   Ju, Jihang ^a   Wen, Zhenke ^a   Goodman, Stuart B ^a   Zhang, Hui ^a   Goronzy, Jörg J ^a   Weyand, Cornelia M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; NUCLEASE; NUCLEASE MRE11A; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE; DNA BINDING PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; HETEROCHROMATIN; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PHENOTYPE; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; TELOMERE; UPREGULATION; ANIMAL; CELL CULTURE; DNA DAMAGE; DNA REPAIR; IMMUNOLOGY; INFLAMMATION; MONONUCLEAR CELL; MOUSE; SYNOVITIS; T LYMPHOCYTE;

ANIMALS; ARTHRITIS, RHEUMATOID; CELL AGING; CELLS, CULTURED; DEOXYRIBONUCLEASES; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MICE; SYNOVITIS; T-LYMPHOCYTES; TELOMERE; UP-REGULATION;

EID: 84994890342     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.09.013     Document Type: Article

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