Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion

Immunity

Volumn 45, Issue 2, 2016, Pages 358-373

  Bengsch, Bertram ^a   Johnson, Andy L ^a   Kurachi, Makoto ^a   Odorizzi, Pamela M ^a   Pauken, Kristen E ^a   Attanasio, John ^a   Stelekati, Erietta ^a   McLane, Laura M ^a   Paley, Michael A ^a   Delgoffe, Greg M ^b   Wherry, E John ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROGRAMMED DEATH 1 RECEPTOR; GLUCOSE; NEUTRALIZING ANTIBODY; PDCD1 PROTEIN, MOUSE; PPARGC1A PROTEIN, MOUSE; PROGRAMMED DEATH 1 LIGAND 1; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; BIOENERGY; CD8+ T LYMPHOCYTE; COMPARATIVE STUDY; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLUCOSE TRANSPORT; GLYCOLYSIS; IN VITRO STUDY; LYMPHOCYTE FUNCTION; LYMPHOCYTIC CHORIOMENINGITIS; METABOLIC DISORDER; METABOLIC REGULATION; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL AGING; CELL CULTURE; ENERGY METABOLISM; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; METABOLISM; NUCLEAR REPROGRAMMING;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD274; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CELLS, CULTURED; CELLULAR REPROGRAMMING; ENERGY METABOLISM; GLUCOSE; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PROGRAMMED CELL DEATH 1 RECEPTOR; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84997706268     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.07.008     Document Type: Article

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