Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Science

Volumn 354, Issue 6316, 2016, Pages 1160-1165

  Pauken, Kristen E ^a   Sammons, Morgan A ^b   Odorizzi, Pamela M ^a   Manne, Sasikanth ^a   Godec, Jernej ^c,d   Khan, Omar ^a   Drake, Adam M ^b   Chen, Zeyu ^a   Sen, Debattama R ^c   Kurachi, Makoto ^a   Barnitz, R Anthony ^c   Bartman, Caroline ^a   Bengsch, Bertram ^a   Huang, Alexander C ^e   Schenkel, Jason M ^f   Vahedi, Golnaz ^b   Haining, W Nicholas ^c,g,h   Berger, Shelley L ^b   Wherry, E John ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; INTERLEUKIN 7; PROGRAMMED DEATH 1 LIGAND 1;

ANTIGEN; CANCER; CELLS AND CELL COMPONENTS; MEMORY; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EPIGENETICS; EXPERIMENTAL MODEL; GENETIC STABILITY; IMMUNOTHERAPY; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINEAGE; FEMALE; GENE REGULATORY NETWORK; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; NUCLEAR REPROGRAMMING; TRANSPLANTATION;

MUS;

ANIMALS; ANTIGENS, CD274; CD8-POSITIVE T-LYMPHOCYTES; CELL LINEAGE; CELLULAR REPROGRAMMING; EPIGENESIS, GENETIC; FEMALE; GENE REGULATORY NETWORKS; IMMUNOLOGIC MEMORY; IMMUNOTHERAPY; INTERLEUKIN-7; MICE; MICE, INBRED C57BL; TRANSCRIPTION, GENETIC;

EID: 84994364943     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf2807     Document Type: Article

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