Impact of aging on antigen presentation cell function of dendritic cells

Current Opinion in Immunology

Volumn 25, Issue 4, 2013, Pages 535-541

  Wong, Christine ^a   Goldstein, Daniel R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE;

AGING; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CELL FUNCTION; CELL METABOLISM; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; INFECTION; INFLAMMATION; INFLUENZA; NONHUMAN; REVIEW; T LYMPHOCYTE; TUMOR IMMUNITY;

AGING; ANIMALS; ANTIGEN PRESENTATION; CELL DIFFERENTIATION; DENDRITIC CELLS; HUMANS; INFLAMMATION; T-LYMPHOCYTES;

EID: 84884148864     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2013.05.016     Document Type: Review

References (39)

1. Miller R.A. The aging immune system: primer and prospectus. Science 1996, 273:70-74.
2. Frasca D., Riley R.L., Blomberg B.B. Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF. Exp Gerontol 2007, 42:192-203.
3. Linton P.J., Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004, 5:133-139.
4. Iwasaki A., Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010, 327:291-295.
5. Mellman I., Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001, 106:255-258.
6. Geissmann F., Manz M.G., Jung S., Sieweke M.H., Merad M., Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010, 327:656-661.
7. Waithman J., Mintern J.D. Dendritic cells and influenza A virus infection. Virulence 2012, 3:603-608.
8. Guiducci C., Ott G., Chan J.H., Damon E., Calacsan C., Matray T., Lee K-D., Coffman R.L., Barrat F.J. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med 2006, 203:1999-2008.
9. Tan S.Y., Cavanagh L.L., d'Advigor W., Shackel N., Fazekas de St Groth B., Weninger W. Phenotype and functions of conventional dendritic cells are not compromised in aged mice. Immunol Cell Biol 2012, 90:722-732.
10. Wong C.P., Magnusson K.R., Ho E. Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine production. Exp Gerontol 2010, 45:163-169.
11. + T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells. Mech Ageing Dev 2011, 132:187-194.
12. Asquith M., Haberthur K., Brown M., Engelmann F., Murphy A., Al-Mahdi Z.I.M. Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta). Pathobiol Aging Age Relat Dis 2012, 10.3402/pba.v2i0.18052.
13. Jing Y., Shaheen E., Drake R.R., Chen N., Gravenstein S., Deng Y. Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood. Human Immunol 2009, 70:777-784.
14. Tesar B.M., Walker W.E., Unternaehrer J., Joshi N.S., Chandele A., Haynes L. Murine myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell 2006, 5:473-486.
15. Jones S.C., Brahmakshatriya V., Huston G., Dibble J., Swain S.L. TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J Immunol 2010, 185:6783-6794.
16. -CD8{alpha}-dendritic cell function. J Gerontol A: Biol Sci Med Sci 2006, 61:1039-1047.
17. Paula C., Motta A., Schmitz C., Nunes C.P., Souza A.P., Bonorino C. Alterations in dendritic cell function in aged mice: potential implications for immunotherapy design. Biogerontology 2009, 10:13-25.
18. + dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Aging Cell 2012, 11:968-977.
19. Gigley J.P., Khan I.A. Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection. PLoS ONE 2011, 6:e20838.
20. Stout-Delgado H.W., Yang X., Walker W.E., Tesar B.M., Goldstein D.R. Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol 2008, 181:6747-6756.
21. Stout-Delgado H.W., Du W., Shirali A.C., Booth C.J., Goldstein D.R. Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe 2009, 6:446-456.
22. Kawai T., Akira S. Toll-like receptor and RIG-1-like receptor signaling. Ann N Y Acad Sci 2008, 1143:1-20.
23. Sridharan A., Esposo M., Kaushal K., Tay J., Osann K., Agrawal S., Gupta S., Agrawal A. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. Age 2011, 33:363-376.
24. Gorina Y., Kelly T., Lubitz J., Hines Z. Trends in influenza and pneumonia among older persons in the United States. Aging Trends 2008, 8:1-11.
25. Qian F., Wang X., Zhang L., Lin A., Zhao H., Fikrig E., Montgomery R.R. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis 2011, 203:1415-1424.
26. Nash D., Mostashari F., Fine A., Miller J., O'Leary D., Murray K., Huang A., Rosenberg A., Greenberg A., Sherman M., et al. The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 2001, 344:1807-1814.
27. Agrawal A., Agrawal S., Cao J-N., Su H., Osann K., Gupta S. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol 2007, 178:6912-6922.
28. Agrawal A., Tay J., Ton S., Agrawal S., Gupta S. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J Immunol 2009, 182:1138-1145.
29. Bartlett D.B., Firth C.M., Phillips A.C., Moss P., Baylis D., Syddall H., Sayer A.A., Cooper C., Lord J.M. The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell 2012, 11:912-915.
30. Tracy R. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging. Int J Obes Relat Metab Disord 2003, (Suppl):S29-S34.
31. Panda A., Qian F., Mohanty S., van Duin D., Newman F.K., Zhang L., Chen S., Towle V., Belshe R.B., Fikrig E., et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010, 184:2518-2527.
32. Komatsubara S., Cinader B.S.M. Functional competence of dendritic cells of ageing C57BL/6 mice. Scand J Immunol 1986, 5:517-525.
33. Shen H., Tesar B.M., Du W., Goldstein D.R. Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation. PLoS ONE 2009, 4:e4097.
34. Moretto M.M., Lawlor E.M., Khan I.A. Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen. J Immunol 2008, 181:7977-7984.
35. Grolleau-Julius A., Harning E.K., Abernathy L.M., Yung R.L. Impaired dendritic cell function in aging leads to defective antitumor immunity. Cancer Res 2008, 68:6341-6349.
36. Katz J.M., Plowden J., Renshaw-Hoelscher M., Lu X., Tumpey T.M., Sambhara S. Immunity to influenza: the challenges of protecting an aging population. Immunol Res 2004, 29:113-124.
37. Jiang J., Fisher E., Bennett A.J., Murasko D.M. Enhancement of virus-specific expansion of transgenic CD8 T cells in aged mice by dendritic cells. Mech Ageing Dev 2010, 131:580-583.
38. Zhao J., Zhao J., Legge K., Perlman S. Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest 2011, 121:4921-4930.
39. Clark H.L., Banks R., Jones L., Hornick T.R., Higgins P.A., Burant C.J., Canaday D.H. Characterization of MHC-II antigen presentation by B cells and monocytes from older individuals. Clin Immunol 2012, 144:172-177.