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Volumn 46, Issue 10, 2016, Pages 2286-2301

Aging of the immune system: Focus on inflammation and vaccination

Author keywords

Aging; B lymphocytes; Longevity; NK cells; Signaling; T lymphocytes; Vaccine

Indexed keywords

AGING; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL MATURATION; HUMAN; IMMUNE AGING; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LONGEVITY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VACCINATION;

EID: 84990847690     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201546178     Document Type: Review
Times cited : (327)

References (180)
  • 1
    • 35948967250 scopus 로고    scopus 로고
    • Pursuing the longevity dividend: scientific goals for an aging world
    • Olshansky, S. J., Perry, D., Miller, R. A. and Butler, R. N., Pursuing the longevity dividend: scientific goals for an aging world. Ann. N.Y. Acad. Sci. 2007. 1114: 11–13.
    • (2007) Ann. N.Y. Acad. Sci. , vol.1114 , pp. 11-13
    • Olshansky, S.J.1    Perry, D.2    Miller, R.A.3    Butler, R.N.4
  • 2
    • 84990866960 scopus 로고    scopus 로고
    • Published by the Alliance for Aging Research, Updated May
    • The Silver Book. Chronic disease and medical innovation in an aging nation. Published by the Alliance for Aging Research, Updated May, 2011 (http://www.silverbook.org).
    • (2011) Chronic disease and medical innovation in an aging nation
  • 5
    • 85047689300 scopus 로고    scopus 로고
    • Cell resilience in species lifespans: a link to inflammation
    • Finch, C. E., Morgan, T. E., Longo, V. D. and de Magalhaes, J. P., Cell resilience in species lifespans: a link to inflammation? Aging Cell 2010. 9:519–526.
    • (2010) Aging Cell , vol.9 , pp. 519-526
    • Finch, C.E.1    Morgan, T.E.2    Longo, V.D.3    de Magalhaes, J.P.4
  • 8
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z. et al., Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006. 12: 1365–71.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5    Rao, S.6    Kazzaz, Z.7
  • 10
    • 84893438578 scopus 로고    scopus 로고
    • You are what you host: microbiome modulation of the aging process
    • Heintz, C. and Mair, W., You are what you host: microbiome modulation of the aging process. Cell 2014. 156: 408–411.
    • (2014) Cell , vol.156 , pp. 408-411
    • Heintz, C.1    Mair, W.2
  • 11
    • 33144460422 scopus 로고    scopus 로고
    • Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study
    • Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A. et al., Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol. 2006. 72: 1027–33.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 1027-1033
    • Mueller, S.1    Saunier, K.2    Hanisch, C.3    Norin, E.4    Alm, L.5    Midtvedt, T.6    Cresci, A.7
  • 12
    • 8144221776 scopus 로고    scopus 로고
    • Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects
    • Woodmansey E. J., McMurdo, M. E., Macfarlane, G. T. and Macfarlane, S., Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects. Appl Environ Microbiol 2004. 70: 6113–6122
    • (2004) Appl Environ Microbiol , vol.70 , pp. 6113-6122
    • Woodmansey, E.J.1    McMurdo, M.E.2    Macfarlane, G.T.3    Macfarlane, S.4
  • 13
    • 77955602581 scopus 로고    scopus 로고
    • Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians
    • Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J. et al., Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One 2010. 5: e10667.
    • (2010) PLoS One , vol.5
    • Biagi, E.1    Nylund, L.2    Candela, M.3    Ostan, R.4    Bucci, L.5    Pini, E.6    Nikkïla, J.7
  • 14
  • 15
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors
    • Campisi, J., Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors. Cell 2005. 120: 513–522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 16
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell non-automous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppé, J. P., Patil, C. K., Rodier, F., Sun, Y., Munoz, D., Goldstein, J., Nelson, P. S. et al., Senescence-associated secretory phenotypes reveal cell non-automous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008. 6: 2853–2868.
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppé, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.5    Goldstein, J.6    Nelson, P.S.7
  • 17
    • 16544366844 scopus 로고    scopus 로고
    • Chemokines in neoplastic progression
    • Mantovani, A., Chemokines in neoplastic progression. Semin. Cancer Biol. 2004. 14: 147–148.
    • (2004) Semin. Cancer Biol. , vol.14 , pp. 147-148
    • Mantovani, A.1
  • 19
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppé, J. P., Desprez, P. Y., Krtolica, A. and Campisi, J., The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 2010. 5: 99–118.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 20
    • 84919480323 scopus 로고    scopus 로고
    • An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
    • Demaria, M., Ohtani, B., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R. M. et al., An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell 2014. 31:722–733.
    • (2014) Dev. Cell , vol.31 , pp. 722-733
    • Demaria, M.1    Ohtani, B.2    Youssef, S.A.3    Rodier, F.4    Toussaint, W.5    Mitchell, J.R.6    Laberge, R.M.7
  • 21
    • 84889565689 scopus 로고    scopus 로고
    • Senescence is a developmental mechanism that contributes to embryonic growth and patterning
    • Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R. et al., Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 2013. 155:1119–1130.
    • (2013) Cell , vol.155 , pp. 1119-1130
    • Storer, M.1    Mas, A.2    Robert-Moreno, A.3    Pecoraro, M.4    Ortells, M.C.5    Di Giacomo, V.6    Yosef, R.7
  • 23
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • Rodier, F., Coppé, J. P., Patil, C. K., Hoeijmakers, W. A., Munoz, D. P., Raza, S. R., Freund, A. et al., Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009. 11: 973–979.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1    Coppé, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Munoz, D.P.5    Raza, S.R.6    Freund, A.7
  • 24
  • 26
    • 77949881805 scopus 로고    scopus 로고
    • Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    • Ohashi, K., Parker, J. L., Ouchi, N., Higuchi, A., Vita, J. A., Gokce, N., Pedersen, A. A. et al., Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem. 2010. 285: 6153–6160.
    • (2010) J Biol Chem , vol.285 , pp. 6153-6160
    • Ohashi, K.1    Parker, J.L.2    Ouchi, N.3    Higuchi, A.4    Vita, J.A.5    Gokce, N.6    Pedersen, A.A.7
  • 27
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • La Cava, A. and Matarese, G., The weight of leptin in immunity. Nat Rev Immunol. 2004. 4: 371–379.
    • (2004) Nat Rev Immunol , vol.4 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 28
    • 17344384196 scopus 로고    scopus 로고
    • Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia
    • Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., 3rd, Flier, J. S. et al., Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med. 1997. 185: 171–175.
    • (1997) J Exp Med , vol.185 , pp. 171-175
    • Sarraf, P.1    Frederich, R.C.2    Turner, E.M.3    Ma, G.4    Jaskowiak, N.T.5    Rivet, D.J.6    Flier, J.S.7
  • 29
    • 83755178932 scopus 로고    scopus 로고
    • Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
    • Lumeng, C. N., Liu, J., Geletka, L., Delaney, C., Delproposto, J., Desai, A., Oatmen, K. et al., Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J Immunol. 2011. 187: 6208–6216.
    • (2011) J Immunol , vol.187 , pp. 6208-6216
    • Lumeng, C.N.1    Liu, J.2    Geletka, L.3    Delaney, C.4    Delproposto, J.5    Desai, A.6    Oatmen, K.7
  • 30
    • 0032887992 scopus 로고    scopus 로고
    • Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro
    • Sewter, C. P., Digby, J. E., Blows, F., Prins, J. and O'Rahilly S., Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro. J Endocrinol. 1999. 163: 33–38.
    • (1999) J Endocrinol , vol.163 , pp. 33-38
    • Sewter, C.P.1    Digby, J.E.2    Blows, F.3    Prins, J.4    O'Rahilly, S.5
  • 31
    • 20444480549 scopus 로고    scopus 로고
    • Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6
    • Park, H. S., Park, J. Y. and Yu, R., Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract. 2005. 69: 29–35.
    • (2005) Diabetes Res Clin Pract , vol.69 , pp. 29-35
    • Park, H.S.1    Park, J.Y.2    Yu, R.3
  • 35
    • 15844364600 scopus 로고    scopus 로고
    • CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to healthy centenarians: implications for T cell memory
    • Cossarizza, A., Ortolani, C., Paganelli, R., Barbieri, D., Monti, D., Sansoni, P., Fagiolo, U. et al., CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to healthy centenarians: implications for T cell memory. Mech Ageing Develop. 1996. 86: 173–195.
    • (1996) Mech Ageing Develop , vol.86 , pp. 173-195
    • Cossarizza, A.1    Ortolani, C.2    Paganelli, R.3    Barbieri, D.4    Monti, D.5    Sansoni, P.6    Fagiolo, U.7
  • 36
    • 84899513393 scopus 로고    scopus 로고
    • Circulating mitochondrial DNA increases with age and is a familiar trait: implications for "inflamm-aging"
    • Pinti, M., Cevenini, E., Nasi, M., De Biasi, S., Salvioli, S., Monti, D., Benatti, S. et al., Circulating mitochondrial DNA increases with age and is a familiar trait: implications for "inflamm-aging". Eur. J. Immunol. 2014. 44: 1552–1562.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 1552-1562
    • Pinti, M.1    Cevenini, E.2    Nasi, M.3    De Biasi, S.4    Salvioli, S.5    Monti, D.6    Benatti, S.7
  • 37
    • 0035216133 scopus 로고    scopus 로고
    • Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
    • Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D. et al., Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J. Leukocyte Biol. 2001. 70: 881–886.
    • (2001) J. Leukocyte Biol. , vol.70 , pp. 881-886
    • Butcher, S.K.1    Chahal, H.2    Nayak, L.3    Sinclair, A.4    Henriquez, N.V.5    Sapey, E.6    O'Mahony, D.7
  • 38
    • 84873555175 scopus 로고    scopus 로고
    • Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age
    • Brubaker, A. L., Rendon, J. L., Ramirez, L., Choudhry, M. A. and Kovacs, E. J., Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J. Immunol. 2013. 190: 1746–1757.
    • (2013) J. Immunol. , vol.190 , pp. 1746-1757
    • Brubaker, A.L.1    Rendon, J.L.2    Ramirez, L.3    Choudhry, M.A.4    Kovacs, E.J.5
  • 39
    • 84892640743 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
    • Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H. et al., Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 2014. 123: 239–248.
    • (2014) Blood , vol.123 , pp. 239-248
    • Sapey, E.1    Greenwood, H.2    Walton, G.3    Mann, E.4    Love, A.5    Aaronson, N.6    Insall, R.H.7
  • 40
    • 84873442127 scopus 로고    scopus 로고
    • Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary inflammation
    • Nomellini, V., Brubaker, A. L., Mahbub, S., Palmer, J. L., Gomez, C. R. and Kovacs, E. J., Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary inflammation. Aging Dis. 2012. 3: 234–47.
    • (2012) Aging Dis , vol.3 , pp. 234-247
    • Nomellini, V.1    Brubaker, A.L.2    Mahbub, S.3    Palmer, J.L.4    Gomez, C.R.5    Kovacs, E.J.6
  • 41
    • 0022991368 scopus 로고
    • Influence of age on polymorphonuclear leukocytes in vitro: phagocytic activity in healthy human subjects
    • Emanuelli, G., Lanzio, M., Anfossi, T., Romano, S., Anfossi, G. and Calcamuggi, G., Influence of age on polymorphonuclear leukocytes in vitro: phagocytic activity in healthy human subjects. Gerontology 1986. 32: 308–316.
    • (1986) Gerontology , vol.32 , pp. 308-316
    • Emanuelli, G.1    Lanzio, M.2    Anfossi, T.3    Romano, S.4    Anfossi, G.5    Calcamuggi, G.6
  • 43
    • 84864378864 scopus 로고    scopus 로고
    • Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus
    • Tseng, C. W., Kyme, P. A., Arruda, A., Ramanujan, V. K., Tawackoli, W. and Liu, G. Y., Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus. PLoS One 2012. 7: e41454.
    • (2012) PLoS One , vol.7
    • Tseng, C.W.1    Kyme, P.A.2    Arruda, A.3    Ramanujan, V.K.4    Tawackoli, W.5    Liu, G.Y.6
  • 44
    • 84927711067 scopus 로고    scopus 로고
    • Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors
    • Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P. et al., Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 2015. 14: 421–432.
    • (2015) Aging Cell , vol.14 , pp. 421-432
    • Metcalf, T.U.1    Cubas, R.A.2    Ghneim, K.3    Cartwright, M.J.4    Grevenynghe, J.V.5    Richner, J.M.6    Olagnier, D.P.7
  • 45
    • 84941286399 scopus 로고    scopus 로고
    • Blood monocytes and their subsets: established features and open questions
    • Ziegler-Heitbrock, L., Blood monocytes and their subsets: established features and open questions. Front. Immunol. 2015. 6: 423.
    • (2015) Front. Immunol. , vol.6 , pp. 423
    • Ziegler-Heitbrock, L.1
  • 46
    • 84866449395 scopus 로고    scopus 로고
    • Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function
    • Hearps, A. C., Martin, G. E., Angelovich, T. A., Cheng, W. J., Maisa, A., Landay, A. L., Jaworowski, A. et al., Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell 2012. 11: 867–875.
    • (2012) Aging Cell , vol.11 , pp. 867-875
    • Hearps, A.C.1    Martin, G.E.2    Angelovich, T.A.3    Cheng, W.J.4    Maisa, A.5    Landay, A.L.6    Jaworowski, A.7
  • 49
    • 84855837075 scopus 로고    scopus 로고
    • Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly
    • Qian, F., Wang, X. M., Zhang, L., Chen, S., Piecychna, M., Allore, H., Bockenstedt, L. et al., Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012. 11: 104–110.
    • (2012) Aging Cell , vol.11 , pp. 104-110
    • Qian, F.1    Wang, X.M.2    Zhang, L.3    Chen, S.4    Piecychna, M.5    Allore, H.6    Bockenstedt, L.7
  • 50
    • 78650648694 scopus 로고    scopus 로고
    • Flagellin as an adjuvant: cellular mechanisms and potential
    • Mizel, S. B. and Bates, J. T., Flagellin as an adjuvant: cellular mechanisms and potential. J. Immunol. 2010 185: 5677–5682.
    • (2010) J. Immunol. , vol.185 , pp. 5677-5682
    • Mizel, S.B.1    Bates, J.T.2
  • 51
    • 84955403645 scopus 로고    scopus 로고
    • The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age
    • Weinberger, B., Joos, C., Reed, S. G., Coler, R. and Grubeck-Loebenstein, B., The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age. Biogerontology 2016. 17: 177–187.
    • (2016) Biogerontology , vol.17 , pp. 177-187
    • Weinberger, B.1    Joos, C.2    Reed, S.G.3    Coler, R.4    Grubeck-Loebenstein, B.5
  • 52
    • 77951886965 scopus 로고    scopus 로고
    • Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response
    • Panda, A., Qian, F., Mohanty, S., van Duin, D., Newman, F. K., Zhang, L., Chen, S. et al., Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010. 184: 2518–2527.
    • (2010) J Immunol , vol.184 , pp. 2518-2527
    • Panda, A.1    Qian, F.2    Mohanty, S.3    van Duin, D.4    Newman, F.K.5    Zhang, L.6    Chen, S.7
  • 53
    • 70349303199 scopus 로고    scopus 로고
    • Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood
    • Jing, Y., Shaheen, E., Drake, R. R., Chen, N., Gravenstein, S. and Deng, Y., Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood. Hum Immunol 2009. 70: 777–784.
    • (2009) Hum Immunol , vol.70 , pp. 777-784
    • Jing, Y.1    Shaheen, E.2    Drake, R.R.3    Chen, N.4    Gravenstein, S.5    Deng, Y.6
  • 56
  • 57
    • 33750624489 scopus 로고    scopus 로고
    • Deterioration of the Langerhans cell network of the human gingival epithelium with aging
    • Zavala, W. D. and Cavicchia, J. C., Deterioration of the Langerhans cell network of the human gingival epithelium with aging. Arch. Oral Biol. 2006. 51: 1150–1155.
    • (2006) Arch. Oral Biol. , vol.51 , pp. 1150-1155
    • Zavala, W.D.1    Cavicchia, J.C.2
  • 58
    • 0842324562 scopus 로고    scopus 로고
    • Skin infections and ageing
    • Laube, S., Skin infections and ageing. Ageing Res. Rev. 2004. 3: 69–89.
    • (2004) Ageing Res. Rev. , vol.3 , pp. 69-89
    • Laube, S.1
  • 59
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal A., Agrawal, S., Cao, J. N., Su, H. F., Osann, K. and Gupta, S., Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 2007. 178: 6912–6922.
    • (2007) J. Immunol. , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.N.3    Su, H.F.4    Osann, K.5    Gupta, S.6
  • 60
    • 84989211614 scopus 로고    scopus 로고
    • Responses of dendritic cells to TLR-4 stimulation are maintained in the elderly and resist the effects of CMV infection seen in the young
    • Janssen, N., Derhovanessian, E., Demuth, I., Arnaout, F., Steinhagen-Thiessen, E. and Pawelec, G., Responses of dendritic cells to TLR-4 stimulation are maintained in the elderly and resist the effects of CMV infection seen in the young. J Gerontol A Biol Sci Med Sci 2016. 71: 1117–1123.
    • (2016) J Gerontol A Biol Sci Med Sci , vol.71 , pp. 1117-1123
    • Janssen, N.1    Derhovanessian, E.2    Demuth, I.3    Arnaout, F.4    Steinhagen-Thiessen, E.5    Pawelec, G.6
  • 61
    • 84946852061 scopus 로고    scopus 로고
    • Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans
    • do Nascimento, M. P., Pinke, K. H., Penitenti, M., Ikoma, M. R. and Lara, V. S., Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans. Aging Clin Exp Res 2015. 27: 785–789.
    • (2015) Aging Clin Exp Res , vol.27 , pp. 785-789
    • do Nascimento, M.P.1    Pinke, K.H.2    Penitenti, M.3    Ikoma, M.R.4    Lara, V.S.5
  • 62
    • 80655125143 scopus 로고    scopus 로고
    • Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
    • Sridharan, A., Esposo, M., Kaushal, K., Tay, J., Osann, K., Agrawal, S., Gupta, S. et al., Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. Age 2011. 33: 363–376.
    • (2011) Age , vol.33 , pp. 363-376
    • Sridharan, A.1    Esposo, M.2    Kaushal, K.3    Tay, J.4    Osann, K.5    Agrawal, S.6    Gupta, S.7
  • 63
    • 0032751559 scopus 로고    scopus 로고
    • Age-related changes in dermal mast cell prevalence in BALB/c mice: functional importance and correlation with dermal mast cell expression of Kit
    • Hart, P. H., Grimbaldeston, M. A., Hosszu, E. K., Swift, G. J., Noonan, F. P. and Finlay-Jones, J. J., Age-related changes in dermal mast cell prevalence in BALB/c mice: functional importance and correlation with dermal mast cell expression of Kit. Immunology 1999. 98: 352–356.
    • (1999) Immunology , vol.98 , pp. 352-356
    • Hart, P.H.1    Grimbaldeston, M.A.2    Hosszu, E.K.3    Swift, G.J.4    Noonan, F.P.5    Finlay-Jones, J.J.6
  • 64
    • 27144517418 scopus 로고    scopus 로고
    • Age-induced reprogramming of mast cell degranulation
    • Nguyen, M., Pace, A. J. and Koller, B. H., Age-induced reprogramming of mast cell degranulation. J Immunol 2005. 175: 5701–5707.
    • (2005) J Immunol , vol.175 , pp. 5701-5707
    • Nguyen, M.1    Pace, A.J.2    Koller, B.H.3
  • 65
    • 0032861585 scopus 로고    scopus 로고
    • Atopic asthma is dominant in elderly onset asthmatics: possibility for an alteration of mast cell function by aging through Fc receptor expression
    • Atsuta, R., Akiyama, K., Shirasawa, T., Okumura, K., Fukuchi, Y. and Ra, C., Atopic asthma is dominant in elderly onset asthmatics: possibility for an alteration of mast cell function by aging through Fc receptor expression. Int Arch Allergy Immunol 1999. 120 Suppl 1: 76–81.
    • (1999) Int Arch Allergy Immunol , vol.120 , pp. 76-81
    • Atsuta, R.1    Akiyama, K.2    Shirasawa, T.3    Okumura, K.4    Fukuchi, Y.5    Ra, C.6
  • 66
    • 39449099608 scopus 로고    scopus 로고
    • Age-related changes in eosinophil function in human subjects
    • Mathur, S. K., Schwantes, E. A., Jarjour, N. N. and Busse, W. W., Age-related changes in eosinophil function in human subjects. Chest 2008. 133: 412–419.
    • (2008) Chest , vol.133 , pp. 412-419
    • Mathur, S.K.1    Schwantes, E.A.2    Jarjour, N.N.3    Busse, W.W.4
  • 68
    • 0037440670 scopus 로고    scopus 로고
    • Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly
    • Cohen, H. J., Harris, T. and Pieper, C. F., Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am. J. Med. 2003 114: 180–187.
    • (2003) Am. J. Med. , vol.114 , pp. 180-187
    • Cohen, H.J.1    Harris, T.2    Pieper, C.F.3
  • 71
    • 67649410701 scopus 로고    scopus 로고
    • An evolutionary perspective on the mechanisms of immunosenescence
    • Shanley, D. P., Aw, D., Manley, N. R. and Palmer D. B., An evolutionary perspective on the mechanisms of immunosenescence. Trends Immunol. 2009. 30: 374–381
    • (2009) Trends Immunol , vol.30 , pp. 374-381
    • Shanley, D.P.1    Aw, D.2    Manley, N.R.3    Palmer, D.B.4
  • 72
    • 33646937694 scopus 로고    scopus 로고
    • Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the extreme limit of human life
    • Nasi, M., Troiano, L., Lugli, E., Pinti, M., Ferraresi, R., Monterastelli, E., Mussi, C. et al., Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the extreme limit of human life. Aging Cell 2006. 5: 167–175.
    • (2006) Aging Cell , vol.5 , pp. 167-175
    • Nasi, M.1    Troiano, L.2    Lugli, E.3    Pinti, M.4    Ferraresi, R.5    Monterastelli, E.6    Mussi, C.7
  • 73
    • 34248139722 scopus 로고    scopus 로고
    • Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data
    • Lugli, E., Pinti, M., Nasi, M., Troiano, L., Ferarresi, R., Mussi, C., Salvioli, G. et al., Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data. Cytometry (part A) 2007. 71A: 334–344.
    • (2007) Cytometry (part A) , vol.71A , pp. 334-344
    • Lugli, E.1    Pinti, M.2    Nasi, M.3    Troiano, L.4    Ferarresi, R.5    Mussi, C.6    Salvioli, G.7
  • 74
    • 84910105185 scopus 로고    scopus 로고
    • Spatial map of human T cell compartmentalization and maintenance over decades of life
    • Thome, J. J., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T. et al., Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell 2014. 159: 814–828.
    • (2014) Cell , vol.159 , pp. 814-828
    • Thome, J.J.1    Yudanin, N.2    Ohmura, Y.3    Kubota, M.4    Grinshpun, B.5    Sathaliyawala, T.6    Kato, T.7
  • 76
    • 84956627545 scopus 로고    scopus 로고
    • Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy
    • Zlamy, M., Almanzar, G., Parson, W., Schmidt, C., Leierer, J., Weinberger, B., Jeller, V. et al., Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy. Immun Ageing 2016. 13: 3.
    • (2016) Immun Ageing , vol.13 , pp. 3
    • Zlamy, M.1    Almanzar, G.2    Parson, W.3    Schmidt, C.4    Leierer, J.5    Weinberger, B.6    Jeller, V.7
  • 77
    • 59649094871 scopus 로고    scopus 로고
    • Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets
    • Kohler, S. and Thiel, A., Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood 2009. 113: 769–774.
    • (2009) Blood , vol.113 , pp. 769-774
    • Kohler, S.1    Thiel, A.2
  • 78
    • 84871148729 scopus 로고    scopus 로고
    • Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults
    • Sauce, D., Larsen, M., Fastenackels, S., Roux, A., Gorochov, G., Katlama, C., Sidi, D. et al., Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults. J. Immunol 2012. 189: 5541–5548.
    • (2012) J. Immunol , vol.189 , pp. 5541-5548
    • Sauce, D.1    Larsen, M.2    Fastenackels, S.3    Roux, A.4    Gorochov, G.5    Katlama, C.6    Sidi, D.7
  • 81
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li, G., Yu, M., Lee, W. W., Tsang, M., Krishnan, E., Weyand, C. M. and Goronzy, J. J., Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med 2012. 18: 1518–1524.
    • (2012) Nat Med , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3    Tsang, M.4    Krishnan, E.5    Weyand, C.M.6    Goronzy, J.J.7
  • 84
    • 84938777751 scopus 로고    scopus 로고
    • Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection
    • Richner, J. M., Gmyrek G. B., Govero, J., Tu, Y., van der Windt, G. J., Metcalf, T. U., Haddad, E. K. et al., Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection. PLoS Pathog. 2016. 11: e1005027.
    • (2016) PLoS Pathog , vol.11
    • Richner, J.M.1    Gmyrek, G.B.2    Govero, J.3    Tu, Y.4    van der Windt, G.J.5    Metcalf, T.U.6    Haddad, E.K.7
  • 85
    • 84958593673 scopus 로고    scopus 로고
    • Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans
    • Schulz, A. R., Malzer, J. N., Domingo, C., Jurchott, K., Grutzkau, A., Babel, N., Nienen, M. et al., Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans. J. Immunol 2015. 195: 4699–4711.
    • (2015) J. Immunol , vol.195 , pp. 4699-4711
    • Schulz, A.R.1    Malzer, J.N.2    Domingo, C.3    Jurchott, K.4    Grutzkau, A.5    Babel, N.6    Nienen, M.7
  • 86
    • 19344370239 scopus 로고    scopus 로고
    • Immune activation and CD8(+) T-cell differentiation towards senescence in HIV-1 infection
    • Papagno, L., Spina, C. A., Marchant, A., Salio, M., Rufer, N., Little, S., Dong, T. et al., Immune activation and CD8(+) T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004. 2: E20.
    • (2004) PLoS Biol , vol.2
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3    Salio, M.4    Rufer, N.5    Little, S.6    Dong, T.7
  • 87
    • 0037561928 scopus 로고    scopus 로고
    • Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    • Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P. et al., Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003. 101: 2711–2720.
    • (2003) Blood , vol.101 , pp. 2711-2720
    • Brenchley, J.M.1    Karandikar, N.J.2    Betts, M.R.3    Ambrozak, D.R.4    Hill, B.J.5    Crotty, L.E.6    Casazza, J.P.7
  • 88
    • 84925428013 scopus 로고    scopus 로고
    • Narrowing of human influenza A virus-specific T cell receptor alpha and beta repertoires with increasing age
    • Gil, A., Yassai, M. B., Naumov, Y. N. and Selin, L. K., Narrowing of human influenza A virus-specific T cell receptor alpha and beta repertoires with increasing age. J. Virol. 2015. 89: 4102–4116.
    • (2015) J. Virol. , vol.89 , pp. 4102-4116
    • Gil, A.1    Yassai, M.B.2    Naumov, Y.N.3    Selin, L.K.4
  • 89
    • 84878066188 scopus 로고    scopus 로고
    • Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA
    • Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Wallace, D. et al., Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA. J. Immunol. 2013. 190: 5363–5372.
    • (2013) J. Immunol. , vol.190 , pp. 5363-5372
    • Griffiths, S.J.1    Riddell, N.E.2    Masters, J.3    Libri, V.4    Henson, S.M.5    Wertheimer, A.6    Wallace, D.7
  • 90
    • 84922056020 scopus 로고    scopus 로고
    • The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
    • Lanna, A., Henson, S. M., Escors, D. and Akbar, A. N., The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat. Immunol. 2014. 15: 965–972.
    • (2014) Nat. Immunol. , vol.15 , pp. 965-972
    • Lanna, A.1    Henson, S.M.2    Escors, D.3    Akbar, A.N.4
  • 92
    • 84929659679 scopus 로고    scopus 로고
    • Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways
    • Henson, S. M., Macaulay, R., Riddell, N. E., Nunn, C. J. and Akbar, A. N., Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways. Eur. J. Immunol. 2015. 45: 1441–1451.
    • (2015) Eur. J. Immunol , vol.45 , pp. 1441-1451
    • Henson, S.M.1    Macaulay, R.2    Riddell, N.E.3    Nunn, C.J.4    Akbar, A.N.5
  • 94
    • 84880692728 scopus 로고    scopus 로고
    • Differential impact of age and cytomegalovirus infection on the gammadelta T cell compartment
    • Roux, A., Mourin, G., Larsen, M., Fastenackels, S., Urrutia, A., Gorochov, G., Autran, B. et al., Differential impact of age and cytomegalovirus infection on the gammadelta T cell compartment. J. Immunol. 2013. 191: 1300–1306.
    • (2013) J. Immunol. , vol.191 , pp. 1300-1306
    • Roux, A.1    Mourin, G.2    Larsen, M.3    Fastenackels, S.4    Urrutia, A.5    Gorochov, G.6    Autran, B.7
  • 95
    • 84879807111 scopus 로고    scopus 로고
    • Age-associated alterations in gammadelta T-cells are present predominantly in individuals infected with cytomegalovirus
    • Wistuba-Hamprecht, K., Frasca, D., Blomberg, B., Pawelec, G. and Derhovanessian, E., Age-associated alterations in gammadelta T-cells are present predominantly in individuals infected with cytomegalovirus. Immun. Ageing 2013. 10: 26.
    • (2013) Immun. Ageing , vol.10 , pp. 26
    • Wistuba-Hamprecht, K.1    Frasca, D.2    Blomberg, B.3    Pawelec, G.4    Derhovanessian, E.5
  • 97
    • 78049252250 scopus 로고    scopus 로고
    • CD56 negative NK cells: origin, function, and role in chronic viral disease
    • Bjorkstrom, N. K., Ljunggren, H. G. and Sandberg, J. K., CD56 negative NK cells: origin, function, and role in chronic viral disease. Trends Immunol. 2010. 31: 401–406.
    • (2010) Trends Immunol , vol.31 , pp. 401-406
    • Bjorkstrom, N.K.1    Ljunggren, H.G.2    Sandberg, J.K.3
  • 98
    • 80052373429 scopus 로고    scopus 로고
    • Immunoaging induced by hematopoietic stem cell aging
    • Wang, J. W., Geiger, H. and Rudolph, K. L., Immunoaging induced by hematopoietic stem cell aging. Curr. Opin. Immunol. 2011. 23: 532–536.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 532-536
    • Wang, J.W.1    Geiger, H.2    Rudolph, K.L.3
  • 102
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
    • Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G. and Fulop, T., Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Sem Immunol 2012. 24: 331–341.
    • (2012) Sem Immunol , vol.24 , pp. 331-341
    • Solana, R.1    Tarazona, R.2    Gayoso, I.3    Lesur, O.4    Dupuis, G.5    Fulop, T.6
  • 104
    • 79955011677 scopus 로고    scopus 로고
    • Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults
    • Lutz, C. T., Karapetyan, A., Al-Attar, A., Shelton, B. J., Holt, K. J., Tucker, J. H. and Presnell, S. R., Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J. Immunol. 2011. 186: 4590–4598.
    • (2011) J. Immunol. , vol.186 , pp. 4590-4598
    • Lutz, C.T.1    Karapetyan, A.2    Al-Attar, A.3    Shelton, B.J.4    Holt, K.J.5    Tucker, J.H.6    Presnell, S.R.7
  • 105
  • 106
    • 84897998839 scopus 로고    scopus 로고
    • Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens
    • White, M. J., Nielsen, C. M., McGregor, R. H., Riley, E. M. and Goodier, M. R., Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens. Immunology 2014. 142: 140–150.
    • (2014) Immunology , vol.142 , pp. 140-150
    • White, M.J.1    Nielsen, C.M.2    McGregor, R.H.3    Riley, E.M.4    Goodier, M.R.5
  • 107
    • 78149419031 scopus 로고    scopus 로고
    • Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
    • Bjorkstrom, N. K., Riese, P., Heuts, F., Andersson, S., Fauriat, C., Ivarsson, M. A., Bjorklund, A. T. et al., Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood 2010. 116: 3853–3864.
    • (2010) Blood , vol.116 , pp. 3853-3864
    • Bjorkstrom, N.K.1    Riese, P.2    Heuts, F.3    Andersson, S.4    Fauriat, C.5    Ivarsson, M.A.6    Bjorklund, A.T.7
  • 108
    • 34247538298 scopus 로고    scopus 로고
    • In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection
    • Zhang, Y., Wallace, D. L., de Lara, C. M., Ghattas, H., Asquith, B., Worth, A., Griffin, G. E. et al., In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection. Immunology 2007. 121: 258–265.
    • (2007) Immunology , vol.121 , pp. 258-265
    • Zhang, Y.1    Wallace, D.L.2    de Lara, C.M.3    Ghattas, H.4    Asquith, B.5    Worth, A.6    Griffin, G.E.7
  • 110
    • 9444273448 scopus 로고    scopus 로고
    • Imprint of human cytomegalovirus infection on the NK cell receptor repertoire
    • Guma, M., Angulo, A., Vilches, C., Gomez-Lozano, N., Malats, N. and Lopez-Botet, M., Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 2004. 104: 3664–3671.
    • (2004) Blood , vol.104 , pp. 3664-3671
    • Guma, M.1    Angulo, A.2    Vilches, C.3    Gomez-Lozano, N.4    Malats, N.5    Lopez-Botet, M.6
  • 111
    • 84876878182 scopus 로고    scopus 로고
    • NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
    • Beziat, V., Liu, L. L., Malmberg, J. A., Ivarsson, M. A., Sohlberg, E., Bjorklund, A. T., Retiere, C. et al., NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs. Blood 2013. 121: 2678–2688.
    • (2013) Blood , vol.121 , pp. 2678-2688
    • Beziat, V.1    Liu, L.L.2    Malmberg, J.A.3    Ivarsson, M.A.4    Sohlberg, E.5    Bjorklund, A.T.6    Retiere, C.7
  • 112
    • 53549114206 scopus 로고    scopus 로고
    • NK cells and cancer immunosurveillance
    • Waldhauer, I. and Steinle, A., NK cells and cancer immunosurveillance. Oncogene 2008. 27: 5932–5943.
    • (2008) Oncogene , vol.27 , pp. 5932-5943
    • Waldhauer, I.1    Steinle, A.2
  • 113
    • 77950857568 scopus 로고    scopus 로고
    • The ageing B cell population: composition and function
    • Ademokun, A., Wu, Y. C. and Dunn-Walters, D., The ageing B cell population: composition and function. Biogerontology 2010. 11: 125–137.
    • (2010) Biogerontology , vol.11 , pp. 125-137
    • Ademokun, A.1    Wu, Y.C.2    Dunn-Walters, D.3
  • 114
    • 84857609917 scopus 로고    scopus 로고
    • Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine
    • Frasca, D., Diaz, A., Romero, M., Phillips, M., Mendez, N. V., Landin, A. M. and Blomberg, B. B., Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine. Int Immunol 2012. 24: 175–182.
    • (2012) Int Immunol , vol.24 , pp. 175-182
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Phillips, M.4    Mendez, N.V.5    Landin, A.M.6    Blomberg, B.B.7
  • 115
    • 45949103917 scopus 로고    scopus 로고
    • Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
    • Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L. and Blomberg, B. B., Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol 2008. 180: 5283–5290.
    • (2008) J Immunol , vol.180 , pp. 5283-5290
    • Frasca, D.1    Landin, A.M.2    Lechner, S.C.3    Ryan, J.G.4    Schwartz, R.5    Riley, R.L.6    Blomberg, B.B.7
  • 116
    • 23844467731 scopus 로고    scopus 로고
    • Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell
    • Shi, Y., Yamazaki, T., Okubo, Y., Uehara, Y., Sugane, K. and Agematsu, K., Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell. J Immunol 2005. 175: 3262–3267.
    • (2005) J Immunol , vol.175 , pp. 3262-3267
    • Shi, Y.1    Yamazaki, T.2    Okubo, Y.3    Uehara, Y.4    Sugane, K.5    Agematsu, K.6
  • 117
    • 33748509736 scopus 로고    scopus 로고
    • A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation
    • Fecteau, J. F., Cote, G. and Neron, S., A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation. J. Immunol. 2006. 177: 3728–3736.
    • (2006) J. Immunol. , vol.177 , pp. 3728-3736
    • Fecteau, J.F.1    Cote, G.2    Neron, S.3
  • 118
    • 70349412916 scopus 로고    scopus 로고
    • A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people
    • Colonna-Romano, G., Bulati, M., Aquino, A., Pellicano, M., Vitello, S., Lio, D., Candore, G. et al., A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech. Ageing Dev. 2009. 130: 681–690.
    • (2009) Mech. Ageing Dev , vol.130 , pp. 681-690
    • Colonna-Romano, G.1    Bulati, M.2    Aquino, A.3    Pellicano, M.4    Vitello, S.5    Lio, D.6    Candore, G.7
  • 120
    • 84976505658 scopus 로고    scopus 로고
    • Aging, cytomegalovirus (CMV) and influenza vaccine responses
    • Frasca, D. and Blomberg, B. B., Aging, cytomegalovirus (CMV) and influenza vaccine responses. Hum. Vaccin. Immunother. 2015. 12: 682–690.
    • (2015) Hum. Vaccin. Immunother , vol.12 , pp. 682-690
    • Frasca, D.1    Blomberg, B.B.2
  • 121
    • 84898802132 scopus 로고    scopus 로고
    • High TNF-alpha levels in resting B cells negatively correlate with their response
    • Frasca, D., Diaz, A., Romero, M., Landin, A. M. and Blomberg, B. B., High TNF-alpha levels in resting B cells negatively correlate with their response. Exp. Gerontol. 2014. 54: 116–122.
    • (2014) Exp. Gerontol. , vol.54 , pp. 116-122
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Landin, A.M.4    Blomberg, B.B.5
  • 122
    • 84924501653 scopus 로고    scopus 로고
    • Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
    • Frasca, D., Diaz, A., Romero, M., Landin, A. M. and Blomberg, B. B., Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine. Vaccine 2015. 33: 1433–1439.
    • (2015) Vaccine , vol.33 , pp. 1433-1439
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Landin, A.M.4    Blomberg, B.B.5
  • 123
    • 84876698358 scopus 로고    scopus 로고
    • Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season
    • Frasca, D., Diaz, A., Romero, M., Mendez, N. V., Landin, A. M. and Blomberg, B. B., Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season. Immun. Ageing 2013. 10: 14.
    • (2013) Immun. Ageing , vol.10 , pp. 14
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Mendez, N.V.4    Landin, A.M.5    Blomberg, B.B.6
  • 124
    • 84866902351 scopus 로고    scopus 로고
    • AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans
    • Khurana, S., Frasca, D., Blomberg, B. and Golding, H., AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans. PLoS Path. 2012. 8: e1002920.
    • (2012) PLoS Path , vol.8
    • Khurana, S.1    Frasca, D.2    Blomberg, B.3    Golding, H.4
  • 125
    • 78649641896 scopus 로고    scopus 로고
    • Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
    • Frasca, D., Diaz, A., Romero, M., Landin, A. M., Phillips, M., Lechner, S. C., Ryan, J. G. et al., Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine 2010. 28: 8077–8084.
    • (2010) Vaccine , vol.28 , pp. 8077-8084
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Landin, A.M.4    Phillips, M.5    Lechner, S.C.6    Ryan, J.G.7
  • 126
    • 84871935156 scopus 로고    scopus 로고
    • Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    • Derhovanessian, E., Theeten, H., Hahnel, K., Van Damme, P., Cools, N. and Pawelec, G., Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine 2013. 31: 685–690.
    • (2013) Vaccine , vol.31 , pp. 685-690
    • Derhovanessian, E.1    Theeten, H.2    Hahnel, K.3    Van Damme, P.4    Cools, N.5    Pawelec, G.6
  • 127
    • 84862776821 scopus 로고    scopus 로고
    • The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
    • McElhaney, J. E., Zhou, X., Talbot, H. K., Soethout, E., Bleackley, R. C., Granville, D. J. and Pawelec, G., The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine 2012. 30: 2060–2067.
    • (2012) Vaccine , vol.30 , pp. 2060-2067
    • McElhaney, J.E.1    Zhou, X.2    Talbot, H.K.3    Soethout, E.4    Bleackley, R.C.5    Granville, D.J.6    Pawelec, G.7
  • 130
    • 81155152466 scopus 로고    scopus 로고
    • Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages
    • Ademokun, A., Wu, Y. C., Martin, V., Mitra, R., Sack, U., Baxendale, H., Kipling, D. et al., Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell 2011. 10: 922–930.
    • (2011) Aging Cell , vol.10 , pp. 922-930
    • Ademokun, A.1    Wu, Y.C.2    Martin, V.3    Mitra, R.4    Sack, U.5    Baxendale, H.6    Kipling, D.7
  • 131
    • 84874092680 scopus 로고    scopus 로고
    • Lineage structure of the human antibody repertoire in response to influenza vaccination
    • Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X. S., Dekker, C. L. et al., Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med 2013. 5: 171ra119.
    • (2013) Sci Transl Med , vol.5 , pp. 171ra119
    • Jiang, N.1    He, J.2    Weinstein, J.A.3    Penland, L.4    Sasaki, S.5    He, X.S.6    Dekker, C.L.7
  • 133
    • 84948972267 scopus 로고    scopus 로고
    • Paradoxical changes in innate immunity in aging: recent progress and new directions
    • Montgomery, R. R. and Shaw, A. C., Paradoxical changes in innate immunity in aging: recent progress and new directions. J. Leukoc. Biol. 2015; 98: 937–943.
    • (2015) J. Leukoc. Biol. , vol.98 , pp. 937-943
    • Montgomery, R.R.1    Shaw, A.C.2
  • 134
    • 33646580485 scopus 로고    scopus 로고
    • Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    • Fortin, C. F., Larbi, A., Lesur, O., Douziech, N. and Fulop, T. Jr., Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J. Leukoc. Biol. 2006. 79: 1061–1072.
    • (2006) J. Leukoc. Biol. , vol.79 , pp. 1061-1072
    • Fortin, C.F.1    Larbi, A.2    Lesur, O.3    Douziech, N.4    Fulop, T.5
  • 135
    • 84901500923 scopus 로고    scopus 로고
    • Cellular signalling pathways in immune aging and regeneration
    • Aspinall, R., Lapenna, A., Lynch, C. and Lang, P. O., Cellular signalling pathways in immune aging and regeneration. Biochem Soc Trans. 2014. 42: 651–656.
    • (2014) Biochem Soc Trans , vol.42 , pp. 651-656
    • Aspinall, R.1    Lapenna, A.2    Lynch, C.3    Lang, P.O.4
  • 136
    • 84868208626 scopus 로고    scopus 로고
    • Signaling pathways in aged T cells - A reflection of T cell differentiation, cell senescence and host environment
    • Goronzy, J. J., Li, G., Yu, M. and Weyand, C. M., Signaling pathways in aged T cells - A reflection of T cell differentiation, cell senescence and host environment. Semin. Immunol. 2012. 24: 365–372.
    • (2012) Semin. Immunol. , vol.24 , pp. 365-372
    • Goronzy, J.J.1    Li, G.2    Yu, M.3    Weyand, C.M.4
  • 137
    • 0033009202 scopus 로고    scopus 로고
    • Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NFkappaB activation in T lymphocytes during aging: evidence for altered IkappaB-alpha phosphorylation and degradation
    • Ponnappan, U., Trebilcock, G. U. and Zheng, M. Z., Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NFkappaB activation in T lymphocytes during aging: evidence for altered IkappaB-alpha phosphorylation and degradation. Exp Gerontol 1999, 34:95–107.
    • (1999) Exp Gerontol , vol.34 , pp. 95-107
    • Ponnappan, U.1    Trebilcock, G.U.2    Zheng, M.Z.3
  • 138
    • 84892818946 scopus 로고    scopus 로고
    • Modulation of signaling in lymphocytes from elderly donors. Inhibition of SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell
    • LePage, A., Fortin, C., Garneau, H., Allard, N., Tsvetkova, K., Larbi, A., Dupuis, G. et al., Modulation of signaling in lymphocytes from elderly donors. Inhibition of SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell. Cell Commun. Signal. 2014; 12:2 (doi: 10.1186/1478-811X-12-2).
    • (2014) Cell Commun. Signal , vol.12 , pp. 2
    • LePage, A.1    Fortin, C.2    Garneau, H.3    Allard, N.4    Tsvetkova, K.5    Larbi, A.6    Dupuis, G.7
  • 139
    • 33645102374 scopus 로고    scopus 로고
    • Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
    • Larbi, A., Dupuis, G., Khalil, A., Douziech, N., Fortin, C. and Fulop, T. Jr., Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging. Cell Signal. 2006. 18: 1017–1030.
    • (2006) Cell Signal , vol.18 , pp. 1017-1030
    • Larbi, A.1    Dupuis, G.2    Khalil, A.3    Douziech, N.4    Fortin, C.5    Fulop, T.6
  • 140
    • 34547954316 scopus 로고    scopus 로고
    • Oxidative stress modulation and T cell activation
    • Larbi, A., Kempf, J. and Pawelec G., Oxidative stress modulation and T cell activation. Exp. Gerontol. 2007. 42:852–858.
    • (2007) Exp. Gerontol. , vol.42 , pp. 852-858
    • Larbi, A.1    Kempf, J.2    Pawelec, G.3
  • 141
    • 0034100421 scopus 로고    scopus 로고
    • Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes
    • Lenton, K. J., Therriault, H., Cantin, A. M., Fülöp, T., Payette, H. and Wagner, J. R., Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes. Am. J. Clin. Nutr. 2000. 71: 1194–2000.
    • (2000) Am. J. Clin. Nutr. , vol.71 , pp. 1194-2000
    • Lenton, K.J.1    Therriault, H.2    Cantin, A.M.3    Fülöp, T.4    Payette, H.5    Wagner, J.R.6
  • 143
    • 84890832543 scopus 로고    scopus 로고
    • From "truly naïve" to "exhausted senescent" T cells: when markers predict functionality
    • Larbi, A. and Fülöp, T., From "truly naïve" to "exhausted senescent" T cells: when markers predict functionality. Cytometry A. 2014. 85:25–35.
    • (2014) Cytometry A , vol.85 , pp. 25-35
    • Larbi, A.1    Fülöp, T.2
  • 146
    • 84935049461 scopus 로고    scopus 로고
    • TCR-signaling events in cellular metabolism and specialization
    • Chisolm, D. A. and Weinmann, A. S., TCR-signaling events in cellular metabolism and specialization. Front. Immunol. 2015. 6: 292.
    • (2015) Front. Immunol. , vol.6 , pp. 292
    • Chisolm, D.A.1    Weinmann, A.S.2
  • 148
    • 34249107969 scopus 로고    scopus 로고
    • Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults
    • van Duin, D., Allore, H. G., Mohanty, S., Ginter, S., Newman, F. K., Belshe, R. B., Medzhitov, R. et al., Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis. 2007. 195: 1590–1597.
    • (2007) J Infect Dis , vol.195 , pp. 1590-1597
    • van Duin, D.1    Allore, H.G.2    Mohanty, S.3    Ginter, S.4    Newman, F.K.5    Belshe, R.B.6    Medzhitov, R.7
  • 149
    • 20344375434 scopus 로고    scopus 로고
    • The effect of age on the cognate function of CD4+ T cells
    • Haynes, L. and Eaton, S. M., The effect of age on the cognate function of CD4+ T cells. Immunol Rev. 2005. 205: 220–228.
    • (2005) Immunol Rev , vol.205 , pp. 220-228
    • Haynes, L.1    Eaton, S.M.2
  • 150
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccination in the elderly: a quantitative review
    • Goodwin, K., Viboud, C. and Simonsen, L., Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2006. 24: 1159–1169.
    • (2006) Vaccine , vol.24 , pp. 1159-1169
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 152
    • 34247132167 scopus 로고    scopus 로고
    • Frailty in elderly people
    • Strandberg, T. E. and Pitkälä, K. H., Frailty in elderly people. Lancet. 2007. 369: 1328–1329
    • (2007) Lancet , vol.369 , pp. 1328-1329
    • Strandberg, T.E.1    Pitkälä, K.H.2
  • 153
    • 2642541669 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
    • Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M. and Walston, J. D., Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res. 2004. 16: 153–157.
    • (2004) Aging Clin Exp Res , vol.16 , pp. 153-157
    • Leng, S.X.1    Cappola, A.R.2    Andersen, R.E.3    Blackman, M.R.4    Koenig, K.5    Blair, M.6    Walston, J.D.7
  • 154
    • 79959758526 scopus 로고    scopus 로고
    • Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults
    • Yao, X., Hamilton, R. G., Weng, N. P., Xue, Q. L., Bream, J. H., Li, H., Tian, J. et al., Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults. Vaccine 2011. 29: 5015–5021.
    • (2011) Vaccine , vol.29 , pp. 5015-5021
    • Yao, X.1    Hamilton, R.G.2    Weng, N.P.3    Xue, Q.L.4    Bream, J.H.5    Li, H.6    Tian, J.7
  • 155
    • 84963631903 scopus 로고    scopus 로고
    • Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures
    • Nakaya, H. I., Hagan, T., Duraisingham, S. S., Lee, E. K., Kwissa, M., Rouphael, N., Frasca, D. et al., Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures. Immunity 2015. 43: 1186–1198
    • (2015) Immunity , vol.43 , pp. 1186-1198
    • Nakaya, H.I.1    Hagan, T.2    Duraisingham, S.S.3    Lee, E.K.4    Kwissa, M.5    Rouphael, N.6    Frasca, D.7
  • 156
    • 84901435905 scopus 로고    scopus 로고
    • Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine
    • Park, H. L., Shim, S. H., Leem E. Y., Cho, W., Park, S., Jeon, H. J., Ahn et al., Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine. Hum Vaccin Immunother. 2014. 10: 1181–1186.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 1181-1186
    • Park, H.L.1    Shim, S.H.2    Leem, E.Y.3    Cho, W.4    Park, S.5    Jeon, H.J.6    Ahn7
  • 158
    • 84955342527 scopus 로고    scopus 로고
    • Inflammaging decreases adaptive and innate immune responses in mice and humans
    • Frasca D. and Blomberg, B. B., Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology 2016. 17: 7–19.
    • (2016) Biogerontology , vol.17 , pp. 7-19
    • Frasca, D.1    Blomberg, B.B.2
  • 159
    • 79951786443 scopus 로고    scopus 로고
    • Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans
    • Zhou, X. and McElhaney, J. E., Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine 2011. 29: 2169–2177.
    • (2011) Vaccine , vol.29 , pp. 2169-2177
    • Zhou, X.1    McElhaney, J.E.2
  • 160
    • 50949102312 scopus 로고    scopus 로고
    • Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial
    • Holland, D., Booy, R., De Looze, F., Eizenberg, P., McDonald, J., Karrasch, J., McKeirnan, M. et al., Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial. J. Infect. Dis. 2008. 198: 650–658.
    • (2008) J. Infect. Dis. , vol.198 , pp. 650-658
    • Holland, D.1    Booy, R.2    De Looze, F.3    Eizenberg, P.4    McDonald, J.5    Karrasch, J.6    McKeirnan, M.7
  • 161
    • 67650665332 scopus 로고    scopus 로고
    • Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
    • Falsey, A. R., Treanor, J. J., Tornieporth, N., Capellan, J. and Gorse, G. J., Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. J. Infect. Dis. 2009. 200: 172–180.
    • (2009) J. Infect. Dis. , vol.200 , pp. 172-180
    • Falsey, A.R.1    Treanor, J.J.2    Tornieporth, N.3    Capellan, J.4    Gorse, G.J.5
  • 162
    • 0028792511 scopus 로고
    • Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59
    • Ott, G., Barchfeld, G. L. and van Nest, G., Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. Vaccine 1995. 13: 1557–1562.
    • (1995) Vaccine , vol.13 , pp. 1557-1562
    • Ott, G.1    Barchfeld, G.L.2    van Nest, G.3
  • 163
    • 77953125928 scopus 로고    scopus 로고
    • Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates
    • Ansaldi, F., Zancolli, M., Durando, P., Montomoli, E., Sticchi, L., Del Giudice, G. and Icardi, G., Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates. Vaccine 2010. 28: 4123–4129.
    • (2010) Vaccine , vol.28 , pp. 4123-4129
    • Ansaldi, F.1    Zancolli, M.2    Durando, P.3    Montomoli, E.4    Sticchi, L.5    Del Giudice, G.6    Icardi, G.7
  • 164
    • 84155162558 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
    • Osterholm, M. T., Kelley, N. S., Sommer, A. and Belongia, E. A., Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect. Dis. 2012. 12: 36–44.
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 36-44
    • Osterholm, M.T.1    Kelley, N.S.2    Sommer, A.3    Belongia, E.A.4
  • 165
    • 84887607325 scopus 로고    scopus 로고
    • Cochrane re-arranged: support for policies to vaccinate elderly people against influenza
    • Beyer, W. E., McElhaney, J., Smith, D. J., Monto, A. S., Nguyen-Van-Tam, J. S. and Osterhaus, A. D., Cochrane re-arranged: support for policies to vaccinate elderly people against influenza. Vaccine 2013. 31: 6030–6033.
    • (2013) Vaccine , vol.31 , pp. 6030-6033
    • Beyer, W.E.1    McElhaney, J.2    Smith, D.J.3    Monto, A.S.4    Nguyen-Van-Tam, J.S.5    Osterhaus, A.D.6
  • 166
    • 85016901093 scopus 로고    scopus 로고
    • Developing universal influenza vaccines: hitting the nail, not just on the head
    • Wiersma, L. C., Rimmelzwaan, G. F. and de Vries, R. D., Developing universal influenza vaccines: hitting the nail, not just on the head. Vaccines (Basel) 2015. 3: 239–262.
    • (2015) Vaccines (Basel) , vol.3 , pp. 239-262
    • Wiersma, L.C.1    Rimmelzwaan, G.F.2    de Vries, R.D.3
  • 167
    • 3242889227 scopus 로고    scopus 로고
    • The 23-valent pneumococcal polysaccharide vaccine. Part I. Efficacy of PPV in the elderly: a comparison of meta-analyses
    • Melegaro, A. and Edmunds, W. J., The 23-valent pneumococcal polysaccharide vaccine. Part I. Efficacy of PPV in the elderly: a comparison of meta-analyses. Eur. J. Epidemiol. 2004. 19: 353–363.
    • (2004) Eur. J. Epidemiol , vol.19 , pp. 353-363
    • Melegaro, A.1    Edmunds, W.J.2
  • 169
    • 84959249701 scopus 로고    scopus 로고
    • The impact of age on the efficacy of 13-valent pneumococcal conjugate vaccine in elderly
    • van Werkhoven, C. H., Huijts, S. M., Bolkenbaas, M., Grobbee, D. E. and Bonten, M. J., The impact of age on the efficacy of 13-valent pneumococcal conjugate vaccine in elderly. Clin. Infect. Dis. 2015. 61: 1835–1838.
    • (2015) Clin. Infect. Dis. , vol.61 , pp. 1835-1838
    • van Werkhoven, C.H.1    Huijts, S.M.2    Bolkenbaas, M.3    Grobbee, D.E.4    Bonten, M.J.5
  • 172
    • 84897122797 scopus 로고    scopus 로고
    • Safety and immunogenicity of an AS01-adjuvanted varicella-zoster virus subunit candidate vaccine against herpes zoster in adults >=50 years of age
    • Chlibek, R., Bayas, J. M., Collins, H., de la Pinta, M. L., Ledent, E., Mols, J. F. and Heineman, T. C., Safety and immunogenicity of an AS01-adjuvanted varicella-zoster virus subunit candidate vaccine against herpes zoster in adults >=50 years of age. J Infect Dis. 2013. 208: 1953–1961.
    • (2013) J Infect Dis , vol.208 , pp. 1953-1961
    • Chlibek, R.1    Bayas, J.M.2    Collins, H.3    de la Pinta, M.L.4    Ledent, E.5    Mols, J.F.6    Heineman, T.C.7
  • 173
    • 84866916280 scopus 로고    scopus 로고
    • A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein e subunit vaccine candidate in young and older adults
    • Leroux-Roels, I., Leroux-Roels, G., Clement, F., Vandepapelière, P., Vassilev, V., Ledent, E. and Heineman, T. C., A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein e subunit vaccine candidate in young and older adults. J Infect Dis. 2012. 206: 1280–1290
    • (2012) J Infect Dis , vol.206 , pp. 1280-1290
    • Leroux-Roels, I.1    Leroux-Roels, G.2    Clement, F.3    Vandepapelière, P.4    Vassilev, V.5    Ledent, E.6    Heineman, T.C.7
  • 174
    • 84905964211 scopus 로고    scopus 로고
    • Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells
    • Didierlaurent, A. M., Collignon, C., Bourguignon, P., Wouters, S., Fierens, K., Fochesato, M., Dendouga, N. et al., Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells. J Immunol. 2014. 193: 1920–1930
    • (2014) J Immunol , vol.193 , pp. 1920-1930
    • Didierlaurent, A.M.1    Collignon, C.2    Bourguignon, P.3    Wouters, S.4    Fierens, K.5    Fochesato, M.6    Dendouga, N.7
  • 176
    • 84868199323 scopus 로고    scopus 로고
    • The importance of pertussis in older adults: a growing case for reviewing vaccination strategy in the elderly
    • Ridda, I., Yin, J. K., King, C., Raina, M. C. and McIntyre, P., The importance of pertussis in older adults: a growing case for reviewing vaccination strategy in the elderly. Vaccine 2012. 30: 6745–6752.
    • (2012) Vaccine , vol.30 , pp. 6745-6752
    • Ridda, I.1    Yin, J.K.2    King, C.3    Raina, M.C.4    McIntyre, P.5
  • 177
    • 33846402146 scopus 로고    scopus 로고
    • Booster vaccination in the elderly: their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers
    • Kaml, M., Weiskirchner, I., Keller, M., Luft, T., Hoster, E., Hasford, J., Young, L. et al., Booster vaccination in the elderly: their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers. Vaccine 2006. 24: 6808–6811.
    • (2006) Vaccine , vol.24 , pp. 6808-6811
    • Kaml, M.1    Weiskirchner, I.2    Keller, M.3    Luft, T.4    Hoster, E.5    Hasford, J.6    Young, L.7
  • 178
    • 84944880371 scopus 로고    scopus 로고
    • Modelling estimates of the burden of respiratory syncytial virus infection in adults and the elderly in the United Kingdom
    • Fleming, D. M., Taylor, R. J., Lustig, R. L., Schuck-Paim, C., Haguinet, F., Webb, D. J., Logie, J. et al., Modelling estimates of the burden of respiratory syncytial virus infection in adults and the elderly in the United Kingdom. BMC Infect. Dis. 2015. 15: 443 (doi: 10.1186/s12879-015-1218-z.).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 443
    • Fleming, D.M.1    Taylor, R.J.2    Lustig, R.L.3    Schuck-Paim, C.4    Haguinet, F.5    Webb, D.J.6    Logie, J.7
  • 180
    • 43349105860 scopus 로고    scopus 로고
    • A case for immunization against nosocomial infections
    • Cross, A. S, Chen, W. H. and Levine, M. M., A case for immunization against nosocomial infections. J. Leukoc. Biol. 2008. 83: 483–488.
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 483-488
    • Cross, A.S.1    Chen, W.H.2    Levine, M.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.