DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia

Blood

Volumn 125, Issue 16, 2015, Pages 2507-2518

  Bignon, Alexandre ^a,b   Régent, Alexis ^c,d   Klipfel, Laurence ^a,b   Desnoyer, Aude ^a,b   De La Grange, Pierre ^e   Martinez, Valérie ^a,b,f   Lortholary, Olivier ^g,h   Dalloul, Ali ^a,b   Mouthon, Luc ^c,d   Balabanian, Karl ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c INSTITUT COCHIN   (France)

^d Département Hospitalo Universitaire Autoimmune and Hormonal Diseases ^*  (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f HÔPITAL ANTOINE BÉCLÈRE   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD40 LIGAND; DUAL SPECIFIC PHOSPHATASE 4; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; SMALL INTERFERING RNA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; DUAL SPECIFICITY PHOSPHATASE; DUSP4 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; TRANSCRIPTOME;

ADULT; AGED; AGING; ARTICLE; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DUSP4 GENE; ENZYME ACTIVATION; FEMALE; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IDIOPATHIC CD4 LYMPHOPENIA; IMMUNOPHENOTYPING; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOPENIA; MALE; MEMORY T LYMPHOCYTE; OPPORTUNISTIC INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VERY ELDERLY; CD4+ T LYMPHOCYTE; CELL AGING; DNA MICROARRAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; RNA INTERFERENCE; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL AGING; DUAL-SPECIFICITY PHOSPHATASES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOPENIA; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, ANTIGEN, T-CELL; RNA INTERFERENCE; T-LYMPHOCYTES; TRANSCRIPTOME; YOUNG ADULT;

EID: 84927934872     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-08-598565     Document Type: Article

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