P38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

Journal of Clinical Investigation

Volumn 124, Issue 9, 2014, Pages 4004-4016

  Henson, Sian M ^a   Lanna, Alessio ^a   Riddel, Natalie E ^a   Franzese, Ornella ^b   Macaulay, Richard ^a   Griffiths, Stephen J ^a   Puleston, Daniel J ^c   Watson, Alexander Scarth ^c   Simon, Anna Katharina ^c   Tooze, Sharon A ^d   Akbar, Arne N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOPHYSIN; TELOMERASE; ATG9A PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; VESICULAR TRANSPORT PROTEIN;

ANAEROBIC GLYCOLYSIS; ARTICLE; AUTOPHAGY; BIOGENESIS; CD8+ T LYMPHOCYTE; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MEMORY T LYMPHOCYTE; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; ADULT; DNA DAMAGE; GLYCOLYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; PHYSIOLOGY;

ADULT; AUTOPHAGY; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; DNA DAMAGE; GLYCOLYSIS; HUMANS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; OXIDATIVE PHOSPHORYLATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TOR SERINE-THREONINE KINASES; VESICULAR TRANSPORT PROTEINS;

EID: 84907011926     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI75051     Document Type: Article

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