메뉴 건너뛰기




Volumn 473, Issue 15, 2016, Pages 2251-2271

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Author keywords

Autophagy; Class III phosphoinositide 3 kinase; Endocytosis; Phosphoinositide 3 kinase; Phosphorylation dephosphorylation; Vps34

Indexed keywords

BECLIN 1; CHAPERONE; GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPASE D1;

EID: 85009423797     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160170     Document Type: Review
Times cited : (170)

References (217)
  • 1
    • 0026564092 scopus 로고
    • An essential role for a protein and lipid kinase complex in secretory protein sorting
    • CrossRef PubMed
    • Herman, P. K., Stack, J. H. and Emr, S. D. (1992) An essential role for a protein and lipid kinase complex in secretory protein sorting. Trends Cell Biol. 2, 363-368 CrossRef PubMed
    • (1992) Trends Cell Biol. , vol.2 , pp. 363-368
    • Herman, P.K.1    Stack, J.H.2    Emr, S.D.3
  • 2
    • 0025200830 scopus 로고
    • Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
    • CrossRef PubMed
    • Herman, P. K. and Emr, S. D. (1990) Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 10, 6742-6754 CrossRef PubMed
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6742-6754
    • Herman, P.K.1    Emr, S.D.2
  • 3
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • CrossRef PubMed
    • Backer, J. M. (2008) The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 410, 1-17 CrossRef PubMed
    • (2008) Biochem. J. , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 4
    • 0036059819 scopus 로고    scopus 로고
    • Mosaic organization of the endocytic pathway
    • CrossRef PubMed
    • Miaczynska, M. and Zerial, M. (2002) Mosaic organization of the endocytic pathway. Exp. Cell Res. 272, 8-14 CrossRef PubMed
    • (2002) Exp. Cell Res. , vol.272 , pp. 8-14
    • Miaczynska, M.1    Zerial, M.2
  • 5
    • 33645078650 scopus 로고    scopus 로고
    • Regulation of membrane traffic by phosphoinositide 3-kinases
    • CrossRef PubMed
    • Lindmo, K. and Stenmark, H. (2006) Regulation of membrane traffic by phosphoinositide 3-kinases. J. Cell Sci. 119, 605-614 CrossRef PubMed
    • (2006) J. Cell Sci. , vol.119 , pp. 605-614
    • Lindmo, K.1    Stenmark, H.2
  • 6
    • 79960225411 scopus 로고    scopus 로고
    • The ESCRT pathway
    • CrossRef PubMed
    • Henne, W. M., Buchkovich, N. J. and Emr, S. D. (2011) The ESCRT pathway. Dev. Cell 21, 77-91 CrossRef PubMed
    • (2011) Dev. Cell , vol.21 , pp. 77-91
    • Henne, W.M.1    Buchkovich, N.J.2    Emr, S.D.3
  • 8
    • 84888380983 scopus 로고    scopus 로고
    • The autophagosome: Origins unknown, biogenesis complex
    • CrossRef PubMed
    • Lamb, C. A., Yoshimori, T. and Tooze, S. A. (2013) The autophagosome: origins unknown, biogenesis complex. Nat. Rev. Mol. Cell Biol. 14, 759-774 CrossRef PubMed
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 759-774
    • Lamb, C.A.1    Yoshimori, T.2    Tooze, S.A.3
  • 9
    • 84892569830 scopus 로고    scopus 로고
    • An overview of autophagy: Morphology, mechanism, and regulation
    • CrossRef PubMed
    • Parzych, K. R. and Klionsky, D. J. (2014) An overview of autophagy: morphology, mechanism, and regulation. Antioxid. Redox Signal. 20, 460-473 CrossRef PubMed
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 460-473
    • Parzych, K.R.1    Klionsky, D.J.2
  • 11
    • 0036300306 scopus 로고    scopus 로고
    • Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
    • CrossRef PubMed
    • Murray, J. T., Panaretou, C., Stenmark, H., Miaczynska, M. and Backer, J. M. (2002) Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic 3, 416-427 CrossRef PubMed
    • (2002) Traffic , vol.3 , pp. 416-427
    • Murray, J.T.1    Panaretou, C.2    Stenmark, H.3    Miaczynska, M.4    Backer, J.M.5
  • 12
    • 33745685061 scopus 로고    scopus 로고
    • Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome
    • CrossRef PubMed
    • Slessareva, J. E., Routt, S. M., Temple, B., Bankaitis, V. A. and Dohlman, H. G. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126, 191-203 CrossRef PubMed
    • (2006) Cell , vol.126 , pp. 191-203
    • Slessareva, J.E.1    Routt, S.M.2    Temple, B.3    Bankaitis, V.A.4    Dohlman, H.G.5
  • 13
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector Beclin 1: A novel BH3-only protein
    • CrossRef PubMed
    • Sinha, S. and Levine, B. (2008) The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 27 (Suppl. 1), S137-S148 CrossRef PubMed
    • (2008) Oncogene , vol.27 , pp. S137-S148
    • Sinha, S.1    Levine, B.2
  • 14
    • 84890848742 scopus 로고    scopus 로고
    • Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
    • CrossRef PubMed
    • Yuan, H. X., Russell, R. C. and Guan, K. L. (2013) Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy 9, 1983-1995 CrossRef PubMed
    • (2013) Autophagy , vol.9 , pp. 1983-1995
    • Yuan, H.X.1    Russell, R.C.2    Guan, K.L.3
  • 16
    • 84872586081 scopus 로고    scopus 로고
    • Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
    • CrossRef PubMed
    • Kim, J., Kim, Y. C., Fang, C., Russell, R. C., Kim, J. H., Fan, W., Liu, R., Zhong, Q. and Guan, K. L. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 CrossRef PubMed
    • (2013) Cell , vol.152 , pp. 290-303
    • Kim, J.1    Kim, Y.C.2    Fang, C.3    Russell, R.C.4    Kim, J.H.5    Fan, W.6    Liu, R.7    Zhong, Q.8    Guan, K.L.9
  • 17
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae
    • CrossRef PubMed
    • Kihara, A., Noda, T., Ishihara, N. and Ohsumi, Y. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530 CrossRef PubMed
    • (2001) J. Cell Biol. , vol.152 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 18
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • CrossRef PubMed
    • Itakura, E., Kishi, C., Inoue, K. and Mizushima, N. (2008) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 19, 5360-5372 CrossRef PubMed
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 19
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
    • CrossRef PubMed
    • Zhong, Y., Wang, Q. J., Li, X., Yan, Y., Backer, J. M., Chait, B. T., Heintz, N. and Yue, Z. (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 11, 468-476 CrossRef PubMed
    • (2009) Nat. Cell Biol. , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6    Heintz, N.7    Yue, Z.8
  • 21
    • 58049192897 scopus 로고    scopus 로고
    • Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
    • CrossRef PubMed
    • Sun, Q., Fan, W., Chen, K., Ding, X., Chen, S. and Zhong, Q. (2008) Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U. S. A. 105, 19211-19216 CrossRef PubMed
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 19211-19216
    • Sun, Q.1    Fan, W.2    Chen, K.3    Ding, X.4    Chen, S.5    Zhong, Q.6
  • 22
    • 78049271501 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
    • CrossRef PubMed
    • Thoresen, S. B., Pedersen, N. M., Liestol, K. and Stenmark, H. (2010) A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp. Cell Res. 316, 3368-3378 CrossRef PubMed
    • (2010) Exp. Cell Res. , vol.316 , pp. 3368-3378
    • Thoresen, S.B.1    Pedersen, N.M.2    Liestol, K.3    Stenmark, H.4
  • 23
    • 84908321680 scopus 로고    scopus 로고
    • Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex
    • CrossRef PubMed
    • McKnight, N. C., Zhong, Y., Wold, M. S., Gong, S., Phillips, G. R., Dou, Z., Zhao, Y., Heintz, N., Zong, W. X. and Yue, Z. (2014) Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS Genet. 10, e1004626 CrossRef PubMed
    • (2014) PLoS Genet. , vol.10 , pp. e1004626
    • McKnight, N.C.1    Zhong, Y.2    Wold, M.S.3    Gong, S.4    Phillips, G.R.5    Dou, Z.6    Zhao, Y.7    Heintz, N.8    Zong, W.X.9    Yue, Z.10
  • 24
    • 67650070480 scopus 로고    scopus 로고
    • Structure and function of Vps15 in the endosomal G protein signaling pathway
    • CrossRef PubMed
    • Heenan, E. J., Vanhooke, J. L., Temple, B. R., Betts, L., Sondek, J. E. and Dohlman, H. G. (2009) Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry 48, 6390-6401 CrossRef PubMed
    • (2009) Biochemistry , vol.48 , pp. 6390-6401
    • Heenan, E.J.1    Vanhooke, J.L.2    Temple, B.R.3    Betts, L.4    Sondek, J.E.5    Dohlman, H.G.6
  • 25
    • 84860875222 scopus 로고    scopus 로고
    • Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy
    • CrossRef PubMed
    • Noda, N. N., Kobayashi, T., Adachi, W., Fujioka, Y., Ohsumi, Y. and Inagaki, F. (2012) Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J. Biol. Chem. 287, 16256-16266 CrossRef PubMed
    • (2012) J. Biol. Chem. , vol.287 , pp. 16256-16266
    • Noda, N.N.1    Kobayashi, T.2    Adachi, W.3    Fujioka, Y.4    Ohsumi, Y.5    Inagaki, F.6
  • 26
    • 79956358522 scopus 로고    scopus 로고
    • Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)
    • CrossRef PubMed
    • Fan, W., Nassiri, A. and Zhong, Q. (2011) Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). Proc. Natl. Acad. Sci. U. S. A. 108, 7769-7774 CrossRef PubMed
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 7769-7774
    • Fan, W.1    Nassiri, A.2    Zhong, Q.3
  • 28
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • CrossRef PubMed
    • Furuya, N., Yu, J., Byfield, M., Pattingre, S. and Levine, B. (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1, 46-52 CrossRef PubMed
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 30
    • 79951993684 scopus 로고    scopus 로고
    • Structure of lipid kinase p110beta/p85beta elucidates an unusual SH2-domain-mediated inhibitory mechanism
    • CrossRef PubMed
    • Zhang, X., Vadas, O., Perisic, O., Anderson, K. E., Clark, J., Hawkins, P. T., Stephens, L. R. and Williams, R. L. (2011) Structure of lipid kinase p110beta/p85beta elucidates an unusual SH2-domain-mediated inhibitory mechanism. Mol. Cell 41, 567-578 CrossRef PubMed
    • (2011) Mol. Cell , vol.41 , pp. 567-578
    • Zhang, X.1    Vadas, O.2    Perisic, O.3    Anderson, K.E.4    Clark, J.5    Hawkins, P.T.6    Stephens, L.R.7    Williams, R.L.8
  • 31
    • 77950212231 scopus 로고    scopus 로고
    • Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34
    • CrossRef PubMed
    • Miller, S., Tavshanjian, B., Oleksy, A., Perisic, O., Houseman, B. T., Shokat, K. M. and Williams, R. L. (2010) Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 327, 1638-1642 CrossRef PubMed
    • (2010) Science , vol.327 , pp. 1638-1642
    • Miller, S.1    Tavshanjian, B.2    Oleksy, A.3    Perisic, O.4    Houseman, B.T.5    Shokat, K.M.6    Williams, R.L.7
  • 32
    • 84862777560 scopus 로고    scopus 로고
    • Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
    • CrossRef PubMed
    • Huang, W., Choi, W., Hu, W., Mi, N., Guo, Q., Ma, M., Liu, M., Tian, Y., Lu, P., Wang, F. L. et al. (2012) Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res. 22, 473-489 CrossRef PubMed
    • (2012) Cell Res. , vol.22 , pp. 473-489
    • Huang, W.1    Choi, W.2    Hu, W.3    Mi, N.4    Guo, Q.5    Ma, M.6    Liu, M.7    Tian, Y.8    Lu, P.9    Wang, F.L.10
  • 33
    • 59849113021 scopus 로고    scopus 로고
    • HVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells
    • CrossRef PubMed
    • Yan, Y., Flinn, R. J., Wu, H., Schnur, R. S. and Backer, J. M. (2009) hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem. J. 417, 747-755 CrossRef PubMed
    • (2009) Biochem. J. , vol.417 , pp. 747-755
    • Yan, Y.1    Flinn, R.J.2    Wu, H.3    Schnur, R.S.4    Backer, J.M.5
  • 34
    • 78650936005 scopus 로고    scopus 로고
    • The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
    • CrossRef PubMed
    • Sun, Q., Zhang, J., Fan, W., Wong, K. N., Ding, X., Chen, S. and Zhong, Q. (2011) The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 286, 185-191 CrossRef PubMed
    • (2011) J. Biol. Chem. , vol.286 , pp. 185-191
    • Sun, Q.1    Zhang, J.2    Fan, W.3    Wong, K.N.4    Ding, X.5    Chen, S.6    Zhong, Q.7
  • 35
    • 84887543464 scopus 로고    scopus 로고
    • Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
    • CrossRef PubMed
    • Araki, Y., Ku, W. C., Akioka, M., May, A. I., Hayashi, Y., Arisaka, F., Ishihama, Y. and Ohsumi, Y. (2013) Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J. Cell Biol. 203, 299-313 CrossRef PubMed
    • (2013) J. Cell Biol. , vol.203 , pp. 299-313
    • Araki, Y.1    Ku, W.C.2    Akioka, M.3    May, A.I.4    Hayashi, Y.5    Arisaka, F.6    Ishihama, Y.7    Ohsumi, Y.8
  • 36
    • 84901304111 scopus 로고    scopus 로고
    • NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity
    • PubMed
    • Lu, J., He, L., Behrends, C., Araki, M., Araki, K., Jun Wang, Q., Catanzaro, J. M., Friedman, S. L., Zong, W. X., Fiel, M. I. et al. (2014) NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat. Commun. 5, 3920 PubMed
    • (2014) Nat. Commun. , vol.5 , pp. 3920
    • Lu, J.1    He, L.2    Behrends, C.3    Araki, M.4    Araki, K.5    Jun Wang, Q.6    Catanzaro, J.M.7    Friedman, S.L.8    Zong, W.X.9    Fiel, M.I.10
  • 37
    • 84903309911 scopus 로고    scopus 로고
    • NRBF2 regulates macroautophagy as a component of Vps34 Complex i
    • CrossRef PubMed
    • Cao, Y., Wang, Y., Abi Saab, W. F., Yang, F., Pessin, J. E. and Backer, J. M. (2014) NRBF2 regulates macroautophagy as a component of Vps34 Complex I. Biochem. J. 461, 315-322 CrossRef PubMed
    • (2014) Biochem. J. , vol.461 , pp. 315-322
    • Cao, Y.1    Wang, Y.2    Abi Saab, W.F.3    Yang, F.4    Pessin, J.E.5    Backer, J.M.6
  • 38
    • 84907215529 scopus 로고    scopus 로고
    • Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels
    • CrossRef PubMed
    • Zhong, Y., Morris, D. H., Jin, L., Patel, M. S., Karunakaran, S. K., Fu, Y. J., Matuszak, E. A., Weiss, H. L., Chait, B. T. and Wang, Q. J. (2014) Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J. Biol. Chem. 289, 26021-26037 CrossRef PubMed
    • (2014) J. Biol. Chem. , vol.289 , pp. 26021-26037
    • Zhong, Y.1    Morris, D.H.2    Jin, L.3    Patel, M.S.4    Karunakaran, S.K.5    Fu, Y.J.6    Matuszak, E.A.7    Weiss, H.L.8    Chait, B.T.9    Wang, Q.J.10
  • 39
    • 0033972940 scopus 로고    scopus 로고
    • Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors
    • CrossRef PubMed
    • Yasumo, H., Masuda, N., Furusawa, T., Tsukamoto, T., Sadano, H. and Osumi, T. (2000) Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. Biochim. Biophys. Acta 1490, 189-197 CrossRef PubMed
    • (2000) Biochim. Biophys. Acta , vol.1490 , pp. 189-197
    • Yasumo, H.1    Masuda, N.2    Furusawa, T.3    Tsukamoto, T.4    Sadano, H.5    Osumi, T.6
  • 40
    • 9744273192 scopus 로고    scopus 로고
    • Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator
    • CrossRef PubMed
    • Flores, A. M., Li, L. and Aneskievich, B. J. (2004) Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator. J. Invest. Dermatol. 123, 1092-1101 CrossRef PubMed
    • (2004) J. Invest. Dermatol. , vol.123 , pp. 1092-1101
    • Flores, A.M.1    Li, L.2    Aneskievich, B.J.3
  • 41
    • 84949649765 scopus 로고    scopus 로고
    • Meiotic clade AAA ATPases: Protein polymer disassembly machines
    • PubMed
    • Monroe, N. and Hill, C. P. (2015) Meiotic clade AAA ATPases: protein polymer disassembly machines. J. Mol. Biol., doi: 10. 1016/j. jmb. 2015. 11. 004 PubMed
    • (2015) J. Mol. Biol.
    • Monroe, N.1    Hill, C.P.2
  • 42
    • 84959372404 scopus 로고    scopus 로고
    • PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
    • PubMed
    • Xu, D. Q., Wang, Z., Wang, C. Y., Zhang, D. Y., Wan, H. D., Zhao, Z. L., Gu, J., Zhang, Y. X., Li, Z. G., Man, K. Y. et al. (2016) PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J. 35, 496-514 PubMed
    • (2016) EMBO J. , vol.35 , pp. 496-514
    • Xu, D.Q.1    Wang, Z.2    Wang, C.Y.3    Zhang, D.Y.4    Wan, H.D.5    Zhao, Z.L.6    Gu, J.7    Zhang, Y.X.8    Li, Z.G.9    Man, K.Y.10
  • 43
    • 33646845634 scopus 로고    scopus 로고
    • Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
    • CrossRef PubMed
    • Zhang, L., Gao, X., Wen, J., Ning, Y. and Chen, Y. G. (2006) Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J. Biol. Chem. 281, 8607-8612 CrossRef PubMed
    • (2006) J. Biol. Chem. , vol.281 , pp. 8607-8612
    • Zhang, L.1    Gao, X.2    Wen, J.3    Ning, Y.4    Chen, Y.G.5
  • 44
    • 84905593646 scopus 로고    scopus 로고
    • Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
    • CrossRef PubMed
    • Ma, B., Cao, W., Li, W., Gao, C., Qi, Z., Zhao, Y., Du, J., Xue, H., Peng, J., Wen, J. et al. (2014) Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation. Cell Res. 24, 912-924 CrossRef PubMed
    • (2014) Cell Res. , vol.24 , pp. 912-924
    • Ma, B.1    Cao, W.2    Li, W.3    Gao, C.4    Qi, Z.5    Zhao, Y.6    Du, J.7    Xue, H.8    Peng, J.9    Wen, J.10
  • 45
    • 84947333774 scopus 로고    scopus 로고
    • RACK1 promotes autophagy by enhancing the Atg14L-Beclin 1-Vps34-Vps15 complex formation upon phosphorylation by AMPK
    • CrossRef PubMed
    • Zhao, Y., Wang, Q., Qiu, G., Zhou, S., Jing, Z., Wang, J., Wang, W., Cao, J., Han, K., Cheng, Q. et al. (2015) RACK1 promotes autophagy by enhancing the Atg14L-Beclin 1-Vps34-Vps15 complex formation upon phosphorylation by AMPK. Cell Rep. 13, 1407-1417 CrossRef PubMed
    • (2015) Cell Rep. , vol.13 , pp. 1407-1417
    • Zhao, Y.1    Wang, Q.2    Qiu, G.3    Zhou, S.4    Jing, Z.5    Wang, J.6    Wang, W.7    Cao, J.8    Han, K.9    Cheng, Q.10
  • 46
    • 84863578884 scopus 로고    scopus 로고
    • DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
    • CrossRef PubMed
    • Lv, Q., Wang, W., Xue, J., Hua, F., Mu, R., Lin, H., Yan, J., Lv, X., Chen, X. and Hu, Z. W. (2012) DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res. 72, 3238-3250 CrossRef PubMed
    • (2012) Cancer Res. , vol.72 , pp. 3238-3250
    • Lv, Q.1    Wang, W.2    Xue, J.3    Hua, F.4    Mu, R.5    Lin, H.6    Yan, J.7    Lv, X.8    Chen, X.9    Hu, Z.W.10
  • 48
    • 84907163183 scopus 로고    scopus 로고
    • ARRB1/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
    • CrossRef PubMed
    • Wang, P., Xu, T. Y., Wei, K., Guan, Y. F., Wang, X., Xu, H., Su, D. F., Pei, G. and Miao, C. Y. (2014) ARRB1/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia. Autophagy 10, 1535-1548 CrossRef PubMed
    • (2014) Autophagy , vol.10 , pp. 1535-1548
    • Wang, P.1    Xu, T.Y.2    Wei, K.3    Guan, Y.F.4    Wang, X.5    Xu, H.6    Su, D.F.7    Pei, G.8    Miao, C.Y.9
  • 49
    • 24144442691 scopus 로고    scopus 로고
    • Rab conversion as a mechanism of progression from early to late endosomes
    • CrossRef PubMed
    • Rink, J., Ghigo, E., Kalaidzidis, Y. and Zerial, M. (2005) Rab conversion as a mechanism of progression from early to late endosomes. Cell 122, 735-749 CrossRef PubMed
    • (2005) Cell , vol.122 , pp. 735-749
    • Rink, J.1    Ghigo, E.2    Kalaidzidis, Y.3    Zerial, M.4
  • 50
    • 84877886601 scopus 로고    scopus 로고
    • CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion
    • CrossRef PubMed
    • Balderhaar, H. J. and Ungermann, C. (2013) CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion. J. Cell Sci. 126, 1307-1316 CrossRef PubMed
    • (2013) J. Cell Sci. , vol.126 , pp. 1307-1316
    • Balderhaar, H.J.1    Ungermann, C.2
  • 51
    • 46449120732 scopus 로고    scopus 로고
    • Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
    • CrossRef PubMed
    • Liang, C., Lee, J. S., Inn, K. S., Gack, M. U., Li, Q., Roberts, E. A., Vergne, I., Deretic, V., Feng, P., Akazawa, C. and Jung, J. U. (2008) Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 10, 776-787 CrossRef PubMed
    • (2008) Nat. Cell Biol. , vol.10 , pp. 776-787
    • Liang, C.1    Lee, J.S.2    Inn, K.S.3    Gack, M.U.4    Li, Q.5    Roberts, E.A.6    Vergne, I.7    Deretic, V.8    Feng, P.9    Akazawa, C.10    Jung, J.U.11
  • 52
    • 78650600158 scopus 로고    scopus 로고
    • Rubicon controls endosome maturation as a Rab7 effector
    • CrossRef PubMed
    • Sun, Q., Westphal, W., Wong, K. N., Tan, I. and Zhong, Q. (2010) Rubicon controls endosome maturation as a Rab7 effector. Proc. Natl. Acad. Sci. U. S. A. 107, 19338-19343 CrossRef PubMed
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 19338-19343
    • Sun, Q.1    Westphal, W.2    Wong, K.N.3    Tan, I.4    Zhong, Q.5
  • 53
    • 84885869476 scopus 로고    scopus 로고
    • WASH inhibits autophagy through suppression of Beclin 1 ubiquitination
    • CrossRef PubMed
    • Xia, P., Wang, S., Du, Y., Zhao, Z., Shi, L., Sun, L., Huang, G., Ye, B., Li, C., Dai, Z. et al. (2013) WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 32, 2685-2696 CrossRef PubMed
    • (2013) EMBO J. , vol.32 , pp. 2685-2696
    • Xia, P.1    Wang, S.2    Du, Y.3    Zhao, Z.4    Shi, L.5    Sun, L.6    Huang, G.7    Ye, B.8    Li, C.9    Dai, Z.10
  • 54
    • 77952554428 scopus 로고    scopus 로고
    • Dsl1p/Zw10: Common mechanisms behind tethering vesicles and microtubules
    • CrossRef PubMed
    • Schmitt, H. D. (2010) Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules. Trends Cell Biol. 20, 257-268 CrossRef PubMed
    • (2010) Trends Cell Biol. , vol.20 , pp. 257-268
    • Schmitt, H.D.1
  • 55
    • 0142138839 scopus 로고    scopus 로고
    • Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells
    • CrossRef PubMed
    • Buxton, P., Zhang, X. M., Walsh, B., Sriratana, A., Schenberg, I., Manickam, E. and Rowe, T. (2003) Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Biochem. J. 375, 433-440 CrossRef PubMed
    • (2003) Biochem. J. , vol.375 , pp. 433-440
    • Buxton, P.1    Zhang, X.M.2    Walsh, B.3    Sriratana, A.4    Schenberg, I.5    Manickam, E.6    Rowe, T.7
  • 56
    • 84871002075 scopus 로고    scopus 로고
    • Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
    • CrossRef PubMed
    • Kim, H. J., Zhong, Q., Sheng, Z. H., Yoshimori, T., Liang, C. and Jung, J. U. (2012) Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J. Cell Sci. 125, 4740-4750 CrossRef PubMed
    • (2012) J. Cell Sci. , vol.125 , pp. 4740-4750
    • Kim, H.J.1    Zhong, Q.2    Sheng, Z.H.3    Yoshimori, T.4    Liang, C.5    Jung, J.U.6
  • 57
    • 84928550400 scopus 로고    scopus 로고
    • ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
    • CrossRef PubMed
    • Diao, J., Liu, R., Rong, Y., Zhao, M., Zhang, J., Lai, Y., Zhou, Q., Wilz, L. M., Li, J., Vivona, S. et al. (2015) ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature 520, 563-566 CrossRef PubMed
    • (2015) Nature , vol.520 , pp. 563-566
    • Diao, J.1    Liu, R.2    Rong, Y.3    Zhao, M.4    Zhang, J.5    Lai, Y.6    Zhou, Q.7    Wilz, L.M.8    Li, J.9    Vivona, S.10
  • 58
    • 77954898129 scopus 로고    scopus 로고
    • A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    • CrossRef PubMed
    • Lipinski, M. M., Hoffman, G., Ng, A., Zhou, W., Py, B. F., Hsu, E., Liu, X., Eisenberg, J., Liu, J., Blenis, J. et al. (2010) A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev. Cell 18, 1041-1052 CrossRef PubMed
    • (2010) Dev. Cell , vol.18 , pp. 1041-1052
    • Lipinski, M.M.1    Hoffman, G.2    Ng, A.3    Zhou, W.4    Py, B.F.5    Hsu, E.6    Liu, X.7    Eisenberg, J.8    Liu, J.9    Blenis, J.10
  • 59
    • 11144356337 scopus 로고    scopus 로고
    • Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    • CrossRef PubMed
    • Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H. and Goldberg, A. L. (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117, 399-412 CrossRef PubMed
    • (2004) Cell , vol.117 , pp. 399-412
    • Sandri, M.1    Sandri, C.2    Gilbert, A.3    Skurk, C.4    Calabria, E.5    Picard, A.6    Walsh, K.7    Schiaffino, S.8    Lecker, S.H.9    Goldberg, A.L.10
  • 60
    • 84861706956 scopus 로고    scopus 로고
    • Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway
    • CrossRef PubMed
    • Yamada, E., Bastie, C. C., Koga, H., Wang, Y., Cuervo, A. M. and Pessin, J. E. (2012) Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. Cell Rep. 1, 557-569 CrossRef PubMed
    • (2012) Cell Rep. , vol.1 , pp. 557-569
    • Yamada, E.1    Bastie, C.C.2    Koga, H.3    Wang, Y.4    Cuervo, A.M.5    Pessin, J.E.6
  • 61
    • 25444457577 scopus 로고    scopus 로고
    • HVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • CrossRef PubMed
    • Byfield, M. P., Murray, J. T. and Backer, J. M. (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280, 33076-33082 CrossRef PubMed
    • (2005) J. Biol. Chem. , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 62
    • 0347986620 scopus 로고    scopus 로고
    • Class III phosphoinositide 3-kinase-Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes
    • CrossRef PubMed
    • Tassa, A., Roux, M. P., Attaix, D. and Bechet, D. M. (2003) Class III phosphoinositide 3-kinase-Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem. J. 376, 577-586 CrossRef PubMed
    • (2003) Biochem. J. , vol.376 , pp. 577-586
    • Tassa, A.1    Roux, M.P.2    Attaix, D.3    Bechet, D.M.4
  • 64
    • 85003048223 scopus 로고    scopus 로고
    • The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
    • PubMed
    • Wei, Y., An, Z., Zou, Z., Sumpter, R., Su, M., Zang, X., Sinha, S., Gaestel, M. and Levine, B. (2015) The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. eLife 4, e05289 PubMed
    • (2015) ELife , vol.4 , pp. e05289
    • Wei, Y.1    An, Z.2    Zou, Z.3    Sumpter, R.4    Su, M.5    Zang, X.6    Sinha, S.7    Gaestel, M.8    Levine, B.9
  • 65
    • 61849102389 scopus 로고    scopus 로고
    • DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
    • CrossRef PubMed
    • Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas-Kramarski, R. and Kimchi, A. (2009) DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 10, 285-292 CrossRef PubMed
    • (2009) EMBO Rep. , vol.10 , pp. 285-292
    • Zalckvar, E.1    Berissi, H.2    Mizrachy, L.3    Idelchuk, Y.4    Koren, I.5    Eisenstein, M.6    Sabanay, H.7    Pinkas-Kramarski, R.8    Kimchi, A.9
  • 66
    • 84859573948 scopus 로고    scopus 로고
    • PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk
    • CrossRef PubMed
    • Eisenberg-Lerner, A. and Kimchi, A. (2012) PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ. 19, 788-797 CrossRef PubMed
    • (2012) Cell Death Differ. , vol.19 , pp. 788-797
    • Eisenberg-Lerner, A.1    Kimchi, A.2
  • 67
    • 84869147050 scopus 로고    scopus 로고
    • Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
    • CrossRef PubMed
    • Wang, R. C., Wei, Y., An, Z., Zou, Z., Xiao, G., Bhagat, G., White, M., Reichelt, J. and Levine, B. (2012) Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 338, 956-959 CrossRef PubMed
    • (2012) Science , vol.338 , pp. 956-959
    • Wang, R.C.1    Wei, Y.2    An, Z.3    Zou, Z.4    Xiao, G.5    Bhagat, G.6    White, M.7    Reichelt, J.8    Levine, B.9
  • 68
    • 84884262668 scopus 로고    scopus 로고
    • EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
    • CrossRef PubMed
    • Wei, Y., Zou, Z., Becker, N., Anderson, M., Sumpter, R., Xiao, G., Kinch, L., Koduru, P., Christudass, C. S., Veltri, R. W. et al. (2013) EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell 154, 1269-1284 CrossRef PubMed
    • (2013) Cell , vol.154 , pp. 1269-1284
    • Wei, Y.1    Zou, Z.2    Becker, N.3    Anderson, M.4    Sumpter, R.5    Xiao, G.6    Kinch, L.7    Koduru, P.8    Christudass, C.S.9    Veltri, R.W.10
  • 71
    • 84873708956 scopus 로고    scopus 로고
    • The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis
    • CrossRef PubMed
    • Veldhoen, R. A., Banman, S. L., Hemmerling, D. R., Odsen, R., Simmen, T., Simmonds, A. J., Underhill, D. A. and Goping, I. S. (2013) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32, 736-746 CrossRef PubMed
    • (2013) Oncogene , vol.32 , pp. 736-746
    • Veldhoen, R.A.1    Banman, S.L.2    Hemmerling, D.R.3    Odsen, R.4    Simmen, T.5    Simmonds, A.J.6    Underhill, D.A.7    Goping, I.S.8
  • 72
    • 77955015995 scopus 로고    scopus 로고
    • Pp60c-Src phosphorylates and activates vacuolar protein sorting 34 to mediate cellular transformation
    • CrossRef PubMed
    • Hirsch, D. S., Shen, Y., Dokmanovic, M. and Wu, W. J. (2010) pp60c-Src phosphorylates and activates vacuolar protein sorting 34 to mediate cellular transformation. Cancer Res. 70, 5974-5983 CrossRef PubMed
    • (2010) Cancer Res. , vol.70 , pp. 5974-5983
    • Hirsch, D.S.1    Shen, Y.2    Dokmanovic, M.3    Wu, W.J.4
  • 73
    • 84895993202 scopus 로고    scopus 로고
    • Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1
    • CrossRef PubMed
    • Hirsch, D. S., Shen, Y., Dokmanovic, M., Yu, J., Mohan, N., Elzarrad, M. K. and Wu, W. J. (2014) Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1. Cell. Signal. 26, 1258-1268 CrossRef PubMed
    • (2014) Cell. Signal. , vol.26 , pp. 1258-1268
    • Hirsch, D.S.1    Shen, Y.2    Dokmanovic, M.3    Yu, J.4    Mohan, N.5    Elzarrad, M.K.6    Wu, W.J.7
  • 76
    • 84862023791 scopus 로고    scopus 로고
    • Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
    • CrossRef PubMed
    • Li, X., He, L., Che, K. H., Funderburk, S. F., Pan, L., Pan, N., Zhang, M., Yue, Z. and Zhao, Y. (2012) Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat. Commun. 3, 662 CrossRef PubMed
    • (2012) Nat. Commun. , vol.3 , pp. 662
    • Li, X.1    He, L.2    Che, K.H.3    Funderburk, S.F.4    Pan, L.5    Pan, N.6    Zhang, M.7    Yue, Z.8    Zhao, Y.9
  • 77
    • 84898639632 scopus 로고    scopus 로고
    • Atomistic autophagy: The structures of cellular self-digestion
    • CrossRef PubMed
    • Hurley, J. H. and Schulman, B. A. (2014) Atomistic autophagy: the structures of cellular self-digestion. Cell 157, 300-311 CrossRef PubMed
    • (2014) Cell , vol.157 , pp. 300-311
    • Hurley, J.H.1    Schulman, B.A.2
  • 78
    • 54449099779 scopus 로고    scopus 로고
    • Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1
    • CrossRef PubMed
    • Noble, C. G., Dong, J. M., Manser, E. and Song, H. (2008) Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1. J. Biol. Chem. 283, 26274-26282 CrossRef PubMed
    • (2008) J. Biol. Chem. , vol.283 , pp. 26274-26282
    • Noble, C.G.1    Dong, J.M.2    Manser, E.3    Song, H.4
  • 79
    • 34249037565 scopus 로고    scopus 로고
    • Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
    • CrossRef PubMed
    • Oberstein, A., Jeffrey, P. D. and Shi, Y. (2007) Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J. Biol. Chem. 282, 13123-13132 CrossRef PubMed
    • (2007) J. Biol. Chem. , vol.282 , pp. 13123-13132
    • Oberstein, A.1    Jeffrey, P.D.2    Shi, Y.3
  • 80
    • 43949139277 scopus 로고    scopus 로고
    • An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins
    • CrossRef PubMed
    • Ku, B., Woo, J. S., Liang, C., Lee, K. H., Jung, J. U. and Oh, B. H. (2008) An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins. Autophagy 4, 519-520 CrossRef PubMed
    • (2008) Autophagy , vol.4 , pp. 519-520
    • Ku, B.1    Woo, J.S.2    Liang, C.3    Lee, K.H.4    Jung, J.U.5    Oh, B.H.6
  • 81
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • CrossRef PubMed
    • Wei, Y., Pattingre, S., Sinha, S., Bassik, M. and Levine, B. (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30, 678-688 CrossRef PubMed
    • (2008) Mol. Cell , vol.30 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 82
    • 78649653044 scopus 로고    scopus 로고
    • Parkin mono-ubiquitinates Bcl-2 and regulates autophagy
    • CrossRef PubMed
    • Chen, D., Gao, F., Li, B., Wang, H., Xu, Y., Zhu, C. and Wang, G. (2010) Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J. Biol. Chem. 285, 38214-38223 CrossRef PubMed
    • (2010) J. Biol. Chem. , vol.285 , pp. 38214-38223
    • Chen, D.1    Gao, F.2    Li, B.3    Wang, H.4    Xu, Y.5    Zhu, C.6    Wang, G.7
  • 83
    • 76349114046 scopus 로고    scopus 로고
    • Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
    • CrossRef PubMed
    • Chang, N. C., Nguyen, M., Germain, M. and Shore, G. C. (2010) Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 29, 606-618 CrossRef PubMed
    • (2010) EMBO J. , vol.29 , pp. 606-618
    • Chang, N.C.1    Nguyen, M.2    Germain, M.3    Shore, G.C.4
  • 86
    • 84929103686 scopus 로고    scopus 로고
    • The Wnt signaling antagonist Dapper1 accelerates dishevelled2 degradation via promoting its ubiquitination and aggregate-induced autophagy
    • CrossRef PubMed
    • Ma, B., Liu, B., Cao, W., Gao, C., Qi, Z., Ning, Y. and Chen, Y. G. (2015) The Wnt signaling antagonist Dapper1 accelerates dishevelled2 degradation via promoting its ubiquitination and aggregate-induced autophagy. J. Biol. Chem. 290, 12346-12354 CrossRef PubMed
    • (2015) J. Biol. Chem. , vol.290 , pp. 12346-12354
    • Ma, B.1    Liu, B.2    Cao, W.3    Gao, C.4    Qi, Z.5    Ning, Y.6    Chen, Y.G.7
  • 87
    • 84946848015 scopus 로고    scopus 로고
    • Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type i IFN/interferon
    • CrossRef PubMed
    • Xu, D., Zhang, T., Xiao, J., Zhu, K., Wei, R., Wu, Z., Meng, H., Li, Y. and Yuan, J. (2015) Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy 11, 617-628 CrossRef PubMed
    • (2015) Autophagy , vol.11 , pp. 617-628
    • Xu, D.1    Zhang, T.2    Xiao, J.3    Zhu, K.4    Wei, R.5    Wu, Z.6    Meng, H.7    Li, Y.8    Yuan, J.9
  • 88
    • 84903363448 scopus 로고    scopus 로고
    • Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy
    • CrossRef PubMed
    • Jang, Y. H., Choi, K. Y. and Min, D. S. (2014) Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death Differ. 21, 533-546 CrossRef PubMed
    • (2014) Cell Death Differ. , vol.21 , pp. 533-546
    • Jang, Y.H.1    Choi, K.Y.2    Min, D.S.3
  • 89
    • 84957620586 scopus 로고    scopus 로고
    • Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T alpha-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway
    • PubMed
    • Liu, F. T., Yang, Y. J., Wu, J. J., Li, S., Tang, Y. L., Zhao, J., Liu, Z. Y., Xiao, B. G., Zuo, J., Liu, W. and Wang, J. (2016) Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T alpha-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway. Brain. Res. 1632, 9-18 PubMed
    • (2016) Brain. Res. , vol.1632 , pp. 9-18
    • Liu, F.T.1    Yang, Y.J.2    Wu, J.J.3    Li, S.4    Tang, Y.L.5    Zhao, J.6    Liu, Z.Y.7    Xiao, B.G.8    Zuo, J.9    Liu, W.10    Wang, J.11
  • 92
    • 77949542302 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
    • CrossRef PubMed
    • Kang, R., Tang, D., Schapiro, N. E., Livesey, K. M., Farkas, A., Loughran, P., Bierhaus, A., Lotze, M. T. and Zeh, H. J. (2010) The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ. 17, 666-676 CrossRef PubMed
    • (2010) Cell Death Differ. , vol.17 , pp. 666-676
    • Kang, R.1    Tang, D.2    Schapiro, N.E.3    Livesey, K.M.4    Farkas, A.5    Loughran, P.6    Bierhaus, A.7    Lotze, M.T.8    Zeh, H.J.9
  • 93
    • 84861550705 scopus 로고    scopus 로고
    • Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex
    • CrossRef PubMed
    • Ma, C., Wang, N., Detre, C., Wang, G., O'Keeffe, M. and Terhorst, C. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287, 18359-18365 CrossRef PubMed
    • (2012) J. Biol. Chem. , vol.287 , pp. 18359-18365
    • Ma, C.1    Wang, N.2    Detre, C.3    Wang, G.4    O'Keeffe, M.5    Terhorst, C.6
  • 94
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • CrossRef PubMed
    • Liang, C., Feng, P., Ku, B., Dotan, I., Canaani, D., Oh, B. H. and Jung, J. U. (2006) Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 8, 688-699 CrossRef PubMed
    • (2006) Nat. Cell Biol. , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 95
    • 84940719535 scopus 로고    scopus 로고
    • MTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
    • CrossRef PubMed
    • Munson, M. J., Allen, G. F., Toth, R., Campbell, D. G., Lucocq, J. M. and Ganley, I. G. (2015) mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 34, 2272-2290 CrossRef PubMed
    • (2015) EMBO J. , vol.34 , pp. 2272-2290
    • Munson, M.J.1    Allen, G.F.2    Toth, R.3    Campbell, D.G.4    Lucocq, J.M.5    Ganley, I.G.6
  • 96
  • 99
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • CrossRef PubMed
    • Maiuri, M. C., Criollo, A., Tasdemir, E., Vicencio, J. M., Tajeddine, N., Hickman, J. A., Geneste, O. and Kroemer, G. (2007) BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 3, 374-376 CrossRef PubMed
    • (2007) Autophagy , vol.3 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6    Geneste, O.7    Kroemer, G.8
  • 100
    • 78649271745 scopus 로고    scopus 로고
    • Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18
    • CrossRef PubMed
    • Tian, S., Lin, J., Jun Zhou, J., Wang, X., Li, Y., Ren, X., Yu, W., Zhong, W., Xiao, J., Sheng, F. et al. (2010) Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy 6, 1032-1041 CrossRef PubMed
    • (2010) Autophagy , vol.6 , pp. 1032-1041
    • Tian, S.1    Lin, J.2    Jun Zhou, J.3    Wang, X.4    Li, Y.5    Ren, X.6    Yu, W.7    Zhong, W.8    Xiao, J.9    Sheng, F.10
  • 101
    • 33747873322 scopus 로고    scopus 로고
    • A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    • CrossRef PubMed
    • Jin, J., Arias, E. E., Chen, J., Harper, J. W. and Walter, J. C. (2006) A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23, 709-721 CrossRef PubMed
    • (2006) Mol. Cell , vol.23 , pp. 709-721
    • Jin, J.1    Arias, E.E.2    Chen, J.3    Harper, J.W.4    Walter, J.C.5
  • 107
    • 0035889088 scopus 로고    scopus 로고
    • Generation of high curvature membranes mediated by direct endophilin bilayer interactions
    • CrossRef PubMed
    • Farsad, K., Ringstad, N., Takei, K., Floyd, S. R., Rose, K. and De Camilli, P. (2001) Generation of high curvature membranes mediated by direct endophilin bilayer interactions. J. Cell Biol. 155, 193-200 CrossRef PubMed
    • (2001) J. Cell Biol. , vol.155 , pp. 193-200
    • Farsad, K.1    Ringstad, N.2    Takei, K.3    Floyd, S.R.4    Rose, K.5    De Camilli, P.6
  • 108
    • 67549096696 scopus 로고    scopus 로고
    • Bif-1/endophilin B1: A candidate for crescent driving force in autophagy
    • CrossRef PubMed
    • Takahashi, Y., Meyerkord, C. L. and Wang, H. G. (2009) Bif-1/endophilin B1: a candidate for crescent driving force in autophagy. Cell Death Differ. 16, 947-955 CrossRef PubMed
    • (2009) Cell Death Differ. , vol.16 , pp. 947-955
    • Takahashi, Y.1    Meyerkord, C.L.2    Wang, H.G.3
  • 109
    • 0035834739 scopus 로고    scopus 로고
    • Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4
    • CrossRef PubMed
    • Mari, M., Macia, E., Le Marchand-Brustel, Y. and Cormont, M. (2001) Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4. J. Biol. Chem. 276, 42501-42508 CrossRef PubMed
    • (2001) J. Biol. Chem. , vol.276 , pp. 42501-42508
    • Mari, M.1    Macia, E.2    Le Marchand-Brustel, Y.3    Cormont, M.4
  • 110
    • 58149181482 scopus 로고    scopus 로고
    • Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain
    • CrossRef PubMed
    • Recacha, R., Boulet, A., Jollivet, F., Monier, S., Houdusse, A., Goud, B. and Khan, A. R. (2009) Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain. Structure 17, 21-30 CrossRef PubMed
    • (2009) Structure , vol.17 , pp. 21-30
    • Recacha, R.1    Boulet, A.2    Jollivet, F.3    Monier, S.4    Houdusse, A.5    Goud, B.6    Khan, A.R.7
  • 113
    • 84959459959 scopus 로고    scopus 로고
    • Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion
    • CrossRef PubMed
    • Liu, K., Jian, Y., Sun, X., Yang, C., Gao, Z., Zhang, Z., Liu, X., Li, Y., Xu, J., Jing, Y. et al. (2016) Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J. Cell Biol. 212, 181-198 CrossRef PubMed
    • (2016) J. Cell Biol. , vol.212 , pp. 181-198
    • Liu, K.1    Jian, Y.2    Sun, X.3    Yang, C.4    Gao, Z.5    Zhang, Z.6    Liu, X.7    Li, Y.8    Xu, J.9    Jing, Y.10
  • 114
    • 77953858790 scopus 로고    scopus 로고
    • TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    • PubMed
    • Shi, C. S. and Kehrl, J. H. (2010) TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci. Signal. 3, ra42 PubMed
    • (2010) Sci. Signal. , vol.3 , pp. ra42
    • Shi, C.S.1    Kehrl, J.H.2
  • 115
    • 84930226935 scopus 로고    scopus 로고
    • Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth
    • CrossRef PubMed
    • Sun, T., Li, X., Zhang, P., Chen, W. D., Zhang, H. L., Li, D. D., Deng, R., Qian, X. J., Jiao, L., Ji, J. et al. (2015) Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat. Commun. 6, 7215 CrossRef PubMed
    • (2015) Nat. Commun. , vol.6 , pp. 7215
    • Sun, T.1    Li, X.2    Zhang, P.3    Chen, W.D.4    Zhang, H.L.5    Li, D.D.6    Deng, R.7    Qian, X.J.8    Jiao, L.9    Ji, J.10
  • 116
    • 33745086418 scopus 로고    scopus 로고
    • Assortment of phosphatidylinositol 3-kinase complexes-Atg14p directs association of complex i to the pre-autophagosomal structure in Saccharomyces cerevisiae
    • CrossRef PubMed
    • Obara, K., Sekito, T. and Ohsumi, Y. (2006) Assortment of phosphatidylinositol 3-kinase complexes-Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol. Biol. Cell 17, 1527-1539 CrossRef PubMed
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1527-1539
    • Obara, K.1    Sekito, T.2    Ohsumi, Y.3
  • 117
    • 77955895424 scopus 로고    scopus 로고
    • Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
    • CrossRef PubMed
    • Matsunaga, K., Morita, E., Saitoh, T., Akira, S., Ktistakis, N. T., Izumi, T., Noda, T. and Yoshimori, T. (2010) Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J. Cell Biol. 190, 511-521 CrossRef PubMed
    • (2010) J. Cell Biol. , vol.190 , pp. 511-521
    • Matsunaga, K.1    Morita, E.2    Saitoh, T.3    Akira, S.4    Ktistakis, N.T.5    Izumi, T.6    Noda, T.7    Yoshimori, T.8
  • 118
    • 84875834380 scopus 로고    scopus 로고
    • A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy
    • CrossRef PubMed
    • Jao, C. C., Ragusa, M. J., Stanley, R. E. and Hurley, J. H. (2013) A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proc. Natl. Acad. Sci. U. S. A. 110, 5486-5491 CrossRef PubMed
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 5486-5491
    • Jao, C.C.1    Ragusa, M.J.2    Stanley, R.E.3    Hurley, J.H.4
  • 120
    • 77955131007 scopus 로고    scopus 로고
    • Plasma membrane contributes to the formation of pre-autophagosomal structures
    • CrossRef PubMed
    • Ravikumar, B., Moreau, K., Jahreiss, L., Puri, C. and Rubinsztein, D. C. (2010) Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat. Cell Biol. 12, 747-757 CrossRef PubMed
    • (2010) Nat. Cell Biol. , vol.12 , pp. 747-757
    • Ravikumar, B.1    Moreau, K.2    Jahreiss, L.3    Puri, C.4    Rubinsztein, D.C.5
  • 122
    • 84890833205 scopus 로고    scopus 로고
    • BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid beta 42
    • CrossRef PubMed
    • Nah, J., Pyo, J. O., Jung, S., Yoo, S. M., Kam, T. I., Chang, J., Han, J., Soo, A. A. S., Onodera, T. and Jung, Y. K. (2013) BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid beta 42. Autophagy 9, 2009-2021 CrossRef PubMed
    • (2013) Autophagy , vol.9 , pp. 2009-2021
    • Nah, J.1    Pyo, J.O.2    Jung, S.3    Yoo, S.M.4    Kam, T.I.5    Chang, J.6    Han, J.7    Soo, A.A.S.8    Onodera, T.9    Jung, Y.K.10
  • 123
    • 84939426946 scopus 로고    scopus 로고
    • Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
    • CrossRef PubMed
    • Liang, J., Xu, Z. X., Ding, Z., Lu, Y., Yu, Q., Werle, K. D., Zhou, G., Park, Y. Y., Peng, G., Gambello, M. J. and Mills, G. B. (2015) Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat. Commun. 6, 7926 CrossRef PubMed
    • (2015) Nat. Commun. , vol.6 , pp. 7926
    • Liang, J.1    Xu, Z.X.2    Ding, Z.3    Lu, Y.4    Yu, Q.5    Werle, K.D.6    Zhou, G.7    Park, Y.Y.8    Peng, G.9    Gambello, M.J.10    Mills, G.B.11
  • 125
    • 67949106616 scopus 로고    scopus 로고
    • The exocyst complex in polarized exocytosis
    • CrossRef PubMed
    • He, B. and Guo, W. (2009) The exocyst complex in polarized exocytosis. Curr. Opin. Cell Biol. 21, 537-542 CrossRef PubMed
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 537-542
    • He, B.1    Guo, W.2
  • 128
    • 84055219407 scopus 로고    scopus 로고
    • Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
    • CrossRef PubMed
    • Platta, H. W., Abrahamsen, H., Thoresen, S. B. and Stenmark, H. (2012) Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1. Biochem. J. 441, 399-406 CrossRef PubMed
    • (2012) Biochem. J. , vol.441 , pp. 399-406
    • Platta, H.W.1    Abrahamsen, H.2    Thoresen, S.B.3    Stenmark, H.4
  • 129
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
    • CrossRef PubMed
    • Liu, J., Xia, H., Kim, M., Xu, L., Li, Y., Zhang, L., Cai, Y., Norberg, H. V., Zhang, T., Furuya, T. et al. (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147, 223-234 CrossRef PubMed
    • (2011) Cell , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3    Xu, L.4    Li, Y.5    Zhang, L.6    Cai, Y.7    Norberg, H.V.8    Zhang, T.9    Furuya, T.10
  • 130
    • 84905582805 scopus 로고    scopus 로고
    • RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy
    • CrossRef PubMed
    • Xia, P., Wang, S., Huang, G., Du, Y., Zhu, P., Li, M. and Fan, Z. (2014) RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res. 24, 943-958 CrossRef PubMed
    • (2014) Cell Res. , vol.24 , pp. 943-958
    • Xia, P.1    Wang, S.2    Huang, G.3    Du, Y.4    Zhu, P.5    Li, M.6    Fan, Z.7
  • 131
    • 84953637768 scopus 로고    scopus 로고
    • Cul3-KLHL20 ubiquitin ligase governs the turnover of ULK1 and VPS34 complexes to control autophagy termination
    • CrossRef PubMed
    • Liu, C. C., Lin, Y. C., Chen, Y. H., Chen, C. M., Pang, L. Y., Chen, H. A., Wu, P. R., Lin, M. Y., Jiang, S. T., Tsai, T. F. and Chen, R. H. (2016) Cul3-KLHL20 ubiquitin ligase governs the turnover of ULK1 and VPS34 complexes to control autophagy termination. Mol. Cell 61, 84-97 CrossRef PubMed
    • (2016) Mol. Cell , vol.61 , pp. 84-97
    • Liu, C.C.1    Lin, Y.C.2    Chen, Y.H.3    Chen, C.M.4    Pang, L.Y.5    Chen, H.A.6    Wu, P.R.7    Lin, M.Y.8    Jiang, S.T.9    Tsai, T.F.10    Chen, R.H.11
  • 132
    • 84961289997 scopus 로고    scopus 로고
    • G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
    • PubMed
    • Zhang, T., Dong, K., Liang, W., Xu, D., Xia, H., Geng, J., Najafov, A., Liu, M., Li, Y., Han, X. et al. (2015) G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. eLife 4, e06734 PubMed
    • (2015) ELife , vol.4 , pp. e06734
    • Zhang, T.1    Dong, K.2    Liang, W.3    Xu, D.4    Xia, H.5    Geng, J.6    Najafov, A.7    Liu, M.8    Li, Y.9    Han, X.10
  • 133
    • 84921451081 scopus 로고    scopus 로고
    • FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation
    • CrossRef PubMed
    • Xiao, J., Zhang, T., Xu, D., Wang, H., Cai, Y., Jin, T., Liu, M., Jin, M., Wu, K. and Yuan, J. (2015) FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes. Dev. 29, 184-196 CrossRef PubMed
    • (2015) Genes. Dev. , vol.29 , pp. 184-196
    • Xiao, J.1    Zhang, T.2    Xu, D.3    Wang, H.4    Cai, Y.5    Jin, T.6    Liu, M.7    Jin, M.8    Wu, K.9    Yuan, J.10
  • 134
    • 74249109983 scopus 로고    scopus 로고
    • Apoptosis blocks Beclin 1-dependent autophagosome synthesis: An effect rescued by Bcl-xL
    • CrossRef PubMed
    • Luo, S. and Rubinsztein, D. C. (2010) Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ. 17, 268-277 CrossRef PubMed
    • (2010) Cell Death Differ. , vol.17 , pp. 268-277
    • Luo, S.1    Rubinsztein, D.C.2
  • 135
    • 84940467196 scopus 로고    scopus 로고
    • Beclin orthologs: Integrative hubs of cell signaling, membrane trafficking, and physiology
    • CrossRef PubMed
    • Levine, B., Liu, R., Dong, X. and Zhong, Q. (2015) Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol. 25, 533-544 CrossRef PubMed
    • (2015) Trends Cell Biol. , vol.25 , pp. 533-544
    • Levine, B.1    Liu, R.2    Dong, X.3    Zhong, Q.4
  • 136
    • 84891747382 scopus 로고    scopus 로고
    • The machinery of macroautophagy
    • CrossRef PubMed
    • Feng, Y., He, D., Yao, Z. and Klionsky, D. J. (2014) The machinery of macroautophagy. Cell Res. 24, 24-41 CrossRef PubMed
    • (2014) Cell Res. , vol.24 , pp. 24-41
    • Feng, Y.1    He, D.2    Yao, Z.3    Klionsky, D.J.4
  • 137
    • 84878943669 scopus 로고    scopus 로고
    • The mechanism and physiological function of macroautophagy
    • CrossRef PubMed
    • Klionsky, D. J. and Codogno, P. (2013) The mechanism and physiological function of macroautophagy. J. Innate Immun. 5, 427-433 CrossRef PubMed
    • (2013) J. Innate Immun. , vol.5 , pp. 427-433
    • Klionsky, D.J.1    Codogno, P.2
  • 138
    • 84901833411 scopus 로고    scopus 로고
    • Autophagy and human disease: Emerging themes
    • CrossRef PubMed
    • Schneider, J. L. and Cuervo, A. M. (2014) Autophagy and human disease: emerging themes. Curr. Opin. Genet. Dev. 26, 16-23 CrossRef PubMed
    • (2014) Curr. Opin. Genet. Dev. , vol.26 , pp. 16-23
    • Schneider, J.L.1    Cuervo, A.M.2
  • 139
    • 84884724979 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
    • PubMed
    • Schink, K. O., Raiborg, C. and Stenmark, H. (2013) Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling. BioEssays 35, 900-912 PubMed
    • (2013) BioEssays , vol.35 , pp. 900-912
    • Schink, K.O.1    Raiborg, C.2    Stenmark, H.3
  • 140
    • 84878766832 scopus 로고    scopus 로고
    • Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
    • CrossRef PubMed
    • Raiborg, C., Schink, K. O. and Stenmark, H. (2013) Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic. FEBS J. 280, 2730-2742 CrossRef PubMed
    • (2013) FEBS J. , vol.280 , pp. 2730-2742
    • Raiborg, C.1    Schink, K.O.2    Stenmark, H.3
  • 141
    • 84907835041 scopus 로고    scopus 로고
    • Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
    • CrossRef PubMed
    • Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. and Alessi, D. R. (2014) Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. Biochem. J. 463, 413-427 CrossRef PubMed
    • (2014) Biochem. J. , vol.463 , pp. 413-427
    • Bago, R.1    Malik, N.2    Munson, M.J.3    Prescott, A.R.4    Davies, P.5    Sommer, E.6    Shpiro, N.7    Ward, R.8    Cross, D.9    Ganley, I.G.10    Alessi, D.R.11
  • 142
    • 84920842452 scopus 로고    scopus 로고
    • Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3, 4-dihydro-2H-pyrimido[1, 2-a]pyrimidin-6-one: A novel potent and selective inhibitor of Vps34 for the treatment of solid tumors
    • CrossRef PubMed
    • Pasquier, B., El-Ahmad, Y., Filoche-Romme, B., Dureuil, C., Fassy, F., Abecassis, P. Y., Mathieu, M., Bertrand, T., Benard, T., Barriere, C. et al. (2015) Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3, 4-dihydro-2H-pyrimido[1, 2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J. Med. Chem. 58, 376-400 CrossRef PubMed
    • (2015) J. Med. Chem. , vol.58 , pp. 376-400
    • Pasquier, B.1    El-Ahmad, Y.2    Filoche-Romme, B.3    Dureuil, C.4    Fassy, F.5    Abecassis, P.Y.6    Mathieu, M.7    Bertrand, T.8    Benard, T.9    Barriere, C.10
  • 143
    • 84908466248 scopus 로고    scopus 로고
    • Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
    • CrossRef PubMed
    • Dowdle, W. E., Nyfeler, B., Nagel, J., Elling, R. A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G. et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16, 1069-1079 CrossRef PubMed
    • (2014) Nat. Cell Biol. , vol.16 , pp. 1069-1079
    • Dowdle, W.E.1    Nyfeler, B.2    Nagel, J.3    Elling, R.A.4    Liu, S.5    Triantafellow, E.6    Menon, S.7    Wang, Z.8    Honda, A.9    Pardee, G.10
  • 145
    • 44149127993 scopus 로고    scopus 로고
    • The class III PI(3)K Vps34 promotes and endocytosis but not TOR signaling in Drosophila
    • CrossRef PubMed
    • Juhasz, G., Hill, J. H., Yan, Y., Sass, M., Baehrecke, E. H., Backer, J. M. and Neufeld, T. P. (2008) The class III PI(3)K Vps34 promotes and endocytosis but not TOR signaling in Drosophila. J. Cell Biol. 181, 655-666 CrossRef PubMed
    • (2008) J. Cell Biol. , vol.181 , pp. 655-666
    • Juhasz, G.1    Hill, J.H.2    Yan, Y.3    Sass, M.4    Baehrecke, E.H.5    Backer, J.M.6    Neufeld, T.P.7
  • 147
    • 58149287669 scopus 로고    scopus 로고
    • MVps34 is activated following high-resistance contractions
    • CrossRef PubMed
    • MacKenzie, M. G., Hamilton, D. L., Murray, J. T., Taylor, P. M. and Baar, K. (2009) mVps34 is activated following high-resistance contractions. J. Physiol. 587, 253-260 CrossRef PubMed
    • (2009) J. Physiol. , vol.587 , pp. 253-260
    • MacKenzie, M.G.1    Hamilton, D.L.2    Murray, J.T.3    Taylor, P.M.4    Baar, K.5
  • 149
    • 84864751451 scopus 로고    scopus 로고
    • Phosphatidylinositol 3, 5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1
    • CrossRef PubMed
    • Bridges, D., Ma, J. T., Park, S., Inoki, K., Weisman, L. S. and Saltiel, A. R. (2012) Phosphatidylinositol 3, 5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol. Biol. Cell 23, 2955-2962 CrossRef PubMed
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2955-2962
    • Bridges, D.1    Ma, J.T.2    Park, S.3    Inoki, K.4    Weisman, L.S.5    Saltiel, A.R.6
  • 150
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • CrossRef PubMed
    • Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A. and Chen, J. (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294, 1942-1945 CrossRef PubMed
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 151
    • 0038339003 scopus 로고    scopus 로고
    • Phospholipase D confers rapamycin resistance in human breast cancer cells
    • CrossRef PubMed
    • Chen, Y., Zheng, Y. and Foster, D. A. (2003) Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene 22, 3937-3942 CrossRef PubMed
    • (2003) Oncogene , vol.22 , pp. 3937-3942
    • Chen, Y.1    Zheng, Y.2    Foster, D.A.3
  • 152
    • 84855731134 scopus 로고    scopus 로고
    • Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    • CrossRef PubMed
    • Yoon, M. S., Du, G., Backer, J. M., Frohman, M. A. and Chen, J. (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J. Cell Biol. 195, 435-447 CrossRef PubMed
    • (2011) J. Cell Biol. , vol.195 , pp. 435-447
    • Yoon, M.S.1    Du, G.2    Backer, J.M.3    Frohman, M.A.4    Chen, J.5
  • 153
    • 79960387847 scopus 로고    scopus 로고
    • Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
    • CrossRef PubMed
    • Xu, L., Salloum, D., Medlin, P. S., Saqcena, M., Yellen, P., Perrella, B. and Foster, D. A. (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J. Biol. Chem. 286, 25477-25486 CrossRef PubMed
    • (2011) J. Biol. Chem. , vol.286 , pp. 25477-25486
    • Xu, L.1    Salloum, D.2    Medlin, P.S.3    Saqcena, M.4    Yellen, P.5    Perrella, B.6    Foster, D.A.7
  • 154
    • 84903158167 scopus 로고    scopus 로고
    • Regulation of mTORC1 by amino acids
    • CrossRef PubMed
    • Bar-Peled, L. and Sabatini, D. M. (2014) Regulation of mTORC1 by amino acids. Trends Cell Biol. 24, 400-406 CrossRef PubMed
    • (2014) Trends Cell Biol. , vol.24 , pp. 400-406
    • Bar-Peled, L.1    Sabatini, D.M.2
  • 155
    • 62849111751 scopus 로고    scopus 로고
    • Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin
    • CrossRef PubMed
    • Toschi, A., Lee, E., Xu, L., Garcia, A., Gadir, N. and Foster, D. A. (2009) Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol. Cell. Biol. 29, 1411-1420 CrossRef PubMed
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1411-1420
    • Toschi, A.1    Lee, E.2    Xu, L.3    Garcia, A.4    Gadir, N.5    Foster, D.A.6
  • 156
    • 84889024832 scopus 로고    scopus 로고
    • Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis
    • CrossRef PubMed
    • Yoon, M. S. and Chen, J. (2013) Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis. Mol. Biol. Cell 24, 3754-3763 CrossRef PubMed
    • (2013) Mol. Biol. Cell , vol.24 , pp. 3754-3763
    • Yoon, M.S.1    Chen, J.2
  • 159
    • 0033202945 scopus 로고    scopus 로고
    • Rab5 regulates motility of early endosomes on microtubules
    • CrossRef PubMed
    • Nielsen, E., Severin, F., Backer, J. M., Hyman, A. A. and Zerial, M. (1999) Rab5 regulates motility of early endosomes on microtubules. Nat. Cell Biol. 1, 376-382 CrossRef PubMed
    • (1999) Nat. Cell Biol. , vol.1 , pp. 376-382
    • Nielsen, E.1    Severin, F.2    Backer, J.M.3    Hyman, A.A.4    Zerial, M.5
  • 160
    • 34347385894 scopus 로고    scopus 로고
    • Parallels between cytokinesis and retroviral budding: A role for the ESCRT machinery
    • CrossRef PubMed
    • Carlton, J. G. and Martin-Serrano, J. (2007) Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science 316, 1908-1912 CrossRef PubMed
    • (2007) Science , vol.316 , pp. 1908-1912
    • Carlton, J.G.1    Martin-Serrano, J.2
  • 162
    • 80053564250 scopus 로고    scopus 로고
    • Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity
    • CrossRef PubMed
    • Kuo, T. C., Chen, C. T., Baron, D., Onder, T. T., Loewer, S., Almeida, S., Weismann, C. M., Xu, P., Houghton, J. M., Gao, F. B. et al. (2011) Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat. Cell Biol. 13, 1214-1223 CrossRef PubMed
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1214-1223
    • Kuo, T.C.1    Chen, C.T.2    Baron, D.3    Onder, T.T.4    Loewer, S.5    Almeida, S.6    Weismann, C.M.7    Xu, P.8    Houghton, J.M.9    Gao, F.B.10
  • 163
    • 84907033415 scopus 로고    scopus 로고
    • Resistance to inhibitors of cholinesterase (Ric)-8A and Galphai contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity
    • CrossRef PubMed
    • Boularan, C., Kamenyeva, O., Cho, H. and Kehrl, J. H. (2014) Resistance to inhibitors of cholinesterase (Ric)-8A and Galphai contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity. PLoS One 9, e86680 CrossRef PubMed
    • (2014) PLoS One , vol.9 , pp. e86680
    • Boularan, C.1    Kamenyeva, O.2    Cho, H.3    Kehrl, J.H.4
  • 164
    • 80052641324 scopus 로고    scopus 로고
    • Arabidopsis AtVPS15 is essential for pollen development and germination through modulating phosphatidylinositol 3-phosphate formation
    • CrossRef PubMed
    • Xu, N., Gao, X. Q., Zhao, X. Y., Zhu, D. Z., Zhou, L. Z. and Zhang, X. S. (2011) Arabidopsis AtVPS15 is essential for pollen development and germination through modulating phosphatidylinositol 3-phosphate formation. Plant Mol. Biol. 77, 251-260 CrossRef PubMed
    • (2011) Plant Mol. Biol. , vol.77 , pp. 251-260
    • Xu, N.1    Gao, X.Q.2    Zhao, X.Y.3    Zhu, D.Z.4    Zhou, L.Z.5    Zhang, X.S.6
  • 165
    • 53749095272 scopus 로고    scopus 로고
    • The Arabidopsis phosphatidylinositol 3-kinase is important for pollen development
    • CrossRef PubMed
    • Lee, Y., Kim, E. S., Choi, Y., Hwang, I., Staiger, C. J., Chung, Y. Y. and Lee, Y. (2008) The Arabidopsis phosphatidylinositol 3-kinase is important for pollen development. Plant Physiol. 147, 1886-1897 CrossRef PubMed
    • (2008) Plant Physiol. , vol.147 , pp. 1886-1897
    • Lee, Y.1    Kim, E.S.2    Choi, Y.3    Hwang, I.4    Staiger, C.J.5    Chung, Y.Y.6    Lee, Y.7
  • 166
    • 84872352440 scopus 로고    scopus 로고
    • Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis
    • CrossRef PubMed
    • Bohdanowicz, M. and Grinstein, S. (2013) Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis. Physiol. Rev. 93, 69-106 CrossRef PubMed
    • (2013) Physiol. Rev. , vol.93 , pp. 69-106
    • Bohdanowicz, M.1    Grinstein, S.2
  • 168
    • 1642539981 scopus 로고    scopus 로고
    • The uniformity of phagosome maturation in macrophages
    • CrossRef PubMed
    • Henry, R. M., Hoppe, A. D., Joshi, N. and Swanson, J. A. (2004) The uniformity of phagosome maturation in macrophages. J. Cell Biol. 164, 185-194 CrossRef PubMed
    • (2004) J. Cell Biol. , vol.164 , pp. 185-194
    • Henry, R.M.1    Hoppe, A.D.2    Joshi, N.3    Swanson, J.A.4
  • 169
    • 81055155988 scopus 로고    scopus 로고
    • Coordination of the Rab5 cycle on macropinosomes
    • CrossRef PubMed
    • Feliciano, W. D., Yoshida, S., Straight, S. W. and Swanson, J. A. (2011) Coordination of the Rab5 cycle on macropinosomes. Traffic 12, 1911-1922 CrossRef PubMed
    • (2011) Traffic , vol.12 , pp. 1911-1922
    • Feliciano, W.D.1    Yoshida, S.2    Straight, S.W.3    Swanson, J.A.4
  • 170
    • 84964891885 scopus 로고    scopus 로고
    • A growth factor signaling cascade confined to circular ruffles in macrophages
    • CrossRef PubMed
    • Welliver, T. P. and Swanson, J. A. (2012) A growth factor signaling cascade confined to circular ruffles in macrophages. Biol. Open 1, 754-760 CrossRef PubMed
    • (2012) Biol. Open , vol.1 , pp. 754-760
    • Welliver, T.P.1    Swanson, J.A.2
  • 172
    • 78649649128 scopus 로고    scopus 로고
    • Class i and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes
    • CrossRef PubMed
    • Bohdanowicz, M., Cosio, G., Backer, J. M. and Grinstein, S. (2010) Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. J. Cell Biol. 191, 999-1012 CrossRef PubMed
    • (2010) J. Cell Biol. , vol.191 , pp. 999-1012
    • Bohdanowicz, M.1    Cosio, G.2    Backer, J.M.3    Grinstein, S.4
  • 173
    • 58149402411 scopus 로고    scopus 로고
    • CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class i or II PI3Ks
    • CrossRef PubMed
    • Anderson, K. E., Boyle, K. B., Davidson, K., Chessa, T. A., Kulkarni, S., Jarvis, G. E., Sindrilaru, A., Scharffetter-Kochanek, K., Rausch, O., Stephens, L. R. and Hawkins, P. T. (2008) CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. Blood 112, 5202-5211 CrossRef PubMed
    • (2008) Blood , vol.112 , pp. 5202-5211
    • Anderson, K.E.1    Boyle, K.B.2    Davidson, K.3    Chessa, T.A.4    Kulkarni, S.5    Jarvis, G.E.6    Sindrilaru, A.7    Scharffetter-Kochanek, K.8    Rausch, O.9    Stephens, L.R.10    Hawkins, P.T.11
  • 175
    • 84863373173 scopus 로고    scopus 로고
    • Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation
    • CrossRef PubMed
    • Yang, C. S., Lee, J. S., Rodgers, M., Min, C. K., Lee, J. Y., Kim, H. J., Lee, K. H., Kim, C. J., Oh, B., Zandi, E. et al. (2012) Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe 11, 264-276 CrossRef PubMed
    • (2012) Cell Host Microbe , vol.11 , pp. 264-276
    • Yang, C.S.1    Lee, J.S.2    Rodgers, M.3    Min, C.K.4    Lee, J.Y.5    Kim, H.J.6    Lee, K.H.7    Kim, C.J.8    Oh, B.9    Zandi, E.10
  • 176
    • 84934287492 scopus 로고    scopus 로고
    • Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
    • CrossRef PubMed
    • Martinez, J., Malireddi, R. K., Lu, Q., Cunha, L. D., Pelletier, S., Gingras, S., Orchard, R., Guan, J. L., Tan, H., Peng, J. et al. (2015) Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nat. Cell Biol. 17, 893-906 CrossRef PubMed
    • (2015) Nat. Cell Biol. , vol.17 , pp. 893-906
    • Martinez, J.1    Malireddi, R.K.2    Lu, Q.3    Cunha, L.D.4    Pelletier, S.5    Gingras, S.6    Orchard, R.7    Guan, J.L.8    Tan, H.9    Peng, J.10
  • 177
    • 80054825045 scopus 로고    scopus 로고
    • Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
    • CrossRef PubMed
    • Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O. and Green, D. R. (2011) Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc. Natl. Acad. Sci. U. S. A. 108, 17396-17401 CrossRef PubMed
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 17396-17401
    • Martinez, J.1    Almendinger, J.2    Oberst, A.3    Ness, R.4    Dillon, C.P.5    Fitzgerald, P.6    Hengartner, M.O.7    Green, D.R.8
  • 178
    • 80455122654 scopus 로고    scopus 로고
    • Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes
    • CrossRef PubMed
    • Florey, O., Kim, S. E., Sandoval, C. P., Haynes, C. M. and Overholtzer, M. (2011) Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat. Cell Biol. 13, 1335-1343 CrossRef PubMed
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1335-1343
    • Florey, O.1    Kim, S.E.2    Sandoval, C.P.3    Haynes, C.M.4    Overholtzer, M.5
  • 179
    • 84863012304 scopus 로고    scopus 로고
    • Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells
    • CrossRef PubMed
    • Lu, N., Shen, Q., Mahoney, T. R., Neukomm, L. J., Wang, Y. and Zhou, Z. (2012) Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 10, e1001245 CrossRef PubMed
    • (2012) PLoS Biol. , vol.10 , pp. e1001245
    • Lu, N.1    Shen, Q.2    Mahoney, T.R.3    Neukomm, L.J.4    Wang, Y.5    Zhou, Z.6
  • 183
    • 0034710650 scopus 로고    scopus 로고
    • SLAM (CDw150) is a cellular receptor for measles virus
    • CrossRef PubMed
    • Tatsuo, H., Ono, N., Tanaka, K. and Yanagi, Y. (2000) SLAM (CDw150) is a cellular receptor for measles virus. Nature 406, 893-897 CrossRef PubMed
    • (2000) Nature , vol.406 , pp. 893-897
    • Tatsuo, H.1    Ono, N.2    Tanaka, K.3    Yanagi, Y.4
  • 185
    • 57749090391 scopus 로고    scopus 로고
    • A C-terminal sequence in the guanine nucleotide exchange factor Sec 7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase
    • CrossRef PubMed
    • Dehring, D. A., Adler, A. S., Hosseini, A. and Hicke, L. (2008) A C-terminal sequence in the guanine nucleotide exchange factor Sec 7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase. J. Biol. Chem. 283, 34188-34196 CrossRef PubMed
    • (2008) J. Biol. Chem. , vol.283 , pp. 34188-34196
    • Dehring, D.A.1    Adler, A.S.2    Hosseini, A.3    Hicke, L.4
  • 186
    • 84930445399 scopus 로고    scopus 로고
    • Remodeling of secretory compartments creates CUPS during nutrient starvation
    • CrossRef PubMed
    • Cruz-Garcia, D., Curwin, A. J., Popoff, J. F., Bruns, C., Duran, J. M. and Malhotra, V. (2014) Remodeling of secretory compartments creates CUPS during nutrient starvation. J. Cell Biol. 207, 695-703 CrossRef PubMed
    • (2014) J. Cell Biol. , vol.207 , pp. 695-703
    • Cruz-Garcia, D.1    Curwin, A.J.2    Popoff, J.F.3    Bruns, C.4    Duran, J.M.5    Malhotra, V.6
  • 187
    • 77953699711 scopus 로고    scopus 로고
    • Termination of autophagy and reformation of lysosomes regulated by mTOR
    • CrossRef PubMed
    • Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F. et al. (2010) Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465, 942-946 CrossRef PubMed
    • (2010) Nature , vol.465 , pp. 942-946
    • Yu, L.1    McPhee, C.K.2    Zheng, L.3    Mardones, G.A.4    Rong, Y.5    Peng, J.6    Mi, N.7    Zhao, Y.8    Liu, Z.9    Wan, F.10
  • 188
    • 84930441800 scopus 로고    scopus 로고
    • A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport
    • CrossRef PubMed
    • Lorenzo, D. N., Badea, A., Davis, J., Hostettler, J., He, J., Zhong, G., Zhuang, X. and Bennett, V. (2014) A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. J. Cell Biol. 207, 735-752 CrossRef PubMed
    • (2014) J. Cell Biol. , vol.207 , pp. 735-752
    • Lorenzo, D.N.1    Badea, A.2    Davis, J.3    Hostettler, J.4    He, J.5    Zhong, G.6    Zhuang, X.7    Bennett, V.8
  • 190
    • 42949092018 scopus 로고    scopus 로고
    • The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
    • CrossRef PubMed
    • Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M. and Zerial, M. (2008) The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133, 486-497 CrossRef PubMed
    • (2008) Cell , vol.133 , pp. 486-497
    • Schenck, A.1    Goto-Silva, L.2    Collinet, C.3    Rhinn, M.4    Giner, A.5    Habermann, B.6    Brand, M.7    Zerial, M.8
  • 194
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • CrossRef PubMed
    • Yue, Z., Jin, S., Yang, C., Levine, A. J. and Heintz, N. (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U. S. A. 100, 15077-15082 CrossRef PubMed
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 195
    • 84942086295 scopus 로고    scopus 로고
    • Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling
    • CrossRef PubMed
    • Nemazanyy, I., Montagnac, G., Russell, R. C., Morzyglod, L., Burnol, A. F., Guan, K. L., Pende, M. and Panasyuk, G. (2015) Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat. Commun. 6, 8283 CrossRef PubMed
    • (2015) Nat. Commun. , vol.6 , pp. 8283
    • Nemazanyy, I.1    Montagnac, G.2    Russell, R.C.3    Morzyglod, L.4    Burnol, A.F.5    Guan, K.L.6    Pende, M.7    Panasyuk, G.8
  • 196
    • 84951335866 scopus 로고    scopus 로고
    • Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival
    • PubMed
    • Dayde, D., Guerard, M., Perron, P., Hatat, A. S., Barrial, C., Eymin, B. and Gazzeri, S. (2015) Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival. Oncogene, doi: 10. 1038/onc. 2015. 480 PubMed
    • (2015) Oncogene
    • Dayde, D.1    Guerard, M.2    Perron, P.3    Hatat, A.S.4    Barrial, C.5    Eymin, B.6    Gazzeri, S.7
  • 198
    • 0035818611 scopus 로고    scopus 로고
    • Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate
    • CrossRef PubMed
    • Virbasius, J. V., Song, X., Pomerleau, D. P., Zhan, Y., Zhou, G. W. and Czech, M. P. (2001) Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc. Natl. Acad. Sci. U. S. A. 98, 12908-12913 CrossRef PubMed
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12908-12913
    • Virbasius, J.V.1    Song, X.2    Pomerleau, D.P.3    Zhan, Y.4    Zhou, G.W.5    Czech, M.P.6
  • 200
    • 80655144753 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy
    • CrossRef PubMed
    • Farkas, T., Daugaard, M. and Jaattela, M. (2011) Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy. J. Biol. Chem. 286, 38904-38912 CrossRef PubMed
    • (2011) J. Biol. Chem. , vol.286 , pp. 38904-38912
    • Farkas, T.1    Daugaard, M.2    Jaattela, M.3
  • 202
    • 34447514348 scopus 로고    scopus 로고
    • Role of the Vps34p-interacting protein Ade5, 7p in hyphal growth and virulence of Candida albicans
    • CrossRef PubMed
    • Jezewski, S., von der Heide, M., Poltermann, S., Hartl, A., Kunkel, W., Zipfel, P. F. and Eck, R. (2007) Role of the Vps34p-interacting protein Ade5, 7p in hyphal growth and virulence of Candida albicans. Microbiology 153, 2351-2362 CrossRef PubMed
    • (2007) Microbiology , vol.153 , pp. 2351-2362
    • Jezewski, S.1    Von Der Heide, M.2    Poltermann, S.3    Hartl, A.4    Kunkel, W.5    Zipfel, P.F.6    Eck, R.7
  • 204
    • 77957046432 scopus 로고    scopus 로고
    • Observing protein interactions and their stoichiometry in living cells by brightness analysis of fluorescence fluctuation experiments
    • CrossRef PubMed
    • Chen, Y., Johnson, J., Macdonald, P., Wu, B. and Mueller, J. D. (2010) Observing protein interactions and their stoichiometry in living cells by brightness analysis of fluorescence fluctuation experiments. Methods Enzymol. 472, 345-363 CrossRef PubMed
    • (2010) Methods Enzymol. , vol.472 , pp. 345-363
    • Chen, Y.1    Johnson, J.2    Macdonald, P.3    Wu, B.4    Mueller, J.D.5
  • 205
    • 84925467139 scopus 로고    scopus 로고
    • Rubicon deficiency enhances cardiac autophagy and protects mice from lipopolysaccharide-induced lethality and reduction in stroke volume
    • CrossRef PubMed
    • Zi, Z., Song, Z., Zhang, S., Ye, Y., Li, C., Xu, M., Zou, Y., He, L. and Zhu, H. (2015) Rubicon deficiency enhances cardiac autophagy and protects mice from lipopolysaccharide-induced lethality and reduction in stroke volume. J. Cardiovasc. Pharmacol. 65, 252-261 CrossRef PubMed
    • (2015) J. Cardiovasc. Pharmacol. , vol.65 , pp. 252-261
    • Zi, Z.1    Song, Z.2    Zhang, S.3    Ye, Y.4    Li, C.5    Xu, M.6    Zou, Y.7    He, L.8    Zhu, H.9
  • 208
    • 84880909187 scopus 로고    scopus 로고
    • The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes
    • CrossRef PubMed
    • Bechtel, W., Helmstadter, M., Balica, J., Hartleben, B., Schell, C. and Huber, T. B. (2013) The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes. Autophagy 9, 1097-1099 CrossRef PubMed
    • (2013) Autophagy , vol.9 , pp. 1097-1099
    • Bechtel, W.1    Helmstadter, M.2    Balica, J.3    Hartleben, B.4    Schell, C.5    Huber, T.B.6
  • 209
    • 78650732055 scopus 로고    scopus 로고
    • Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration
    • CrossRef PubMed
    • Wang, L., Budolfson, K. and Wang, F. (2011) Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. Neuroscience 172, 427-442 CrossRef PubMed
    • (2011) Neuroscience , vol.172 , pp. 427-442
    • Wang, L.1    Budolfson, K.2    Wang, F.3
  • 210
    • 77952722628 scopus 로고    scopus 로고
    • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
    • CrossRef PubMed
    • Zhou, X., Wang, L., Hasegawa, H., Amin, P., Han, B. X., Kaneko, S., He, Y. and Wang, F. (2010) Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc. Natl. Acad. Sci. U. S. A. 107, 9424-9429 CrossRef PubMed
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 9424-9429
    • Zhou, X.1    Wang, L.2    Hasegawa, H.3    Amin, P.4    Han, B.X.5    Kaneko, S.6    He, Y.7    Wang, F.8
  • 212
    • 84921268569 scopus 로고    scopus 로고
    • The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation
    • CrossRef PubMed
    • Issman-Zecharya, N. and Schuldiner, O. (2014) The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation. Dev. Cell 31, 461-473 CrossRef PubMed
    • (2014) Dev. Cell , vol.31 , pp. 461-473
    • Issman-Zecharya, N.1    Schuldiner, O.2
  • 213
    • 81455154986 scopus 로고    scopus 로고
    • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Ralpha surface expression
    • CrossRef PubMed
    • McLeod, I. X., Zhou, X., Li, Q. J., Wang, F. and He, Y. W. (2011) The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Ralpha surface expression. J. Immunol. 187, 5051-5061 CrossRef PubMed
    • (2011) J. Immunol. , vol.187 , pp. 5051-5061
    • McLeod, I.X.1    Zhou, X.2    Li, Q.J.3    Wang, F.4    He, Y.W.5
  • 214
    • 84861889657 scopus 로고    scopus 로고
    • Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis
    • CrossRef PubMed
    • Willinger, T. and Flavell, R. A. (2012) Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis. Proc. Natl. Acad. Sci. U. S. A. 109, 8670-8675 CrossRef PubMed
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 8670-8675
    • Willinger, T.1    Flavell, R.A.2
  • 216
    • 84922506218 scopus 로고    scopus 로고
    • Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila
    • CrossRef PubMed
    • Anding, A. L. and Baehrecke, E. H. (2015) Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila. Cell Death Differ. 22, 457-464 CrossRef PubMed
    • (2015) Cell Death Differ. , vol.22 , pp. 457-464
    • Anding, A.L.1    Baehrecke, E.H.2
  • 217
    • 52449106253 scopus 로고    scopus 로고
    • The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-t hieno[3, 2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class i PI3 kinase for the treatment of cancer
    • CrossRef PubMed
    • Folkes, A. J., Ahmadi, K., Alderton, W. K., Alix, S., Baker, S. J., Box, G., Chuckowree, I. S., Clarke, P. A., Depledge, P., Eccles, S. A. et al. (2008) The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-t hieno[3, 2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J. Med. Chem. 51, 5522-5532 CrossRef PubMed
    • (2008) J. Med. Chem. , vol.51 , pp. 5522-5532
    • Folkes, A.J.1    Ahmadi, K.2    Alderton, W.K.3    Alix, S.4    Baker, S.J.5    Box, G.6    Chuckowree, I.S.7    Clarke, P.A.8    Depledge, P.9    Eccles, S.A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.