A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Nature chemical biology

Volumn 10, Issue 12, 2014, Pages 1013-1019

  Ronan, Baptiste ^a   Flamand, Odile ^a   Vescovi, Lionel ^a   Dureuil, Christine ^a   Durand, Laurence ^a   Fassy, Florence ^a   Bachelot, Marie France ^a   Lamberton, Annabelle ^a   Mathieu, Magali ^a   Bertrand, Thomas ^a   Marquette, Jean Pierre ^a   El Ahmad, Youssef ^a   Filoche Romme, Bruno ^a   Schio, Laurent ^a   Garcia Echeverria, Carlos ^a   Goulaouic, Hélène ^a   Pasquier, Benoit ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; EVEROLIMUS; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; RAPAMYCIN; RECOMBINANT PROTEIN; SAR405; TARGET OF RAPAMYCIN KINASE;

ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; AUTOPHAGY; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG POTENTIATION; ENDOSOME; ENZYME ACTIVE SITE; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HUMAN; KIDNEY; KINETICS; LYSOSOME; METABOLISM; MOLECULAR DOCKING; PATHOLOGY; SIGNAL TRANSDUCTION; SYNTHESIS; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CLASS III PHOSPHATIDYLINOSITOL 3-KINASES; DRUG SYNERGISM; ENDOSOMES; GENE EXPRESSION; HUMANS; KIDNEY; KINETICS; LYSOSOMES; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; PYRIDINES; PYRIMIDINONES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84911906578     PISSN: None     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1681     Document Type: Article

References (0)