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Volumn 21, Issue 4, 2014, Pages 533-546

Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy

Author keywords

autophagy; cancer therapy; PLD1

Indexed keywords

AUTOPHAGY PROTEIN 1; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BECLIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE D; UNCLASSIFIED DRUG;

EID: 84903363448     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.174     Document Type: Article
Times cited : (43)

References (52)
  • 2
  • 3
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140: 313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 4
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032-1036.
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3    Yamamoto, A.4    Nakaya, H.5    Yoshimori, T.6
  • 5
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 6
    • 77950509348 scopus 로고    scopus 로고
    • Autophagy and tumorigenesis
    • Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett 2010; 584: 1427-1435.
    • (2010) FEBS Lett , vol.584 , pp. 1427-1435
    • Chen, N.1    Debnath, J.2
  • 7
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10: 51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 8
    • 78751556979 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cancer
    • Chen N, Karantza V. Autophagy as a therapeutic target in cancer. Cancer Biol Ther 2011; 11: 157-168.
    • (2011) Cancer Biol Ther , vol.11 , pp. 157-168
    • Chen, N.1    Karantza, V.2
  • 9
    • 77956172813 scopus 로고    scopus 로고
    • Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
    • Kuma A, Mizushima N. Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol 2010; 21: 683-690.
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 683-690
    • Kuma, A.1    Mizushima, N.2
  • 10
    • 77951231349 scopus 로고    scopus 로고
    • MTOR and cancer: Many loops in one pathway
    • Efeyan A, Sabatini DM. mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol 2010; 22: 169-176.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 169-176
    • Efeyan, A.1    Sabatini, D.M.2
  • 11
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13: 132-141.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 12
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331: 456-461.
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5    Mair, W.6
  • 13
    • 77953543377 scopus 로고    scopus 로고
    • The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond
    • Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol 2010; 20: 355-362.
    • (2010) Trends Cell Biol , vol.20 , pp. 355-362
    • Funderburk, S.F.1    Wang, Q.J.2    Yue, Z.3
  • 14
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-939.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 15
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30: 678-688.
    • (2008) Mol Cell , vol.30 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 16
    • 33846438568 scopus 로고    scopus 로고
    • Regulation of mTOR by phosphatidic acid?
    • Foster DA. Regulation of mTOR by phosphatidic acid? Cancer Res 2007; 67: 1-4.
    • (2007) Cancer Res , vol.67 , pp. 1-4
    • Foster, D.A.1
  • 17
    • 54149107123 scopus 로고    scopus 로고
    • MTOR signaling: PLD takes center stage
    • Sun Y, Chen J. mTOR signaling: PLD takes center stage. Cell Cycle 2008; 7: 3118-3123.
    • (2008) Cell Cycle , vol.7 , pp. 3118-3123
    • Sun, Y.1    Chen, J.2
  • 18
    • 78751480479 scopus 로고    scopus 로고
    • Phospholipase D meets Wnt signaling: A new target for cancer therapy
    • Kang DW, Choi KY, Min do S. Phospholipase D meets Wnt signaling: a new target for cancer therapy. Cancer Res 2011; 71: 293-297.
    • (2011) Cancer Res , vol.71 , pp. 293-297
    • Kang, D.W.1    Choi, K.Y.2    Min Do, S.3
  • 19
    • 34248373648 scopus 로고    scopus 로고
    • The potential for phospholipase D as a new therapeutic target
    • Huang P, Frohman MA. The potential for phospholipase D as a new therapeutic target. Expert Opin Ther Targets 2007; 11: 707-716.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 707-716
    • Huang, P.1    Frohman, M.A.2
  • 20
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137: 1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5    Chen, H.Y.6
  • 21
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3: 452-460.
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 22
    • 70349634805 scopus 로고    scopus 로고
    • Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux
    • Farkas T, Hoyer-Hansen M, Jaattela M. Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux. Autophagy 2009; 5: 1018-1025.
    • (2009) Autophagy , vol.5 , pp. 1018-1025
    • Farkas, T.1    Hoyer-Hansen, M.2    Jaattela, M.3
  • 24
    • 33646204392 scopus 로고    scopus 로고
    • Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    • Hosokawa N, Hara Y, Mizushima N. Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2007; 581: 2623-2629.
    • (2007) FEBS Lett , vol.581 , pp. 2623-2629
    • Hosokawa, N.1    Hara, Y.2    Mizushima, N.3
  • 25
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice
    • Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I et al. Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169: 425-434.
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3    Iwata, J.4    Murata, S.5    Tanida, I.6
  • 26
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006; 5: 671-688.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 28
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571-580.
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 29
    • 32244442749 scopus 로고    scopus 로고
    • Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
    • Zeng X, Overmeyer JH, Maltese WA. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 2006; 119: 259-270.
    • (2006) J Cell Sci , vol.119 , pp. 259-270
    • Zeng, X.1    Overmeyer, J.H.2    Maltese, W.A.3
  • 30
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N, Yu J, Byfield M, Pattingre S, Levine B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005; 1: 46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 31
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15: 5308-5316.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    Dipaola, R.S.2
  • 32
    • 34347394714 scopus 로고    scopus 로고
    • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    • Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007; 110: 313-322.
    • (2007) Blood , vol.110 , pp. 313-322
    • Carew, J.S.1    Nawrocki, S.T.2    Kahue, C.N.3    Zhang, H.4    Yang, C.5    Chung, L.6
  • 33
    • 80052697287 scopus 로고    scopus 로고
    • The role of autophagy in cancer: Therapeutic implications
    • Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011; 10: 1533-1541.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1533-1541
    • Yang, Z.J.1    Chee, C.E.2    Huang, S.3    Sinicrope, F.A.4
  • 34
    • 66449115318 scopus 로고    scopus 로고
    • Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    • Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009; 119: 1359-1372.
    • (2009) J Clin Invest , vol.119 , pp. 1359-1372
    • Salazar, M.1    Carracedo, A.2    Salanueva, I.J.3    Hernandez-Tiedra, S.4    Lorente, M.5    Egia, A.6
  • 35
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 2007; 117: 326-336.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3    Bui, T.4    Christophorou, M.A.5    Evan, G.I.6
  • 37
    • 31544466778 scopus 로고    scopus 로고
    • Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10
    • Kim J, Lee YH, Kwon TK, Chang JS, Chung KC, Min DS. Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer Res 2006; 66: 784-793.
    • (2006) Cancer Res , vol.66 , pp. 784-793
    • Kim, J.1    Lee, Y.H.2    Kwon, T.K.3    Chang, J.S.4    Chung, K.C.5    Min, D.S.6
  • 39
    • 33646831810 scopus 로고    scopus 로고
    • Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
    • Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R et al. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 2006; 281: 8518-8527.
    • (2006) J Biol Chem , vol.281 , pp. 8518-8527
    • Lavieu, G.1    Scarlatti, F.2    Sala, G.3    Carpentier, S.4    Levade, T.5    Ghidoni, R.6
  • 41
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 2005; 102: 8204-8209.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 42
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-134.
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3    Syed, N.4    Smith, P.5    Harrison, P.R.6
  • 44
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of class III PI3Ks: Novel roles for Vps34
    • Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem J 2008; 410: 1-17.
    • (2008) Biochem J , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 46
    • 84855731134 scopus 로고    scopus 로고
    • Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    • Yoon MS, Du G, Backer JM, Frohman MA, Chen J. Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol 2011; 195: 435-447.
    • (2011) J Cell Biol , vol.195 , pp. 435-447
    • Yoon, M.S.1    Du, G.2    Backer, J.M.3    Frohman, M.A.4    Chen, J.5
  • 47
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9: 1102-1109.
    • (2007) Nat Cell Biol , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 49
    • 77953524763 scopus 로고    scopus 로고
    • Autophagy takes an alternative pathway
    • Shimizu S, Arakawa S, Nishida Y. Autophagy takes an alternative pathway. Autophagy 2010; 6: 290-291.
    • (2010) Autophagy , vol.6 , pp. 290-291
    • Shimizu, S.1    Arakawa, S.2    Nishida, Y.3
  • 50
    • 53749104349 scopus 로고    scopus 로고
    • Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
    • Degtyarev M, De Maziere A, Orr C, Lin J, Lee BB, Tien JY et al. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol 2008; 183: 101-116.
    • (2008) J Cell Biol , vol.183 , pp. 101-116
    • Degtyarev, M.1    De Maziere, A.2    Orr, C.3    Lin, J.4    Lee, B.B.5    Tien, J.Y.6
  • 51
    • 55049140159 scopus 로고    scopus 로고
    • Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes
    • Jang YH, Ahn BH, Namkoong S, Kim YM, Jin JK, Kim YS et al. Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes. Cell Signal 2008; 20: 2190-2207.
    • (2008) Cell Signal , vol.20 , pp. 2190-2207
    • Jang, Y.H.1    Ahn, B.H.2    Namkoong, S.3    Kim, Y.M.4    Jin, J.K.5    Kim, Y.S.6
  • 52
    • 79953009004 scopus 로고    scopus 로고
    • Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(alpha) and extracellular signal-regulated kinase signaling pathways
    • Jang YH, Min do S. Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(alpha) and extracellular signal-regulated kinase signaling pathways. J Biol Chem 2011; 286: 4680-4689.
    • (2011) J Biol Chem , vol.286 , pp. 4680-4689
    • Jang, Y.H.1    Min Do, S.2


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