Inhibition of autophagy by TAB2 and TAB3

EMBO Journal

Volumn 30, Issue 24, 2011, Pages 4908-4920

  Criollo, Alfredo ^a,b,c   Niso Santano, Mireia ^a,b,c   Malik, Shoaib Ahmad ^a,b,c   Michaud, Mickael ^a,b,c   Morselli, Eugenia ^a,b,c   Mariño, Guillermo ^a,b,c   Lachkar, Sylvie ^a,b,c   Arkhipenko, Alexander V ^a,b   Harper, Francis ^b,d   Pierron, Gérard ^b,d   Rain, Jean Christophe ^e   Ninomiya Tsuji, Jun ^f   Fuentes, José M ^g   Lavandero, Sergio ^h,i   Galluzzi, Lorenzo ^a,b,c   Maiuri, Maria Chiara ^a,b,c   Kroemer, Guido ^a,b,j,k,l  

^a INSERM   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d CNRS   (France)

^e Hybrigenics SA   (France)

^f NORTH CAROLINA STATE UNIVERSITY   (United States)

^g UNIVERSITY OF EXTREMADURA   (Spain)

^h UNIVERSITY OF CHILE   (Chile)

ⁱ UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^j CENTRE DE RECHERCHE DES CORDELIERS   (France)

^k HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^l UNIVERSITÉ PARIS DESCARTES   (France)

more..

Author keywords

Beclin 1 interactome; mTOR; p53; pifithrin ; rapamycin; stress response

Indexed keywords

BECLIN 1; BINDING PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B KINASE; PROTEIN P62; PROTEIN TAB2; PROTEIN TAB3; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISSOCIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PROTEIN STRUCTURE, TERTIARY; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 83555168258     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.413     Document Type: Article

References (46)

1. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT (2008) Autophagosome formation from membrane compartments enriched in phosphati-dylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182: 685-701
2. Baud V, Karin M (2009) Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8: 33-40
3. Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466: 68-76
4. Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG (2007) TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem 282: 3918-3928 (Pubitemid 47084482)
5. Boehrer S, Ades L, Braun T, Galluzzi L, Grosjean J, Fabre C, Le Roux G, Gardin C, Martin A, de Botton S, Fenaux P, Kroemer G (2008) Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study. Blood 111 : 2170-2180 (Pubitemid 351451531)
6. Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G (2005) Inhibition of macro-autophagy triggers apoptosis. Mol Cell Biol 25: 1025-1040
7. Comb WC, Cogswell P, Sitcheran R, Baldwin AS (2011) IKK-depen-dent, NF-kappaB-independent control of autophagic gene expression. Oncogene 30: 1727-1732
8. Criollo A, Galluzzi L, Maiuri MC, Tasdemir E, Lavandero S, Kroemer G (2007a) Mitochondrial control of cell death induced by hyper-osmotic stress. Apoptosis 12: 3-18 (Pubitemid 46009500)
9. Criollo A, Maiuri MC, Tasdemir E, Vitale I, Fiebig AA, Andrews D, Molgo J, Diaz J, Lavandero S, Harper F, Pierron G, di Stefano D, Rizzuto R, Szabadkai G, Kroemer G (2007b) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14: 1029-1039 (Pubitemid 46629841)
10. Criollo A, Senovilla L, Authier H, Maiuri MC, Morselli E, Vitale I, Kepp O, Tasdemir E, Galluzzi L, Shen S, Tailler M, Delahaye N, Tesniere A, De Stefano D, Younes AB, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A et al (2010) The IKK complex contributes to the induction of autophagy. EMBO J 29: 619-631
11. Ding Y, Kim JK, Kim SI, Na HJ, Jun SY, Lee SJ, Choi ME (2010) TGF-b1 protects against mesangial cell apoptosis via induction of autophagy. J Biol Chem 285: 37909-37919
12. Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447: 1121-1125 (Pubitemid 47014434)
13. Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre O, Doye V et al (2005) Protein interaction mapping: a Drosophila case study. Genome Res 15: 376-384 (Pubitemid 40467779)
14. Fromont-Racine M, Rain JC, Legrain P (2002) Building protein-protein networks by two-hybrid mating strategy. Methods Enzymol 350: 513-524 (Pubitemid 34619510)
15. Green DR, Galluzzi L, Kroemer G (2011) Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333: 1109-1112
16. He C, Levine B (2010) The Beclin 1 interactome. Curr Opin Cell Biol 22: 140-149
17. Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M (2009) TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 28: 677-685
18. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (2003) Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J 22: 6277-6288 (Pubitemid 37522585)
19. Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B (2004) Identification of a human NF-kappaB-activating protein, TAB3. Proc Natl Acad Sci USA 101 : 2028-2033 (Pubitemid 38229009)
20. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728
21. Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ (2004) TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15: 535-548 (Pubitemid 39141781)
22. Kang R, Zeh HJ, Lotze MT, Tang D (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18: 571-580
23. Klionsky DJ (2004) Cell biology: regulated self-cannibalism. Nature 431: 31-32
24. Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40: 280-293
25. Landstrom M (2010) The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol 42: 585-589
26. Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU (2006) Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 8: 688-699
27. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676 (Pubitemid 129516338)
28. Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, Hickman JA, Geneste O, Kroemer G (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 26: 2527-2539 (Pubitemid 46788315)
29. Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Marino G, Benyounes A, Benit P, Rustin P, Maiuri MC, Kroemer G (2011a) BH3 mimetics activate multiple pro-autophagic pathways. Oncogene 30: 3918-3929
30. Malik SA, Shen S, Marino G, BenYounes A, Maiuri MC, Kroemer G (2011b) BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades. Autophagy 7: 914-916
31. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075 (Pubitemid 351317450)
32. Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140: 313-326
33. Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (1999) The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-256
34. Ono K, Ohtomo T, Ninomiya-Tsuji J, Tsuchiya M (2003) A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta. Biochem Biophys Res Commun 307: 332-337 (Pubitemid 36818874)
35. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939 (Pubitemid 41345209)
36. Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M (2010) p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci USA 107: 18511-18516
37. Shi CS, Kehrl JH (2010) TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 3: ra42
38. Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q (2008) Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 105 : 19211-19216
39. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (2000) TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 5: 649-658
40. Takaesu G, Kobayashi T, Yoshimura A (2011) TGFb-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. J Biochem (doi:10.1093/jb/mvr123)
41. Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB (2003) TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol 326: 105-115 (Pubitemid 36279361)
42. Tasdemir E, Galluzzi L, Maiuri MC, Criollo A, Vitale I, Hangen E, Modjtahedi N, Kroemer G (2008a) Methods for assessing autophagy and autophagic cell death. Methods Mol Biol 445: 29-76
43. Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G et al (2008b) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10: 676-687 (Pubitemid 351772933)
44. Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35: 921-933
45. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J (2007) Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci USA 104: 19023-19028
46. Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 11 : 468-476