메뉴 건너뛰기




Volumn 22, Issue 3, 2012, Pages 473-489

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

Author keywords

autophagy; Beclin 1; crystal structure; membrane binding; membrane deformation; omegasome

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN;

EID: 84862777560     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.24     Document Type: Article
Times cited : (174)

References (54)
  • 6
    • 0030897485 scopus 로고    scopus 로고
    • Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products
    • DOI 10.1083/jcb.137.1.79
    • Seaman MN, Marcusson EG, Cereghino JL, Emr SD. Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol 1997; 137:79-92. (Pubitemid 27167297)
    • (1997) Journal of Cell Biology , vol.137 , Issue.1 , pp. 79-92
    • Seaman, M.N.J.1    Marcusson, E.G.2    Cereghino, J.L.3    Emr, S.D.4
  • 7
    • 0032575551 scopus 로고    scopus 로고
    • Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae
    • DOI 10.1074/jbc.273.35.22284
    • Kametaka S, Okano T, Ohsumi M, Ohsumi Y. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 1998; 273:22284-22291. (Pubitemid 28399786)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.35 , pp. 22284-22291
    • Kametaka, S.1    Okano, T.2    Ohsumi, M.3    Ohsumi, Y.4
  • 8
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19:5360-5372.
    • (2008) Mol Biol Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 9
    • 66349103167 scopus 로고    scopus 로고
    • Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes
    • Itakura E, Mizushima N. Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy 2009; 5:534-536.
    • (2009) Autophagy , vol.5 , pp. 534-536
    • Itakura, E.1    Mizushima, N.2
  • 10
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • DOI 10.1093/embo-reports/kve061
    • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001; 2:330-335. (Pubitemid 32401529)
    • (2001) EMBO Reports , vol.2 , Issue.4 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 11
    • 79251577061 scopus 로고    scopus 로고
    • The regulation of autophagy -unanswered questions
    • Chen Y, Klionsky DJ. The regulation of autophagy -unanswered questions. J Cell Sci 2011; 124:161-170.
    • (2011) J Cell Sci , vol.124 , pp. 161-170
    • Chen, Y.1    Klionsky, D.J.2
  • 12
    • 77950465542 scopus 로고    scopus 로고
    • Current knowledge of the pre-autophagosomal structure (PAS)
    • Suzuki K, Ohsumi Y. Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett 2010; 584:1280-1286.
    • (2010) FEBS Lett , vol.584 , pp. 1280-1286
    • Suzuki, K.1    Ohsumi, Y.2
  • 13
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N, Yu J, Byfield M, Pattingre S, Levine B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005; 1:46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 14
    • 34249037565 scopus 로고    scopus 로고
    • L-beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
    • DOI 10.1074/jbc.M700492200
    • Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282:13123-13132. (Pubitemid 47100641)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.17 , pp. 13123-13132
    • Oberstein, A.1    Jeffrey, P.D.2    Shi, Y.3
  • 15
    • 34547689505 scopus 로고    scopus 로고
    • Molecular Basis of Bcl-xL's Target Recognition Versatility Revealed by the Structure of Bcl-xL in Complex with the BH3 Domain of Beclin-1
    • DOI 10.1016/j.jmb.2007.06.069, PII S0022283607008765
    • Feng W, Huang S, Wu H, Zhang M. Molecular basis of BclxL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. J Mol Biol 2007; 372:223-235. (Pubitemid 47223231)
    • (2007) Journal of Molecular Biology , vol.372 , Issue.1 , pp. 223-235
    • Feng, W.1    Huang, S.2    Wu, H.3    Zhang, M.4
  • 17
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8:688-699.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3
  • 18
    • 58049192897 scopus 로고    scopus 로고
    • Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
    • Sun Q, Fan W, Chen K, et al. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 2008; 105:19211-19216.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19211-19216
    • Sun, Q.1    Fan, W.2    Chen, K.3
  • 19
    • 0027440362 scopus 로고
    • Protein structure comparison by alignment of distance matrices
    • DOI 10.1006/jmbi.1993.1489
    • Holm L, Sander C. Protein structure comparison by alignment of distance matrices. J Mol Biol 1993; 233:123-138. (Pubitemid 23288916)
    • (1993) Journal of Molecular Biology , vol.233 , Issue.1 , pp. 123-138
    • Holm, L.1    Sander, C.2
  • 20
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ. Mammalian autophagy: Core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22:124-131.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 22
    • 38549092474 scopus 로고    scopus 로고
    • Membrane recognition by phospholipid-binding domains
    • DOI 10.1038/nrm2328, PII NRM2328
    • Lemmon MA. Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol 2008; 9:99-111. (Pubitemid 351158910)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 99-111
    • Lemmon, M.A.1
  • 24
    • 0028167730 scopus 로고
    • Iodixanol: A nonionic isoosmotic centrifugation medium for the formation of selfgenerated gradients
    • Ford T, Graham J Rickwood D. Iodixanol: A nonionic isoosmotic centrifugation medium for the formation of selfgenerated gradients. Anal Biochem 1994; 220:360-366.
    • (1994) Anal Biochem , vol.220 , pp. 360-366
    • Ford, T.1    Graham J Rickwood, D.2
  • 25
    • 37449021786 scopus 로고    scopus 로고
    • Purification of human respiratory syncytial virus by ultracentrifugation in iodixanol density gradient
    • Gias E, Nielsen SU, Morgan LA, Toms GL. Purification of human respiratory syncytial virus by ultracentrifugation in iodixanol density gradient. J Virol Methods 2008; 147:328-332.
    • (2008) J Virol Methods , vol.147 , pp. 328-332
    • Gias, E.1    Nielsen, S.U.2    Morgan, L.A.3    Toms, G.L.4
  • 26
    • 2342500301 scopus 로고    scopus 로고
    • Milk fat globule epidermal growth factor 8 (MFG-E8) binds to oxidized phosphatidylserine: Implications for macrophage clearance of apoptotic cells [3]
    • DOI 10.1038/sj.cdd.4401421
    • Borisenko GG, Iverson SL, Ahlberg S, Kagan VE, Fadeel B. Milk fat globule epidermal growth factor 8 (MFG-E8) binds to oxidized phosphatidylserine: Implications for macrophage clearance of apoptotic cells. Cell Death Differ 2004; 11:943-945. (Pubitemid 39139754)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.8 , pp. 943-945
    • Borisenko, G.G.1    Iverson, S.L.2    Ahlberg, S.3    Kagan, V.E.4    Fadeel, B.5
  • 27
    • 33645581647 scopus 로고    scopus 로고
    • Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity
    • Nakatani H, Aoki N, Nakagawa Y, et al. Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity. Biochem J 2006; 395:21-30.
    • (2006) Biochem J , vol.395 , pp. 21-30
    • Nakatani, H.1    Aoki, N.2    Nakagawa, Y.3
  • 28
    • 4344696843 scopus 로고    scopus 로고
    • The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8
    • DOI 10.1111/j.1356-9597.2004.00750.x
    • Sugawara K, Suzuki NN, Fujioka Y, et al. The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells 2004; 9:611-618. (Pubitemid 39117535)
    • (2004) Genes to Cells , vol.9 , Issue.7 , pp. 611-618
    • Sugawara, K.1    Suzuki, N.N.2    Fujioka, Y.3    Mizushima, N.4    Ohsumi, Y.5    Inagaki, F.6
  • 30
    • 78649636176 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    • Wirawan E, Vande Walle L, Kersse K, et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 2010; 1:e18.
    • (2010) Cell Death Dis , vol.1
    • Wirawan, E.1    Vande Walle, L.2    Kersse, K.3
  • 31
    • 0035870257 scopus 로고    scopus 로고
    • Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function
    • Liang XH, Yu J, Brown K, Levine B. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 2001; 61:3443-3449. (Pubitemid 32695039)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3443-3449
    • Xiao Huan Liang1    Yu, J.2    Brown, K.3    Levine, B.4
  • 32
    • 79953230490 scopus 로고    scopus 로고
    • Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis
    • Zhu Y, Zhao L, Liu L, et al. Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein Cell 2010; 1:468-477.
    • (2010) Protein Cell , vol.1 , pp. 468-477
    • Zhu, Y.1    Zhao, L.2    Liu, L.3
  • 33
    • 77952495224 scopus 로고    scopus 로고
    • Mitochondria supply membranes for autophagosome biogenesis during starvation
    • Hailey DW, Rambold AS, Satpute-Krishnan P, et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010; 141:656-667.
    • (2010) Cell , vol.141 , pp. 656-667
    • Hailey, D.W.1    Rambold, A.S.2    Satpute-Krishnan, P.3
  • 34
    • 33644846421 scopus 로고    scopus 로고
    • How proteins produce cellular membrane curvature
    • DOI 10.1038/nrm1784, PII N1784
    • Zimmerberg J, Kozlov MM. How proteins produce cellular membrane curvature. Nat Rev Mol Cell Biol 2006; 7:9-19. (Pubitemid 43361568)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.1 , pp. 9-19
    • Zimmerberg, J.1    Kozlov, M.M.2
  • 35
    • 77955052751 scopus 로고    scopus 로고
    • Interplay of proteins and lipids in generating membrane curvature
    • Graham TR, Kozlov MM. Interplay of proteins and lipids in generating membrane curvature. Curr Opin Cell Biol; 22:430-436.
    • Curr Opin Cell Biol , vol.22 , pp. 430-436
    • Graham, T.R.1    Kozlov, M.M.2
  • 36
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector Beclin 1: A novel BH3-only protein
    • Sinha S, Levine B. The autophagy effector Beclin 1: A novel BH3-only protein. Oncogene 2008; 27 Suppl 1:S137-S148.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Sinha, S.1    Levine, B.2
  • 37
    • 77953543377 scopus 로고    scopus 로고
    • The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond
    • Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol 2010; 20:355-362.
    • (2010) Trends Cell Biol , vol.20 , pp. 355-362
    • Funderburk, S.F.1    Wang, Q.J.2    Yue, Z.3
  • 38
    • 79955025448 scopus 로고    scopus 로고
    • Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes
    • Renner LD, Weibel DB. Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes. Proc Natl Acad Sci USA 2011; 108:6264-6269.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6264-6269
    • Renner, L.D.1    Weibel, D.B.2
  • 39
    • 72449137691 scopus 로고    scopus 로고
    • Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: Implications for Barth syndrome
    • Gebert N, Joshi AS, Kutik S, et al. Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: Implications for Barth syndrome. Curr Biol 2009; 19:2133-2139.
    • (2009) Curr Biol , vol.19 , pp. 2133-2139
    • Gebert, N.1    Joshi, A.S.2    Kutik, S.3
  • 40
    • 0031551023 scopus 로고    scopus 로고
    • Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane?
    • DOI 10.1016/S0005-2736(96)00240-4, PII S0005273696002404
    • de Kroon AI, Dolis D, Mayer A, Lill R, de Kruijff B. Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane? Biochim Biophys Acta 1997; 1325:108-116. (Pubitemid 27138481)
    • (1997) Biochimica et Biophysica Acta - Biomembranes , vol.1325 , Issue.1 , pp. 108-116
    • De Kroon, A.I.P.M.1    Dolis, D.2    Mayer, A.3    Lill, R.4    De Kruijff, B.5
  • 41
    • 0027425316 scopus 로고
    • PH-dissociation characteristics of cardiolipin and its 2'-deoxy analogue
    • Kates M, Syz JY, Gosser D, Haines TH. pH-dissociation characteristics of cardiolipin and its 2'-deoxy analogue. Lipids 1993; 28:877-882. (Pubitemid 23297115)
    • (1993) Lipids , vol.28 , Issue.10 , pp. 877-882
    • Kates, M.1    Syz, J.-Y.2    Gosser, D.3    Halnes, T.H.4
  • 42
    • 50249084987 scopus 로고    scopus 로고
    • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
    • Axe EL, Walker SA, Manifava M, et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182:685-701.
    • (2008) J Cell Biol , vol.182 , pp. 685-701
    • Axe, E.L.1    Walker, S.A.2    Manifava, M.3
  • 43
    • 77955895424 scopus 로고    scopus 로고
    • Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
    • Matsunaga K, Morita E, Saitoh T, et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol 2010; 190:511-521.
    • (2010) J Cell Biol , vol.190 , pp. 511-521
    • Matsunaga, K.1    Morita, E.2    Saitoh, T.3
  • 44
    • 77953726483 scopus 로고    scopus 로고
    • Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
    • Polson HE, de Lartigue J, Rigden DJ, et al. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy 2010; 6:506-522.
    • (2010) Autophagy , vol.6 , pp. 506-522
    • Polson, H.E.1    De Lartigue, J.2    Rigden, D.J.3
  • 47
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • DOI 10.1016/S0076-6879(97)76066-X
    • Otwinowski Z, Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 1997; 276:307-326. (Pubitemid 27085611)
    • (1997) Methods in Enzymology , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 48
    • 0028103275 scopus 로고
    • Collaborative computational project N. The CCP4 suite: Programs for protein crystallography
    • Collaborative Computational Project N. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr 1994; D50:760-763.
    • (1994) Acta Crystallogr , vol.D50 , pp. 760-763
  • 52
    • 33748337934 scopus 로고    scopus 로고
    • The Buccaneer software for automated model building
    • Cowtan K. The Buccaneer software for automated model building. Acta Crystallogr D 2006; 62:1002-1011.
    • (2006) Acta Crystallogr D , vol.62 , pp. 1002-1011
    • Cowtan, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.