Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

Journal of Cell Biology

Volumn 155, Issue 1, 2001, Pages 19-25

  Vieira, Otilia V ^a,b   Botelho, Roberto J ^a   Rameh, Lucia ^c   Brachmann, Saskia M ^c,d   Matsuo, Tsuyoshi ^c   Davidson, Howard W ^e   Schreiber, Alan ^f   Backer, Jonathan M ^g   Cantley, Lewis C ^c   Grinstein, Sergio ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c HARVARD INSTITUTES OF MEDICINE   (United States)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

EEA1; FYVE domain; Lysosomes; Phagocytosis; Phosphatidylinositol

Indexed keywords

CHIMERIC PROTEIN; ISOENZYME; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; BIOGENESIS; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; LYSOSOME; MATURATION; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELLS, CULTURED; ENZYME INHIBITORS; FIBROBLASTS; GENES, REPORTER; HUMANS; IMMUNOGLOBULIN G; ISOENZYMES; LYSOSOMES; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROINJECTIONS; PHAGOCYTOSIS; PHAGOSOMES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

ANIMALIA;

EID: 0035494493     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200107069     Document Type: Article

References (27)

1. Mechanisms of phagocytosis in macrophages
2. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
3. Purification and characterization of phosphoinositide 3-kinase from rat liver
4. Phosphatidylinositol-3-OH kinases are Rab5 effectors
5. A requirement for phosphatidylinositol 3-kinase in pseudopod extension
6. Mycobacterium tuberculosis phagosome
7. Phagosomal maturation, acidification, and inhibition of bacterial growth in nonphagocytic cells transfected with Fcgam-maRIIA receptors
8. Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages
9. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
10. FYVE fingers bind PtdIns(3)P
11. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
12. Diversiry in phagocytic signalling
13. The molecular dissection of Fc gamma receptor mediated phagocytosis
14. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization
15. Restricted accumulation of phosphatidylinosirol 3-kinase products in a plasmalemmal subdomain during fcgamma receptor-mediated phagocytosis
16. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
17. A functional PtdIns(3)P-binding motif
18. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
19. Dynamics of rab5 activation in endocytosis and phagocytosis
20. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation
21. Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation
22. Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
23. Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate
24. Phagosome dynamics and function
25. Signalling through the lipid products of phosphoinositide-3-OH kinase
26. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
27. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells