Role of the Vps34p-interacting protein Ade5, 7p in hyphal growth and virulence of Candida albicans

Microbiology

Volumn 153, Issue 7, 2007, Pages 2351-2362

  Jezewski, Susann ^a,c   von der Heide, Monika ^a   Poltermann, Sophia ^a   Härtl, Albert ^a   Künkel, Waldemar ^b   Zipfel, Peter F ^a   Eck, Raimund ^b,d  

^a HANS KNÖLL INSTITUTE   (Germany)

^b UNIVERSITY OF APPLIED SCIENCES JENA   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d SIRS Lab GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; FUNGAL ENZYME; METAL ION; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ADE5 7P; PROTEIN VPS34P; PURINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CHEMOSENSITIVITY; COMPLEX FORMATION; CONTROLLED STUDY; FUNGAL VIRULENCE; FUNGUS HYPHAE; IN VITRO STUDY; INVASIVE CANDIDIASIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TWO HYBRID SYSTEM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CANDIDA ALBICANS; CARBOXY-LYASES; HYPHAE; PEPTIDE SYNTHASES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; TWO-HYBRID SYSTEM TECHNIQUES; VIRULENCE;

CANDIDA ALBICANS;

EID: 34447514348     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2006/004028-0     Document Type: Article

References (42)

1. Arnaud, M. B., Costanzo, M. C., Skrzypek, G., Lane, C., Miyasato, S. R. & Sherlock G. (2005). The Candida Genome Database (CGD), a community resource for Candida albicans gene and protein information. Nucleic Acids Res 33, D358-D363.
2. Arndt, K. T., Styles, C. & Fink G. R. (1987). Multiple global regulators control HIS4 transcription in yeast. Science 237, 874-880.
3. Brown, D. H., Jr, Giusani, A. D., Chen, X. & Kumamoto, C. A. (1999). Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 gene. Mol Microbiol 34, 651-662.
4. Bruckmann, A., Künkel, W., Härtl, A., Wetzker, R. & Eck R. (2000). A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth, and virulence. Microbiology 146, 2755-2764.
5. Cheng, S., Nguyen, M. H., Zhang, Z., Jia, H., Handfield, M. & Clancy, C. J. (2003). Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus. Infect Immun 71, 6101-6103.
6. Cutler, J. E (1991). Putative virulence factors of Candida albicans. Annu Rev Microbiol 45, 187-218.
7. D'Enfert C., Goyard, S., Rodriguez-Arnaveilhe, S., Frangeul, L., Jones, L., Tekaia, F., Bader, O., Albrecht A., Castillo, L. & other authors (2005). CandidaDB: A genome database for Candida albicans pathogenomics. Nucleic Acids Res 33, D353-D357.
8. Daignan-Fornier, B. & Fink, G. R. (1992). Coregulation of purine and histidine biosynthesis by the transcriptional activators BASI and BAS2. Proc Nad Acad Sci U S A 89, 6746-6750.
9. Davis, D., Edwards, J. E., Jr, Mitchell, A. P. & Ibrahim, A. S. (2000). Candida albicans RIM101 PH response pathway is required for host-pathogen interactions. Infect Immun 68, 5953-5959.
10. Deutschbauer, A. M., Jaramillo, D. F., Proctor, M., Kumm, J., Hillenmeyer, M. E., Davis, R. W., Nislow, C. & Giaever, G. (2005). Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics 169, 1915-1925.
11. Donovan, M., Schumuke, J. J., Fonzi, W. A., Boner, S. L., Gheesling-Mullis, K, Jacob, G. S., Davisson, V. J. & Dotson, S. B. (2001). Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis. Infect Immun 69, 2542-2548.
12. Eck, R., Bruckmann, A., Wetzker, R. & Künkel, W. (2000). A phosphatidylinositol. 3-kinase of Candida albicans: Molecular cloning and characterization. Yeast 16, 933-944.
13. +-ATPase subunit Vma7p. Int J Med Microbiol 295, 57-66.
14. Ernst J. F. (2000). Transcription factors in Candida albicans - environmental control of morphogenesis. Microbiology 146 , 1763-1774.
15. Fonzi, W. A. & Irwin, M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
16. Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L, Veronneau, S., Dow, S., Lucau-Danila, A., Anderson, K & other authors (2002). Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391.
17. Giusani, A. D., Vinces, M. & Kumamoto, C. A. (2002). Invasive filamentous growth of Candida albicans is promoted by Czflp-dependent relief of Efglp-mediated repression. Genetics 160, 1749-1753.
18. Gola, S., Martin, R., Walther, A., Dunkler, A. & Wendland, J. (2003). New modules for PCR-based gene targeting in Candida albicans: Rapid and efficient gene targeting using 100 bp of flanking homology region. Yeast 20, 1339-1347.
19. Härtl, A., Hillesheim, H. G., Künkel, W. & Schrinner, E J. (1995). The Candida infected hen's egg. An alternative test system for systemic anti Candida activity. Arzneimittelforschung 45, 926-928.
20. Härtl, A., Möllmann, U., Schrinner, E. & Stelzner, A. (1997). Pseudomonas aeruginosa infection in embryonated hen's eggs. Arzneimittel-forschung 47, 1061-1064.
21. Henikoff, S. (1987). Multifunctional polypeptides; for purine de novo synthesis. Bioessays 6, 8-13.
22. Ho, Y, Gruhler, A., Halibut A., Bader, G. D., Moore, L, Adams, S. L., Millar, A., Taylor, P., Bennett, K. & other authors (2002). Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180-183.
23. Jones, E. W. & Fink, G. R. (1982). In The Molecular Biology of the Yeast Saccharomyces - Metabolism and Gene Expression, pp. 181-299. Edited by J. N. Strathem, E. W. Jones & J. R. Broach. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
24. Kitanovic, A., Nguyen, M., Vogel, G., Hartmann, A., Günther, J., Wurzner, R., Künkel, W., Wölfl, S. & Eck R. (2005). Phosphatidylinositol. 3-kinase VPS34 of Candida albicans is involved in filamentous growth, Saps secretion, and intracellular detoxification. FEMS Yeast Res 5, 431-439.
25. Köhler, J. R. & Fink G. R. (1996). Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated. protein kinase signaling components have defects in hyphal development. Proc Natl Acad Sci U S A 93, 13223-13228.
26. Kranz, A., Kinner, A. & Kölling, R. (2001). A family of small coiled-coil-forming proteins functioning at the late endosome in yeast. Mol Biol Cell 12, 711-723.
27. Lay, J., Henry, L K, Clifford, J., Koltin, Y., Bulawa, C. E. & Becker, J. M. (1998). Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies. Infect Immun 66, 5301-5306.
28. Lee, K L., Buckley, H. R. & Campbell, C. C. (1975). An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 13, 148-153.
29. Liu, T. T., Lee, R. E. B., Barker, K S., Lee, R. E., Wei, L., Homayouni, R. & Rogers, P. D. (2005). Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob Agents Chemother 49, 2226-2236.
30. Madani, N. D., Malloy, P. J., Rodriguez-Pombo, P., Krishnan, A. V. & Feldman, D. (1994). Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol. Proc Natl Acad Sci U S A 91, 922-926.
31. Negredo, A., Monteoliva, L., Gil, C., Pla, J. & Nombela, C. (1997). Cloning, analysis and one-step disruption of the ARG5,6 gene of Candida albicans. Microbiology 143, 297-302.
32. Odds, F. C. (1994). Pathogenesis of Candida infections. J Am Acad Dermatol 31, S2-S5.
33. + -ATPase null mutants. J Biol Chem 275, 40088-40095.
34. Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R. V., Howard, S., Mantel, N., McPherson, K., Peto, J. & Smith, P. G. (1977). Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35, 1-39.
35. Poltermann, S., Nguyen, M., Günther, J., Wendland, J., Härtl, A., Künkel, W., Zipfel, P. F. & Eck, R. (2005). The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence. Microbiology 151, 1645-1655.
36. Riggle, P. J. & Kumamoto, C. A. (2000). Role of the Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. J Bacteriol 182, 4899-4905.
37. Rolfes, R. J. & Hinnebusch, A. G. (1993). Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol Cell Biol 13, 5099-5111.
38. Tripathi, G., Wiltshire, C., Macaskill, S., Tournu, H., Budge, S. & Brown, A. J. P. (2002). Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans. EMBO J 21, 5448-5456.
39. Underwood, E. J. (1977). Trace Elements in Human and Animal Nutrition. London: Academic Press.
40. Wilson, R. B., Davis, D. & Mitchell, A. P. (1999). Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J Bacteriol 181, 1868-1874.
41. Yin, Z., Stead, D., Selway, L., Walker, J., Riba-Garcia, I., McInerney, T., Gaskell, S., Oliver, S. G., Cash, P. & Brown, A. J. P. (2004). Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae. Proteomics 4, 2425-2436.
42. Zalkin, H. Z. & Dixon, J. E (1992). De novo purine nucleotide biosynthesis. Prog Nucleic Acid Res Mol Biol 42, 259-287.