Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Biochemical Journal

Volumn 463, Issue 3, 2014, Pages 413-427

  Bago, Ruzica ^a   Malik, Nazma ^a   Munson, Michael J ^a   Prescott, Alan R ^a   Davies, Paul ^a   Sommer, Eeva ^a   Shpiro, Natalia ^a   Ward, Richard ^b   Cross, Darren ^b   Ganley, Ian G ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Mammalian target of rapamycin (mTOR); N Myc downstream regulated gene 1 (NDRG1); Phosphoinositide 3 kinase (PI3K); Protein kinase inhibitor; Signal transduction inhibitor

Indexed keywords

BUPARLISIB; INOSITOL POLYPHOSPHATE 4 PHOSPHATASE TYPE II; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 PHOSPHATE BINDING SGK3 PROTEIN KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PICTILISIB; PROTEIN KINASE B; PROTEIN SH2; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UNCLASSIFIED DRUG; VSP34 IN1; 1-((2-((2-CHLOROPYRIDIN-4YL)AMINO)-4′-(CYCLOPROPYLMETHYL)-(4,5′-BIPYRIMIDIN)-2′-YL)AMINO)-2-METHYLPROPAN-2-OL; AMINOPYRIDINE DERIVATIVE; INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE; INPPL1 PROTEIN, HUMAN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE; POLYPHOSPHOINOSITIDE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; PYRIMIDINE DERIVATIVE; SGK3 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOSOME; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME PHOSPHORYLATION; HYDROPHOBICITY; IC50; IN VITRO STUDY; MONITORING; MUTATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN MOTIF; REGULATORY MECHANISM; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL PHENOMENA; HUMAN; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; AMINOPYRIDINES; CELL LINE; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; CLASS II PHOSPHATIDYLINOSITOL 3-KINASES; CLASS III PHOSPHATIDYLINOSITOL 3-KINASES; ENDOSOMES; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES;

EID: 84907835041     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140889     Document Type: Article

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