Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator

Journal of Investigative Dermatology

Volumn 123, Issue 6, 2004, Pages 1092-1101

  Flores, Anthony M ^a   Li, Lu ^a   Aneskievich, Brian J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Coactivators; Keratinocytes; Nuclear receptors; Transcription factors; Two hybrid assays

Indexed keywords

ACTIVATING FUNCTION 2 DOMAIN; CELL NUCLEUS RECEPTOR; COMODULATOR OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 1 PROTEIN; COMODULATOR OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 2 PROTEIN; COMPLEMENTARY DNA; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROLINE; PROTEIN DERIVATIVE; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DNA LIBRARY; EPIDERMIS; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN MOTIF;

EID: 9744273192     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23424.x     Document Type: Article

References (44)

1. Aneskievich BJ: Deletion of RAR carboxyl terminus reveals promoter- and receptor-specific AF-1 effects. Biochem Biophys Res Commun 289:950-956, 2001
2. Aneskievich BJ, Fuchs E: Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements. Mol Cell Biol 12:4862-4871, 1992
3. Aneskievich BJ, Fuchs E: The A/B domain of truncated retinoic acid receptors can block differentiation and promote features of malignancy. J Cell Sci 108:195-205, 1995
4. Banks EB, Crish JF, Eckert RL: Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell types. Biochem J 337:507-512, 1999
5. Bartel F, Taubert H, Harris LC: Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2:9-15, 2002
6. Carroll JM, Taichman LB: Characterization of the human involucrin promoter using a transient beta-galactosidase assay. J Cell Sci 103:925-930, 1992
7. Chien CT, Bartel PL, Sternglanz R, Fields S: The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest. Proc Natl Acad Sci USA 88:9578-9582, 1991
8. Delage-Mourroux R, Martini PG, Choi I, Kraichely DM, Hoeksema J, Katzenellenbogen BS: Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA. J Biol Chem 275:35848-35856, 2000
9. Feng X, Peng ZH, Di W, et al: Suprabasal expression of a dominant-negative RXRα mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. Genes Dev 11:59-71, 1997
10. Fernandes I, Bastien Y, Wai T, et al: Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. Mol Cell 11:139-150, 2003
11. Fowler AJ, Sheu MY, Schmuth M, et al: Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: Liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120:246-255, 2003
12. Hanley K, Jiang Y, Crumrine D, et al: Activators of the nuclear hormone receptors PPARα and FXR accelerate the development of the fetal epidermal permeability barrier. J Clin Invest 100:705-712, 1997
13. Hanley K, Jiang Y, He SS, et al: Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. J Invest Dermatol 110:368-375, 1998
14. Hanley K, Komuves LG, Ng DC, et al: Farnesol stimulates differentiation in epidermal keratinocytes via PPARα. J Biol Chem 275:11484-11491, 2000
15. Hao CM, Redha R, Morrow J, Breyer MD: Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress. J Biol Chem 277:21341-21345, 2002
16. Inui S, Lee YF, Haake AR, Goldsmith LA, Chang C: Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes. J Invest Dermatol 112:426-431, 1999
17. Kalkhoven E, Valentine JE, Heery DM, Parker MG: Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J 17:232-243, 1998
18. Kawabata H, Kawahara K, Kanekura T, et al: Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium induced keratinocyte differentiation. J Biol Chem 10:10, 2001
19. Kippenberger S, Loitsch SM, Grundmann-Kollmann M, et al: Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation. J Invest Dermatol 117:1430-1436, 2001
20. Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S: Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. J Biol Chem 275:33201-33204, 2000
21. Krogsdam AM, Nielsen CA, Neve S, et al: Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J 363:157-165, 2002
22. Lampen A, Carlberg C, Nau H: Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. Eur J Pharmacol 431:25-33, 2001
23. Li D, Wang F, Samuels HH: Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation. Mol Cell Biol 21:8371-8384, 2001
24. Li M, Chiba H, Warot X, Messaddeq N, Gerard C, Chambon P, Metzger D: RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 128:675-688, 2001
25. Luo Y, Batalao A, Zhou H, Zhu L: Mammalian two-hybrid system: A complementary approach to the yeast two-hybrid system. Biotechniques 22:350-352, 1997
26. Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM: A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell 66:555-561, 1991
27. McInerney EM, Rose DW, Flynn SE, et al: Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev 12:3357-3368, 1998
28. Michalik L, Desvergne B, Tan NS, et al: Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta (delta) mutant mice. J Cell Biol 154:799-814, 2001
29. Modrek B, Lee C: A genomic view of alternative splicing. Nat Genet 30:13-19, 2002
30. Monden T, Kishi M, Hosoya T, et al: p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. Mol Endocrinol 13:1695-1703, 1999
31. Moraitis AN, Giguere V, Thompson CC: Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants. Mol Cell Biol 22:6831-6841, 2002
32. Potter GB, Beaudoin GM, DeRenzo CL, Zarach JM, Chen SH, Thompson CC: The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev 15:2687-2701, 2001
33. Rivier M, Safonova I, Lebrun P, Griffiths CE, Ailhaud G, Michel S: Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-1121, 1998
34. Rosenfeld MG, Glass CK: Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 276:36865-36868, 2001
35. Schaufele F, Chang CY, Liu W, et al: Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. Mol Endocrinol 14:2024-2209, 2000
36. Schoop VM, Mirancea N, Fusenig NE: Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts. J Invest Dermatol 112:343-353, 1999
37. Seol W, Mahon MJ, Lee YK, Moore DD: Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol Endocrinol 10:1646-1655, 1996
38. Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH: Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem 278:4467-4473, 2003
39. Thompson PD, Remus LS, Hsieh JC, et al: Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts. J Mol Endocrinol 27:211-227, 2001
40. Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA: A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol 12:864-881, 1998
41. Westergaard M, Henningsen J, Jonansen C, et al: Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin. J Invest Dermatol 121:1104-1117, 2003
42. Westergaard M, Henningsen J, Svendsen ML, et al: Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116:702-712, 2001
43. Yasumo H, Masuda N, Furusawa T, Tsukamoto T, Sadano H, Osumi T: Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. Biochim Biophys Acta 1490:189-197, 2000
44. Zhang J, Hu X, Lazar MA: A novel role for helix 12 of retinoid X receptor in regulating repression. Mol Cell Biol 19:6448-6457, 1999