Inhibition of autophagy in mitotic animal cells

Traffic

Volumn 3, Issue 12, 2002, Pages 878-893

  Eskelinen, Eeva Liisa ^a,d   Prescott, Alan R ^a   Cooper, Jennifer ^a   Brachmann, Saskia M ^b   Wang, Lijun ^a   Tang, Xiuwen ^a   Backer, Jonathan M ^c   Lucocq, John M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; AMINO ACID; NOCODAZOLE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P85; RAPAMYCIN; WORTMANNIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 3-METHYLADENINE; ADENINE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MORPHOLINE DERIVATIVE; PROTEIN KINASE; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6 KINASE;

ANAPHASE; ANIMAL CELL; AUTOPHAGY; CELL CULTURE; CELL CYCLE PARAMETERS; CELL MEMBRANE TRANSPORT; CELL NUCLEUS MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; EMBRYO CELL; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERPHASE; METAPHASE; MICROINJECTION; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROPHASE; RAT; REVIEW; STEM CELL; TELOPHASE; ANIMAL; ARTICLE; CELL LINE; DRUG ANTAGONISM; HELA CELL; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOSIS; PHASE CONTRAST MICROSCOPY; TIME; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENINE; ANAPHASE; ANDROSTADIENES; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE; CHROMONES; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; GOLGI APPARATUS; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; METAPHASE; MICROSCOPY, IMMUNOELECTRON; MICROSCOPY, PHASE-CONTRAST; MITOSIS; MORPHOLINES; NOCODAZOLE; PROTEIN KINASES; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIROLIMUS; TELOPHASE; TIME FACTORS;

EID: 0036899730     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2002.31204.x     Document Type: Review

References (54)

1. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717-1721.
2. Kisen GO, Tessitore L, Costelli P, Gordon PB, Schwarze PE, Baccino FM, Seglen PO. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993;14:2501-2505.
3. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999;402:672-676.
4. Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, Mora M, Riggs JE, Oh SJ, Koga Y, Sue CM, Yamamoto A, Murakami N, Shanske S, Byrne E et al. Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature 2000;406:906-910.
5. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, Janssen PML, Blanz J, von Figura K, Saftig P. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 2000;406:902-906.
6. Farmaki T, Ponnambalam S, Prescott AR, Clausen H, Tang BL, Hong W, Lucocq JM. Forward and retrograde trafficking in mitotic animal cells. ER-Golgi transport arrest restricts protein export from the ER into COPII-coated structures. J Cell Sci 1999;112:589-600.
7. Featherstone C, Griffiths G, Warren G. Newly synthesized G protein of vesicular stomatitis virus is not transported to the Golgi complex in mitotic cells. J Cell Biol 1985;101:2036-2046.
8. Prescott AR, Farmaki T, Thomson C, James J, Paccaud JP, Tang BL, Hong W, Quinn M, Ponnambalam S, Lucocq J. Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates. Traffic 2001;2:321-335.
9. Lowe M, Nakamura N, Warren G. Golgi division and membrane traffic. Trends Cell Biol 1998;8:40-44.
10. Warren G. Membrane partitioning during cell division. Annu Rev Biochem 1993;62:323-348.
11. Dunn WA. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol 1990;110:1923-1933.
12. Liou W, Geuze HJ, Geelen MJH, Slot JW. The autophagic and endocytic pathways converge at the nascent autophagic vacuole. J Cell Biol 1997;136:61-70.
13. Eskelinen EL, Illert AL, Tanaka Y, Blanz J, von Figura K, Saftig P. Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell 2002;13:3355-3368.
14. Aplin A, Jasionowski T, Tuttle DL, Lenk SE, Dunn WA. Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles. J Cell Physiol 1992;152:458-466.
15. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-5728.
16. Blommaart EFC, Krause U, Schellens JPM, Vreeling-Sindelarova H, Meijer AJ. The phosphatidyl-inositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997;243:240-246.
17. Petiot A, Ogier-Denis E, Blommaart EFC, Meijer AJ, Codogno P. Distinct classes of phosphatidyl-inositol 3′-kinase are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000;275:992-998.
18. Seglen PO, Gordon PB. 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 1982;79:1889-1892.
19. Dunn WA. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. J Cell Biol 1990;110:1935-1945.
20. Blommaart EFC, Luiken JJFP, Blommaart PJE, van Woerkom GM, Meijer AJ. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 1995;270:2320-2326.
21. Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001;276:35243-35246.
22. Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000;346:561-576.
23. Williams MR, Arthur JSC, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 2000;10:439-448.
24. Fruman DA, Meyers RE, Cantley LC. Phosphoinositide kinases. Annu Rev Biochem 1998;67:481-507
25. Siddhanta U, Mcllroy J, Shah A, Zhang Y, Backer JM. Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J Cell Biol 1998;143:1647-1659.
26. Futter CE, Collinson LM, Backer JM, Hopkins CR. Human VPS34 is required for internal vesicle formation within multivesicular endosomes. J Cell Biol 2001;155:1251-1263.
27. Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol 2001;155:19-25.
28. Talloczy Z, Jiang W, Virgin IVHW, Leib D, Scheuner D, Kaufman R, Eskelinen EL, Levine B. Regulation of starvation and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci USA 2002;99:190-195.
29. Colanzi A, Deerinck TJ, Ellisman MH, Malhotra V. A specific activation of the mitogen-activated protein kinase kinase 1 (MEK1) is required for Golgi fragmentation during mitosis. J Cell Biol 2000;149:331-339.
30. Kano F, Takenaka K, Yamamoto A, Nagayama K, Nishida E, Murata M. MEK and Cdc2 kinase are sequentially required for Golgi disassembly in MDCK cells by the mitotic Xenopus extracts. J Cell Biol 2000;149:357-368.
31. Lin CY, Madsen ML, Yarm FR, Jang YJ, Liu X. Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2. Proc Natl Acad Sci USA 2000;97:12589-12594.
32. Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P. Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. J Biol Chem 2001;276:8104-8110.
33. Pypaert M, Mundy D, Souter E, Labbe JC, Warren G. Mitotic cytosol inhibits invagination of coated pits in broken mitotic cells. J Cell Biol 1991;114:1159-1166.
34. Tuomikoski T, Felix MA, Doree M, Gruenberg J. Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2. Nature 1989;342:942-945.
35. De Nadai C, Huitorel P, Chiri S, Ciapa B. Effect of wortmannin, an inhibitor of phosphatidylinositol 3-kinase, on the first mitotic divisions of the fertilized sea urchin egg. J Cell Sci 1998;111:2507-2518.
36. Alvarez B, Martinez AC, Burgering BM, Carrera AC. Forkhead transcription factors contribute to execution of the mitotic programme in mammals. Nature 2001;413:744-747.
37. Stromhaug PE, Klionsky DJ. Approaching the molecular mechanism of autophagy. Traffic 2001;2:524-531.
38. Shirahama K, Noda T, Ohsumi Y. Mutational analysis of Csc1/NPs4p: involvement of endosome in regulation of autophagy in yeast. Cell Struct Funct 1997;22:501-509.
39. Mortimore GE, Lardeux BR, Adams CE. Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation. J Biol Chem 1988;263:2606-2512.
40. Rameh LE, Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999;274:8347-8350.
41. Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell 2000;103:185-188.
42. Hayne C, Tzivion G, Luo Z. Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole. J Biol Chem 2000;275:31876-31882.
43. Philipova R, Whitaker M. MAP kinase activity increases during mitosis in early sea urchin embryos. J Cell Sci 1998;111:2497-2505.
44. Takenaka K, Moriguchi T, Nishida E. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. Science 1998;280:599-602.
45. Zhou BBS, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK. Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting Ataxia-Telangiectasia-mutated kinase activity. J Biol Chem 2000;275:10342-10348.
46. Schmelzle T, Hall MN. TOR, central controller of cell growth. Cell 2000;103:253-262.
47. van Sluijters DA, Dubbelhuis PF, Blommaart EF, Meijer AJ. Amino-acid-dependent signal transduction. Biochem J 2000;351:545-550.
48. Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000;150:1507-1513.
49. Ogura K, Wicky C, Magnenat L, Tobler H, Mori I, Muller F, Ohshima Y. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. Genes Dev 1994;8:2389-2400.
50. Yan J, Kuroyanagi H, Kuroiwa A, Matsuda Y, Tokumitsu H, Tomoda T, Shirasawa T, Muramatsu M. Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun 1998;246:222-227.
51. Kopitz J, Kisen GO, Gordon PB, Bohley P, Seglen PO. Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes. J Cell Biol 1990;111:941-953.
52. Sit KH, Paramanantham R, Bay BH, Chan HL, Wong KP, Thong P, Watt F. Sequestration of mitotic (M-phase) chromosomes in autophagosomes: mitotic programmed cell death in human Chang liver cells induced by an OH* burst from vanadyl(4). Anat Rec 1996;245:1-8.
53. Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 1998;273:3963-3966.
54. Wang L, Wang X, Proud CG. Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive Steps. Am J Physiol Heart Circ Physiol 2000;278:H1056-H1068.