Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway

Brain Research

Volumn 1632, Issue , 2016, Pages 9-18

  Liu, Feng Tao ^a,b   Yang, Yu Jie ^a,b   Wu, Jian Jun ^a,b   Li, Shan ^b   Tang, Yi Lin ^a,b   Zhao, Jue ^a,b   Liu, Zhen Yang ^a,b   Xiao, Bao Guo ^a,b   Zuo, Ji ^b   Liu, Wen ^b   Wang, Jian ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

A53T synuclein; Fasudil; Macroautophagy; Rho kinase

Indexed keywords

3 METHYLADENINE; ALPHA SYNUCLEIN; BECLIN 1; FASUDIL; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; RHO KINASE; RHO KINASE 2; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN KINASE INHIBITOR;

ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MACROAUTOPHAGY; NERVE CELL LESION; NERVE FIBER GROWTH; NEURITE; NEUROPROTECTION; NEUROTOXICITY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; AUTOPHAGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ALPHA-SYNUCLEIN; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BECLIN-1; CELL LINE, TUMOR; HUMANS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 8; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 84957620586     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.12.002     Document Type: Article

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