Functional interaction between autophagy and ciliogenesis

Nature

Volumn 502, Issue 7470, 2013, Pages 194-200

  Pampliega, Olatz ^a   Orhon, Idil ^b   Patel, Bindi ^a   Sridhar, Sunandini ^a   Díaz Carretero, Antonio ^a   Beau, Isabelle ^b   Codogno, Patrice ^b   Satir, Birgit H ^a   Satir, Peter ^a   Cuervo, Ana Maria ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN;

MOLECULAR ANALYSIS; NUTRIENT; PROTEIN; SMALL MAMMAL;

ANIMAL CELL; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELLULAR DISTRIBUTION; CILIATED EPITHELIUM; CILIOGENESIS; CONTROLLED STUDY; DEVELOPMENT; ELECTRON MICROSCOPY; FIBROBLAST; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOGOLD LABELING; INTRACELLULAR SPACE; MACROAUTOPHAGY; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CELL LINE; CILIA; HEDGEHOG PROTEINS; MICE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 84885661260     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12639     Document Type: Article

References (30)

1. Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008).
2. Hamasaki, M., Shibutani, S. T. & Yoshimori, T. Up-to-date membrane biogenesis in the autophagosome formation. Curr. Opin. Cell Biol. 25, 455-460 (2013).
3. Yang, Z. & Klionsky, D. J. Mammalian autophagy: core molecular machinery and signaling regulation. Curr. Opin. Cell Biol. 22, 124-131 (2010).
4. Satir, P., Pedersen, L. B. & Christensen, S. T. The primary cilium at a glance. J. Cell Sci. 123, 499-503 (2010).
5. Taschner, M., Bhogaraju, S. & Lorentzen, E. Architecture and function of IFT complex proteins in ciliogenesis. Differentiation 83, S12-S22 (2012).
6. Follit, J. A., Xu, F., Keady, B. T.&Pazour, G. J.Characterization ofmouse IFT complex B. Cell Motil. Cytoskeleton 66, 457-468 (2009).
7. Liem, K. F. et al. The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197, 789-800 (2012).
8. Rohatgi, R., Milenkovic, L. & Scott, M. P. Patched1 regulates Hedgehog signaling at the primary cilium. Science 317, 372-376 (2007).
9. Kiprilov, E. N. et al. Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J. Cell Biol. 180, 897-904 (2008).
10. Onodera, J. & Ohsumi, Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J. Biol. Chem. 280, 31582-31586 (2005).
11. Tanida, I., Minematsu-Ikeguchi, N., Ueno, T. & Kominami, E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1, 84-91 (2005).
12. Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544 (2012).
13. Pazour, G. J., San Agustin, J. T., Follit, J. A., Rosenbaum, J. L. & Witman, G. B. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr. Biol. 12, R378-R380 (2002).
14. Schneider, L. et al. PDGFRaa signaling is regulated through the primary cilium in fibroblasts. Curr. Biol. 15, 1861-1866 (2005).
15. Boehlke, C. et al. Primary cilia regulatemTORC1activity andcell size throughLkb1. Nature Cell Biol. 12, 1115-1122 (2010).
16. Finetti, F. et al. Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nature Cell Biol. 11, 1332-1339 (2009).
17. Ravikumar, B., Moreau, K., Jahreiss, L., Puri, C. & Rubinsztein, D. C. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nature Cell Biol. 12, 747-757 (2010).
18. Veland, I. R. et al. Inversin/nephrocystin-2 is required for fibroblast polarity and directional cell migration. PLoS ONE 8, e60193 (2013).
19. Sridhar, S. et al. The lipid kinase PI4KIIIb preserves lysosomal identity. EMBO J. 32, 324-339 (2012).
20. Richey, E. A. & Qin, H. Dissecting the sequential assembly and localization of intraflagellar transport particle complex B in Chlamydomonas. PLoS ONE 7, e43118 (2012).
21. Satir, P. The new biology of cilia: review and annotation of a symposium. Dev. Dyn. 241, 426-430 (2012).
22. Li, H. et al. Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 303, H1319-H1331 (2012).
23. Jimenez-Sanchez, M. et al.TheHedgehog signalling pathway regulates autophagy. Nature Comm. 3, 1200 (2012).
24. Wang, Y., Han, C., Lu, L., Magliato, S. & Wu, T. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology 58, 995-1010 (2013).
25. Petralia, R. S. et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol. Open 2, 499-504 (2013).
26. Singh, R. et al. Autophagy regulates lipid metabolism. Nature 458, 1131-1135 (2009).
27. Auteri, J. S., Okada, A., Bochaki, V. & Dice, J. F. Regulation of intracellular protein degradation in IMR-90 human diploid fibroblasts. J. Cell. Physiol. 115, 167-174 (1983).
28. Huang, B. Q. et al. Isolation and characterization of cholangiocyte primary cilia.Am. J. Physiol. Gastrointest. Liver Physiol. 291, G500-G509 (2006).
29. Marzella, L., Ahlberg, J. & Glaumann, H. Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization. J. Cell Biol. 93, 144-154 (1982).
30. Wada, K. et al. Application of photoacoustic microscopy to analysis of biological components in tissue sections. Chem. Pharm. Bull. (Tokyo) 34, 1688-1693 (1986).