-
1
-
-
77049197836
-
Tissue fractionation studies 5 the association of acid phosphatase with a special class of cytoplasmic granules in rat liver
-
Appelmans, F., Wattiaux, R. & De Duve, C. Tissue fractionation studies. 5. The association of acid phosphatase with a special class of cytoplasmic granules in rat liver. Biochem. J. 59, 438-445 (1955).
-
(1955)
Biochem. J.
, vol.59
, pp. 438-445
-
-
Appelmans, F.1
Wattiaux, R.2
De Duve, C.3
-
2
-
-
77049229661
-
Tissue fractionation studies 6. Intracellular distribution patterns of enzymes in rat-liver tissue
-
De Duve, C., Pressman, B. C., Gianetto, R., Wattiaux, R. & Appelmans, F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem. J. 60, 604-617 (1955).
-
(1955)
Biochem. J
, vol.60
, pp. 604-617
-
-
De Duve, C.1
Pressman, B.C.2
Gianetto, R.3
Wattiaux, R.4
Appelmans, F.5
-
3
-
-
0005577657
-
Tissue fractionation studies 13 Analysis of mitochondrial fractions from rat liver by density-gradient centrifuging
-
Beaufay, H., Bendall, D. S., Baudhun, P., Wattiaux, R. & De Duve, C. Tissue fractionation studies. 13. Analysis of mitochondrial fractions from rat liver by density-gradient centrifuging. Biochem. J. 73, 628-637 (1959).
-
(1959)
Biochem. J.
, vol.73
, pp. 628-637
-
-
Beaufay, H.1
Bendall, D.S.2
Baudhun, P.3
Wattiaux, R.4
De Duve, C.5
-
4
-
-
27144519492
-
Electron microscopy of lysosomerich fractions from rat liver
-
Novikoff, A. B., Beaufay, H. & De Duve, C. Electron microscopy of lysosomerich fractions from rat liver. J. Biophys. Biochem. Cytol. 2, 179-184 (1956).
-
(1956)
J. Biophys. Biochem. Cytol
, vol.2
, pp. 179-184
-
-
Novikoff, A.B.1
Beaufay, H.2
De Duve, C.3
-
5
-
-
0042585963
-
Localization of acid phosphatase activity in hepatic lysosomes by means of electron microscopy
-
Essner, E. & Novikoff, A. B. Localization of acid phosphatase activity in hepatic lysosomes by means of electron microscopy. J. Biophys. Biochem. Cytol. 9, 773-784 (1961).
-
(1961)
J. Biophys. Biochem. Cytol
, vol.9
, pp. 773-784
-
-
Essner, E.1
Novikoff, A.B.2
-
6
-
-
33646121170
-
Rapid cytochemical identification of phagosomes in various tissues of the rat and their differentiation from mitochondria by the peroxidase method
-
Straus, W. Rapid cytochemical identification of phagosomes in various tissues of the rat and their differentiation from mitochondria by the peroxidase method. J. Biophys. Biochem. Cytol. 5, 193-204 (1959).
-
(1959)
J. Biophys. Biochem. Cytol
, vol.5
, pp. 193-204
-
-
Straus, W.1
-
7
-
-
0040858668
-
Cytochemical observations on the relationship between lysosomes and phagosomes in kidney and liver by combined staining for acid phosphatase and intravenously injected horseradish peroxidase
-
Straus, W. Cytochemical observations on the relationship between lysosomes and phagosomes in kidney and liver by combined staining for acid phosphatase and intravenously injected horseradish peroxidase. J. Cell Biol. 20, 497-507 (1964).
-
(1964)
J. Cell Biol
, vol.20
, pp. 497-507
-
-
Straus, W.1
-
8
-
-
0000189281
-
Cellular differentiation in the kidneys of newborn mice studies with the electron microscope
-
Clark, S. L. Jr. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J. Biophys. Biochem. Cytol. 3, 349-362 (1957).
-
(1957)
J. Biophys. Biochem. Cytol
, vol.3
, pp. 349-362
-
-
Clark, S.L.1
-
9
-
-
1642559773
-
The proximal tubule cell in experimental hydronephrosis
-
Novikoff, A. B. The proximal tubule cell in experimental hydronephrosis. J. Biophys. Biochem. Cytol. 6, 136-138 (1959).
-
(1959)
J. Biophys. Biochem. Cytol
, vol.6
, pp. 136-138
-
-
Novikoff, A.B.1
-
10
-
-
0000730374
-
Cytoplasmic components in hepatic cell lysosomes
-
Ashford, T. P. & Porter, K. R. Cytoplasmic components in hepatic cell lysosomes. J. Cell Biol. 12, 198-202 (1962).
-
(1962)
J. Cell Biol
, vol.12
, pp. 198-202
-
-
Ashford, T.P.1
Porter, K.R.2
-
11
-
-
0038208502
-
Cytolysomes and mitochondrial degeneration
-
Novikoff, A. B. & Essner, E. Cytolysomes and mitochondrial degeneration. J. Cell Biol. 15, 140-146 (1962).
-
(1962)
J. Cell Biol
, vol.15
, pp. 140-146
-
-
Novikoff, A.B.1
Essner, E.2
-
12
-
-
0039455131
-
Cytoplasmic bodies containing mitochondria, ribosomes, and rough surfaced endoplasmic membranes in the epithelium of the small intestine of newborn rats
-
Moe, H. & Behnke, O. Cytoplasmic bodies containing mitochondria, ribosomes, and rough surfaced endoplasmic membranes in the epithelium of the small intestine of newborn rats. J. Cell Biol. 13, 168-171 (1962).
-
(1962)
J. Cell Biol
, vol.13
, pp. 168-171
-
-
Moe, H.1
Behnke, O.2
-
13
-
-
0000751958
-
Focal cytoplasmic degradation
-
Hruban, Z., Spargo, B., Swift, H., Wissler, R. W. & Kleinfeld, R. G. Focal cytoplasmic degradation. Am. J. Pathol. 42, 657-683 (1963).
-
(1963)
Am. J. Pathol
, vol.42
, pp. 657-683
-
-
Hruban, Z.1
Spargo, B.2
Swift, H.3
Wissler, R.W.4
Kleinfeld, R.G.5
-
14
-
-
0002986998
-
Glucagon: A protein catabolic hormone in the isolated perfused rat liver
-
Miller, L. L. Glucagon: A protein catabolic hormone in the isolated perfused rat liver. Nature 185, 248 (1960).
-
(1960)
Nature
, vol.185
, pp. 248
-
-
Miller, L.L.1
-
15
-
-
0002549377
-
The lysosome
-
De Duve, C. The lysosome. Sci. Am. 208, 64-72 (1963).
-
(1963)
Sci. Am
, vol.208
, pp. 64-72
-
-
De Duve, C.1
-
17
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008).
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
18
-
-
0014359297
-
Studies on cellular autophagocytosis the formation of autophagic vacuoles in the liver after glucagon administration
-
Arstila, A. U. & Trump, B. F. Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am. J. Pathol. 53, 687-733 (1968).
-
(1968)
Am. J. Pathol
, vol.53
, pp. 687-733
-
-
Arstila, A.U.1
Trump, B.F.2
-
19
-
-
0014556024
-
Studies on induced cellular autophagy. II. Characterization of the membranes bordering autophagosomes in parenchymal liver cells
-
Ericsson, J. L. Studies on induced cellular autophagy. II. Characterization of the membranes bordering autophagosomes in parenchymal liver cells. Exp. Cell Res. 56, 393-405 (1969).
-
(1969)
Exp. Cell Res
, vol.56
, pp. 393-405
-
-
Ericsson, J.L.1
-
20
-
-
0025358894
-
Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes
-
Furuno, K. et al. Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes. Exp. Cell Res. 189, 261-268 (1990).
-
(1990)
Exp. Cell Res
, vol.189
, pp. 261-268
-
-
Furuno, K.1
-
21
-
-
0025363276
-
Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
-
Dunn, W. A. Jr. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J. Cell Biol. 110, 1923-1933 (1990).
-
(1990)
J. Cell Biol
, vol.110
, pp. 1923-1933
-
-
Dunn, W.A.1
-
22
-
-
0023202836
-
Cytochrome p-450 and nadph-cytochrome p-450 reductase are degraded in the autolysosomes in rat liver
-
Masaki, R., Yamamoto, A. & Tashiro, Y. Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver. J. Cell Biol. 104, 1207-1215 (1987).
-
(1987)
J. Cell Biol
, vol.104
, pp. 1207-1215
-
-
Masaki, R.1
Yamamoto, A.2
Tashiro, Y.3
-
23
-
-
0016665507
-
The role of the Golgi complex in the isolation and digestion of organelles
-
Locke, M. & Sykes, A. K. The role of the Golgi complex in the isolation and digestion of organelles. Tissue Cell 7, 143-158 (1975).
-
(1975)
Tissue Cell
, vol.7
, pp. 143-158
-
-
Locke, M.1
Sykes, A.K.2
-
24
-
-
0025217177
-
Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry
-
Yamamoto, A., Masaki, R. & Tashiro, Y. Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry. J. Histochem. Cytochem. 38, 573-580 (1990).
-
(1990)
J. Histochem. Cytochem
, vol.38
, pp. 573-580
-
-
Yamamoto, A.1
Masaki, R.2
Tashiro, Y.3
-
25
-
-
0025673675
-
Non-selective autophagy
-
Seglen, P. O., Gordon, P. B. & Holen, I. Non-selective autophagy. Semin. Cell Biol. 1, 441-448 (1990).
-
(1990)
Semin. Cell Biol
, vol.1
, pp. 441-448
-
-
Seglen, P.O.1
Gordon, P.B.2
Holen, I.3
-
26
-
-
0018904155
-
Freeze-fracture of drug-induced autophagocytosis in the mouse exocrine pancreas
-
Rez, G. & Meldolesi, J. Freeze-fracture of drug-induced autophagocytosis in the mouse exocrine pancreas. Lab. Invest. 43, 269-277 (1980).
-
(1980)
Lab. Invest
, vol.43
, pp. 269-277
-
-
Rez, G.1
Meldolesi, J.2
-
27
-
-
0028230738
-
Ultrastructural analysis of the autophagic process in yeast: Detection of autophagosomes and their characterization
-
Baba, M., Takeshige, K., Baba, N. & Ohsumi, Y. Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J. Cell Biol. 124, 903-913 (1994).
-
(1994)
J. Cell Biol
, vol.124
, pp. 903-913
-
-
Baba, M.1
Takeshige, K.2
Baba, N.3
Ohsumi, Y.4
-
28
-
-
0027424777
-
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
-
Tsukada, M. & Ohsumi, Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 333, 169-174 (1993).
-
(1993)
FEBS Lett
, vol.333
, pp. 169-174
-
-
Tsukada, M.1
Ohsumi, Y.2
-
29
-
-
0027936092
-
Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
-
Thumm, M. et al. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett. 349, 275-280 (1994).
-
(1994)
FEBS Lett
, vol.349
, pp. 275-280
-
-
Thumm, M.1
-
30
-
-
0029953575
-
Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
-
Harding, T. M., Hefner-Gravink, A., Thumm, M. & Klionsky, D. J. Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J. Biol. Chem. 271, 17621-17624 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 17621-17624
-
-
Harding, T.M.1
Hefner-Gravink, A.2
Thumm, M.3
Klionsky, D.J.4
-
31
-
-
10744225487
-
A unified nomenclature for yeast autophagy-related genes
-
Klionsky, D. J. et al. A unified nomenclature for yeast autophagy-related genes. Dev. Cell 5, 539-545 (2003).
-
(2003)
Dev. Cell
, vol.5
, pp. 539-545
-
-
Klionsky, D.J.1
-
32
-
-
77955131007
-
Plasma membrane contributes to the formation of pre-Autophagosomal structures
-
Ravikumar, B., Moreau, K., Jahreiss, L., Puri, C. & Rubinsztein, D. C. Plasma membrane contributes to the formation of pre-Autophagosomal structures. Nat. Cell Biol. 12, 747-757 (2010).
-
(2010)
Nat. Cell Biol
, vol.12
, pp. 747-757
-
-
Ravikumar, B.1
Moreau, K.2
Jahreiss, L.3
Puri, C.4
Rubinsztein, D.C.5
-
33
-
-
71649112895
-
3D tomography reveals connections between the phagophore and endoplasmic reticulum
-
Yla-Anttila, P., Vihinen, H., Jokitalo, E. & Eskelinen, E. L. 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 5, 1180-1185 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 1180-1185
-
-
Yla-Anttila, P.1
Vihinen, H.2
Jokitalo, E.3
Eskelinen, E.L.4
-
34
-
-
71649087199
-
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
-
Hayashi-Nishino, M. et al. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 11, 1433-1437 (2009).
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 1433-1437
-
-
Hayashi-Nishino, M.1
-
35
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
Hamasaki, M. et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-393 (2013).
-
(2013)
Nature
, vol.495
, pp. 389-393
-
-
Hamasaki, M.1
-
36
-
-
75749135725
-
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
-
Yen, W. L. et al. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J. Cell Biol. 188, 101-114 (2010).
-
(2010)
J. Cell Biol
, vol.188
, pp. 101-114
-
-
Yen, W.L.1
-
37
-
-
84895930872
-
Liver autophagy: Much more than just taking out the trash
-
Schneider, J. L. & Cuervo, A. M. Liver autophagy: much more than just taking out the trash. Nat. Rev. Gastroenterol. Hepatol. 11, 187-200 (2014).
-
(2014)
Nat. Rev. Gastroenterol. Hepatol
, vol.11
, pp. 187-200
-
-
Schneider, J.L.1
Cuervo, A.M.2
-
38
-
-
67649467294
-
Dynamics and diversity in autophagy mechanisms: Lessons from yeast
-
Nakatogawa, H., Suzuki, K., Kamada, Y. & Ohsumi, Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol. 10, 458-467 (2009).
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 458-467
-
-
Nakatogawa, H.1
Suzuki, K.2
Kamada, Y.3
Ohsumi, Y.4
-
39
-
-
80054025654
-
The role of Atg proteins in autophagosome formation
-
Mizushima, N., Yoshimori, T. & Ohsumi, Y. The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132 (2011).
-
(2011)
Annu. Rev. Cell Dev. Biol
, vol.27
, pp. 107-132
-
-
Mizushima, N.1
Yoshimori, T.2
Ohsumi, Y.3
-
40
-
-
33845924783
-
AMP-Activated protein kinase and the regulation of autophagic proteolysis
-
Meley, D. et al. AMP-Activated protein kinase and the regulation of autophagic proteolysis. J. Biol. Chem. 281, 34870-34879 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 34870-34879
-
-
Meley, D.1
-
41
-
-
79551598347
-
Ampk and mtor regulate autophagy through direct phosphorylation of ulk1
-
Kim, J., Kundu, M., Viollet, B. & Guan, K. L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132-141 (2011).
-
(2011)
Nat. Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
42
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
Noda, T. & Ohsumi, Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
43
-
-
0034683568
-
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
-
Kamada, Y. et al. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol. 150, 1507-1513 (2000).
-
(2000)
J. Cell Biol
, vol.150
, pp. 1507-1513
-
-
Kamada, Y.1
-
44
-
-
65249119430
-
Nutrient-dependent mtorc1 association with the ulk1-Atg13-fip200 complex required for autophagy
-
Hosokawa, N. et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991 (2009).
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
-
45
-
-
65249176304
-
Ulk-Atg13-fip200 complexes mediate mtor signaling to the autophagy machinery
-
Jung, C. H. et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992-2003 (2009).
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
-
46
-
-
84870880174
-
The hairpin-Type tail-Anchored snare syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
-
Itakura, E., Kishi-Itakura, C. & Mizushima, N. The hairpin-Type tail-Anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151, 1256-1269 (2012).
-
(2012)
Cell
, vol.151
, pp. 1256-1269
-
-
Itakura, E.1
Kishi-Itakura, C.2
Mizushima, N.3
-
47
-
-
84928550400
-
Atg14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
-
Diao, J. et al. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature 520, 563-566 (2015).
-
(2015)
Nature
, vol.520
, pp. 563-566
-
-
Diao, J.1
-
48
-
-
84920448565
-
Plekhm1 regulates autophagosome-lysosome fusion through hops complex and lc3/gabarap proteins
-
McEwan, D. G. et al. PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol. Cell 57, 39-54 (2015).
-
(2015)
Mol. Cell
, vol.57
, pp. 39-54
-
-
McEwan, D.G.1
-
49
-
-
84955242756
-
Ubiquitin-dependent and independent signals in selective autophagy
-
Khaminets, A., Behl, C. & Dikic, I. Ubiquitin-dependent and independent signals in selective autophagy. Trends Cell Biol. 26, 6-16 (2016).
-
(2016)
Trends Cell Biol
, vol.26
, pp. 6-16
-
-
Khaminets, A.1
Behl, C.2
Dikic, I.3
-
50
-
-
84892859905
-
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
-
Rogov, V., Dotsch, V., Johansen, T. & Kirkin, V. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol. Cell 53, 167-178 (2014).
-
(2014)
Mol. Cell
, vol.53
, pp. 167-178
-
-
Rogov, V.1
Dotsch, V.2
Johansen, T.3
Kirkin, V.4
-
51
-
-
84886897936
-
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
-
Fujita, N. et al. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J. Cell Biol. 203, 115-128 (2013).
-
(2013)
J. Cell Biol
, vol.203
, pp. 115-128
-
-
Fujita, N.1
-
52
-
-
84939804206
-
The ubiquitin kinase pink1 recruits autophagy receptors to induce mitophagy
-
Lazarou, M. et al. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524, 309-314 (2015).
-
(2015)
Nature
, vol.524
, pp. 309-314
-
-
Lazarou, M.1
-
53
-
-
84901751574
-
Ubiquitin is phosphorylated by pink1 to activate parkin
-
Koyano, F. et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510, 162-166 (2014).
-
(2014)
Nature
, vol.510
, pp. 162-166
-
-
Koyano, F.1
-
54
-
-
84899539731
-
Pink1 phosphorylates ubiquitin to activate parkin e3 ubiquitin ligase activity
-
Kane, L. A. et al. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J. Cell Biol. 205, 143-153 (2014).
-
(2014)
J. Cell Biol
, vol.205
, pp. 143-153
-
-
Kane, L.A.1
-
55
-
-
84903179483
-
The mitochondrial deubiquitinase usp30 opposes parkin-mediated mitophagy
-
Bingol, B. et al. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature 510, 370-375 (2014).
-
(2014)
Nature
, vol.510
, pp. 370-375
-
-
Bingol, B.1
-
56
-
-
84951930787
-
The pink1-parkin mitochondrial ubiquitylation pathway drives a program of optn/ndp52 recruitment and tbk1 activation to promote mitophagy
-
Heo, J. M., Ordureau, A., Paulo, J. A., Rinehart, J. & Harper, J. W. The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy. Mol. Cell 60, 7-20 (2015).
-
(2015)
Mol. Cell
, vol.60
, pp. 7-20
-
-
Heo, J.M.1
Ordureau, A.2
Paulo, J.A.3
Rinehart, J.4
Harper, J.W.5
-
57
-
-
84963566230
-
Phosphorylation of optn by tbk1 enhances its binding to ub chains and promotes selective autophagy of damaged mitochondria
-
Richter, B. et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc. Natl Acad. Sci. USA 113, 4039-4044 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 4039-4044
-
-
Richter, B.1
-
58
-
-
84960082750
-
The peroxisome as a cell signaling organelle
-
Tripathi, D. N. & Walker, C. L. The peroxisome as a cell signaling organelle. Curr. Opin. Cell Biol. 39, 109-112 (2016).
-
(2016)
Curr. Opin. Cell Biol
, vol.39
, pp. 109-112
-
-
Tripathi, D.N.1
Walker, C.L.2
-
59
-
-
84859741506
-
Pexophagy: The selective degradation of peroxisomes
-
Till, A., Lakhani, R., Burnett, S. F. & Subramani, S. Pexophagy: The selective degradation of peroxisomes. Int. J. Cell Biol. 2012, 512721 (2012).
-
(2012)
Int. J. Cell Biol 2012
, pp. 512721
-
-
Till, A.1
Lakhani, R.2
Burnett, S.F.3
Subramani, S.4
-
60
-
-
58549084167
-
Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes
-
Kim, P. K., Hailey, D. W., Mullen, R. T. & Lippincott-Schwartz, J. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc. Natl Acad. Sci. USA 105, 20567-20574 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 20567-20574
-
-
Kim, P.K.1
Hailey, D.W.2
Mullen, R.T.3
Lippincott-Schwartz, J.4
-
61
-
-
33645221489
-
Excess peroxisomes are degraded by autophagic machinery in mammals
-
Iwata, J. et al. Excess peroxisomes are degraded by autophagic machinery in mammals. J. Biol. Chem. 281, 4035-4041 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 4035-4041
-
-
Iwata, J.1
-
62
-
-
0033607810
-
Localization of a portion of extranuclear ATM to peroxisomes
-
Watters, D. et al. Localization of a portion of extranuclear ATM to peroxisomes. J. Biol. Chem. 274, 34277-34282 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 34277-34282
-
-
Watters, D.1
-
63
-
-
84942982653
-
Atm functions at the peroxisome to induce pexophagy in response to ros
-
Zhang, J. et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat. Cell Biol. 17, 1259-1269 (2015).
-
(2015)
Nat. Cell Biol
, vol.17
, pp. 1259-1269
-
-
Zhang, J.1
-
64
-
-
84881413580
-
Reactive nitrogen species regulate autophagy through atm-Ampk-Tsc2-mediated suppression of mtorc1
-
Tripathi, D. N. et al. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc. Natl Acad. Sci. USA 110, E2950-E2957 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. E2950-E2957
-
-
Tripathi, D.N.1
-
65
-
-
84910142171
-
Hif-2 promotes degradation of mammalian peroxisomes by selective autophagy
-
Walter, K. M. et al. Hif-2a promotes degradation of mammalian peroxisomes by selective autophagy. Cell Metab. 20, 882-897 (2014).
-
(2014)
Cell Metab
, vol.20
, pp. 882-897
-
-
Walter, K.M.1
-
66
-
-
84876345355
-
Nbr1 acts as an autophagy receptor for peroxisomes
-
Deosaran, E. et al. NBR1 acts as an autophagy receptor for peroxisomes. J. Cell Sci. 126, 939-952 (2013).
-
(2013)
J. Cell Sci
, vol.126
, pp. 939-952
-
-
Deosaran, E.1
-
67
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh, R. et al. Autophagy regulates lipid metabolism. Nature 458, 1131-1135 (2009).
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
-
68
-
-
84937545993
-
Autophagy and lipid droplets in the liver
-
Martinez-Lopez, N. & Singh, R. Autophagy and lipid droplets in the liver. Annu. Rev. Nutr. 35, 215-237 (2015).
-
(2015)
Annu. Rev. Nutr
, vol.35
, pp. 215-237
-
-
Martinez-Lopez, N.1
Singh, R.2
-
69
-
-
79960951346
-
Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
-
Kaushik, S. et al. Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab. 14, 173-183 (2011).
-
(2011)
Cell Metab
, vol.14
, pp. 173-183
-
-
Kaushik, S.1
-
70
-
-
84856953003
-
Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation
-
Coupe, B. et al. Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metab. 15, 247-255 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 247-255
-
-
Coupe, B.1
-
71
-
-
84930182353
-
Degradation of lipid droplet-Associated proteins by chaperone-mediated autophagy facilitates lipolysis
-
Kaushik, S. & Cuervo, A. M. Degradation of lipid droplet-Associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat. Cell Biol. 17, 759-770 (2015).
-
(2015)
Nat. Cell Biol
, vol.17
, pp. 759-770
-
-
Kaushik, S.1
Cuervo, A.M.2
-
72
-
-
84955384729
-
Autophagy in the CNS and periphery coordinate lipophagy and lipolysis in the brown adipose tissue and liver
-
Martinez-Lopez, N. et al. Autophagy in the CNS and periphery coordinate lipophagy and lipolysis in the brown adipose tissue and liver. Cell Metab. 23, 113-127 (2016).
-
(2016)
Cell Metab
, vol.23
, pp. 113-127
-
-
Martinez-Lopez, N.1
-
73
-
-
78049409236
-
Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism
-
Jiang, S. et al. Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism. J. Biol. Chem. 285, 34960-34971 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 34960-34971
-
-
Jiang, S.1
-
74
-
-
80053338210
-
Starch-binding domain-containing protein 1 (stbd1) and glycogen metabolism: Identification of the atg8 family interacting motif (aim) in stbd1 required for interaction with gabarapl1
-
Jiang, S., Wells, C. D. & Roach, P. J. Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1. Biochem. Biophys. Res. Commun. 413, 420-425 (2011).
-
(2011)
Biochem. Biophys. Res. Commun
, vol.413
, pp. 420-425
-
-
Jiang, S.1
Wells, C.D.2
Roach, P.J.3
-
75
-
-
84906833059
-
The carbohydrate-binding domain of overexpressed stbd1 is important for its stability and protein-protein interactions
-
Zhu, Y., Zhang, M., Kelly, A. R. & Cheng, A. The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein-protein interactions. Biosci. Rep. 34, e00117 (2014).
-
(2014)
Biosci. Rep
, vol.34
, pp. e00117
-
-
Zhu, Y.1
Zhang, M.2
Kelly, A.R.3
Cheng, A.4
-
76
-
-
84982868447
-
Starch binding domain-containing protein 1 plays a dominant role in glycogen transport to lysosomes in liver
-
Sun, T., Yi, H., Yang, C., Kishnani, P. S. & Sun, B. Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver. J. Biol. Chem. 291, 16479-16484 (2016).
-
(2016)
J. Biol. Chem
, vol.291
, pp. 16479-16484
-
-
Sun, T.1
Yi, H.2
Yang, C.3
Kishnani, P.S.4
Sun, B.5
-
77
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor nrf2 through inactivation of keap1
-
Komatsu, M. et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 12, 213-223 (2010).
-
(2010)
Nat. Cell Biol
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
-
78
-
-
77954599053
-
P62/sqstm1 is a target gene for transcription factor nrf2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain, A. et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 285, 22576-22591 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
-
79
-
-
77953366801
-
A noncanonical mechanism of nrf2 activation by autophagy deficiency: Direct interaction between keap1 and p62
-
Lau, A. et al. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol. Cell. Biol. 30, 3275-3285 (2010).
-
(2010)
Mol. Cell. Biol
, vol.30
, pp. 3275-3285
-
-
Lau, A.1
-
80
-
-
84865287281
-
Keap1 degradation by autophagy for the maintenance of redox homeostasis
-
Taguchi, K. et al. Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc. Natl Acad. Sci. USA 109, 13561-13566 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 13561-13566
-
-
Taguchi, K.1
-
81
-
-
84883830467
-
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
-
Ichimura, Y. et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol. Cell 51, 618-631 (2013).
-
(2013)
Mol. Cell
, vol.51
, pp. 618-631
-
-
Ichimura, Y.1
-
82
-
-
84872137966
-
Sestrins activate nrf2 by promoting p62-dependent autophagic degradation of keap1 and prevent oxidative liver damage
-
Bae, S. H. et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 17, 73-84 (2013).
-
(2013)
Cell Metab
, vol.17
, pp. 73-84
-
-
Bae, S.H.1
-
83
-
-
84908371000
-
Sestrin2 promotes unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
-
Ro, S. H. et al. Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 281, 3816-3827 (2014).
-
(2014)
FEBS J
, vol.281
, pp. 3816-3827
-
-
Ro, S.H.1
-
84
-
-
0015265211
-
Inverted diurnal rhythm of cellular autophagy in liver cells of rats fed a single daily meal
-
Pfeifer, U. Inverted diurnal rhythm of cellular autophagy in liver cells of rats fed a single daily meal. Virchows Arch. B Cell Pathol. 10, 1-3 (1972).
-
(1972)
Virchows Arch. B Cell Pathol
, vol.10
, pp. 1-3
-
-
Pfeifer, U.1
-
85
-
-
77953861522
-
Ammonia derived from glutaminolysis is a diffusible regulator of autophagy
-
Eng, C. H., Yu, K., Lucas, J., White, E. & Abraham, R. T. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci. Signal. 3, ra31 (2010).
-
(2010)
Sci. Signal
, vol.3
, pp. ra31
-
-
Eng, C.H.1
Yu, K.2
Lucas, J.3
White, E.4
Abraham, R.T.5
-
86
-
-
79960585318
-
Ammonia-induced autophagy is independent of ulk1/ulk2 kinases
-
Cheong, H., Lindsten, T., Wu, J., Lu, C. & Thompson, C. B. Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc. Natl Acad. Sci. USA 108, 11121-11126 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11121-11126
-
-
Cheong, H.1
Lindsten, T.2
Wu, J.3
Lu, C.4
Thompson, C.B.5
-
87
-
-
0017816161
-
Inhibition by insulin of the formation of autophagic vacuoles in rat liver A morphometric approach to the kinetics of intracellular degradation by autophagy
-
Pfeifer, U. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J. Cell Biol. 78, 152-167 (1978).
-
(1978)
J. Cell Biol
, vol.78
, pp. 152-167
-
-
Pfeifer, U.1
-
88
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart, E. F., Luiken, J. J., Blommaart, P. J., van Woerkom, G. M. & Meijer, A. J. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 270, 2320-2326 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 2320-2326
-
-
Blommaart, E.F.1
Luiken, J.J.2
Blommaart, P.J.3
Van Woerkom, G.M.4
Meijer, A.J.5
-
89
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
-
Petiot, A., Ogier-Denis, E., Blommaart, E. F., Meijer, A. J. & Codogno, P. Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275, 992-998 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.3
Meijer, A.J.4
Codogno, P.5
-
90
-
-
84880567639
-
Differential contribution of insulin and amino acids to the mtorc1-Autophagy pathway in the liver and muscle
-
Naito, T., Kuma, A. & Mizushima, N. Differential contribution of insulin and amino acids to the mTORC1-Autophagy pathway in the liver and muscle. J. Biol. Chem. 288, 21074-21081 (2013).
-
(2013)
J. Biol. Chem
, vol.288
, pp. 21074-21081
-
-
Naito, T.1
Kuma, A.2
Mizushima, N.3
-
91
-
-
0014954713
-
Starvation in man
-
Cahill, G. F. Starvation in Man. N. Engl. J. Med. 282, 668-675 (1970).
-
(1970)
N. Engl. J. Med
, vol.282
, pp. 668-675
-
-
Cahill, G.F.1
-
92
-
-
0017697151
-
Induction of autophagy by amino-Acid deprivation in perfused rat liver
-
Mortimore, G. E. & Schworer, C. M. Induction of autophagy by amino-Acid deprivation in perfused rat liver. Nature 270, 174-176 (1977).
-
(1977)
Nature
, vol.270
, pp. 174-176
-
-
Mortimore, G.E.1
Schworer, C.M.2
-
93
-
-
0019501619
-
Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver
-
Schworer, C. M., Shiffer, K. A. & Mortimore, G. E. Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver. J. Biol. Chem. 256, 7652-7658 (1981).
-
(1981)
J. Biol. Chem
, vol.256
, pp. 7652-7658
-
-
Schworer, C.M.1
Shiffer, K.A.2
Mortimore, G.E.3
-
94
-
-
0020412799
-
Multifunctional control of amino acids of deprivation-induced proteolysis in liver: Role of leucine
-
Poso, A. R., Wert, J. J. Jr & Mortimore, G. E. Multifunctional control of amino acids of deprivation-induced proteolysis in liver: role of leucine. J. Biol. Chem. 257, 12114-12120 (1982).
-
(1982)
J. Biol. Chem
, vol.257
, pp. 12114-12120
-
-
Poso, A.R.1
Wert, J.J.2
Mortimore, G.E.3
-
95
-
-
0020510501
-
Quantitative correlation between proteolysis and macro-And microautophagy in mouse hepatocytes during starvation and refeeding
-
Mortimore, G. E., Hutson, N. J. & Surmacz, C. A. Quantitative correlation between proteolysis and macro-And microautophagy in mouse hepatocytes during starvation and refeeding. Proc. Natl Acad. Sci. USA 80, 2179-2183 (1983).
-
(1983)
Proc. Natl Acad. Sci. USA
, vol.80
, pp. 2179-2183
-
-
Mortimore, G.E.1
Hutson, N.J.2
Surmacz, C.A.3
-
96
-
-
0018927246
-
Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes
-
Seglen, P. O., Gordon, P. B. & Poli, A. Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes. Biochim. Biophys. Acta 630, 103-118 (1980).
-
(1980)
Biochim. Biophys. Acta
, vol.630
, pp. 103-118
-
-
Seglen, P.O.1
Gordon, P.B.2
Poli, A.3
-
97
-
-
0019417043
-
Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes
-
Kovacs, A. L., Grinde, B. & Seglen, P. O. Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes. Exp. Cell Res. 133, 431-436 (1981).
-
(1981)
Exp. Cell Res
, vol.133
, pp. 431-436
-
-
Kovacs, A.L.1
Grinde, B.2
Seglen, P.O.3
-
98
-
-
84903158167
-
Regulation of mtorc1 by amino acids
-
Bar-Peled, L. & Sabatini, D. M. Regulation of mTORC1 by amino acids. Trends Cell Biol. 24, 400-406 (2014).
-
(2014)
Trends Cell Biol
, vol.24
, pp. 400-406
-
-
Bar-Peled, L.1
Sabatini, D.M.2
-
99
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
Hara, K. et al. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273, 14484-14494 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
-
100
-
-
59049087460
-
Bidirectional transport of amino acids regulates mtor and autophagy
-
Nicklin, P. et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136, 521-534 (2009).
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
-
101
-
-
84952915479
-
Sestrin2 is a leucine sensor for the mtorc1 pathway
-
Wolfson, R. L. et al. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351, 43-48 (2016).
-
(2016)
Science
, vol.351
, pp. 43-48
-
-
Wolfson, R.L.1
-
102
-
-
84959880781
-
The castor proteins are arginine sensors for the mtorc1 pathway
-
Chantranupong, L. et al. The CASTOR proteins are arginine sensors for the mTORC1 pathway. Cell 165, 153-164 (2016).
-
(2016)
Cell
, vol.165
, pp. 153-164
-
-
Chantranupong, L.1
-
103
-
-
84862777407
-
Leucyl-Trna synthetase is an intracellular leucine sensor for the mtorc1-signaling pathway
-
Han, J. M. et al. Leucyl-TRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149, 410-424 (2012).
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
-
104
-
-
84864931233
-
Glutaminolysis activates rag-mtorc1 signaling
-
Duran, R. V. et al. Glutaminolysis activates Rag-mTORC1 signaling. Mol. Cell 47, 349-358 (2012).
-
(2012)
Mol. Cell
, vol.47
, pp. 349-358
-
-
Duran, R.V.1
-
105
-
-
0019133275
-
L-Leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
-
Sener, A. & Malaisse, W. J. L-Leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 288, 187-189 (1980).
-
(1980)
Nature
, vol.288
, pp. 187-189
-
-
Sener, A.1
Malaisse, W.J.2
-
106
-
-
84925777835
-
Slc38a9 is a component of the lysosomal amino acid sensing machinery that controls mtorc1
-
Rebsamen, M. et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature 519, 477-481 (2015).
-
(2015)
Nature
, vol.519
, pp. 477-481
-
-
Rebsamen, M.1
-
107
-
-
84922743269
-
Lysosomal amino acid transporter slc38a9 signals arginine sufficiency to mtorc1
-
Wang, S. et al. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science 347, 188-194 (2015).
-
(2015)
Science
, vol.347
, pp. 188-194
-
-
Wang, S.1
-
108
-
-
84932638310
-
Amino acid-dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9
-
Jung, J., Genau, H. M. & Behrends, C. Amino acid-dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9. Mol. Cell. Biol. 35, 2479-2494 (2015).
-
(2015)
Mol. Cell. Biol
, vol.35
, pp. 2479-2494
-
-
Jung, J.1
Genau, H.M.2
Behrends, C.3
-
109
-
-
0014083718
-
Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes
-
Deter, R. L. & De Duve, C. Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes. J. Cell Biol. 33, 437-449 (1967).
-
(1967)
J. Cell Biol
, vol.33
, pp. 437-449
-
-
Deter, R.L.1
De Duve, C.2
-
110
-
-
0014148066
-
Participation of lysosomes in cellular autophagy induced in rat liver by glucagon
-
Deter, R. L., Baudhuin, P. & De Duve, C. Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J. Cell Biol. 35, C11-C16 (1967).
-
(1967)
J. Cell Biol
, vol.35
, pp. C11-C16
-
-
Deter, R.L.1
Baudhuin, P.2
De Duve, C.3
-
111
-
-
0015020481
-
Quantitative characterization of dense body, autophagic vacuole, and acid phosphatase-bearing particle populations during the early phases of glucagon-induced autophagy in rat liver
-
Deter, R. L. Quantitative characterization of dense body, autophagic vacuole, and acid phosphatase-bearing particle populations during the early phases of glucagon-induced autophagy in rat liver. J. Cell Biol. 48, 473-489 (1971).
-
(1971)
J. Cell Biol
, vol.48
, pp. 473-489
-
-
Deter, R.L.1
-
112
-
-
0015816967
-
Studies on cellular autophagocytosis cyclic amp-And dibutyryl cyclic amp-stimulated autophagy in rat liver
-
Shelburne, J. D., Arstila, A. U. & Trump, B. F. Studies on cellular autophagocytosis. Cyclic AMP-And dibutyryl cyclic AMP-stimulated autophagy in rat liver. Am. J. Pathol. 72, 521-540 (1973).
-
(1973)
Am. J. Pathol
, vol.72
, pp. 521-540
-
-
Shelburne, J.D.1
Arstila, A.U.2
Trump, B.F.3
-
113
-
-
84960103464
-
Glycogen metabolism in humans
-
Adeva-Andany, M. M., Gonzalez-Lucan, M., Donapetry-Garcia, C., Fernandez-Fernandez, C. & Ameneiros-Rodriguez, E. Glycogen metabolism in humans. BBA Clin. 5, 85-100 (2016).
-
(2016)
BBA Clin
, vol.5
, pp. 85-100
-
-
Adeva-Andany, M.M.1
Gonzalez-Lucan, M.2
Donapetry-Garcia, C.3
Fernandez-Fernandez, C.4
Ameneiros-Rodriguez, E.5
-
114
-
-
0019156179
-
Random presumably hydrolytic, and lysosomal glycogenolysis in the livers of rats treated with phlorizin and of newborn rats
-
Devos, P. & Hers, H. G. Random, presumably hydrolytic, and lysosomal glycogenolysis in the livers of rats treated with phlorizin and of newborn rats. Biochem. J. 192, 177-181 (1980).
-
(1980)
Biochem. J
, vol.192
, pp. 177-181
-
-
Devos, P.1
Hers, H.G.2
-
115
-
-
48249111779
-
The role of autophagy in neonatal tissues: Just a response to amino acid starvation?
-
Schiaffino, S., Mammucari, C. & Sandri, M. The role of autophagy in neonatal tissues: just a response to amino acid starvation? Autophagy 4, 727-730 (2008).
-
(2008)
Autophagy
, vol.4
, pp. 727-730
-
-
Schiaffino, S.1
Mammucari, C.2
Sandri, M.3
-
116
-
-
0024445798
-
Cyclic amp stimulates somatostatin gene transcription by phosphorylation of creb at serine 133
-
Gonzalez, G. A. & Montminy, M. R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680 (1989).
-
(1989)
Cell
, vol.59
, pp. 675-680
-
-
Gonzalez, G.A.1
Montminy, M.R.2
-
117
-
-
27144506185
-
The creb coactivator torc2 is a key regulator of fasting glucose metabolism
-
Koo, S. H. et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-1111 (2005).
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.H.1
-
118
-
-
5344228270
-
The creb coactivator torc2 functions as a calcium-And camp-sensitive coincidence detector
-
Screaton, R. A. et al. The CREB coactivator TORC2 functions as a calcium-And cAMP-sensitive coincidence detector. Cell 119, 61-74 (2004).
-
(2004)
Cell
, vol.119
, pp. 61-74
-
-
Screaton, R.A.1
-
119
-
-
0035855905
-
Creb regulates hepatic gluconeogenesis through the coactivator pgc-1
-
Herzig, S. et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413, 179-183 (2001).
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
-
120
-
-
0038457556
-
Microphthalamia-Associated transcription factor: A critical regulator of pigment cell development and survival
-
Widlund, H. R. & Fisher, D. E. Microphthalamia-Associated transcription factor: A critical regulator of pigment cell development and survival. Oncogene 22, 3035-3041 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 3035-3041
-
-
Widlund, H.R.1
Fisher, D.E.2
-
121
-
-
80955177196
-
Tfeb links autophagy to lysosomal biogenesis
-
Settembre, C. et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433 (2011).
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
-
122
-
-
84878533962
-
Mxl-3 and hlh-30 transcriptionally link lipolysis and autophagy to nutrient availability
-
ORourke, E. J. & Ruvkun, G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat. Cell Biol. 15, 668-676 (2013).
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 668-676
-
-
Orourke, E.J.1
Ruvkun, G.2
-
123
-
-
84883063789
-
The tfeb orthologue hlh-30 regulates autophagy and modulates longevity in caenorhabditis elegans
-
Lapierre, L. R. et al. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat. Commun. 4, 2267 (2013).
-
(2013)
Nat. Commun
, vol.4
, pp. 2267
-
-
Lapierre, L.R.1
-
124
-
-
84878606239
-
Tfeb controls cellular lipid metabolism through a starvation-induced autoregulatory loop
-
Settembre, C. et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat. Cell Biol. 15, 647-658 (2013).
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 647-658
-
-
Settembre, C.1
-
125
-
-
84864874958
-
Mtorc1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of tfeb
-
Martina, J. A., Chen, Y., Gucek, M. & Puertollano, R. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8, 903-914 (2012).
-
(2012)
Autophagy
, vol.8
, pp. 903-914
-
-
Martina, J.A.1
Chen, Y.2
Gucek, M.3
Puertollano, R.4
-
126
-
-
84862539692
-
The transcription factor tfeb links mtorc1 signaling to transcriptional control of lysosome homeostasis
-
Roczniak-Ferguson, A. et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci. Signal. 5, ra42 (2012).
-
(2012)
Sci. Signal
, vol.5
, pp. ra42
-
-
Roczniak-Ferguson, A.1
-
127
-
-
84857997408
-
A lysosome-To-nucleus signalling mechanism senses and regulates the lysosome via mtor and tfeb
-
Settembre, C. et al. A lysosome-To-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 31, 1095-1108 (2012).
-
(2012)
EMBO J
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
-
128
-
-
78650848337
-
MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
-
Sengupta, S., Peterson, T. R., Laplante, M., Oh, S. & Sabatini, D. M. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468, 1100-1104 (2010).
-
(2010)
Nature
, vol.468
, pp. 1100-1104
-
-
Sengupta, S.1
Peterson, T.R.2
Laplante, M.3
Oh, S.4
Sabatini, D.M.5
-
129
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu, Y. et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456, 269-273 (2008).
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
-
130
-
-
77954225200
-
Cytosolic foxo1 is essential for the induction of autophagy and tumour suppressor activity
-
Zhao, Y. et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12, 665-675 (2010).
-
(2010)
Nat. Cell Biol
, vol.12
, pp. 665-675
-
-
Zhao, Y.1
-
131
-
-
71449091240
-
Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: Inhibition of FoxO1-dependent expression of key autophagy genes by insulin
-
Liu, H. Y. et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J. Biol. Chem. 284, 31484-31492 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 31484-31492
-
-
Liu, H.Y.1
-
132
-
-
84869005229
-
The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism
-
Xiong, X., Tao, R., DePinho, R. A. & Dong, X. C. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J. Biol. Chem. 287, 39107-39114 (2012).
-
(2012)
J. Biol. Chem
, vol.287
, pp. 39107-39114
-
-
Xiong, X.1
Tao, R.2
DePinho, R.A.3
Dong, X.C.4
-
133
-
-
41549138483
-
A role for the nad-dependent deacetylase sirt1 in the regulation of autophagy
-
Lee, I. H. et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl Acad. Sci. USA 105, 3374-3379 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3374-3379
-
-
Lee, I.H.1
-
134
-
-
79959952405
-
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
-
Ezaki, J. et al. Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy 7, 727-736 (2011).
-
(2011)
Autophagy
, vol.7
, pp. 727-736
-
-
Ezaki, J.1
-
135
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum, J. J. et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248 (2005).
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
-
136
-
-
46849115787
-
Autophagy is essential for preimplantation development of mouse embryos
-
Tsukamoto, S. et al. Autophagy is essential for preimplantation development of mouse embryos. Science 321, 117-120 (2008).
-
(2008)
Science
, vol.321
, pp. 117-120
-
-
Tsukamoto, S.1
-
137
-
-
24744441497
-
Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation
-
Onodera, J. & Ohsumi, Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J. Biol. Chem. 280, 31582-31586 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 31582-31586
-
-
Onodera, J.1
Ohsumi, Y.2
-
138
-
-
79952166584
-
Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction
-
Suzuki, S. W., Onodera, J. & Ohsumi, Y. Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction. PLoS ONE 6, e17412 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e17412
-
-
Suzuki, S.W.1
Onodera, J.2
Ohsumi, Y.3
-
140
-
-
84862849835
-
Redox implications of AMPK-mediated signal transduction beyond energetic clues
-
Cardaci, S., Filomeni, G. & Ciriolo, M. R. Redox implications of AMPK-mediated signal transduction beyond energetic clues. J. Cell Sci. 125, 2115-2125 (2012).
-
(2012)
J. Cell Sci
, vol.125
, pp. 2115-2125
-
-
Cardaci, S.1
Filomeni, G.2
Ciriolo, M.R.3
-
141
-
-
77957674533
-
Under the ROSthiol network is the principal suspect for autophagy commitment
-
Filomeni, G., Desideri, E., Cardaci, S., Rotilio, G. & Ciriolo, M. R. Under the ROSthiol network is the principal suspect for autophagy commitment. Autophagy 6, 999-1005 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 999-1005
-
-
Filomeni, G.1
Desideri, E.2
Cardaci, S.3
Rotilio, G.4
Ciriolo, M.R.5
-
142
-
-
34247186472
-
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
-
Scherz-Shouval, R. et al. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 26, 1749-1760 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 1749-1760
-
-
Scherz-Shouval, R.1
-
143
-
-
63549121490
-
Nrf2 and keap1 mutations: Permanent activation of an adaptive response in cancer
-
Hayes, J. D. & McMahon, M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem. Sci. 34, 176-188 (2009).
-
(2009)
Trends Biochem. Sci
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
144
-
-
78751703950
-
Molecular mechanisms of the keap1-nrf2 pathway in stress response and cancer evolution
-
Taguchi, K., Motohashi, H. & Yamamoto, M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 16, 123-140 (2011).
-
(2011)
Genes Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
145
-
-
0032860808
-
The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities
-
Vittorini, S. et al. The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities. J. Gerontol. A Biol. Sci. Med. Sci. 54, B318-B323 (1999).
-
(1999)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.54
, pp. B318-B323
-
-
Vittorini, S.1
-
146
-
-
0035098277
-
The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-Ageing food restriction
-
Cavallini, G., Donati, A., Gori, Z., Pollera, M. & Bergamini, E. The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-Ageing food restriction. Exp. Gerontol. 36, 497-506 (2001).
-
(2001)
Exp. Gerontol
, vol.36
, pp. 497-506
-
-
Cavallini, G.1
Donati, A.2
Gori, Z.3
Pollera, M.4
Bergamini, E.5
-
147
-
-
0034954561
-
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
-
Donati, A. et al. Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes. J. Gerontol. A Biol. Sci. Med. Sci. 56, B288-B293 (2001).
-
(2001)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.56
, pp. B288-B293
-
-
Donati, A.1
-
148
-
-
84862308683
-
Autophagic activity in thymus and liver during aging
-
Uddin, M. N., Nishio, N., Ito, S., Suzuki, H. & Isobe, K. Autophagic activity in thymus and liver during aging. Age (Dordr.) 34, 75-85 (2012).
-
(2012)
Age (Dordr)
, vol.34
, pp. 75-85
-
-
Uddin, M.N.1
Nishio, N.2
Ito, S.3
Suzuki, H.4
Isobe, K.5
-
150
-
-
0023689993
-
Multiple tissues express alpha 1-Antitrypsin in transgenic mice and man
-
Carlson, J. A. et al. Multiple tissues express alpha 1-Antitrypsin in transgenic mice and man. J. Clin. Invest. 82, 26-36 (1988).
-
(1988)
J. Clin. Invest
, vol.82
, pp. 26-36
-
-
Carlson, J.A.1
-
151
-
-
0024547734
-
Accumulation of PiZ aα1-Antitrypsin causes liver damage in transgenic mice
-
Carlson, J. A. et al. Accumulation of PiZ aα1-Antitrypsin causes liver damage in transgenic mice. J. Clin. Invest. 83, 1183-1190 (1989).
-
(1989)
J. Clin. Invest
, vol.83
, pp. 1183-1190
-
-
Carlson, J.A.1
-
152
-
-
0029788023
-
Degradation of a mutant secretory protein, alpha1-Antitrypsin Z, in the endoplasmic reticulum requires proteasome activity
-
Qu, D., Teckman, J. H., Omura, S. & Perlmutter, D. H. Degradation of a mutant secretory protein, alpha1-Antitrypsin Z, in the endoplasmic reticulum requires proteasome activity. J. Biol Chem. 271, 22791-22795 (1996).
-
(1996)
J. Biol Chem
, vol.271
, pp. 22791-22795
-
-
Qu, D.1
Teckman, J.H.2
Omura, S.3
Perlmutter, D.H.4
-
153
-
-
0035976919
-
The proteasome participates in degradation of mutant alpha 1-Antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes
-
Teckman, J. H. et al. The proteasome participates in degradation of mutant alpha 1-Antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes. J Biol. Chem. 276, 44865-44872 (2001).
-
(2001)
J Biol. Chem
, vol.276
, pp. 44865-44872
-
-
Teckman, J.H.1
-
154
-
-
0033671965
-
Retention of mutant aα1-Antitrypsin Z in endoplasmic reticulum is associated with an autophagic response
-
Teckman, J. H. & Perlmutter, D. H. Retention of mutant aα1-Antitrypsin Z in endoplasmic reticulum is associated with an autophagic response. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G961-G974 (2000).
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.279
, pp. G961-G974
-
-
Teckman, J.H.1
Perlmutter, D.H.2
-
155
-
-
33645216184
-
Intracellular inclusions containing mutant aα1-Antitrypsin Z are propagated in the absence of autophagic activity
-
Kamimoto, T. et al. Intracellular inclusions containing mutant aα1-Antitrypsin Z are propagated in the absence of autophagic activity. J. Biol. Chem. 281, 4467-4476 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 4467-4476
-
-
Kamimoto, T.1
-
156
-
-
84874712704
-
Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-Anti-Trypsin deficiency
-
Pastore, N. et al. Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-Anti-Trypsin deficiency. EMBO Mol. Med. 5, 397-412 (2013).
-
(2013)
EMBO Mol. Med
, vol.5
, pp. 397-412
-
-
Pastore, N.1
-
157
-
-
77954597127
-
An autophagy-enhancing drug promotes degradation of mutant aα1-Antitrypsin Z and reduces hepatic fibrosis
-
Hidvegi, T. et al. An autophagy-enhancing drug promotes degradation of mutant aα1-Antitrypsin Z and reduces hepatic fibrosis. Science 329, 229-232 (2010).
-
(2010)
Science
, vol.329
, pp. 229-232
-
-
Hidvegi, T.1
-
159
-
-
84900326348
-
Fluphenazine reduces proteotoxicity in C. Elegans and mammalian models of alpha-1-Antitrypsin deficiency
-
Li, J. et al. Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-Antitrypsin deficiency. PLoS ONE 9, e87260 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e87260
-
-
Li, J.1
-
160
-
-
84934449988
-
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
-
Mochida, K. et al. Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature 522, 359-362 (2015).
-
(2015)
Nature
, vol.522
, pp. 359-362
-
-
Mochida, K.1
-
161
-
-
84934449989
-
Regulation of endoplasmic reticulum turnover by selective autophagy
-
Khaminets, A. et al. Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 522, 354-358 (2015).
-
(2015)
Nature
, vol.522
, pp. 354-358
-
-
Khaminets, A.1
-
162
-
-
84991716246
-
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
-
Fumagalli, F. et al. Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Nat. Cell Biol. 18, 1173-1184 (2016).
-
(2016)
Nat. Cell Biol
, vol.18
, pp. 1173-1184
-
-
Fumagalli, F.1
-
163
-
-
0017099344
-
Liver disease in alpha1-Antitrypsin deficiency detected by screening of 200, 000 infants
-
Sveger, T. Liver disease in alpha1-Antitrypsin deficiency detected by screening of 200, 000 infants. N. Engl. J. Med. 294, 1316-1321 (1976).
-
(1976)
N. Engl. J. Med
, vol.294
, pp. 1316-1321
-
-
Sveger, T.1
-
164
-
-
27144481559
-
Aα1-Antitrypsin deficiency in 26-year-old subjects: Lung, liver, and protease/protease inhibitor studies
-
Piitulainen, E., Carlson, J., Ohlsson, K. & Sveger, T. aα1-Antitrypsin deficiency in 26-year-old subjects: lung, liver, and protease/protease inhibitor studies. Chest 128, 2076-2081 (2005).
-
(2005)
Chest
, vol.128
, pp. 2076-2081
-
-
Piitulainen, E.1
Carlson, J.2
Ohlsson, K.3
Sveger, T.4
-
165
-
-
0036144410
-
P62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
-
Zatloukal, K. et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am. J. Pathol. 160, 255-263 (2002).
-
(2002)
Am. J. Pathol
, vol.160
, pp. 255-263
-
-
Zatloukal, K.1
-
166
-
-
34249697629
-
From mallory to mallory-denk bodies: What, how and why?
-
Zatloukal, K. et al. From Mallory to Mallory-Denk bodies: what, how and why? Exp. Cell Res. 313, 2033-2049 (2007).
-
(2007)
Exp Cell Res
, vol.313
, pp. 2033-2049
-
-
Zatloukal, K.1
-
167
-
-
77956578400
-
P62+ hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease
-
Aishima, S. et al. p62+ hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. Am. J. Clin. Pathol. 134, 457-465 (2010).
-
(2010)
Am. J. Clin. Pathol
, vol.134
, pp. 457-465
-
-
Aishima, S.1
-
168
-
-
84907881796
-
Abnormality of autophagic function and cathepsin expression in the liver from patients with non-Alcoholic fatty liver disease
-
Fukuo, Y. et al. Abnormality of autophagic function and cathepsin expression in the liver from patients with non-Alcoholic fatty liver disease. Hepatol. Res. 44, 1026-1036 (2014).
-
(2014)
Hepatol. Res
, vol.44
, pp. 1026-1036
-
-
Fukuo, Y.1
-
169
-
-
84901062946
-
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of nafld
-
Gonzalez-Rodriguez, A. et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 5, e1179 (2014).
-
(2014)
Cell Death Dis
, vol.5
, pp. e1179
-
-
Gonzalez-Rodriguez, A.1
-
170
-
-
84989930703
-
Hepatitis b virus stimulates g6pd expression through hbx-mediated nrf2 activation
-
Liu, B. et al. Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation. Cell Death Dis. 6, e1980 (2015).
-
(2015)
Cell Death Dis
, vol.6
, pp. e1980
-
-
Liu, B.1
-
171
-
-
84971441862
-
A mechanistic review of cell death in alcohol-induced liver injury
-
Wang, S., Pacher, P., De Lisle, R. C., Huang, H. & Ding, W. X. A mechanistic review of cell death in alcohol-induced liver injury. Alcohol. Clin. Exp. Res. 40, 1215-1223 (2016).
-
(2016)
Alcohol. Clin. Exp. Res
, vol.40
, pp. 1215-1223
-
-
Wang, S.1
Pacher, P.2
De Lisle, R.C.3
Huang, H.4
Ding, W.X.5
-
172
-
-
78049467743
-
Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice
-
Ding, W. X. et al. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 139, 1740-1752 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 1740-1752
-
-
Ding, W.X.1
-
173
-
-
84877788725
-
Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-Treated rats: An immunohistochemical and electron microscopic study
-
Eid, N., Ito, Y., Maemura, K. & Otsuki, Y. Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-Treated rats: An immunohistochemical and electron microscopic study. J. Mol. Histol 44, 311-326 (2013).
-
(2013)
J. Mol. Histol
, vol.44
, pp. 311-326
-
-
Eid, N.1
Ito, Y.2
Maemura, K.3
Otsuki, Y.4
-
174
-
-
0030605976
-
Ethanol consumption alters trafficking of lysosomal enzymes and affects the processing of procathepsin L in rat liver
-
Kharbanda, K. K., McVicker, D. L., Zetterman, R. K. & Donohue, T. M. Jr. Ethanol consumption alters trafficking of lysosomal enzymes and affects the processing of procathepsin L in rat liver. Biochim. Biophys. Acta 1291, 45-52 (1996).
-
(1996)
Biochim. Biophys. Acta
, vol.1291
, pp. 45-52
-
-
Kharbanda, K.K.1
McVicker, D.L.2
Zetterman, R.K.3
Donohue, T.M.4
-
175
-
-
0030848421
-
Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration
-
Kharbanda, K. K., McVicker, D. L., Zetterman, R. K., MacDonald, R. G. & Donohue, T. M. Jr. Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration. Hepatology 26, 929-934 (1997).
-
(1997)
Hepatology
, vol.26
, pp. 929-934
-
-
Kharbanda, K.K.1
McVicker, D.L.2
Zetterman, R.K.3
MacDonald, R.G.4
Donohue, T.M.5
-
176
-
-
0033883793
-
Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model
-
Stumptner, C., Omary, M. B., Fickert, P., Denk, H. & Zatloukal, K. Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am. J. Pathol. 156, 77-90 (2000).
-
(2000)
Am. J. Pathol
, vol.156
, pp. 77-90
-
-
Stumptner, C.1
Omary, M.B.2
Fickert, P.3
Denk, H.4
Zatloukal, K.5
-
177
-
-
77749292148
-
The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
-
Sir, D. et al. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc. Natl Acad. Sci. USA 107, 4383-4388 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 4383-4388
-
-
Sir, D.1
-
178
-
-
80052045217
-
Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment
-
Li, J. et al. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. J. Virol. 85, 6319-6333 (2011).
-
(2011)
J. Virol
, vol.85
, pp. 6319-6333
-
-
Li, J.1
-
179
-
-
84855824374
-
Autophagy required for hepatitis B virus replication in transgenic mice
-
Tian, Y., Sir, D., Kuo, C. F., Ann, D. K. & Ou, J. H. Autophagy required for hepatitis B virus replication in transgenic mice. J. Virol. 85, 13453-13456 (2011).
-
(2011)
J. Virol
, vol.85
, pp. 13453-13456
-
-
Tian, Y.1
Sir, D.2
Kuo, C.F.3
Ann, D.K.4
Ou, J.H.5
-
180
-
-
84932631777
-
Autophagy mediates hbx-induced nuclear factor-κb activation and release of il-6 il-8, and cxcl2 in hepatocytes
-
Luo, M. X. et al. Autophagy mediates HBx-induced nuclear factor-κB activation and release of IL-6, IL-8, and CXCL2 in hepatocytes. J. Cell. Physiol. 230, 2382-2389 (2015).
-
(2015)
J. Cell. Physiol
, vol.230
, pp. 2382-2389
-
-
Luo, M.X.1
-
181
-
-
84896929395
-
Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation
-
Liu, B. et al. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy 10, 416-430 (2014).
-
(2014)
Autophagy
, vol.10
, pp. 416-430
-
-
Liu, B.1
-
182
-
-
70349634804
-
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles
-
Tanida, I. et al. Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy 5, 937-945 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 937-945
-
-
Tanida, I.1
-
183
-
-
69549135689
-
The autophagy machinery is required to initiate hepatitis C virus replication
-
Dreux, M., Gastaminza, P., Wieland, S. F. & Chisari, F. V. The autophagy machinery is required to initiate hepatitis C virus replication. Proc. Natl Acad. Sci. USA 106, 14046-14051 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 14046-14051
-
-
Dreux, M.1
Gastaminza, P.2
Wieland, S.F.3
Chisari, F.V.4
-
184
-
-
77955515860
-
Autophagy protein atg5 interacts transiently with the hepatitis c virus RNA polymerase (ns5b) early during infection
-
Guevin, C. et al. Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection. Virology 405, 1-7 (2010).
-
(2010)
Virology
, vol.405
, pp. 1-7
-
-
Guevin, C.1
-
185
-
-
84861556595
-
Replication of hepatitis C virus RNA on autophagosomal membranes
-
Sir, D. et al. Replication of hepatitis C virus RNA on autophagosomal membranes. J. Biol. Chem. 287, 18036-18043 (2012).
-
(2012)
J. Biol. Chem
, vol.287
, pp. 18036-18043
-
-
Sir, D.1
-
186
-
-
77956294587
-
Ultrastructural and biochemical analyses of hepatitis C virus-Associated host cell membranes
-
Ferraris, P., Blanchard, E. & Roingeard, P. Ultrastructural and biochemical analyses of hepatitis C virus-Associated host cell membranes. J. Gen. Virol. 91, 2230-2237 (2010).
-
(2010)
J. Gen. Virol
, vol.91
, pp. 2230-2237
-
-
Ferraris, P.1
Blanchard, E.2
Roingeard, P.3
-
187
-
-
79959408872
-
Changes in autophagic response in patients with chronic hepatitis C virus infection
-
Rautou, P. E. et al. Changes in autophagic response in patients with chronic hepatitis C virus infection. Am. J. Pathol. 178, 2708-2715 (2011).
-
(2011)
Am. J. Pathol
, vol.178
, pp. 2708-2715
-
-
Rautou, P.E.1
-
188
-
-
33644547706
-
Nonalcoholic fatty liver disease: From steatosis to cirrhosis
-
Farrell, G. C. & Larter, C. Z. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43, 99-112 (2006).
-
(2006)
Hepatology
, vol.43
, pp. 99-112
-
-
Farrell, G.C.1
Larter, C.Z.2
-
189
-
-
84882827495
-
Decoding cell death signals in liver inflammation
-
Brenner, C., Galluzzi, L., Kepp, O. & Kroemer, G. Decoding cell death signals in liver inflammation. J. Hepatol. 59, 583-594 (2013).
-
(2013)
J. Hepatol
, vol.59
, pp. 583-594
-
-
Brenner, C.1
Galluzzi, L.2
Kepp, O.3
Kroemer, G.4
-
190
-
-
84912031921
-
Pathogenesis and therapeutic approaches for non-Alcoholic fatty liver disease
-
Yoon, H. & Cha, B. S. Pathogenesis and therapeutic approaches for non-Alcoholic fatty liver disease. World J. Hepatol. 6, 800-811 (2014).
-
(2014)
World J. Hepatol
, vol.6
, pp. 800-811
-
-
Yoon, H.1
Cha, B.S.2
-
191
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang, L., Li, P., Fu, S., Calay, E. S. & Hotamisligil, G. S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11, 467-478 (2010).
-
(2010)
Cell Metab
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
192
-
-
84922133228
-
Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers
-
Park, H. W. et al. Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers. Nat. Commun. 5, 4834 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 4834
-
-
Park, H.W.1
-
193
-
-
84876287362
-
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-Alcoholic fatty liver conditions in mice
-
Lin, C. W. et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-Alcoholic fatty liver conditions in mice. J. Hepatol. 58, 993-999 (2013).
-
(2013)
J. Hepatol
, vol.58
, pp. 993-999
-
-
Lin, C.W.1
-
194
-
-
84896488935
-
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
-
Sinha, R. A. et al. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology 59, 1366-1380 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 1366-1380
-
-
Sinha, R.A.1
-
195
-
-
84949183529
-
Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway
-
Sun, L. et al. Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway. Am. J. Physiol. Endocrinol. Metab. 309, E925-E935 (2015).
-
(2015)
Am. J. Physiol. Endocrinol. Metab
, vol.309
, pp. E925-E935
-
-
Sun, L.1
-
196
-
-
46249115957
-
Autophagy activation by rapamycin eliminates mouse mallory-denk bodies and blocks their proteasome inhibitor-mediated formation
-
Harada, M., Hanada, S., Toivola, D. M., Ghori, N. & Omary, M. B. Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology 47, 2026-2035 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 2026-2035
-
-
Harada, M.1
Hanada, S.2
Toivola, D.M.3
Ghori, N.4
Omary, M.B.5
-
197
-
-
42949163491
-
Mechanisms of hepatic fibrogenesis
-
Friedman, S. L. Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 1655-1669
-
-
Friedman, S.L.1
-
198
-
-
84859444880
-
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
-
Hernandez-Gea, V. et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 142, 938-946 (2012).
-
(2012)
Gastroenterology
, vol.142
, pp. 938-946
-
-
Hernandez-Gea, V.1
-
199
-
-
84920415711
-
The role for autophagy in cancer
-
White, E. The role for autophagy in cancer. J. Clin. Invest. 125, 42-46 (2015).
-
(2015)
J. Clin. Invest
, vol.125
, pp. 42-46
-
-
White, E.1
-
200
-
-
84892882660
-
A dual role for autophagy in a murine model of lung cancer
-
Rao, S. et al. A dual role for autophagy in a murine model of lung cancer. Nat. Commun. 5, 3056 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 3056
-
-
Rao, S.1
-
201
-
-
84879777723
-
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
-
Guo, J. Y. et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 27, 1447-1461 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 1447-1461
-
-
Guo, J.Y.1
-
202
-
-
84891738225
-
Autophagy and human diseases
-
Jiang, P. & Mizushima, N. Autophagy and human diseases. Cell Res. 24, 69-79 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 69-79
-
-
Jiang, P.1
Mizushima, N.2
-
203
-
-
84922378824
-
Autophagy in cancer
-
Zhi, X. & Zhong, Q. Autophagy in cancer. F1000Prime Rep. 7, 18 (2015).
-
(2015)
F1000Prime Rep
, vol.7
, pp. 18
-
-
Zhi, X.1
Zhong, Q.2
-
204
-
-
84890432985
-
P53 status determines the role of autophagy in pancreatic tumour development
-
Rosenfeldt, M. T. et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 504, 296-300 (2013).
-
(2013)
Nature
, vol.504
, pp. 296-300
-
-
Rosenfeldt, M.T.1
-
205
-
-
79955492012
-
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
-
Inami, Y. et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J. Cell Biol. 193, 275-284 (2011).
-
(2011)
J. Cell Biol
, vol.193
, pp. 275-284
-
-
Inami, Y.1
-
206
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
Takamura, A. et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 25, 795-800 (2011).
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
-
207
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112, 1809-1820 (2003).
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
-
208
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077-15082 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
209
-
-
84906315540
-
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy
-
Ni, H. M. et al. Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J. Hepatol. 61, 617-625 (2014).
-
(2014)
J. Hepatol
, vol.61
, pp. 617-625
-
-
Ni, H.M.1
-
210
-
-
84891957021
-
Sqstm1 is a pathogenic target of 5q copy number gains in kidney cancer
-
Li, L. et al. SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer. Cancer Cell 24, 738-750 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 738-750
-
-
Li, L.1
-
211
-
-
84855946746
-
Krasg12d-induced ikk2/β/nf-κb activation by il-1aα and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma
-
Ling, J. et al. KrasG12D-induced IKK2/β/NF-κB activation by IL-1aα and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 21, 105-120 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 105-120
-
-
Ling, J.1
-
212
-
-
41249084239
-
The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis
-
Duran, A. et al. The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis. Cancer Cell 13, 343-354 (2008).
-
(2008)
Cancer Cell
, vol.13
, pp. 343-354
-
-
Duran, A.1
-
213
-
-
84921671279
-
Kaposis sarcoma-Associated herpesvirus induces nrf2 activation in latently infected endothelial cells through sqstm1 phosphorylation and interaction with polyubiquitinated keap1
-
Gjyshi, O. et al. Kaposis sarcoma-Associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1. J. Virol. 89, 2268-2286 (2015).
-
(2015)
J. Virol
, vol.89
, pp. 2268-2286
-
-
Gjyshi, O.1
-
214
-
-
84891745585
-
Autophagy regulation by nutrient signaling
-
Russell, R. C., Yuan, H. X. & Guan, K. L. Autophagy regulation by nutrient signaling. Cell Res. 24, 42-57 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 42-57
-
-
Russell, R.C.1
Yuan, H.X.2
Guan, K.L.3
-
215
-
-
84922374677
-
Livers with constitutive mtorc1 activity resist steatosis independent of feedback suppression of akt
-
Kenerson, H. L., Subramanian, S., McIntyre, R., Kazami, M. & Yeung, R. S. Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. PLoS ONE 10, e0117000 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0117000
-
-
Kenerson, H.L.1
Subramanian, S.2
McIntyre, R.3
Kazami, M.4
Eung, R.S.5
-
216
-
-
84876494494
-
Akt and mTORC1 have different roles during liver tumorigenesis in mice
-
Kenerson, H. L. et al. Akt and mTORC1 have different roles during liver tumorigenesis in mice. Gastroenterology 144, 1055-1065 (2013).
-
(2013)
Gastroenterology
, vol.144
, pp. 1055-1065
-
-
Kenerson, H.L.1
-
217
-
-
84864348569
-
NRF2 and cancer: The good, the bad and the importance of context
-
Sporn, M. B. & Liby, K. T. NRF2 and cancer: The good, the bad and the importance of context. Nat. Rev. Cancer 12, 564-571 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 564-571
-
-
Sporn, M.B.1
Liby, K.T.2
-
218
-
-
84922551107
-
Trans-Ancestry mutational landscape of hepatocellular carcinoma genomes
-
Totoki, Y. et al. Trans-Ancestry mutational landscape of hepatocellular carcinoma genomes. Nat. Genet. 46, 1267-1273 (2014).
-
(2014)
Nat. Genet
, vol.46
, pp. 1267-1273
-
-
Totoki, Y.1
-
219
-
-
84866894408
-
Cancer genome atlas research network comprehensive genomic characterization of squamous cell lung cancers
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-525 (2012).
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
220
-
-
80054767730
-
Renal cyst formation in fh1-deficient mice is independent of the hif/phd pathway: Roles for fumarate in keap1 succination and nrf2 signaling
-
Adam, J. et al. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 20, 524-537 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 524-537
-
-
Adam, J.1
-
221
-
-
80054772589
-
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
-
Ooi, A. et al. An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 20, 511-523 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 511-523
-
-
Ooi, A.1
-
222
-
-
84863764614
-
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
-
Mitsuishi, Y. et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22, 66-79 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 66-79
-
-
Mitsuishi, Y.1
-
223
-
-
84976586533
-
P62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
-
Saito, T. et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat. Commun. 7, 12030 (2016).
-
(2016)
Nat. Commun
, vol.7
, pp. 12030
-
-
Saito, T.1
-
224
-
-
84975468197
-
P62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells
-
Umemura, A. et al. p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell 29, 935-948 (2016).
-
(2016)
Cancer Cell
, vol.29
, pp. 935-948
-
-
Umemura, A.1
|