Keap1 degradation by autophagy for the maintenance of redox homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13561-13566

  Taguchi, Keiko ^a   Fujikawa, Nanako ^a   Komatsu, Masaaki ^b   Ishii, Tetsuro ^c   Unno, Michiaki ^a   Akaike, Takaaki ^d   Motohashi, Hozumi ^a   Yamamoto, Masayuki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Electrophile; Polyubiquitination

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEASOME; TERT BUTYLHYDROQUINONE;

ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; HOMEOSTASIS; LIVER CELL DAMAGE; LIVER FUNCTION; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; CYTOSKELETAL PROTEINS; HEP G2 CELLS; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; TRANSCRIPTION FACTORS; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

EID: 84865287281     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121572109     Document Type: Article

References (41)

1. Itoh K, et al. (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86.
2. Itoh K, et al. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8:379-391.
3. Kobayashi A, Ohta T, Yamamoto M (2004) Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. Methods Enzymol 378:273-286.
4. Kobayashi M, Yamamoto M (2005) Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7:385-394.
5. Motohashi H, Yamamoto M (2004) Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10:549-557.
6. Taguchi K, Motohashi H, Yamamoto M (2011) Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 16:123-140.
7. Kobayashi A, et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24:7130-7139.
8. Rushmore TH, Morton MR, Pickett CB (1991) The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 266:11632-11639.
9. Kwak MK, et al. (2003) Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 278:8135-8145.
10. Mizushima N (2007) Autophagy: Process and function. Genes Dev 21:2861-2873.
11. Mehrpour M, Esclatine A, Beau I, Codogno P (2010) Overview of macroautophagy regulation in mammalian cells. Cell Res 20:748-762.
12. Mortimore GE, Pösö AR (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu Rev Nutr 7:539-564.
13. Levine B, Klionsky DJ (2004) Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 6:463-477.
14. Moscat J, Diaz-Meco MT (2009) p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137:1001-1004.
15. Komatsu M, et al. (2004) A novel protein-conjugating system for Ufm1, a ubiquitinfold modifier. EMBO J 23:1977-1986.
16. Komatsu M, et al. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131:1149-1163.
17. Pankiv S, et al. (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282:24131-24145.
18. Seibenhener ML, Geetha T, Wooten MW (2007) Sequestosome 1/p62-More than just a scaffold. FEBS Lett 581:175-179.
19. Seibenhener ML, et al. (2004) Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol 24:8055-8068.
20. Komatsu M, et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12:213-223.
21. Zhang DD, et al. (2005) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem 280:30091-30099.
22. Lee OH, Jain AK, Papusha V, Jaiswal AK (2007) An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance. J Biol Chem 282:36412-36420.
23. Kobayashi M, et al. (2009) The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol 29:493-502.
24. Ishii T, et al. (2000) Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023-16029.
25. Warabi E, et al. (2007) Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species. Free Radic Biol Med 42:260-269.
26. Jain A, et al. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285:22576-22591.
27. Copple IM, et al. (2010) Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway. J Biol Chem 285:16782-16788.
28. Clausen TH, et al. (2010) p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 6:330-344.
29. Kirkin V, et al. (2009) A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 33:505-516.
30. Gao C, Chen YG (2011) Selective removal of dishevelled by autophagy: A role of p62. Autophagy 7:334-335.
31. Fan W, et al. (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6:6.
32. Behrends C, Harper JW (2011) Constructing and decoding unconventional ubiquitin chains. Nat Struct Mol Biol 18:520-528.
33. Komander D (2009) The emerging complexity of protein ubiquitination. Biochem Soc Trans 37:937-953.
34. Pickart CM, Fushman D (2004) Polyubiquitin chains: Polymeric protein signals. Curr Opin Chem Biol 8:610-616.
35. Wooten MW, et al. (2008) Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. J Biol Chem 283:6783-6789.
36. Itoh K, et al. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322.
37. Okawa H, et al. (2006) Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 339:79-88.
38. Komatsu M, et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169:425-434.
39. Mura C, Le Gac G, Jacolot S, Férec C (2004) Transcriptional regulation of the human HFE gene indicates high liver expression and erythropoiesis coregulation. FASEB J 18:1922-1924.
40. Maruyama A, et al. (2008) Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements. Arch Biochem Biophys 477:139-145.
41. Watai Y, et al. (2007) Subcellular localization and cytoplasmic complex status of endogenous Keap1. Genes Cells 12:1163-1178.