Intracellular inclusions containing mutant α1-antitrypsin Z are propagated in the absence of autophagic activity

Journal of Biological Chemistry

Volumn 281, Issue 7, 2006, Pages 4467-4476

  Kamimoto, Takahiro ^a   Shoji, Shisako ^a,b,c   Hidvegi, Tunda ^d   Mizushima, Noboru ^c,e,f   Umebayashi, Kyohei ^a   Perlmutter, David H ^d   Yoshimori, Tamotsu ^a,b,c,f  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^e TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOLOGICAL ORGANS; CELLS; DISEASES; TOXIC MATERIALS;

AUTOPHAGIC DEGRADATION; DEGRADATIVE PATHWAY; TRANSGENIC MOUSE;

BIOCHEMISTRY;

ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN Z; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATG5 GENE; AUTOPHAGY; CELL INCLUSION; CONTROLLED STUDY; GENE; GENE DELETION; LIVER INJURY; MEMBRANE FUSION; MEMBRANE MARKER; MOUSE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; CELL CULTURE; ENDOPLASMIC RETICULUM; METABOLISM; MUTATION; PHYSIOLOGY;

MUS MUSCULUS;

ALPHA 1-ANTITRYPSIN; ANIMALS; AUTOPHAGY; CELLS, CULTURED; ENDOPLASMIC RETICULUM; INCLUSION BODIES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION;

EID: 33645216184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509409200     Document Type: Article

References (42)

1. Teckman, J. H., Qu, D., and Perlmutter, D. H. (1996) Hepatology 24, 1504-1516
2. Lomas, D. A., and Mahadeva, R. (2002) J. Clin. Investig. 110, 1585-1590
3. Perlmutter, D. H. (2002) J. Clin. Investig. 110, 1579-1583
4. Wu, Y., Whitman, I., Molmenti, E., Moore, K., Hippenmeyer, P., and Perlmutter, D. H. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9014-9018
5. Sivasothy, P., Dafforn, T. R., Gettins, P. G., and Lomas, D. A. (2000) J. Biol. Chem. 275, 33663-33668
6. Yoshida, Y. (2003) J. Biochem. (Tokyo) 134, 183-190
7. Ellgaard, L., and Helenius, A. (2003) Nat. Rev. Mol. Cell Biol. 4, 181-191
8. Qu, D., Teckman, J. H., Omura, S., and Perlmutter, D. H. (1996) J. Biol. Chem. 271, 22791-22795
9. Teckman, J. H., Gilmore, R., and Perlmutter, D. H. (2000) Am. J. Physiol. 278, G39-G48
10. Teckman, J. H., Burrows, J., Hidvegi, T., Schmidt, B., Hale, P. D., and Perlmutter, D. H. (2001) J. Biol. Chem. 276, 44865-44872
11. Cabral, C. M., Choudhury, P., Liu, Y., and Sifers, R. N. (2000) J. Biol. Chem. 275, 25015-25022
12. Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., and Ohsumi, Y. (1998) Nature 395, 395-398
13. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T. (2000) EMBO J. 19, 5720-5728
14. Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., and Yoshimori, T. (2001) J. Cell Biol. 152, 657-668
15. Mizushima, N., Yoshimori, T., and Ohsumi, Y. (2003) Int. J. Biochem. Cell Biol. 35, 553-561
16. Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., and Yoshimori, T. (2004) J. Cell Sci. 117, 2805-2812
17. Yoshimori, T. (2004) Biochem. Biophys. Res. Commun. 313, 453-458
18. Levine, B., and Klionsky, D. J. (2004) Dev. Cell 6, 463-477
19. Teckman, J. H., and Perlmutter, D. H. (2000) Am. J. Physiol. 279, G961-G974
20. Teckman, J. H., An, J. K., Loethen, S., and Perlmutter, D. H. (2002) Am. J. Physiol. 283, G1156-G1165
21. Teckman, J. H., An, J. K., Blomenkamp, K., Schmidt, B., and Perlmutter, D. (2004) Am. J. Physiol. 286, G851-G862
22. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., and Ohsumi, Y. (2004) Mol. Biol. Cell 15, 1101-1111
23. Dantuma, N. P., Lindsten, K., Glas, R., Jellne, M., and Masucci, M. G. (2000) Nat. Biotechnol. 18, 538-543
24. Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. (2004) Nature 432, 1032-1036
25. Lin, L., Schmidt, B., Teckman, J., and Perlmutter, D. H. (2001) J. Biol. Chem. 276, 33893-33898
26. Hidvegi, T., Schmidt, B. Z., Hale, P., and Perlmutter, D. H. (2005) J. Biol. Chem. 280, 39002-39015
27. Rudnick, D. A., Liao, Y., An, J. K., Muglia, L. J., Perlmutter, D. H., and Teckman, J. H. (2004) Hepatology 39, 1048-1055
28. Le, A., Ferrell, G. A., Dishon, D. S., Le, Q. Q., and Sifers, R. N. (1992) J. Biol. Chem. 267, 1072-1080
29. Marcus, N. Y., and Perlmutter, D. H. (2000) J. Biol. Chem. 275, 1987-1992
30. Jager, S., Bucci, C., Tanida, I., Ueno, T., Kominami, E., Saftig, P., and Eskelinen, E. L. (2004) J. Cell Sci. 117, 4837-4848
31. Gutierrez, M. G., Munafo, D. B., Beron, W., and Colombo, M. I. (2004) J. Cell Sci. 117, 2687-2697
32. Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., and Tashiro, Y. (1998) Cell Struct. Funct. 23, 33-42
33. Molmenti, E. P., Perlmutter, D. H., and Rubin, D. C. (1993) J. Clin. Investig. 92, 2022-2034
34. Rudnick, D. A., and Perlmutter, D. H. (2005) Hepatology 42, 514-521
35. Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., Hamada, S., and Yoshimori, T. (2004) Science 306, 1037-1040
36. Bolender, R. P., and Weibel, E. R. (1973) J. Cell Biol. 56, 746-761
37. Masaki, R., Yamamoto, A., and Tashiro, Y. (1987) J. Cell Biol. 104, 1207-1215
38. Kamhi-Nesher, S., Shenkman, M., Tolchinsky, S., Fromm, S. V., Ehrlich, R., and Lederkremer, G. Z. (2001) Mol. Biol. Cell 12, 1711-1723
39. Okiyoneda, T., Harada, K., Takeya, M., Yamahira, K., Wada, I., Shuto, T., Suico, M. A., Hashimoto, Y., and Kai, H. (2004) Mol. Biol. Cell 15, 563-574
40. Johnston, J. A., Ward, C. L., and Kopito, R. R. (1998) J. Cell Biol. 143, 1883-1898
41. Kopito, R. R., and Sitia, R. (2000) EMBO Rep. 1, 225-231
42. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., and Chiba, T. (2005) J. Cell Biol. 169, 425-434