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Volumn 20, Issue 4, 2011, Pages 511-523

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ALDO KETO REDUCTASE FAMILY 1 MEMBER B10; CIS ACTING ELEMENT; FUMARATE HYDRATASE; FUMARIC ACID; OXIDOREDUCTASE; PROTEIN; PROTEIN MEN2A; SUCCINATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

EID: 80054772589     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2011.08.024     Document Type: Article
Times cited : (331)

References (66)
  • 1
    • 12444259659 scopus 로고    scopus 로고
    • Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency
    • Alam N.A., Rowan A.J., Wortham N.C., Pollard P.J., Mitchell M., Tyrer J.P., Barclay E., Calonje E., Manek S., Adams S.J., et al. Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. Hum. Mol. Genet. 2003, 12:1241-1252.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1241-1252
    • Alam, N.A.1    Rowan, A.J.2    Wortham, N.C.3    Pollard, P.J.4    Mitchell, M.5    Tyrer, J.P.6    Barclay, E.7    Calonje, E.8    Manek, S.9    Adams, S.J.10
  • 4
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 1995, 57:289-300.
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 5
    • 42549083245 scopus 로고    scopus 로고
    • Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes
    • Blatnik M., Thorpe S.R., Baynes J.W. Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes. Ann. N Y Acad. Sci. 2008, 1126:272-275.
    • (2008) Ann. N Y Acad. Sci. , vol.1126 , pp. 272-275
    • Blatnik, M.1    Thorpe, S.R.2    Baynes, J.W.3
  • 7
    • 0035836698 scopus 로고    scopus 로고
    • An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen
    • Chan K., Han X.D., Kan Y.W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. USA 2001, 98:4611-4616.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.D.2    Kan, Y.W.3
  • 10
    • 70350018290 scopus 로고    scopus 로고
    • Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin
    • Frizzell N., Rajesh M., Jepson M.J., Nagai R., Carson J.A., Thorpe S.R., Baynes J.W. Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin. J. Biol. Chem. 2009, 284:25772-25781.
    • (2009) J. Biol. Chem. , vol.284 , pp. 25772-25781
    • Frizzell, N.1    Rajesh, M.2    Jepson, M.J.3    Nagai, R.4    Carson, J.A.5    Thorpe, S.R.6    Baynes, J.W.7
  • 11
    • 33847250856 scopus 로고    scopus 로고
    • Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on gene expression profiling
    • Furge K.A., Tan M.H., Dykema K., Kort E., Stadler W., Yao X., Zhou M., Teh B.T. Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on gene expression profiling. Oncogene 2007, 26:1346-1350.
    • (2007) Oncogene , vol.26 , pp. 1346-1350
    • Furge, K.A.1    Tan, M.H.2    Dykema, K.3    Kort, E.4    Stadler, W.5    Yao, X.6    Zhou, M.7    Teh, B.T.8
  • 12
    • 11144264663 scopus 로고    scopus 로고
    • BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
    • Furukawa M., Xiong Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol. Cell. Biol. 2005, 25:162-171.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 162-171
    • Furukawa, M.1    Xiong, Y.2
  • 14
    • 0035965945 scopus 로고    scopus 로고
    • Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
    • Hayes J.D., McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 2001, 174:103-113.
    • (2001) Cancer Lett. , vol.174 , pp. 103-113
    • Hayes, J.D.1    McMahon, M.2
  • 15
    • 77952311188 scopus 로고    scopus 로고
    • Thioredoxin and thioredoxin reductase: current research with special reference to human disease
    • Holmgren A., Lu J. Thioredoxin and thioredoxin reductase: current research with special reference to human disease. Biochem. Biophys. Res. Commun. 2010, 396:120-124.
    • (2010) Biochem. Biophys. Res. Commun. , vol.396 , pp. 120-124
    • Holmgren, A.1    Lu, J.2
  • 16
    • 33746111834 scopus 로고    scopus 로고
    • Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2
    • Hsieh T.C., Lu X., Wang Z., Wu J.M. Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2. Med. Chem. 2006, 2:275-285.
    • (2006) Med. Chem. , vol.2 , pp. 275-285
    • Hsieh, T.C.1    Lu, X.2    Wang, Z.3    Wu, J.M.4
  • 18
    • 77950188986 scopus 로고    scopus 로고
    • Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas
    • Huang Y.W., Luo J., Weng Y.I., Mutch D.G., Goodfellow P.J., Miller D.S., Huang T.H. Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas. Gynecol. Oncol. 2010, 117:239-247.
    • (2010) Gynecol. Oncol. , vol.117 , pp. 239-247
    • Huang, Y.W.1    Luo, J.2    Weng, Y.I.3    Mutch, D.G.4    Goodfellow, P.J.5    Miller, D.S.6    Huang, T.H.7
  • 19
    • 67650354551 scopus 로고    scopus 로고
    • Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking
    • Hübner R.H., Schwartz J.D., De Bishnu P., Ferris B., Omberg L., Mezey J.G., Hackett N.R., Crystal R.G. Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. Mol. Med. 2009, 15:203-219.
    • (2009) Mol. Med. , vol.15 , pp. 203-219
    • Hübner, R.H.1    Schwartz, J.D.2    De Bishnu, P.3    Ferris, B.4    Omberg, L.5    Mezey, J.G.6    Hackett, N.R.7    Crystal, R.G.8
  • 20
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
    • Isaacs J.S., Jung Y.J., Mole D.R., Lee S., Torres-Cabala C., Chung Y.L., Merino M., Trepel J., Zbar B., Toro J., et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 2005, 8:143-153.
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5    Chung, Y.L.6    Merino, M.7    Trepel, J.8    Zbar, B.9    Toro, J.10
  • 23
    • 9744276042 scopus 로고    scopus 로고
    • Hereditary leiomyomatosis and renal cell cancer (HLRCC)
    • Kiuru M., Launonen V. Hereditary leiomyomatosis and renal cell cancer (HLRCC). Curr. Mol. Med. 2004, 4:869-875.
    • (2004) Curr. Mol. Med. , vol.4 , pp. 869-875
    • Kiuru, M.1    Launonen, V.2
  • 24
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • Koivunen P., Hirsilä M., Remes A.M., Hassinen I.E., Kivirikko K.I., Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 2007, 282:4524-4532.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsilä, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 25
    • 70450278715 scopus 로고    scopus 로고
    • Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
    • Koshikawa N., Hayashi J., Nakagawara A., Takenaga K. Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J. Biol. Chem. 2009, 284:33185-33194.
    • (2009) J. Biol. Chem. , vol.284 , pp. 33185-33194
    • Koshikawa, N.1    Hayashi, J.2    Nakagawara, A.3    Takenaga, K.4
  • 26
    • 0038578527 scopus 로고    scopus 로고
    • Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
    • Kwak M.K., Kensler T.W., Casero R.A. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochem. Biophys. Res. Commun. 2003, 305:662-670.
    • (2003) Biochem. Biophys. Res. Commun. , vol.305 , pp. 662-670
    • Kwak, M.K.1    Kensler, T.W.2    Casero, R.A.3
  • 33
    • 70249138697 scopus 로고    scopus 로고
    • Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
    • MacLeod A.K., McMahon M., Plummer S.M., Higgins L.G., Penning T.M., Igarashi K., Hayes J.D. Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis 2009, 30:1571-1580.
    • (2009) Carcinogenesis , vol.30 , pp. 1571-1580
    • MacLeod, A.K.1    McMahon, M.2    Plummer, S.M.3    Higgins, L.G.4    Penning, T.M.5    Igarashi, K.6    Hayes, J.D.7
  • 34
    • 77952671413 scopus 로고    scopus 로고
    • HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells
    • Malec V., Gottschald O.R., Li S., Rose F., Seeger W., Hänze J. HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells. Free Radic. Biol. Med. 2010, 48:1626-1635.
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 1626-1635
    • Malec, V.1    Gottschald, O.R.2    Li, S.3    Rose, F.4    Seeger, W.5    Hänze, J.6
  • 35
    • 0035870298 scopus 로고    scopus 로고
    • The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
    • McMahon M., Itoh K., Yamamoto M., Chanas S.A., Henderson C.J., McLellan L.I., Wolf C.R., Cavin C., Hayes J.D. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 2001, 61:3299-3307.
    • (2001) Cancer Res. , vol.61 , pp. 3299-3307
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Chanas, S.A.4    Henderson, C.J.5    McLellan, L.I.6    Wolf, C.R.7    Cavin, C.8    Hayes, J.D.9
  • 38
    • 34548577395 scopus 로고    scopus 로고
    • A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
    • Nioi P., Nguyen T. A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity. Biochem. Biophys. Res. Commun. 2007, 362:816-821.
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , pp. 816-821
    • Nioi, P.1    Nguyen, T.2
  • 41
    • 57749120460 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    • Ohtsuji M., Katsuoka F., Kobayashi A., Aburatani H., Hayes J.D., Yamamoto M. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J. Biol. Chem. 2008, 283:33554-33562.
    • (2008) J. Biol. Chem. , vol.283 , pp. 33554-33562
    • Ohtsuji, M.1    Katsuoka, F.2    Kobayashi, A.3    Aburatani, H.4    Hayes, J.D.5    Yamamoto, M.6
  • 42
    • 33745513491 scopus 로고    scopus 로고
    • 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells
    • Pae H.O., Oh G.S., Lee B.S., Rim J.S., Kim Y.M., Chung H.T. 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Atherosclerosis 2006, 187:274-284.
    • (2006) Atherosclerosis , vol.187 , pp. 274-284
    • Pae, H.O.1    Oh, G.S.2    Lee, B.S.3    Rim, J.S.4    Kim, Y.M.5    Chung, H.T.6
  • 43
    • 11144284227 scopus 로고    scopus 로고
    • Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome
    • Pollard P., Wortham N., Barclay E., Alam A., Elia G., Manek S., Poulsom R., Tomlinson I. Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. J. Pathol. 2005, 205:41-49.
    • (2005) J. Pathol. , vol.205 , pp. 41-49
    • Pollard, P.1    Wortham, N.2    Barclay, E.3    Alam, A.4    Elia, G.5    Manek, S.6    Poulsom, R.7    Tomlinson, I.8
  • 46
    • 41849146057 scopus 로고    scopus 로고
    • Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
    • Rachakonda G., Xiong Y., Sekhar K.R., Stamer S.L., Liebler D.C., Freeman M.L. Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3. Chem. Res. Toxicol. 2008, 21:705-710.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 705-710
    • Rachakonda, G.1    Xiong, Y.2    Sekhar, K.R.3    Stamer, S.L.4    Liebler, D.C.5    Freeman, M.L.6
  • 47
    • 0025061933 scopus 로고
    • Visceral pathology of hereditary tyrosinemia type I
    • Russo P., O'Regan S. Visceral pathology of hereditary tyrosinemia type I. Am. J. Hum. Genet. 1990, 47:317-324.
    • (1990) Am. J. Hum. Genet. , vol.47 , pp. 317-324
    • Russo, P.1    O'Regan, S.2
  • 48
    • 18244386712 scopus 로고    scopus 로고
    • Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2
    • Sakurai A., Nishimoto M., Himeno S., Imura N., Tsujimoto M., Kunimoto M., Hara S. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. J. Cell. Physiol. 2005, 203:529-537.
    • (2005) J. Cell. Physiol. , vol.203 , pp. 529-537
    • Sakurai, A.1    Nishimoto, M.2    Himeno, S.3    Imura, N.4    Tsujimoto, M.5    Kunimoto, M.6    Hara, S.7
  • 49
    • 33746513199 scopus 로고    scopus 로고
    • High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32
    • Sango K., Suzuki T., Yanagisawa H., Takaku S., Hirooka H., Tamura M., Watabe K. High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32. J. Neurochem. 2006, 98:446-458.
    • (2006) J. Neurochem. , vol.98 , pp. 446-458
    • Sango, K.1    Suzuki, T.2    Yanagisawa, H.3    Takaku, S.4    Hirooka, H.5    Tamura, M.6    Watabe, K.7
  • 52
    • 33846809497 scopus 로고    scopus 로고
    • Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway
    • Siow R.C., Ishii T., Mann G.E. Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway. Redox Rep. 2007, 12:11-15.
    • (2007) Redox Rep. , vol.12 , pp. 11-15
    • Siow, R.C.1    Ishii, T.2    Mann, G.E.3
  • 53
    • 33644872577 scopus 로고    scopus 로고
    • Limma: linear models for microarray data
    • Springer, New York, R. Gentleman, V. Carey, S. Dudoit, R.A. Irizarry, W. Huber (Eds.)
    • Smyth G.K. Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor 2005, 397-420. Springer, New York. R. Gentleman, V. Carey, S. Dudoit, R.A. Irizarry, W. Huber (Eds.).
    • (2005) Bioinformatics and Computational Biology Solutions using R and Bioconductor , pp. 397-420
    • Smyth, G.K.1
  • 54
    • 77958483637 scopus 로고    scopus 로고
    • Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma
    • Sourbier C., Valera-Romero V., Giubellino A., Yang Y., Sudarshan S., Neckers L., Linehan W.M. Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma. Cell Cycle 2010, 9:4183-4189.
    • (2010) Cell Cycle , vol.9 , pp. 4183-4189
    • Sourbier, C.1    Valera-Romero, V.2    Giubellino, A.3    Yang, Y.4    Sudarshan, S.5    Neckers, L.6    Linehan, W.M.7
  • 55
    • 0025637578 scopus 로고
    • Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues
    • Spencer S.R., Wilczak C.A., Talalay P. Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues. Cancer Res. 1990, 50:7871-7875.
    • (1990) Cancer Res. , vol.50 , pp. 7871-7875
    • Spencer, S.R.1    Wilczak, C.A.2    Talalay, P.3
  • 56
    • 67651204610 scopus 로고    scopus 로고
    • Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
    • Sudarshan S., Sourbier C., Kong H.S., Block K., Valera Romero V.A., Yang Y., Galindo C., Mollapour M., Scroggins B., Goode N., et al. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol. Cell. Biol. 2009, 29:4080-4090.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4080-4090
    • Sudarshan, S.1    Sourbier, C.2    Kong, H.S.3    Block, K.4    Valera Romero, V.A.5    Yang, Y.6    Galindo, C.7    Mollapour, M.8    Scroggins, B.9    Goode, N.10
  • 57
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Multiple Leiomyoma Consortium
    • Tomlinson I.P., Alam N.A., Rowan A.J., Barclay E., Jaeger E.E., Kelsell D., Leigh I., Gorman P., Lamlum H., Rahman S., et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat. Genet. 2002, 30:406-410. Multiple Leiomyoma Consortium.
    • (2002) Nat. Genet. , vol.30 , pp. 406-410
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3    Barclay, E.4    Jaeger, E.E.5    Kelsell, D.6    Leigh, I.7    Gorman, P.8    Lamlum, H.9    Rahman, S.10
  • 60
    • 0032542213 scopus 로고    scopus 로고
    • Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
    • Venugopal R., Jaiswal A.K. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene 1998, 17:3145-3156.
    • (1998) Oncogene , vol.17 , pp. 3145-3156
    • Venugopal, R.1    Jaiswal, A.K.2
  • 61
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • Wang R., An J., Ji F., Jiao H., Sun H., Zhou D. Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem. Biophys. Res. Commun. 2008, 373:151-154.
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3    Jiao, H.4    Sun, H.5    Zhou, D.6
  • 63
    • 70949105507 scopus 로고    scopus 로고
    • UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
    • Yang Y., Valera V.A., Padilla-Nash H.M., Sourbier C., Vocke C.D., Vira M.A., Abu-Asab M.S., Bratslavsky G., Tsokos M., Merino M.J., et al. UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet. Cytogenet. 2010, 196:45-55.
    • (2010) Cancer Genet. Cytogenet. , vol.196 , pp. 45-55
    • Yang, Y.1    Valera, V.A.2    Padilla-Nash, H.M.3    Sourbier, C.4    Vocke, C.D.5    Vira, M.A.6    Abu-Asab, M.S.7    Bratslavsky, G.8    Tsokos, M.9    Merino, M.J.10
  • 64
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • Zhang D.D., Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol. Cell. Biol. 2003, 23:8137-8151.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 65
    • 24044466764 scopus 로고    scopus 로고
    • Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
    • Zhang D.D., Lo S.C., Sun Z., Habib G.M., Lieberman M.W., Hannink M. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 2005, 280:30091-30099.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30091-30099
    • Zhang, D.D.1    Lo, S.C.2    Sun, Z.3    Habib, G.M.4    Lieberman, M.W.5    Hannink, M.6
  • 66
    • 33750543308 scopus 로고    scopus 로고
    • Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum
    • Zhang Y., Crouch D.H., Yamamoto M., Hayes J.D. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem. J. 2006, 399:373-385.
    • (2006) Biochem. J. , vol.399 , pp. 373-385
    • Zhang, Y.1    Crouch, D.H.2    Yamamoto, M.3    Hayes, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.