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Volumn 44, Issue 3, 2013, Pages 311-326

Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: An immunohistochemical and electron microscopic study

Author keywords

Autophagy; Ethanol; Lipophagy; Liver; Mitophagy; Rat

Indexed keywords

ALCOHOL; CATHEPSIN; CELL MARKER; CYTOCHROME C; FAT DROPLET; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PROTEIN PINK1; UNCLASSIFIED DRUG;

EID: 84877788725     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-013-9483-x     Document Type: Article
Times cited : (98)

References (69)
  • 1
    • 84865957147 scopus 로고    scopus 로고
    • Resveratrol-mediated downregulation of rictor attenuates autophagic process and suppresses UV-Induced skin carcinogenesis
    • 22272775 10.1111/j.1751-1097.2012.01097.x 1:CAS:528:DC%2BC38XhsVenu73E
    • Back JH, Zhu Y, Calabro A, Queenan C, Kim AS, Arbesman J, Kim AL (2012) Resveratrol-mediated downregulation of rictor attenuates autophagic process and suppresses UV-Induced skin carcinogenesis. Photochem Photobiol 88(5):1165-1172
    • (2012) Photochem Photobiol , vol.88 , Issue.5 , pp. 1165-1172
    • Back, J.H.1    Zhu, Y.2    Calabro, A.3    Queenan, C.4    Kim, A.S.5    Arbesman, J.6    Kim, A.L.7
  • 2
    • 77952766891 scopus 로고    scopus 로고
    • Autophagy: Assays and artifacts
    • 20225337 10.1002/path.2694 1:CAS:528:DC%2BC3cXnvFKjtbw%3D
    • Barth S, Glick D, Macleod KF (2010) Autophagy: assays and artifacts. J Pathol 221:117-124
    • (2010) J Pathol , vol.221 , pp. 117-124
    • Barth, S.1    Glick, D.2    MacLeod, K.F.3
  • 3
    • 78650006375 scopus 로고    scopus 로고
    • PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells
    • 20971498 10.1016/j.humpath.2010.05.016 1:CAS:528:DC%2BC3cXhsFCqs7nJ
    • Berthier A, Navarro S, Jiménez-Sáinz J, Roglá I, Ripoll F, Cervera J, Pulido R (2011) PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells. Hum Pathol 42:75-87
    • (2011) Hum Pathol , vol.42 , pp. 75-87
    • Berthier, A.1    Navarro, S.2    Jiménez-Sáinz, J.3    Roglá, I.4    Ripoll, F.5    Cervera, J.6    Pulido, R.7
  • 5
    • 77953877676 scopus 로고    scopus 로고
    • A pivotal role for PINK1 and autophagy in mitochondrial quality control: Implications for Parkinson disease
    • 20385539 10.1093/hmg/ddq143 1:CAS:528:DC%2BC3cXmsVSrtrc%3D
    • Chu CT (2010) A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet 19:R28-R37
    • (2010) Hum Mol Genet , vol.19
    • Chu, C.T.1
  • 7
    • 77951464621 scopus 로고    scopus 로고
    • Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: Pathophysiological implications
    • 20089934 10.1152/ajpcell.00527.2009 1:CAS:528:DC%2BC3cXmtlWjsrs%3D
    • Czaja MJ (2010) Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications. Am J Physiol Cell Physiol 298(5):C973-C978
    • (2010) Am J Physiol Cell Physiol , vol.298 , Issue.5
    • Czaja, M.J.1
  • 8
    • 79958167078 scopus 로고    scopus 로고
    • Functions of autophagy in hepatic and pancreatic physiology and disease
    • 10.1053/j.gastro.2011.04.038
    • Czaja MJ (2011) Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterol 140:1895-1908
    • (2011) Gastroenterol , vol.140 , pp. 1895-1908
    • Czaja, M.J.1
  • 9
    • 69449107552 scopus 로고    scopus 로고
    • Lipases in lysosomes, what for?
    • 19502773
    • Czaja MJ, Cuervo AM (2009) Lipases in lysosomes, what for? Autophagy 5(6):866-867
    • (2009) Autophagy , vol.5 , Issue.6 , pp. 866-867
    • Czaja, M.J.1    Cuervo, A.M.2
  • 10
    • 50249168137 scopus 로고    scopus 로고
    • Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: Implications for Parkinson's disease
    • 18594198 1:CAS:528:DC%2BD1cXhtVynt7nM
    • Dagda RK, Zhu J, Kulich SM, Chu CT (2008) Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy 4:770-782
    • (2008) Autophagy , vol.4 , pp. 770-782
    • Dagda, R.K.1    Zhu, J.2    Kulich, S.M.3    Chu, C.T.4
  • 11
    • 84867773087 scopus 로고    scopus 로고
    • Mitophagy: Mechanisms, pathophysiological roles, and analysis
    • 22944659 1:CAS:528:DC%2BC38Xht1Sju7zK
    • Ding WX, Yin XM (2012) Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem 393:547-564
    • (2012) Biol Chem , vol.393 , pp. 547-564
    • Ding, W.X.1    Yin, X.M.2
  • 13
    • 79551554585 scopus 로고    scopus 로고
    • Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets
    • 21150309 10.4161/auto.7.2.14347
    • Ding WX, Li M, Yin XM (2011a) Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets. Autophagy 7:248-249
    • (2011) Autophagy , vol.7 , pp. 248-249
    • Ding, W.X.1    Li, M.2    Yin, X.M.3
  • 14
    • 79958847922 scopus 로고    scopus 로고
    • The emerging role of autophagy in alcoholic liver disease
    • 10.1258/ebm.2011.010360 1:CAS:528:DC%2BC3MXns1Smsbk%3D
    • Ding WX, Manley S, Ni HM (2011b) The emerging role of autophagy in alcoholic liver disease. Exp Biol Med 236:546-556
    • (2011) Exp Biol Med , vol.236 , pp. 546-556
    • Ding, W.X.1    Manley, S.2    Ni, H.M.3
  • 16
    • 79958828558 scopus 로고    scopus 로고
    • Regulation of lipid droplets by autophagy
    • 21419642 10.1016/j.tem.2011.02.003 1:CAS:528:DC%2BC3MXnslOgtb8%3D
    • Dong H, Czaja MJ (2011) Regulation of lipid droplets by autophagy. Trends Endocrinol Metab 22:234-240
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 234-240
    • Dong, H.1    Czaja, M.J.2
  • 17
    • 0036268720 scopus 로고    scopus 로고
    • Involvement of Fas system and active caspases in apoptotic signalling in testicular germ cells of ethanol-treated rats
    • 12031044 10.1046/j.1365-2605.2002.00341.x 1:CAS:528:DC%2BD38Xmtlagsb0%3D
    • Eid NA, Shibata MA, Ito Y, Kusakabe K, Hammad H, Otsuki Y (2002) Involvement of Fas system and active caspases in apoptotic signalling in testicular germ cells of ethanol-treated rats. Int J Androl 25:159-167
    • (2002) Int J Androl , vol.25 , pp. 159-167
    • Eid, N.A.1    Shibata, M.A.2    Ito, Y.3    Kusakabe, K.4    Hammad, H.5    Otsuki, Y.6
  • 18
    • 84856512307 scopus 로고    scopus 로고
    • Enhanced mitophagy in Sertoli cells of ethanol-treated rats: Morphological evidence and clinical relevance
    • 22076330 10.1007/s10735-011-9372-0 1:CAS:528:DC%2BC38Xht1OhtLc%3D
    • Eid N, Ito Y, Otsuki Y (2012) Enhanced mitophagy in Sertoli cells of ethanol-treated rats: morphological evidence and clinical relevance. J Mol Histol 43:71-80
    • (2012) J Mol Histol , vol.43 , pp. 71-80
    • Eid, N.1    Ito, Y.2    Otsuki, Y.3
  • 19
    • 38949136372 scopus 로고    scopus 로고
    • To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells
    • 17986849
    • Eskelinen EL (2008) To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells. Autophagy 4:257-260
    • (2008) Autophagy , vol.4 , pp. 257-260
    • Eskelinen, E.L.1
  • 21
    • 79959501180 scopus 로고    scopus 로고
    • Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease
    • 21254858 10.1089/ars.2011.3897 1:CAS:528:DC%2BC3MXnslOjsLo%3D
    • Feldstein AE, Bailey SM (2011) Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. Antioxid Redox Signal 15:421-424
    • (2011) Antioxid Redox Signal , vol.15 , pp. 421-424
    • Feldstein, A.E.1    Bailey, S.M.2
  • 22
    • 67649382475 scopus 로고    scopus 로고
    • Impaired autolysosome formation correlates with Lamp-2 depletion: Role of apoptosis, autophagy, and necrosis in pancreatitis
    • 10.1053/j.gastro.2009.04.003 1:CAS:528:DC%2BD1MXovFOgtbY%3D
    • Fortunato F, Burgers H, Bergmann F, Rieger P, Büchler MW, Kroemer G, Werner J (2009) Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. Gastroenterol 137:350-360
    • (2009) Gastroenterol , vol.137 , pp. 350-360
    • Fortunato, F.1    Burgers, H.2    Bergmann, F.3    Rieger, P.4    Büchler, M.W.5    Kroemer, G.6    Werner, J.7
  • 24
    • 34447511422 scopus 로고    scopus 로고
    • Cytoplasmic lipid droplets: Rediscovery of an old structure as a unique platform
    • 17185509 10.1196/annals.1377.010 1:CAS:528:DC%2BD2sXhtVWhtLs%3D
    • Fujimoto T, Ohsaki Y (2006) Cytoplasmic lipid droplets: rediscovery of an old structure as a unique platform. Ann NY Acad Sci 1086:104-115
    • (2006) Ann NY Acad Sci , vol.1086 , pp. 104-115
    • Fujimoto, T.1    Ohsaki, Y.2
  • 25
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: Pathogenesis and new therapeutic targets
    • 21920463 10.1053/j.gastro.2011.09.002 1:CAS:528:DC%2BC3MXhtlOksbzK
    • Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141:1572-1585
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 26
    • 0015906501 scopus 로고
    • Mitochondrial functions in an ethanol-induced fatty liver
    • 4356624 1:CAS:528:DyaE2cXhtVCmtLg%3D
    • Gordon ER (1973) Mitochondrial functions in an ethanol-induced fatty liver. J Biol Chem 248(23):8271-8280
    • (1973) J Biol Chem , vol.248 , Issue.23 , pp. 8271-8280
    • Gordon, E.R.1
  • 27
    • 84863101514 scopus 로고    scopus 로고
    • Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells
    • 22542809 10.1016/j.canlet.2012.04.012 1:CAS:528:DC%2BC38XntlSmtbw%3D
    • Hah YS, Noh HS, Ha JH, Ahn JS, Hahm JR, Cho HY, Kim DR (2012) Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells. Cancer Lett 323(2):208-214
    • (2012) Cancer Lett , vol.323 , Issue.2 , pp. 208-214
    • Hah, Y.S.1    Noh, H.S.2    Ha, J.H.3    Ahn, J.S.4    Hahm, J.R.5    Cho, H.Y.6    Kim, D.R.7
  • 28
    • 79955556566 scopus 로고    scopus 로고
    • The development of an immunohistochemical method to detect the autophagy-associated protein LC3-II in human tumor xenografts
    • 21441228 10.1177/0192623310396903 1:CAS:528:DC%2BC3MXnvFKmtbo%3D
    • Holt SV, Wyspianska B, Randall KJ, James D, Foster JR, Wilkinson RW (2011) The development of an immunohistochemical method to detect the autophagy-associated protein LC3-II in human tumor xenografts. Toxicol Pathol 39:516-523
    • (2011) Toxicol Pathol , vol.39 , pp. 516-523
    • Holt, S.V.1    Wyspianska, B.2    Randall, K.J.3    James, D.4    Foster, J.R.5    Wilkinson, R.W.6
  • 29
    • 0013899589 scopus 로고
    • The ultrastructure of fatty liver induced by prolonged ethanol ingestion
    • 5936783 1:STN:280:DyaF287ktVWrsw%3D%3D
    • Iseri OA, Lieber CS, Gottlieb LS (1966) The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Pathol 48(4):535-555
    • (1966) Am J Pathol , vol.48 , Issue.4 , pp. 535-555
    • Iseri, O.A.1    Lieber, C.S.2    Gottlieb, L.S.3
  • 30
    • 84857850213 scopus 로고    scopus 로고
    • Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
    • 10.1242/jcs.094110
    • Itakura E, Kishi-Itakura C, Koyama-Honda I, Mizushima N (2012) Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J Cell Sci 15(125):1488-1499
    • (2012) J Cell Sci , vol.15 , Issue.125 , pp. 1488-1499
    • Itakura, E.1    Kishi-Itakura, C.2    Koyama-Honda, I.3    Mizushima, N.4
  • 31
    • 84861204926 scopus 로고    scopus 로고
    • PINK1- and Parkin-mediated mitophagy at a glance
    • 22448035 10.1242/jcs.093849 1:CAS:528:DC%2BC38Xmsl2ntbo%3D
    • Jin SM, Youle RJ (2012) PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci 125:795-799
    • (2012) J Cell Sci , vol.125 , pp. 795-799
    • Jin, S.M.1    Youle, R.J.2
  • 32
    • 33749580026 scopus 로고    scopus 로고
    • Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: Role of cathepsin-D in methamphetamine- induced apoptotic cell death
    • 17105920 10.1196/annals.1369.022 1:CAS:528:DC%2BD28XhtFGgs7zI
    • Kanthasamy A, Anantharam V, Ali SF, Kanthasamy AG (2006) Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-D in methamphetamine-induced apoptotic cell death. Ann NY Acad Sci 1074:234-244
    • (2006) Ann NY Acad Sci , vol.1074 , pp. 234-244
    • Kanthasamy, A.1    Anantharam, V.2    Ali, S.F.3    Kanthasamy, A.G.4
  • 33
    • 34249934085 scopus 로고    scopus 로고
    • Selective degradation of mitochondria by mitophagy
    • 17475204 10.1016/j.abb.2007.03.034 1:CAS:528:DC%2BD2sXmt1ygs70%3D
    • Kim I, Rodriguez-Enriquez S, Lemasters JJ (2007) Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462:245-253
    • (2007) Arch Biochem Biophys , vol.462 , pp. 245-253
    • Kim, I.1    Rodriguez-Enriquez, S.2    Lemasters, J.J.3
  • 34
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • 18188003 1:CAS:528:DC%2BD1cXksFGrtLg%3D
    • Klionsky DJ, Abeliovich H, Agostinis P et al (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3
  • 36
    • 0017806745 scopus 로고
    • Ultrastructural and biochemical aspects of liver mitochondria during recovery from ethanol-induced alterations. Experimental evidence of mitochondrial division
    • 623205 1:CAS:528:DyaE1cXhsVOit7Y%3D
    • Koch OR, Roatta de Conti LL, Bolaños LP, Stoppani AO (1978) Ultrastructural and biochemical aspects of liver mitochondria during recovery from ethanol-induced alterations. Experimental evidence of mitochondrial division. Am J Pathol 90:325-344
    • (1978) Am J Pathol , vol.90 , pp. 325-344
    • Koch, O.R.1    Roatta De Conti, L.L.2    Bolaños, L.P.3    Stoppani, A.O.4
  • 37
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • 20965422 10.1016/j.molcel.2010.09.023 1:CAS:528:DC%2BC3cXhtlCjtr%2FM
    • Kroemer G, Mariño G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40:280-293
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 38
    • 0024326007 scopus 로고
    • Experimental methods of ethanol administration
    • 2673971 10.1002/hep.1840100417 1:CAS:528:DyaL1MXmt1KltLo%3D
    • Lieber CS, De Carli LM, Sorrell MF (1989) Experimental methods of ethanol administration. Hepatology 10:501-510
    • (1989) Hepatology , vol.10 , pp. 501-510
    • Lieber, C.S.1    De Carli, L.M.2    Sorrell, M.F.3
  • 39
    • 61949233502 scopus 로고    scopus 로고
    • Autophagy in atherosclerosis: A cell survival and death phenomenon with therapeutic potential
    • 19213965 10.1161/CIRCRESAHA.108.188318 1:CAS:528:DC%2BD1MXhsV2jsLk%3D
    • Martinet W, De Meyer GR (2009) Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential. Circ Res 104:304-317
    • (2009) Circ Res , vol.104 , pp. 304-317
    • Martinet, W.1    De Meyer, G.R.2
  • 42
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • 14699058 10.1091/mbc.E03-09-0704 1:CAS:528:DC%2BD2cXitlGhu7g%3D
    • Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15:1101-1111
    • (2004) Mol Biol Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 43
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • 20144757 10.1016/j.cell.2010.01.028 1:CAS:528:DC%2BC3cXlt1KlsLc%3D
    • Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313-326
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 44
    • 77958494723 scopus 로고    scopus 로고
    • Protective effects of crude garlic by reducing iron-mediated oxidative stress, proliferation and autophagy in rats
    • 20700633 10.1007/s10735-010-9283-5
    • Nahdi A, Hammami I, Kouidhi W, Chargui A, Ben Ammar A, Hamdaoui MH, El May A, El May M (2010) Protective effects of crude garlic by reducing iron-mediated oxidative stress, proliferation and autophagy in rats. J Mol Histol 41:233-245
    • (2010) J Mol Histol , vol.41 , pp. 233-245
    • Nahdi, A.1    Hammami, I.2    Kouidhi, W.3    Chargui, A.4    Ben Ammar, A.5    Hamdaoui, M.H.6    El May, A.7    El May, M.8
  • 45
    • 79954577302 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction: Role for PINK1 and Parkin in mitochondrial quality control
    • 21194381 10.1089/ars.2010.3799 1:CAS:528:DC%2BC3MXkvVSqsro%3D
    • Narendra DP, Youle RJ (2011) Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal 14:1929-1938
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1929-1938
    • Narendra, D.P.1    Youle, R.J.2
  • 47
    • 84863430453 scopus 로고    scopus 로고
    • Mitophagy: A complex mechanism of mitochondrial removal
    • 22077334 10.1089/ars.2011.4407 1:CAS:528:DC%2BC38XpsFKmu7c%3D
    • Novak I (2012) Mitophagy: a complex mechanism of mitochondrial removal. Antioxid Redox Signal 17:794-802
    • (2012) Antioxid Redox Signal , vol.17 , pp. 794-802
    • Novak, I.1
  • 48
    • 35748962285 scopus 로고    scopus 로고
    • An immunohistochemical approach to differentiate hepatic lipidosis from hepatic phospholipidosis in rats
    • 17763287 10.1080/01926230701481956 1:CAS:528:DC%2BD2sXhtVaktrjM
    • Obert LA, Sobocinski GP, Bobrowski WF, Metz AL, Rolsma MD, Altrogge DM, Dunstan RW (2007) An immunohistochemical approach to differentiate hepatic lipidosis from hepatic phospholipidosis in rats. Toxicol Pathol 35:728-734
    • (2007) Toxicol Pathol , vol.35 , pp. 728-734
    • Obert, L.A.1    Sobocinski, G.P.2    Bobrowski, W.F.3    Metz, A.L.4    Rolsma, M.D.5    Altrogge, D.M.6    Dunstan, R.W.7
  • 49
    • 79957802692 scopus 로고    scopus 로고
    • Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis
    • 21633655 10.3748/wjg.v17.i20.2507
    • Osna NA, Thomes PG, Donohue TM Jr (2011) Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J Gastroenterol 17:2507-2514
    • (2011) World J Gastroenterol , vol.17 , pp. 2507-2514
    • Osna, N.A.1    Thomes, P.G.2    Donohue, Jr.T.M.3
  • 50
    • 70349750492 scopus 로고    scopus 로고
    • Rapamycin protects against rotenone-induced apoptosis through autophagy induction
    • 19682553 10.1016/j.neuroscience.2009.08.014 1:CAS:528:DC%2BD1MXht1Gns7jP
    • Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W (2009) Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience 164:541-551
    • (2009) Neuroscience , vol.164 , pp. 541-551
    • Pan, T.1    Rawal, P.2    Wu, Y.3    Xie, W.4    Jankovic, J.5    Le, W.6
  • 51
    • 70350059677 scopus 로고    scopus 로고
    • Postischemic treatment of neonatal cerebral ischemia should target autophagy
    • 19551849 10.1002/ana.21714 1:CAS:528:DC%2BD1MXhtlCgt7fF
    • Puyal J, Vaslin A, Mottier V, Clarke PG (2009) Postischemic treatment of neonatal cerebral ischemia should target autophagy. Ann Neurol 66:378-389
    • (2009) Ann Neurol , vol.66 , pp. 378-389
    • Puyal, J.1    Vaslin, A.2    Mottier, V.3    Clarke, P.G.4
  • 52
    • 79953136700 scopus 로고    scopus 로고
    • Autophagy and lipids: Tightening the knot
    • 20730586 10.1007/s00281-010-0219-7 1:CAS:528:DC%2BC3cXhsFCgt73L
    • Rodriguez-Navarro JA, Cuervo AM (2010) Autophagy and lipids: tightening the knot. Semin Immunopathol 32:343-353
    • (2010) Semin Immunopathol , vol.32 , pp. 343-353
    • Rodriguez-Navarro, J.A.1    Cuervo, A.M.2
  • 53
    • 77949398364 scopus 로고    scopus 로고
    • Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis
    • 19959713 10.1681/ASN.2009040383 1:CAS:528:DC%2BC3cXislSqtLk%3D
    • Sansanwal P, Yen B, Gahl WA, Ma Y, Ying L, Wong LJ, Sarwal MM (2010) Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis. J Am Soc Nephrol 21:272-283
    • (2010) J Am Soc Nephrol , vol.21 , pp. 272-283
    • Sansanwal, P.1    Yen, B.2    Gahl, W.A.3    Ma, Y.4    Ying, L.5    Wong, L.J.6    Sarwal, M.M.7
  • 54
    • 80052414817 scopus 로고    scopus 로고
    • Immunohistochemical localization of autophagosomal membrane-associated protein LC3 in granular cell tumor and schwannoma
    • 10.1007/s00428-011-1104-z 21674156
    • Shintaku M (2011) Immunohistochemical localization of autophagosomal membrane-associated protein LC3 in granular cell tumor and schwannoma. Virchows Arch. doi: 10.1007/s00428-011-1104-z
    • (2011) Virchows Arch
    • Shintaku, M.1
  • 55
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: Connecting autophagy and lipid metabolism
    • 10.1155/2012/282041 22536247
    • Singh R, Cuervo AM (2012) Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol 2012:282041. doi: 10.1155/2012/282041
    • (2012) Int J Cell Biol , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 59
    • 84855779289 scopus 로고    scopus 로고
    • Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment
    • 22142844 10.1016/j.bbrc.2011.11.097 1:CAS:528:DC%2BC38Xos1Onug%3D%3D
    • Thomes PG, Trambly CS, Thiele GM, Duryee MJ, Fox HS, Haorah J, Donohue TM Jr (2012) Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment. Biochem Biophys Res Commun 417:262-267
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 262-267
    • Thomes, P.G.1    Trambly, C.S.2    Thiele, G.M.3    Duryee, M.J.4    Fox, H.S.5    Haorah, J.6    Donohue, Jr.T.M.7
  • 62
    • 84867273800 scopus 로고    scopus 로고
    • ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
    • 22889933 1:CAS:528:DC%2BC3sXisVGgsLk%3D
    • Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK (2012) ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 8:1462-1476
    • (2012) Autophagy , vol.8 , pp. 1462-1476
    • Wang, Y.1    Nartiss, Y.2    Steipe, B.3    McQuibban, G.A.4    Kim, P.K.5
  • 64
    • 34249859423 scopus 로고    scopus 로고
    • Ethanol induced mitochondria injury and permeability transition pore opening: Role of mitochondria in alcoholic liver disease
    • 17511037 10.3748/wjg.13.6598 1:CAS:528:DC%2BD2sXntFyjurg%3D
    • Yan M, Zhu P, Liu HM, Zhang HT, Liu L (2007) Ethanol induced mitochondria injury and permeability transition pore opening: role of mitochondria in alcoholic liver disease. World J Gastroenterol 13:2352-2356
    • (2007) World J Gastroenterol , vol.13 , pp. 2352-2356
    • Yan, M.1    Zhu, P.2    Liu, H.M.3    Zhang, H.T.4    Liu, L.5
  • 65
    • 59649088562 scopus 로고    scopus 로고
    • Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases
    • 19216904 10.1016/S0076-6879(08)04006-8 1:CAS:528:DC%2BD1MXpsFaqu7g%3D
    • Yang DS, Lee JH, Nixon RA (2009) Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases. Methods Enzymol 453:111-114
    • (2009) Methods Enzymol , vol.453 , pp. 111-114
    • Yang, D.S.1    Lee, J.H.2    Nixon, R.A.3
  • 66
    • 79251555655 scopus 로고    scopus 로고
    • Histopathological evaluation of fatty and alcoholic liver diseases
    • 21091934 10.1111/j.1751-2980.2010.00472.x
    • Yerian L (2011) Histopathological evaluation of fatty and alcoholic liver diseases. J Dig Dis. 12:17-24
    • (2011) J Dig Dis. , vol.12 , pp. 17-24
    • Yerian, L.1
  • 67
    • 78650467974 scopus 로고    scopus 로고
    • Mechanisms of mitophagy
    • 21179058 10.1038/nrm3028 1:CAS:528:DC%2BC3cXhsF2murvF
    • Youle RJ, Narendra DP (2011) Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12:9-14
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 9-14
    • Youle, R.J.1    Narendra, D.P.2
  • 68
    • 84863122866 scopus 로고    scopus 로고
    • Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: Role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis
    • 22234172 10.1016/j.ajpath.2011.11.017 1:CAS:528:DC%2BC38XksFaqsLY%3D
    • Zhong W, Zhao Y, Tang Y, Wei X, Shi X, Sun W, Sun X, Yin X, Sun X, Kim S, McClain CJ, Zhang X, Zhou Z (2012) Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. Am J Pathol 180:998-1007
    • (2012) Am J Pathol , vol.180 , pp. 998-1007
    • Zhong, W.1    Zhao, Y.2    Tang, Y.3    Wei, X.4    Shi, X.5    Sun, W.6    Sun, X.7    Yin, X.8    Sun, X.9    Kim, S.10    McClain, C.J.11    Zhang, X.12    Zhou, Z.13


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