Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Li, Jie ^a,b   Pak, Stephen C ^a,b   O'Reilly, Linda P ^a,b   Benson, Joshua A ^a,b   Wang, Yan ^a,b   Hidvegi, Tunda ^a,b   Hale, Pamela ^a,b   Dippold, Christine ^a,b   Ewing, Michael ^a,b   Silverman, Gary A ^a,b   Perlmutter, David H ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; FLUPHENAZINE;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; BIOACCUMULATION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER FIBROSIS; MOUSE; NONHUMAN; PATHOGEN LOAD; PHENOTYPE; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEOTOXICITY; UPREGULATION;

ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIPSYCHOTIC AGENTS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; FLUPHENAZINE; GREEN FLUORESCENT PROTEINS; HELA CELLS; HEP G2 CELLS; HUMANS; IMMUNOBLOTTING; LIVER; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MUTATION; PHAGOSOMES; SURVIVAL ANALYSIS;

EID: 84900326348     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087260     Document Type: Article

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