메뉴 건너뛰기




Volumn 10, Issue 7, 2009, Pages 458-467

Dynamics and diversity in autophagy mechanisms: Lessons from yeast

Author keywords

[No Author keywords available]

Indexed keywords

ATG1 KINASE; ATG12 PROTEIN; ATG13 PROTEIN; ATG17 PROTEIN; ATG29 PROTEIN; ATG31 PROTEIN; ATG8 PROTEIN; AUTOPHAGY RELATED GENE PROTEIN; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

EID: 67649467294     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2708     Document Type: Review
Times cited : (1410)

References (103)
  • 1
    • 0014148066 scopus 로고
    • Participation of lysosomes in cellular autophagy induced in rat liver by glucagon
    • Deter, R. L., Baudhuin, P. & De Duve, C. Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J. Cell Biol. 35, C11-C16 (1967).
    • (1967) J. Cell Biol , vol.35
    • Deter, R.L.1    Baudhuin, P.2    De Duve, C.3
  • 2
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • Klionsky, D. J. Autophagy: from phenomenology to molecular understanding in less than a decade. Nature Rev. Mol. Cell Biol. 8, 931-937 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 931-937
    • Klionsky, D.J.1
  • 3
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima, N. Autophagy: process and function. Genes Dev. 21, 2861-2873 (2007).
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 4
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008).
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 5
    • 0026668042 scopus 로고
    • Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
    • Takeshige, K., Baba, M., Tsuboi, S., Noda, T. & Ohsumi, Y. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J. Cell Biol. 119, 301-311 (1992).
    • (1992) J. Cell Biol , vol.119 , pp. 301-311
    • Takeshige, K.1    Baba, M.2    Tsuboi, S.3    Noda, T.4    Ohsumi, Y.5
  • 6
    • 0028230738 scopus 로고
    • Ultrastructural analysis of the autophagic process in yeast: Detection of autophagosomes and their characterization
    • Baba, M., Takeshige, K., Baba, N. & Ohsumi, Y. Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J. Cell Biol. 124, 903-913 (1994).
    • (1994) J. Cell Biol , vol.124 , pp. 903-913
    • Baba, M.1    Takeshige, K.2    Baba, N.3    Ohsumi, Y.4
  • 7
    • 0029414780 scopus 로고
    • Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method
    • Baba, M., Osumi, M. & Ohsumi, Y. Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method. Cell Struct. Funct. 20, 465-471 (1995).
    • (1995) Cell Struct. Funct , vol.20 , pp. 465-471
    • Baba, M.1    Osumi, M.2    Ohsumi, Y.3
  • 8
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
    • Tsukada, M. & Ohsumi, Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 333, 169-174 (1993).
    • (1993) FEBS Lett , vol.333 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 9
    • 0031417385 scopus 로고    scopus 로고
    • Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome
    • Baba, M., Osumi, M., Scott, S. V., Klionsky, D. J. & Ohsumi, Y. Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. J.Cell Biol. 139, 1687-1695 (1997).
    • (1997) J.Cell Biol , vol.139 , pp. 1687-1695
    • Baba, M.1    Osumi, M.2    Scott, S.V.3    Klionsky, D.J.4    Ohsumi, Y.5
  • 10
    • 0029953575 scopus 로고    scopus 로고
    • Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
    • Harding, T. M., Hefner-Gravink, A., Thumm, M. & Klionsky, D. J. Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J. Biol. Chem. 271, 17621-17624 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 17621-17624
    • Harding, T.M.1    Hefner-Gravink, A.2    Thumm, M.3    Klionsky, D.J.4
  • 11
    • 0027936092 scopus 로고
    • Isolation of autophagocytasis mutants of Saccharomyces cerevisiae
    • Thumm, M. et al. Isolation of autophagocytasis mutants of Saccharomyces cerevisiae. FEBS Lett. 349, 275-280 (1994).
    • (1994) FEBS Lett , vol.349 , pp. 275-280
    • Thumm, M.1
  • 12
    • 0030883562 scopus 로고    scopus 로고
    • Glucose-induced microautophagy in Pichia pastoris requires the α-subunit of phosphofructokinase
    • Yuan, W., Tuttle, D. L., Shi, Y. J., Ralph, G. S. & Dunn, W. A. Jr. Glucose-induced microautophagy in Pichia pastoris requires the α-subunit of phosphofructokinase. J. Cell Sci. 110, 1935-1945 (1997).
    • (1997) J. Cell Sci , vol.110 , pp. 1935-1945
    • Yuan, W.1    Tuttle, D.L.2    Shi, Y.J.3    Ralph, G.S.4    Dunn Jr., W.A.5
  • 13
    • 0032482219 scopus 로고    scopus 로고
    • Peroxisome degradation by microautophagy in Pichia pastoris: Identification of specific steps and morphological intermediates
    • Sakai, Y., Koller, A., Rangell, L. K., Keller, G. A. & Subramani, S. Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates. J.Cell Biol. 141, 625-636 (1998).
    • (1998) J.Cell Biol , vol.141 , pp. 625-636
    • Sakai, Y.1    Koller, A.2    Rangell, L.K.3    Keller, G.A.4    Subramani, S.5
  • 14
    • 0036163982 scopus 로고    scopus 로고
    • Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy
    • Mukaiyama, H. et al. Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy. Genes Cells 7, 75-90 (2002).
    • (2002) Genes Cells , vol.7 , pp. 75-90
    • Mukaiyama, H.1
  • 15
    • 0028855063 scopus 로고
    • Isolation and characterization of mutants impaired in the selective degradation of peroxisomes in the yeast Hansenula polymorpha
    • Titorenko, V. I., Keizer, I., Harder, W. & Veenhuis, M. Isolation and characterization of mutants impaired in the selective degradation of peroxisomes in the yeast Hansenula polymorpha. J. Bacteriol. 177, 357-363 (1995).
    • (1995) J. Bacteriol , vol.177 , pp. 357-363
    • Titorenko, V.I.1    Keizer, I.2    Harder, W.3    Veenhuis, M.4
  • 16
    • 10744225487 scopus 로고    scopus 로고
    • A unified nomenclature for yeast autophagy-related genes
    • Klionsky, D. J. et al. A unified nomenclature for yeast autophagy-related genes. Dev. Cell 5, 539-545 (2003).
    • (2003) Dev. Cell , vol.5 , pp. 539-545
    • Klionsky, D.J.1
  • 17
    • 0034683568 scopus 로고    scopus 로고
    • Tor-mediated induction of autophagy via an Apg1 protein kinase complex
    • Kamada, Y. et al. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Celil Biol. 150, 1507-1513(2000).
    • (2000) J. Celil Biol , vol.150 , pp. 1507-1513
    • Kamada, Y.1
  • 18
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
    • Kihara, A., Noda, T., Ishihara, N. & Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530 (2001).
    • (2001) J. Cell Biol , vol.152 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 19
    • 0032563798 scopus 로고    scopus 로고
    • A protein conjugation system essential for autophagy
    • Mizushima, N. et al. A protein conjugation system essential for autophagy. Nature 395, 395-398 (1998).
    • (1998) Nature , vol.395 , pp. 395-398
    • Mizushima, N.1
  • 20
    • 0034707036 scopus 로고    scopus 로고
    • A ubiquitin-like system mediates protein lipidation
    • Ichimura, Y. et al. A ubiquitin-like system mediates protein lipidation. Nature 408, 488-492 (2000).
    • (2000) Nature , vol.408 , pp. 488-492
    • Ichimura, Y.1
  • 21
    • 0035839551 scopus 로고    scopus 로고
    • Apg2p functions in autophagosome formation on the perivacuolar structure
    • Shintani, T., Suzuki, K., Kamada, Y., Noda, T. & Ohsumi, Y. Apg2p functions in autophagosome formation on the perivacuolar structure. J. Biol. Chem. 276, 30452-30460 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 30452-30460
    • Shintani, T.1    Suzuki, K.2    Kamada, Y.3    Noda, T.4    Ohsumi, Y.5
  • 22
    • 0035839430 scopus 로고    scopus 로고
    • Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways
    • Wang, C. W. et al. Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J. Biol. Chem. 276, 30442-30451 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 30442-30451
    • Wang, C.W.1
  • 23
    • 0034614934 scopus 로고    scopus 로고
    • Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways
    • Noda, T. et al. Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J. Cell Biol. 148, 465-480 (2000).
    • (2000) J. Cell Biol , vol.148 , pp. 465-480
    • Noda, T.1
  • 24
    • 0035834395 scopus 로고    scopus 로고
    • Autophagy and the cytoplasm to vacuole targeting pathway both require Aut1 Op
    • Barth, H., Meiling-Wesse, K., Epple, U. D. & Thumm, M. Autophagy and the cytoplasm to vacuole targeting pathway both require Aut1 Op. FESS Lett. 508, 23-28 (2001).
    • (2001) FESS Lett , vol.508 , pp. 23-28
    • Barth, H.1    Meiling-Wesse, K.2    Epple, U.D.3    Thumm, M.4
  • 25
    • 0032701984 scopus 로고    scopus 로고
    • Formation process of autophagosome is traced with Apg8/Aut7p in yeast
    • Kirisako, T. et al. Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J. Cell Biol. 147, 435-446 (1999).
    • (1999) J. Cell Biol , vol.147 , pp. 435-446
    • Kirisako, T.1
  • 26
    • 0035503594 scopus 로고    scopus 로고
    • The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
    • Suzuki, K. et al. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 20, 5971-5981 (2001).
    • (2001) EMBO J , vol.20 , pp. 5971-5981
    • Suzuki, K.1
  • 27
    • 33846514235 scopus 로고    scopus 로고
    • Hierarchy of Atg proteins in pre-autophagosomal structure organization
    • Suzuki, K., Kubota, Y., Sekito, T. & Ohsumi, Y. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12, 209-218 (2007).
    • (2007) Genes Cells , vol.12 , pp. 209-218
    • Suzuki, K.1    Kubota, Y.2    Sekito, T.3    Ohsumi, Y.4
  • 28
    • 50249154070 scopus 로고    scopus 로고
    • In vivo reconstitution of autophagy in Saccharomyces cerevisiae
    • Cao, Y., Cheong, H., Song, H. & Klionsky, D. J. In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J. Cell Biol. 182, 703-713 (2008).
    • (2008) J. Cell Biol , vol.182 , pp. 703-713
    • Cao, Y.1    Cheong, H.2    Song, H.3    Klionsky, D.J.4
  • 29
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • Noda, T. & Ohsumi, Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 30
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R. & Hall, M. N. TOR signaling in growth and metabolism. Cell 124, 471-484 (2006).
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 31
    • 34948828483 scopus 로고    scopus 로고
    • Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae
    • Yorimitsu, T., Zaman, S., Broach, J. R. & Klionsky, D. J. Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol. Biol. Cell 18, 4180-4189 (2007).
    • (2007) Mol. Biol. Cell , vol.18 , pp. 4180-4189
    • Yorimitsu, T.1    Zaman, S.2    Broach, J.R.3    Klionsky, D.J.4
  • 32
    • 2442645050 scopus 로고    scopus 로고
    • The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae
    • Budovskaya, Y. V., Stephan, J. S., Reggiori, F., Klionsky, D. J. & Herman, P. K. The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J. Biol. Chem. 279, 20663-20671 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 20663-20671
    • Budovskaya, Y.V.1    Stephan, J.S.2    Reggiori, F.3    Klionsky, D.J.4    Herman, P.K.5
  • 33
    • 0030983504 scopus 로고    scopus 로고
    • Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
    • Matsuura, A., Tsukada, M., Wada, Y. & Ohsumi, Y. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192, 245-250 (1997).
    • (1997) Gene , vol.192 , pp. 245-250
    • Matsuura, A.1    Tsukada, M.2    Wada, Y.3    Ohsumi, Y.4
  • 34
    • 0030919092 scopus 로고    scopus 로고
    • Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae
    • Funakoshi, T., Matsuura, A., Noda, T. & Ohsumi, Y. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene 192, 207-213 (1997).
    • (1997) Gene , vol.192 , pp. 207-213
    • Funakoshi, T.1    Matsuura, A.2    Noda, T.3    Ohsumi, Y.4
  • 35
    • 18244394277 scopus 로고    scopus 로고
    • Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy
    • Kabeya, Y. et al. Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol. Biol. Cell 16, 2544-2553 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2544-2553
    • Kabeya, Y.1
  • 36
    • 27844461994 scopus 로고    scopus 로고
    • Characterization of a novel autophagy-specific gene, ATG29
    • Kawamata, T. et al. Characterization of a novel autophagy-specific gene, ATG29. Biochem. Biophys. Res. Commun. 338, 1884-1889 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.338 , pp. 1884-1889
    • Kawamata, T.1
  • 37
    • 33947378818 scopus 로고    scopus 로고
    • Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae
    • Kabeya, Y., Kawamata, T., Suzuki, K. & Ohsumi, Y. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 356, 405-410 (2007).
    • (2007) Biochem. Biophys. Res. Commun , vol.356 , pp. 405-410
    • Kabeya, Y.1    Kawamata, T.2    Suzuki, K.3    Ohsumi, Y.4
  • 38
    • 43149125546 scopus 로고    scopus 로고
    • Organization of the pre-autophagosomal structure responsible for autophagosome formation
    • Kawamata, T., Kamada, Y., Kabeya, Y., Sekito, T. & Ohsumi, Y. Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol. Biol. Cell 19, 2039-2050 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2039-2050
    • Kawamata, T.1    Kamada, Y.2    Kabeya, Y.3    Sekito, T.4    Ohsumi, Y.5
  • 39
    • 39449108917 scopus 로고    scopus 로고
    • The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae
    • Cheong, H., Nair, U., Geng, J. & Klionsky, D. J. The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol. Biol. Cell 19, 668-681 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 668-681
    • Cheong, H.1    Nair, U.2    Geng, J.3    Klionsky, D.J.4
  • 40
    • 21844470747 scopus 로고    scopus 로고
    • Atg17 regulates the magnitude of the autophagic response
    • Cheong, H. et al. Atg17 regulates the magnitude of the autophagic response. Mol. Biol. Cell 16, 3438-3453 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3438-3453
    • Cheong, H.1
  • 41
    • 65449186232 scopus 로고    scopus 로고
    • Atg17 recruits Atg9 to organize the pre-autophagosomal structure
    • Sekito, T., Kawamata, T., Ichikawa, R., Suzuki, K. & Ohsumi, Y. Atg17 recruits Atg9 to organize the pre-autophagosomal structure. Genes Cells 14, 525-538 (2009).
    • (2009) Genes Cells , vol.14 , pp. 525-538
    • Sekito, T.1    Kawamata, T.2    Ichikawa, R.3    Suzuki, K.4    Ohsumi, Y.5
  • 42
    • 14044277429 scopus 로고    scopus 로고
    • The molecular machinery of autophagy: Unanswered questions
    • Klionsky, D. J. The molecular machinery of autophagy: unanswered questions. J. Cell Sci. 118, 7-18 (2005).
    • (2005) J. Cell Sci , vol.118 , pp. 7-18
    • Klionsky, D.J.1
  • 43
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • Hara, T. et al. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 181, 497-510 (2008).
    • (2008) J. Cell Biol , vol.181 , pp. 497-510
    • Hara, T.1
  • 44
    • 58149473473 scopus 로고    scopus 로고
    • Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
    • Chan, E. Y., Longatti, A., McKnight, N. C. & Tooze, S. A. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol. Cell. Biol. 29, 157-171 (2009).
    • (2009) Mol. Cell. Biol , vol.29 , pp. 157-171
    • Chan, E.Y.1    Longatti, A.2    McKnight, N.C.3    Tooze, S.A.4
  • 45
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1-Atg1 3-FIP200 complex required for autophagy
    • Hosokawa, N. et al. Nutrient-dependent mTORC1 association with the ULK1-Atg1 3-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1
  • 46
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    • Chang, Y. Y. & Neufeld, T. P. An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol. Biol. Cell 20, 2004-2014 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 47
    • 65249176304 scopus 로고    scopus 로고
    • ULK - Atg13 - FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • Jung. et al. ULK - Atg13 - FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992-2003 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1992-2003
    • Jung1
  • 48
    • 66449083078 scopus 로고    scopus 로고
    • ULKI, ATG13, FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley. et al. ULKI, ATG13, FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem. 284, 12297-12305.
    • J. Biol. Chem , vol.284 , pp. 12297-12305
    • Ganley1
  • 49
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot, A., Ogier-Denis, E., Blommaart, E. F., Meijer, A. J. & Codogno, P. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275, 992-998 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 50
    • 53049102656 scopus 로고    scopus 로고
    • The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function
    • Obara, K., Sekito, T., Niimi. K. & Ohsumi, Y. The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J. Biol. Chem. 283, 23972-23980 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 23972-23980
    • Obara, K.1    Sekito, T.2    Niimi, K.3    Ohsumi, Y.4
  • 51
    • 0027905021 scopus 로고
    • Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
    • Schu, P. V. et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260, 88-91 (1993).
    • (1993) Science , vol.260 , pp. 88-91
    • Schu, P.V.1
  • 52
    • 33745086418 scopus 로고    scopus 로고
    • Assortment of phosphatidylinositol 3-kinase complexes-Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae
    • Obara, K., Sekito, T. & Ohsumi, Y. Assortment of phosphatidylinositol 3-kinase complexes-Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol. Biol. Cell 17, 1527-1539 (2006).
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1527-1539
    • Obara, K.1    Sekito, T.2    Ohsumi, Y.3
  • 53
    • 3142583199 scopus 로고    scopus 로고
    • Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
    • Dove, S. K. et al. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 23, 1922-1933 (2004).
    • (2004) EMBO J , vol.23 , pp. 1922-1933
    • Dove, S.K.1
  • 54
    • 3342951135 scopus 로고    scopus 로고
    • Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy
    • Stromhaug, P. E., Reggiori, F, Guan, J., Wang, C. W. & Klionsky, D. J. Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol. Biol. Cell 15, 3553-3566 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 3553-3566
    • Stromhaug, P.E.1    Reggiori, F.2    Guan, J.3    Wang, C.W.4    Klionsky, D.J.5
  • 55
    • 35848929068 scopus 로고    scopus 로고
    • Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate
    • Efe, J. A., Botelho, R. J. & Emr, S. D. Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol. Biol. Cell 18, 4232-4244 (2007).
    • (2007) Mol. Biol. Cell , vol.18 , pp. 4232-4244
    • Efe, J.A.1    Botelho, R.J.2    Emr, S.D.3
  • 56
    • 44449115788 scopus 로고    scopus 로고
    • Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in S. cerevisiae
    • Obara, K., Noda, T., Niimi, K. & Ohsumi, Y. Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in S. cerevisiae. Genes Cells, 13, 537-547 (2008).
    • (2008) Genes Cells , vol.13 , pp. 537-547
    • Obara, K.1    Noda, T.2    Niimi, K.3    Ohsumi, Y.4
  • 57
    • 0346503885 scopus 로고    scopus 로고
    • The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure
    • Reggiori, F., Tucker, K. A., Stromhaug, P. E. & Klionsky, D. J. The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev. Cell 6, 79-90 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 79-90
    • Reggiori, F.1    Tucker, K.A.2    Stromhaug, P.E.3    Klionsky, D.J.4
  • 58
    • 33750366092 scopus 로고    scopus 로고
    • Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
    • Young, A. R. et al. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J. Cell Sci. 119, 3888-3900 (2006).
    • (2006) J. Cell Sci , vol.119 , pp. 3888-3900
    • Young, A.R.1
  • 59
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • Xie, Z. & Klionsky, D. J. Autophagosome formation: core machinery and adaptations. Nature Cell Biol. 9, 1102-1109 (2007).
    • (2007) Nature Cell Biol , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 60
    • 59449097721 scopus 로고    scopus 로고
    • Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy
    • He, C., Baba, M., Cao, Y. & Klionsky, D. J. Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol. Biol. Cell 19, 5506-5516 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5506-5516
    • He, C.1    Baba, M.2    Cao, Y.3    Klionsky, D.J.4
  • 61
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • Mizushima, N. et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 152, 657-668 (2001).
    • (2001) J. Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1
  • 62
    • 0034676037 scopus 로고    scopus 로고
    • The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
    • Kirisako, T. et al. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell Biol. 151, 263-276 (2000).
    • (2000) J. Cell Biol , vol.151 , pp. 263-276
    • Kirisako, T.1
  • 63
    • 0035825175 scopus 로고    scopus 로고
    • Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex
    • Kim, J., Huang, W. P. & Klionsky, D. J. Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J. Cell Biol. 152, 51-64 (2001).
    • (2001) J. Cell Biol , vol.152 , pp. 51-64
    • Kim, J.1    Huang, W.P.2    Klionsky, D.J.3
  • 64
    • 34447099450 scopus 로고    scopus 로고
    • Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
    • Nakatogawa, H., Ichimura, Y. & Ohsumi, Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130, 165-178 (2007).
    • (2007) Cell , vol.130 , pp. 165-178
    • Nakatogawa, H.1    Ichimura, Y.2    Ohsumi, Y.3
  • 65
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBOJ. 19, 5720-5728(2000).
    • (2000) EMBOJ , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 66
    • 14744268915 scopus 로고    scopus 로고
    • Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy
    • Yoshimoto, K. et al. Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell 16, 2967-2983 (2004).
    • (2004) Plant Cell , vol.16 , pp. 2967-2983
    • Yoshimoto, K.1
  • 67
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151-175 (2008).
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1
  • 68
    • 4644362024 scopus 로고    scopus 로고
    • in vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy
    • Ichimura, Y. et al. in vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J. Biol. Chem. 279, 40584-40592 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 40584-40592
    • Ichimura, Y.1
  • 69
    • 47549092694 scopus 로고    scopus 로고
    • Atg8 controls phagophore expansion during autophagosome formation
    • Xie, Z., Nair, U. & Klionsky, D. J. Atg8 controls phagophore expansion during autophagosome formation. Mol. Biol. Cell 19, 3290-3298 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3290-3298
    • Xie, Z.1    Nair, U.2    Klionsky, D.J.3
  • 70
    • 58149290220 scopus 로고    scopus 로고
    • An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure
    • Fujita, N. et al. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol. Biol. Cell 19, 4651-4659 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4651-4659
    • Fujita, N.1
  • 71
    • 57549094368 scopus 로고    scopus 로고
    • The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
    • Sou, Y. S. et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol. Biol. Cell 19, 4762-4775 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4762-4775
    • Sou, Y.S.1
  • 72
    • 0033565655 scopus 로고    scopus 로고
    • Apg16p is required for the function of the Apg12p - Apg5p conjugate in the yeast autophagy pathway
    • Mizushima, N., Noda, T. & Ohsumi, Y. Apg16p is required for the function of the Apg12p - Apg5p conjugate in the yeast autophagy pathway. EMBO J. 18, 3888-3896 (1999).
    • (1999) EMBO J , vol.18 , pp. 3888-3896
    • Mizushima, N.1    Noda, T.2    Ohsumi, Y.3
  • 73
    • 0037166241 scopus 로고    scopus 로고
    • Formation of the approximately 350-kDa Apg12 -Apg5, Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
    • Kuma, A., Mizushima, N., Ishihara, N. & Ohsumi, Y. Formation of the approximately 350-kDa Apg12 -Apg5, Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 277, 18619-18625 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 18619-18625
    • Kuma, A.1    Mizushima, N.2    Ishihara, N.3    Ohsumi, Y.4
  • 74
    • 0038325675 scopus 로고    scopus 로고
    • Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
    • Mizushima, N. et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 116, 1679-1688 (2003).
    • (2003) J. Cell Sci , vol.116 , pp. 1679-1688
    • Mizushima, N.1
  • 75
    • 47549086520 scopus 로고    scopus 로고
    • Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy
    • Geng, J., Baba, M., Nair, U. & Klionsky, D. J. Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J. Cell Biol. 182, 129-140 (2008).
    • (2008) J. Cell Biol , vol.182 , pp. 129-140
    • Geng, J.1    Baba, M.2    Nair, U.3    Klionsky, D.J.4
  • 76
    • 33745088813 scopus 로고    scopus 로고
    • Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy
    • Hanada, T. & Ohsumi, Y. Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy 1, 110-118 (2005).
    • (2005) Autophagy , vol.1 , pp. 110-118
    • Hanada, T.1    Ohsumi, Y.2
  • 77
    • 38049098543 scopus 로고    scopus 로고
    • The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
    • Hanada, T. et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J. Biol. Chem. 282, 37298-37302 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 37298-37302
    • Hanada, T.1
  • 78
    • 38349152489 scopus 로고    scopus 로고
    • In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy
    • Fujioka, Y. et al. In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy. J. Biol. Chem. 283, 1921-1928 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 1921-1928
    • Fujioka, Y.1
  • 79
    • 33645652024 scopus 로고    scopus 로고
    • Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16
    • Sou, Y. S., Tanida, I., Komatsu, M., Ueno, T. & Kominami, E. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J. Biol. Chem. 281, 3017-3024 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 3017-3024
    • Sou, Y.S.1    Tanida, I.2    Komatsu, M.3    Ueno, T.4    Kominami, E.5
  • 80
    • 52049091287 scopus 로고    scopus 로고
    • Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8
    • Oh-oka, K., Nakatogawa, H. & Ohsumi, Y. Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8. J. Biol. Chem. 283, 21847-21852 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 21847-21852
    • Oh-oka, K.1    Nakatogawa, H.2    Ohsumi, Y.3
  • 81
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
    • Fujita, N. et al. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol. Biol. Cell 19, 2092-2100 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1
  • 82
    • 0030997923 scopus 로고    scopus 로고
    • Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway
    • Kim, J., Scott, S. V., Oda, M. N. & Klionsky, D. J. Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway. J. Cell Biol. 137, 609-618 (1997).
    • (1997) J. Cell Biol , vol.137 , pp. 609-618
    • Kim, J.1    Scott, S.V.2    Oda, M.N.3    Klionsky, D.J.4
  • 83
    • 0034964443 scopus 로고    scopus 로고
    • Cvt19 isa receptor for the cytoplasm-to-vacuole targeting pathway
    • Scott, S. V., Guan, J., Hutchins, M. U., Kim, J. & Klionsky, D. J. Cvt19 isa receptor for the cytoplasm-to-vacuole targeting pathway. Mol. Cell 7, 1131-1141 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 1131-1141
    • Scott, S.V.1    Guan, J.2    Hutchins, M.U.3    Kim, J.4    Klionsky, D.J.5
  • 84
    • 0036901104 scopus 로고    scopus 로고
    • Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway
    • Shintani, T., Huang, W. P., Stromhaug, P. E. & Klionsky, D. J. Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev. Cell 3, 825-837 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 825-837
    • Shintani, T.1    Huang, W.P.2    Stromhaug, P.E.3    Klionsky, D.J.4
  • 85
    • 33947149637 scopus 로고    scopus 로고
    • Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy
    • Chang, C. Y. & Huang, W. P. Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy. Mol. Biol. Cell 18, 919-929 (2007).
    • (2007) Mol. Biol. Cell , vol.18 , pp. 919-929
    • Chang, C.Y.1    Huang, W.P.2
  • 86
    • 57249083972 scopus 로고    scopus 로고
    • Structural basis of target recognition by Atg8/LC3 during selective autophagy
    • Noda, N. N. et al. Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells 13, 1211-1218 (2008).
    • (2008) Genes Cells , vol.13 , pp. 1211-1218
    • Noda, N.N.1
  • 87
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy, G. et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J.Cell Biol. 171, 603-614 (2005).
    • (2005) J.Cell Biol , vol.171 , pp. 603-614
    • Bjorkoy, G.1
  • 88
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1
  • 89
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149-1163 (2007).
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1
  • 90
    • 52649121942 scopus 로고    scopus 로고
    • The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes
    • Shvets, E., Fass, E., Scherz-Shouval, R. & Elazar, Z. The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J. Cell Sci. 121, 2685-2695 (2008).
    • (2008) J. Cell Sci , vol.121 , pp. 2685-2695
    • Shvets, E.1    Fass, E.2    Scherz-Shouval, R.3    Elazar, Z.4
  • 91
    • 53049103308 scopus 로고    scopus 로고
    • Structural basis for sorting mechanism of p62 in selective autophagy
    • Ichimura, Y. et al. Structural basis for sorting mechanism of p62 in selective autophagy. J. Biol. Chem. 283, 22847-22857 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 22847-22857
    • Ichimura, Y.1
  • 92
    • 0037119448 scopus 로고    scopus 로고
    • Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy
    • Nice, D. C., Sato, T. K., Stromhaug, P. E., Emr, S. D. & Klionsky, D. J. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J. Biol. Chem. 277, 30198-30207 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 30198-30207
    • Nice, D.C.1    Sato, T.K.2    Stromhaug, P.E.3    Emr, S.D.4    Klionsky, D.J.5
  • 93
    • 0035897414 scopus 로고    scopus 로고
    • Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole
    • Kim, J. et al. Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J.Cell Biol. 153, 381-396 (2001).
    • (2001) J.Cell Biol , vol.153 , pp. 381-396
    • Kim, J.1
  • 94
    • 3142677196 scopus 로고    scopus 로고
    • Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway
    • Shintani, T. & Klionsky, D. J. Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J. Biol. Chem. 279, 29889-29894 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 29889-29894
    • Shintani, T.1    Klionsky, D.J.2
  • 95
    • 16344365254 scopus 로고    scopus 로고
    • Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway
    • Yorimitsu, T. & Klionsky, D. J. Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol. Biol. Cell 16, 1593-1605 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1593-1605
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 96
    • 42049094041 scopus 로고    scopus 로고
    • PpAtg30 tags peroxisomes for turnover by selective autophagy
    • Farre, J. C., Manjithaya, R., Mathewson, R. D. & Subramani, S. PpAtg30 tags peroxisomes for turnover by selective autophagy. Dev. Cell 14, 365-376 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 365-376
    • Farre, J.C.1    Manjithaya, R.2    Mathewson, R.D.3    Subramani, S.4
  • 97
    • 57749121573 scopus 로고    scopus 로고
    • Mitophagy in yeast occurs through a selective mechanism
    • Kanki, T. & Klionsky, D. J. Mitophagy in yeast occurs through a selective mechanism. J. Biol. Chem. 283, 32386-32393 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 32386-32393
    • Kanki, T.1    Klionsky, D.J.2
  • 98
    • 1842577042 scopus 로고    scopus 로고
    • Dictyostelium macroautophagy mutants vary in the severity of their developmental defects
    • Otto, G. P., Wu, M. Y., Kazgan, N., Anderson, O. R. & Kessin, R. H. Dictyostelium macroautophagy mutants vary in the severity of their developmental defects. J. Biol. Chem. 279, 15621-15629 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 15621-15629
    • Otto, G.P.1    Wu, M.Y.2    Kazgan, N.3    Anderson, O.R.4    Kessin, R.H.5
  • 99
    • 34250669930 scopus 로고    scopus 로고
    • An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination
    • Fujiki, Y. et al. An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol. 143, 1132-1139 (2007).
    • (2007) Plant Physiol , vol.143 , pp. 1132-1139
    • Fujiki, Y.1
  • 100
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • Ravikumar, B. et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genet. 36, 585-595 (2004).
    • (2004) Nature Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1
  • 101
    • 57749173129 scopus 로고    scopus 로고
    • Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae
    • Kageyama, T., Suzuki, K. & Ohsumi, Y. Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 378, 551-557 (2009).
    • (2009) Biochem. Biophys. Res. Commun , vol.378 , pp. 551-557
    • Kageyama, T.1    Suzuki, K.2    Ohsumi, Y.3
  • 102
    • 1942469479 scopus 로고    scopus 로고
    • Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae
    • Onodera, J. & Ohsumi, Y. Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae. J. Biol. Chem. 279, 16071-16076 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 16071-16076
    • Onodera, J.1    Ohsumi, Y.2
  • 103
    • 43049138051 scopus 로고    scopus 로고
    • Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
    • Kraft, C., Deplazes, A., Sohrmann, M. & Peter, M. Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nature Cell Biol. 10, 602-610 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 602-610
    • Kraft, C.1    Deplazes, A.2    Sohrmann, M.3    Peter, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.