Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 15, 2016, Pages 4039-4044

  Richter, Benjamin ^a   Sliter, Danielle A ^b   Herhaus, Lina ^a   Stolz, Alexandra ^a   Wang, Chunxin ^b   Beli, Petra ^c   Zaffagnini, Gabriele ^d   Wild, Philipp ^a,g   Martens, Sascha ^d   Wagner, Sebastian A ^e   Youle, Richard J ^b   Dikic, Ivan ^a,e,f  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

^d UNIVERSITY OF VIENNA   (Austria)

^e GOETHE UNIVERSITY   (Germany)

^f UNIVERSITY OF SPLIT   (Croatia)

^g ETH ZURICH   (Switzerland)

Author keywords

Mitophagy; OPTN; Phosphorylation; TBK1; Ubiquitin

Indexed keywords

OPTINEURIN; PEPTIDES AND PROTEINS; TANK BINDING KINASE 1; UBIQUITIN; UNCLASSIFIED DRUG; OPTN PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR IIIA;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MITOCHONDRION; MITOPHAGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; AUTOPHAGY; HELA CELL LINE; METABOLISM; PHOSPHORYLATION;

AUTOPHAGY; HELA CELLS; HUMANS; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR TFIIIA; UBIQUITIN;

EID: 84963566230     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523926113     Document Type: Article

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