메뉴 건너뛰기




Volumn 35, Issue 1, 2015, Pages 215-237

Autophagy and Lipid Droplets in the Liver

Author keywords

Lipases; Lipophagy; Lysosome; Metabolism; Steatosis

Indexed keywords

FAT DROPLET; TRIACYLGLYCEROL LIPASE; ATG7 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN 7; UBIQUITIN PROTEIN LIGASE;

EID: 84937545993     PISSN: 01999885     EISSN: 15454312     Source Type: Book Series    
DOI: 10.1146/annurev-nutr-071813-105336     Document Type: Review
Times cited : (262)

References (147)
  • 1
    • 39749116856 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 1a growth and induction of autophagy
    • Ait-Goughoulte M, Kanda T, Meyer K, Ryerse JS, Ray RB, et al. 2008. Hepatitis C virus genotype 1a growth and induction of autophagy. J. Virol. 82:2241-49
    • (2008) J. Virol , vol.82 , pp. 2241-2249
    • Ait-Goughoulte, M.1    Kanda, T.2    Meyer, K.3    Ryerse, J.S.4    Ray, R.B.5
  • 3
    • 84880274453 scopus 로고    scopus 로고
    • Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation
    • Amir M, Zhao E, Fontana L, Rosenberg H, Tanaka K, et al. 2013. Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation. Cell Death Differ. 20:878-87
    • (2013) Cell Death Differ , vol.20 , pp. 878-887
    • Amir, M.1    Zhao, E.2    Fontana, L.3    Rosenberg, H.4    Tanaka, K.5
  • 4
    • 35448994487 scopus 로고    scopus 로고
    • Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
    • Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, et al. 2007. Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity. Hum. Mol. Genet. 16:2600-15
    • (2007) Hum. Mol. Genet , vol.16 , pp. 2600-2615
    • Atwal, R.S.1    Xia, J.2    Pinchev, D.3    Taylor, J.4    Epand, R.M.5
  • 5
    • 84861663288 scopus 로고    scopus 로고
    • Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner
    • Bejarano E, Girao H, Yuste A, Patel B, Marques C, et al. 2012. Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol. Biol. Cell 23:2156-69
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2156-2169
    • Bejarano, E.1    Girao, H.2    Yuste, A.3    Patel, B.4    Marques, C.5
  • 7
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, et al. 2005. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171:603-14
    • (2005) J. Cell Biol , vol.171 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5
  • 8
    • 33645926989 scopus 로고    scopus 로고
    • P62/SQSTM1: A missing link between protein aggregates and the autophagy machinery
    • Bjorkoy G, Lamark T, Johansen T. 2006. p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery. Autophagy 2:138-39
    • (2006) Autophagy , vol.2 , pp. 138-139
    • Bjorkoy, G.1    Lamark, T.2    Johansen, T.3
  • 9
    • 84901647945 scopus 로고    scopus 로고
    • Lysosomal multienzyme complex: Pros and cons of working together
    • Bonten EJ, Annunziata I, d Azzo A. 2014. Lysosomal multienzyme complex: pros and cons of working together. Cell Mol. Life Sci. 71:2017-32
    • (2014) Cell Mol. Life Sci , vol.71 , pp. 2017-2032
    • Bonten, E.J.1    Annunziata, I.2    Dazzo, A.3
  • 10
    • 84908052498 scopus 로고    scopus 로고
    • Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury
    • ChoHI, Choi JW, Lee SM. 2014. Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury. Alcohol 48:717-25
    • (2014) Alcohol , vol.48 , pp. 717-725
    • Cho, H.I.1    Choi, J.W.2    Lee, S.M.3
  • 11
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi AM, Ryter SW, Levine B. 2013. Autophagy in human health and disease. N. Engl. J.Med. 368:651-62
    • (2013) N. Engl. J.Med , vol.368 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 12
    • 0037155197 scopus 로고    scopus 로고
    • Lipid droplet binding and oligomerization properties of the Parkinson s disease protein alpha-synuclein
    • Cole NB,MurphyDD,Grider T, Rueter S, BrasaemleD, et al. 2002. Lipid droplet binding and oligomerization properties of the Parkinson s disease protein alpha-synuclein. J. Biol. Chem. 277:6344-52
    • (2002) J. Biol. Chem , vol.277 , pp. 6344-6352
    • Cole, N.B.1    Murphy, D.D.2    Grider, T.3    Rueter, S.4    Brasaemle, D.5
  • 13
    • 84891741302 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: Roles in disease and aging
    • Cuervo AM,Wong E. 2014. Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 24:92-104
    • (2014) Cell Res , vol.24 , pp. 92-104
    • Cuervo, A.M.1    Wong, E.2
  • 14
    • 69449107552 scopus 로고    scopus 로고
    • Lipases in lysosomes, what for
    • Czaja MJ, Cuervo AM. 2009. Lipases in lysosomes, what for? Autophagy 5:866-67
    • (2009) Autophagy , vol.5 , pp. 866-867
    • Czaja, M.J.1    Cuervo, A.M.2
  • 15
    • 0036116213 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis (NASH): Where are we now and where are we going
    • Day CP. 2002. Non-alcoholic steatohepatitis (NASH): Where are we now and where are we going? Gut 50:585-88
    • (2002) Gut , vol.50 , pp. 585-588
    • Day, C.P.1
  • 16
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits
    • Day CP, James OF. 1998. Steatohepatitis: a tale of two "hits"? Gastroenterology 114:842-45
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 17
    • 84871508519 scopus 로고    scopus 로고
    • Deciphering the contribution of lipid droplets in leprosy: Multifunctional organelles with roles in Mycobacterium leprae pathogenesis
    • de MattosKA, Sarno EN, PessolaniMC, Bozza PT. 2012. Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis. Mem. Inst. Oswaldo Cruz 107(Suppl. 1):156-66
    • (2012) Mem. Inst. Oswaldo Cruz , vol.107 , pp. 156-166
    • De Mattos, K.A.1    Sarno, E.N.2    Pessolani, M.C.3    Bozza, P.T.4
  • 20
    • 69549135689 scopus 로고    scopus 로고
    • The autophagymachinery is required to initiate hepatitis C virus replication
    • DreuxM,Gastaminza P,Wieland SF, Chisari FV. 2009. The autophagymachinery is required to initiate hepatitis C virus replication. PNAS 106:14046-51
    • (2009) PNAS , vol.106 , pp. 14046-14051
    • Dreux, M.1    Gastaminza, P.2    Wieland, S.F.3    Chisari, F.V.4
  • 21
    • 84896542255 scopus 로고    scopus 로고
    • Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis
    • Dupont N, Chauhan S, Arko-Mensah J, Castillo EF, Masedunskas A, et al. 2014. Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr. Biol. 24:609-20
    • (2014) Curr. Biol , vol.24 , pp. 609-620
    • Dupont, N.1    Chauhan, S.2    Arko-Mensah, J.3    Castillo, E.F.4    Masedunskas, A.5
  • 22
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation ofULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • EganDF, Shackelford DB,Mihaylova MM, Gelino S, Kohnz RA, et al. 2011. Phosphorylation ofULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331:456-61
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5
  • 23
    • 79956358522 scopus 로고    scopus 로고
    • Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)
    • Fan W, Nassiri A, Zhong Q. 2011. Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). PNAS 108:7769-74
    • (2011) PNAS , vol.108 , pp. 7769-7774
    • Fan, W.1    Nassiri, A.2    Zhong, Q.3
  • 24
    • 84927623326 scopus 로고    scopus 로고
    • Hepatitis C virus and lipid droplets: Finding a niche
    • Filipe A, McLauchlan J. 2014. Hepatitis C virus and lipid droplets: finding a niche. Trends Mol. Med. 21:34-42
    • (2014) Trends Mol. Med , vol.21 , pp. 34-42
    • Filipe, A.1    McLauchlan, J.2
  • 25
  • 26
    • 84907881796 scopus 로고    scopus 로고
    • Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease
    • Fukuo Y, Yamashina S, Sonoue H, Arakawa A, Nakadera E, et al. 2014. Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease. Hepatol. Res. 44:1026-36
    • (2014) Hepatol. Res , vol.44 , pp. 1026-1036
    • Fukuo, Y.1    Yamashina, S.2    Sonoue, H.3    Arakawa, A.4    Nakadera, E.5
  • 28
  • 29
    • 38049098543 scopus 로고    scopus 로고
    • The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
    • Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, et al. 2007. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J. Biol. Chem. 282:37298-302
    • (2007) J. Biol. Chem , vol.282 , pp. 37298-37302
    • Hanada, T.1    Noda, N.N.2    Satomi, Y.3    Ichimura, Y.4    Fujioka, Y.5
  • 30
    • 0028707909 scopus 로고
    • Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress
    • Hardie DG, Carling D, Halford N. 1994. Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. Semin. Cell Biol. 5:409-16
    • (1994) Semin. Cell Biol , vol.5 , pp. 409-416
    • Hardie, D.G.1    Carling, D.2    Halford, N.3
  • 31
    • 0029953575 scopus 로고    scopus 로고
    • Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
    • Harding TM, Hefner-Gravink A, Thumm M, Klionsky DJ. 1996. Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J. Biol. Chem. 271:17621-24
    • (1996) J. Biol. Chem , vol.271 , pp. 17621-17624
    • Harding, T.M.1    Hefner-Gravink, A.2    Thumm, M.3    Klionsky, D.J.4
  • 32
    • 71649087199 scopus 로고    scopus 로고
    • A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
    • Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, et al. 2009. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 11:1433-37
    • (2009) Nat. Cell Biol , vol.11 , pp. 1433-1437
    • Hayashi-Nishino, M.1    Fujita, N.2    Noda, T.3    Yamaguchi, A.4    Yoshimori, T.5
  • 33
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. 2009. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43:67-93
    • (2009) Annu. Rev. Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 34
    • 0025200830 scopus 로고
    • Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
    • Herman PK, Emr SD. 1990. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell Biol. 10:6742-54
    • (1990) Mol. Cell Biol , vol.10 , pp. 6742-6754
    • Herman, P.K.1    Emr, S.D.2
  • 35
    • 0026086456 scopus 로고
    • A genetic and structural analysis of the yeast Vps15 protein kinase: Evidence for a direct role of Vps15p in vacuolar protein delivery
    • Herman PK, Stack JH, Emr SD. 1991. A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J. 10:4049-60
    • (1991) EMBO J , vol.10 , pp. 4049-4060
    • Herman, P.K.1    Stack, J.H.2    Emr, S.D.3
  • 36
    • 84859444880 scopus 로고    scopus 로고
    • Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
    • Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, et al. 2012. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 142:938-46
    • (2012) Gastroenterology , vol.142 , pp. 938-946
    • Hernandez-Gea, V.1    Ghiassi-Nejad, Z.2    Rozenfeld, R.3    Gordon, R.4    Fiel, M.I.5
  • 37
    • 84921294994 scopus 로고    scopus 로고
    • Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast
    • Huang H, Kawamata T, Horie T, Tsugawa H, Nakayama Y, et al. 2015. Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast. EMBO J. 34:154-68
    • (2015) EMBO J , vol.34 , pp. 154-168
    • Huang, H.1    Kawamata, T.2    Horie, T.3    Tsugawa, H.4    Nakayama, Y.5
  • 38
    • 78650643194 scopus 로고    scopus 로고
    • Macroautophagy regulates energy metabolism during effector T cell activation
    • Hubbard VM, Valdor R, Patel B, Singh R, Cuervo AM, et al. 2010. Macroautophagy regulates energy metabolism during effector T cell activation. J. Immunol. 185:7349-57
    • (2010) J. Immunol , vol.185 , pp. 7349-7357
    • Hubbard, V.M.1    Valdor, R.2    Patel, B.3    Singh, R.4    Cuervo, A.M.5
  • 39
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura E, Kishi C, Inoue K, Mizushima N. 2008. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 19:5360-72
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 40
    • 84870880174 scopus 로고    scopus 로고
    • The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
    • Itakura E, Kishi-Itakura C, Mizushima N. 2012. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151:1256-69
    • (2012) Cell , vol.151 , pp. 1256-1269
    • Itakura, E.1    Kishi-Itakura, C.2    Mizushima, N.3
  • 41
    • 84864884124 scopus 로고    scopus 로고
    • Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells
    • Kaini RR, Sillerud LO, Zhaorigetu S, Hu CA. 2012. Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells. Prostate 72:1412-22
    • (2012) Prostate , vol.72 , pp. 1412-1422
    • Kaini, R.R.1    Sillerud, L.O.2    Zhaorigetu, S.3    Hu, C.A.4
  • 42
    • 84903903918 scopus 로고    scopus 로고
    • Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers
    • Kashima J, Shintani-Ishida K, Nakajima M, Maeda H, Unuma K, et al. 2014. Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. Hepatol. Res. 44:779-87
    • (2014) Hepatol. Res , vol.44 , pp. 779-787
    • Kashima, J.1    Shintani-Ishida, K.2    Nakajima, M.3    Maeda, H.4    Unuma, K.5
  • 43
    • 84863229947 scopus 로고    scopus 로고
    • Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
    • Kaushik S, Arias E, Kwon H, Lopez NM, Athonvarangkul D, et al. 2012. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Rep. 13:258-65
    • (2012) EMBO Rep , vol.13 , pp. 258-265
    • Kaushik, S.1    Arias, E.2    Kwon, H.3    Lopez, N.M.4    Athonvarangkul, D.5
  • 44
    • 79960951346 scopus 로고    scopus 로고
    • Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    • Kaushik S, Rodriguez-Navarro JA, Arias E, Kiffin R, Sahu S, et al. 2011. Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab. 14:173-83
    • (2011) Cell Metab , vol.14 , pp. 173-183
    • Kaushik, S.1    Rodriguez-Navarro, J.A.2    Arias, E.3    Kiffin, R.4    Sahu, S.5
  • 48
    • 0033791650 scopus 로고    scopus 로고
    • Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
    • Kim J, Klionsky DJ. 2000. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 69:303-42
    • (2000) Annu. Rev. Biochem , vol.69 , pp. 303-342
    • Kim, J.1    Klionsky, D.J.2
  • 49
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13:132-41
    • (2011) Nat. Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 50
    • 77950607704 scopus 로고    scopus 로고
    • Adoption of PERILIPIN as a unifying nomenclature for themammalian PAT-family of intracellular lipid storage droplet proteins
    • Kimmel AR, BrasaemleDL, McAndrews-Hill M, Sztalryd C, Londos C. 2010. Adoption of PERILIPIN as a unifying nomenclature for themammalian PAT-family of intracellular lipid storage droplet proteins. J. Lipid Res. 51:468-71
    • (2010) J. Lipid Res , vol.51 , pp. 468-471
    • Kimmel, A.R.1    Brasaemle, D.L.2    McAndrews-Hill, M.3    Sztalryd, C.4    Londos, C.5
  • 52
    • 77955789211 scopus 로고    scopus 로고
    • Altered lipid content inhibits autophagic vesicular fusion
    • Koga H, Kaushik S, Cuervo AM. 2010. Altered lipid content inhibits autophagic vesicular fusion. FASEB J. 24:3052-65
    • (2010) FASEB J , vol.24 , pp. 3052-3065
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 53
    • 77955904371 scopus 로고    scopus 로고
    • Inhibitory effect of intracellular lipid load on macroautophagy
    • Koga H, Kaushik S, Cuervo AM. 2010. Inhibitory effect of intracellular lipid load on macroautophagy. Autophagy 6:825-27
    • (2010) Autophagy , vol.6 , pp. 825-827
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 54
    • 34547581106 scopus 로고    scopus 로고
    • Regulation of adipocyte lipolysis by degradation of the perilipin protein: Nelfinavir enhances lysosome-mediated perilipin proteolysis
    • Kovsan J, Ben-Romano R, Souza SC, Greenberg AS, Rudich A. 2007. Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis. J. Biol. Chem. 282:21704-11
    • (2007) J. Biol. Chem , vol.282 , pp. 21704-21711
    • Kovsan, J.1    Ben-Romano, R.2    Souza, S.C.3    Greenberg, A.S.4    Rudich, A.5
  • 55
    • 43049138051 scopus 로고    scopus 로고
    • Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring theUbp3p/Bre5p ubiquitin protease
    • Kraft C, Deplazes A, Sohrmann M, Peter M. 2008. Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring theUbp3p/Bre5p ubiquitin protease. Nat. Cell Biol. 10:602-10
    • (2008) Nat. Cell Biol , vol.10 , pp. 602-610
    • Kraft, C.1    Deplazes, A.2    Sohrmann, M.3    Peter, M.4
  • 56
    • 84899751909 scopus 로고    scopus 로고
    • OsATG7 is required for autophagydependent lipid metabolism in rice postmeiotic anther development
    • Kurusu T, Koyano T, Hanamata S, Kubo T, Noguchi Y, et al. 2014. OsATG7 is required for autophagydependent lipid metabolism in rice postmeiotic anther development. Autophagy 10:878-88
    • (2014) Autophagy , vol.10 , pp. 878-888
    • Kurusu, T.1    Koyano, T.2    Hanamata, S.3    Kubo, T.4    Noguchi, Y.5
  • 57
    • 80053312481 scopus 로고    scopus 로고
    • Autophagy and lipid metabolism coordinately modulate life span in germline-less C
    • Lapierre LR, Gelino S, Melendez A, Hansen M. 2011. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.Curr. Biol. 21:1507-14
    • (2011) Elegans.Curr. Biol , vol.21 , pp. 1507-1514
    • Lapierre, L.R.1    Gelino, S.2    Melendez, A.3    Hansen, M.4
  • 58
    • 84923031534 scopus 로고    scopus 로고
    • Nutrient-sensing nuclear receptors coordinate autophagy
    • Lee JM, Wagner M, Xiao R, KimKH, Feng D, et al. 2014. Nutrient-sensing nuclear receptors coordinate autophagy. Nature 516:112-15
    • (2014) Nature , vol.516 , pp. 112-115
    • Lee, J.M.1    Wagner, M.2    Xiao, R.3    Kim, K.H.4    Feng, D.5
  • 59
    • 84887447290 scopus 로고    scopus 로고
    • FoxO1 controls lysosomal acid lipase in adipocytes: Implication of lipophagy during nutrient restriction and metformin treatment
    • Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo MR. 2013. FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment. Cell Death Dis. 4:e861
    • (2013) Cell Death Dis , vol.4 , pp. e861
    • Lettieri, B.D.1    Tatulli, G.2    Aquilano, K.3    Ciriolo, M.R.4
  • 60
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • LiangXH, Jackson S, SeamanM,Brown K, KempkesB, et al. 1999. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402:672-76
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5
  • 61
    • 84876287362 scopus 로고    scopus 로고
    • Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice
    • Lin CW, Zhang H, Li M, Xiong X, Chen X, et al. 2013. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J. Hepatol. 58:993-99
    • (2013) J. Hepatol , vol.58 , pp. 993-999
    • Lin, C.W.1    Zhang, H.2    Li, M.3    Xiong, X.4    Chen, X.5
  • 62
    • 84866061320 scopus 로고    scopus 로고
    • AMPK-dependent phosphorylation ofULK1 regulates ATG9 localization
    • Mack HI,Zheng B, Asara JM,Thomas SM. 2012. AMPK-dependent phosphorylation ofULK1 regulates ATG9 localization. Autophagy 8:1197-214
    • (2012) Autophagy , vol.8 , pp. 1197-1214
    • Mack, H.I.1    Zheng, B.2    Asara, J.M.3    Thomas, S.M.4
  • 63
    • 33744904687 scopus 로고    scopus 로고
    • The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion
    • Marcinkiewicz A, Gauthier D, Garcia A, Brasaemle DL. 2006. The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion. J. Biol. Chem. 281:11901-9
    • (2006) J. Biol. Chem , vol.281 , pp. 11901-11909
    • Marcinkiewicz, A.1    Gauthier, D.2    Garcia, A.3    Brasaemle, D.L.4
  • 64
    • 82955193292 scopus 로고    scopus 로고
    • The puzzling origin of the autophagosomal membrane
    • Mari M, Tooze SA, Reggiori F. 2011. The puzzling origin of the autophagosomal membrane. F1000 Biol. Rep. 3:25
    • (2011) F1000 Biol. Rep , vol.3 , pp. 25
    • Mari, M.1    Tooze, S.A.2    Reggiori, F.3
  • 65
    • 77951665859 scopus 로고    scopus 로고
    • Cargo recognition failure is responsible for inefficient autophagy in Huntington s disease
    • Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, et al. 2010. Cargo recognition failure is responsible for inefficient autophagy in Huntington s disease. Nat. Neurosci. 13:567-76
    • (2010) Nat. Neurosci , vol.13 , pp. 567-576
    • Martinez-Vicente, M.1    Talloczy, Z.2    Wong, E.3    Tang, G.4    Koga, H.5
  • 66
  • 67
    • 30844437022 scopus 로고    scopus 로고
    • ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells
    • Masuda Y, Itabe H, Odaki M, Hama K, Fujimoto Y, et al. 2006. ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. J. Lipid Res. 47:87-98
    • (2006) J. Lipid Res , vol.47 , pp. 87-98
    • Masuda, Y.1    Itabe, H.2    Odaki, M.3    Hama, K.4    Fujimoto, Y.5
  • 68
    • 67349268146 scopus 로고    scopus 로고
    • Lipid droplets and hepatitis C virus infection
    • McLauchlan J. 2009. Lipid droplets and hepatitis C virus infection. Biochim. Biophys. Acta 1791:552-59
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 552-559
    • McLauchlan, J.1
  • 69
    • 30044438117 scopus 로고    scopus 로고
    • Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase
    • Moore HP, Silver RB, Mottillo EP, Bernlohr DA, Granneman JG. 2005. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J. Biol. Chem. 280:43109-20
    • (2005) J. Biol. Chem , vol.280 , pp. 43109-43120
    • Moore, H.P.1    Silver, R.B.2    Mottillo, E.P.3    Bernlohr, D.A.4    Granneman, J.G.5
  • 70
    • 84875892111 scopus 로고    scopus 로고
    • Autophagy as a stress-response and quality-controlmechanism: Implications for cell injury and human disease
    • MurrowL,Debnath J. 2013. Autophagy as a stress-response and quality-controlmechanism: implications for cell injury and human disease. Annu. Rev. Pathol. 8:105-37
    • (2013) Annu. Rev. Pathol , vol.8 , pp. 105-137
    • Murrow, L.1    Debnath, J.2
  • 71
    • 79960798816 scopus 로고    scopus 로고
    • SNARE proteins are required for macroautophagy
    • Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, et al. 2011. SNARE proteins are required for macroautophagy. Cell 146:290-302
    • (2011) Cell , vol.146 , pp. 290-302
    • Nair, U.1    Jotwani, A.2    Geng, J.3    Gammoh, N.4    Richerson, D.5
  • 72
    • 84899844485 scopus 로고    scopus 로고
    • Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3
    • Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, et al. 2014. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat. Cell Biol. 16:415-24
    • (2014) Nat. Cell Biol , vol.16 , pp. 415-424
    • Nath, S.1    Dancourt, J.2    Shteyn, V.3    Puente, G.4    Fong, W.M.5
  • 73
    • 84876488191 scopus 로고    scopus 로고
    • MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
    • Nazio F, Strappazzon F, Antonioli M, Bielli P, Cianfanelli V, et al. 2013. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat. Cell Biol. 15:406-16
    • (2013) Nat. Cell Biol , vol.15 , pp. 406-416
    • Nazio, F.1    Strappazzon, F.2    Antonioli, M.3    Bielli, P.4    Cianfanelli, V.5
  • 74
    • 78751624556 scopus 로고    scopus 로고
    • Autophagy-related lipase FgATG15 of Fusarium graminearum is important for lipid turnover and plant infection
    • Nguyen LN, Bormann J, Le GT, Starkel C, Olsson S, et al. 2011. Autophagy-related lipase FgATG15 of Fusarium graminearum is important for lipid turnover and plant infection. Fungal Genet. Biol. 48:217-24
    • (2011) Fungal Genet. Biol , vol.48 , pp. 217-224
    • Nguyen, L.N.1    Bormann, J.2    Le, G.T.3    Starkel, C.4    Olsson, S.5
  • 76
    • 84878533962 scopus 로고    scopus 로고
    • MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
    • O Rourke EJ, Ruvkun G. 2013. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat. Cell Biol. 15:668-76
    • (2013) Nat. Cell Biol , vol.15 , pp. 668-676
    • Rourke, E.J.1    Ruvkun, G.2
  • 77
    • 84866762582 scopus 로고    scopus 로고
    • Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery
    • Ogasawara J, Kitadate K, Nishioka H, Fujii H, Sakurai T, et al. 2012. Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery. Natural Prod. Commun. 7:1193-96
    • (2012) Natural Prod. Commun , vol.7 , pp. 1193-1196
    • Ogasawara, J.1    Kitadate, K.2    Nishioka, H.3    Fujii, H.4    Sakurai, T.5
  • 78
    • 84891745088 scopus 로고    scopus 로고
    • Historical landmarks of autophagy research
    • Ohsumi Y. 2014. Historical landmarks of autophagy research. Cell Res. 24:9-23
    • (2014) Cell Res , vol.24 , pp. 9-23
    • Ohsumi, Y.1
  • 79
    • 84901002067 scopus 로고    scopus 로고
    • The emerging role of autophagy in peroxisome dynamics and lipid metabolism of phyllosphere microorganisms
    • Oku M, Takano Y, Sakai Y. 2014. The emerging role of autophagy in peroxisome dynamics and lipid metabolism of phyllosphere microorganisms. Front. Plant Sci. 5:81
    • (2014) Front. Plant Sci , vol.5 , pp. 81
    • Oku, M.1    Takano, Y.2    Sakai, Y.3
  • 80
    • 79958030075 scopus 로고    scopus 로고
    • Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
    • Ouimet M, Franklin V, Mak E, Liao X, Tabas I, et al. 2011. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 13:655-67
    • (2011) Cell Metab , vol.13 , pp. 655-667
    • Ouimet, M.1    Franklin, V.2    Mak, E.3    Liao, X.4    Tabas, I.5
  • 81
    • 84857653989 scopus 로고    scopus 로고
    • Regulation of lipid droplet cholesterol efflux from macrophage foam cells
    • Ouimet M, Marcel YL. 2012. Regulation of lipid droplet cholesterol efflux from macrophage foam cells. Arterioscler. Thromb. Vasc. Biol. 32:575-81
    • (2012) Arterioscler. Thromb. Vasc. Biol , vol.32 , pp. 575-581
    • Ouimet, M.1    Marcel, Y.L.2
  • 82
    • 80052716148 scopus 로고    scopus 로고
    • Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
    • Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, et al. 2011. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum. Mol. Genet. 20:3852-66
    • (2011) Hum. Mol. Genet , vol.20 , pp. 3852-3866
    • Palmieri, M.1    Impey, S.2    Kang, H.3    Di Ronza, A.4    Pelz, C.5
  • 83
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, et al. 2007. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282:24131-45
    • (2007) J. Biol. Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5
  • 84
    • 84873178472 scopus 로고    scopus 로고
    • Effect of short-and long-term high-fat feeding on autophagy flux and lysosomal activity in rat liver
    • Papackova Z, Dankova H, Palenickova E, Kazdova L, Cahova M. 2012. Effect of short-and long-term high-fat feeding on autophagy flux and lysosomal activity in rat liver. Physiol. Res. 61(Suppl. 2):S67-76
    • (2012) Physiol. Res , vol.61 , pp. S67-76
    • Papackova, Z.1    Dankova, H.2    Palenickova, E.3    Kazdova, L.4    Cahova, M.5
  • 85
    • 84922133228 scopus 로고    scopus 로고
    • Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers
    • Park HW, ParkH, Semple IA, Jang I, Ro SH, et al. 2014. Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers. Nat. Commun. 5:4834
    • (2014) Nat. Commun , vol.5 , pp. 4834
    • Park, H.W.1    Park, H.2    Semple, I.A.3    Jang, I.4    Ro, S.H.5
  • 86
    • 84872340936 scopus 로고    scopus 로고
    • Tightrope act: Autophagy in stem cell renewal, differentiation, proliferation, and aging
    • Phadwal K,Watson AS, Simon AK. 2013. Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging. Cell Mol. Life Sci. 70:89-103
    • (2013) Cell Mol. Life Sci , vol.70 , pp. 89-103
    • Phadwal, K.1    Watson, A.S.2    Simon, A.K.3
  • 87
    • 45149130031 scopus 로고    scopus 로고
    • The ATG12-conjugating enzyme ATG10 is essential for autophagic vesicle formation in Arabidopsis thaliana
    • Phillips AR, Suttangkakul A, Vierstra RD. 2008. The ATG12-conjugating enzyme ATG10 is essential for autophagic vesicle formation in Arabidopsis thaliana. Genetics 178:1339-53
    • (2008) Genetics , vol.178 , pp. 1339-1353
    • Phillips, A.R.1    Suttangkakul, A.2    Vierstra, R.D.3
  • 88
    • 77953726483 scopus 로고    scopus 로고
    • Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
    • PolsonHE,deLartigue J, Rigden DJ, ReedijkM,Urbe S, et al. 2010. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy 6:506-22
    • (2010) Autophagy , vol.6 , pp. 506-522
    • Polson, H.E.1    Delartigue, J.2    Rigden, D.J.3    Reedijk, M.4    Urbe, S.5
  • 89
    • 84887174631 scopus 로고    scopus 로고
    • The interplay between autophagy and aging
    • Pyo JO, Yoo SM, Jung YK. 2013. The interplay between autophagy and aging. Diabetes Metab. J. 37:333-39
    • (2013) Diabetes Metab. J , vol.37 , pp. 333-339
    • Pyo, J.O.1    Yoo, S.M.2    Jung, Y.K.3
  • 90
    • 26944465404 scopus 로고    scopus 로고
    • Diverse polyubiquitin interaction properties of ubiquitin-associated domains
    • Raasi S, Varadan R, Fushman D, Pickart CM. 2005. Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat. Struct. Mol. Biol. 12:708-14
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 708-714
    • Raasi, S.1    Varadan, R.2    Fushman, D.3    Pickart, C.M.4
  • 91
  • 92
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, et al. 2004. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36:585-95
    • (2004) Nat. Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1    Vacher, C.2    Berger, Z.3    Davies, J.E.4    Luo, S.5
  • 93
    • 45149123679 scopus 로고    scopus 로고
    • Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
    • Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, et al. 2008. Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J. Biol. Chem. 283:13087-99
    • (2008) J. Biol. Chem , vol.283 , pp. 13087-13099
    • Reid, B.N.1    Ables, G.P.2    Otlivanchik, O.A.3    Schoiswohl, G.4    Zechner, R.5
  • 94
    • 84869210001 scopus 로고    scopus 로고
    • Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation
    • Romanov J, Walczak M, Ibiricu I, Schuchner S, Ogris E, et al. 2012. Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J. 31:4304-17
    • (2012) EMBO J , vol.31 , pp. 4304-4317
    • Romanov, J.1    Walczak, M.2    Ibiricu, I.3    Schuchner, S.4    Ogris, E.5
  • 96
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, et al. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5
  • 97
    • 79957881200 scopus 로고    scopus 로고
    • Chasing the elusive mammalian microautophagy
    • Santambrogio L, Cuervo AM. 2011. Chasing the elusive mammalian microautophagy. Autophagy 7:652-54
    • (2011) Autophagy , vol.7 , pp. 652-654
    • Santambrogio, L.1    Cuervo, A.M.2
  • 98
    • 74849083093 scopus 로고    scopus 로고
    • Lysosomal enhancement: A CLEAR answer to cellular degradative needs
    • Sardiello M, Ballabio A. 2009. Lysosomal enhancement: a CLEAR answer to cellular degradative needs. Cell Cycle 8:4021-22
    • (2009) Cell Cycle , vol.8 , pp. 4021-4022
    • Sardiello, M.1    Ballabio, A.2
  • 100
  • 101
    • 84887527969 scopus 로고    scopus 로고
    • Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes
    • Schulze RJ,Weller SG, Schroeder B, Krueger EW, Chi S, et al. 2013. Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J. Cell Biol. 203:315-26
    • (2013) J. Cell Biol , vol.203 , pp. 315-326
    • Schulze, R.J.1    Weller, S.G.2    Schroeder, B.3    Krueger, E.W.4    Chi, S.5
  • 102
    • 84922968506 scopus 로고    scopus 로고
    • Transcriptional regulation of autophagy by an FXRCREB axis
    • Seok S, Fu T, Choi SE, Li Y, Zhu R, et al. 2014. Transcriptional regulation of autophagy by an FXRCREB axis. Nature 516:108-11
    • (2014) Nature , vol.516 , pp. 108-111
    • Seok, S.1    Fu, T.2    Choi, S.E.3    Li, Y.4    Zhu, R.5
  • 103
    • 84878606239 scopus 로고    scopus 로고
    • TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
    • Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, et al. 2013. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat. Cell Biol. 15:647-58
    • (2013) Nat. Cell Biol , vol.15 , pp. 647-658
    • Settembre, C.1    De Cegli, R.2    Mansueto, G.3    Saha, P.K.4    Vetrini, F.5
  • 105
    • 84857997408 scopus 로고    scopus 로고
    • A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
    • Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, et al. 2012. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 31:1095-108
    • (2012) EMBO J , vol.31 , pp. 1095-1108
    • Settembre, C.1    Zoncu, R.2    Medina, D.L.3    Vetrini, F.4    Erdin, S.5
  • 107
    • 79955631150 scopus 로고    scopus 로고
    • Autophagy in the cellular energetic balance
    • Singh R, Cuervo AM. 2011. Autophagy in the cellular energetic balance. Cell Metab. 13:495-504
    • (2011) Cell Metab , vol.13 , pp. 495-504
    • Singh, R.1    Cuervo, A.M.2
  • 109
    • 84896488935 scopus 로고    scopus 로고
    • Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
    • Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, et al. 2014. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology 59:1366-80
    • (2014) Hepatology , vol.59 , pp. 1366-1380
    • Sinha, R.A.1    Farah, B.L.2    Singh, B.K.3    Siddique, M.M.4    Li, Y.5
  • 110
    • 77749292148 scopus 로고    scopus 로고
    • The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
    • Sir D, Tian Y, Chen WL, Ann DK, Yen TS, et al. 2010. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. PNAS 107:4383-88
    • (2010) PNAS , vol.107 , pp. 4383-4388
    • Sir, D.1    Tian, Y.2    Chen, W.L.3    Ann, D.K.4    Yen, T.S.5
  • 111
    • 84864947432 scopus 로고    scopus 로고
    • Autophagy-lysosomal pathway is involved in lipid degradation in rat liver
    • Skop V, Cahova M, Papackova Z, Palenickova E,Dankova H, et al. 2012. Autophagy-lysosomal pathway is involved in lipid degradation in rat liver. Physiol. Res. 61:287-97
    • (2012) Physiol. Res , vol.61 , pp. 287-297
    • Skop, V.1    Cahova, M.2    Papackova, Z.3    Palenickova, E.4    Dankova, H.5
  • 112
    • 0037040911 scopus 로고    scopus 로고
    • Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system
    • Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, et al. 2002. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J. Biol. Chem. 277:8267-72
    • (2002) J. Biol. Chem , vol.277 , pp. 8267-8272
    • Souza, S.C.1    Muliro, K.V.2    Liscum, L.3    Lien, P.4    Yamamoto, M.T.5
  • 113
    • 79953147165 scopus 로고    scopus 로고
    • Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region
    • Spandl J, Lohmann D, Kuerschner L, Moessinger C, Thiele C. 2011. Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region. J. Biol. Chem. 286:5599-606
    • (2011) J. Biol. Chem , vol.286 , pp. 5599-5606
    • Spandl, J.1    Lohmann, D.2    Kuerschner, L.3    Moessinger, C.4    Thiele, C.5
  • 114
    • 84867746835 scopus 로고    scopus 로고
    • Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation
    • StankovMV, Panayotova-Dimitrova D, LeverkusM,Vondran FW, BauerfeindR, et al. 2012. Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. AIDS 26:1995-2006
    • (2012) AIDS , vol.26 , pp. 1995-2006
    • Stankov, M.V.1    Panayotova-Dimitrova, D.2    Leverkus, M.3    Vondran, F.W.4    Bauerfeind, R.5
  • 115
    • 25144498379 scopus 로고    scopus 로고
    • A human protein-protein interaction network: A resource for annotating the proteome
    • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, et al. 2005. A human protein-protein interaction network: a resource for annotating the proteome. Cell 122:957-68
    • (2005) Cell , vol.122 , pp. 957-968
    • Stelzl, U.1    Worm, U.2    Lalowski, M.3    Haenig, C.4    Brembeck, F.H.5
  • 116
    • 0035910423 scopus 로고    scopus 로고
    • The human homolog of Saccharomyces cerevisiae Apg7p is a protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3
    • Tanida I, Tanida-Miyake E, Ueno T, Kominami E. 2001. The human homolog of Saccharomyces cerevisiae Apg7p is a protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J. Biol. Chem. 276:1701-6
    • (2001) J. Biol. Chem , vol.276 , pp. 1701-1706
    • Tanida, I.1    Tanida-Miyake, E.2    Ueno, T.3    Kominami, E.4
  • 118
    • 35148815242 scopus 로고    scopus 로고
    • Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy
    • Tasdemir E, Maiuri MC, Tajeddine N, Vitale I, Criollo A, et al. 2007. Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy. Cell Cycle 6:2263-67
    • (2007) Cell Cycle , vol.6 , pp. 2263-2267
    • Tasdemir, E.1    Maiuri, M.C.2    Tajeddine, N.3    Vitale, I.4    Criollo, A.5
  • 120
    • 70350450808 scopus 로고    scopus 로고
    • The TBK1 adaptor and autophagy receptorNDP52 restricts the proliferation of ubiquitin-coated bacteria
    • Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. 2009. The TBK1 adaptor and autophagy receptorNDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat. Immunol. 10:1215-21
    • (2009) Nat. Immunol , vol.10 , pp. 1215-1221
    • Thurston, T.L.1    Ryzhakov, G.2    Bloor, S.3    Von Muhlinen, N.4    Randow, F.5
  • 121
    • 77956414236 scopus 로고    scopus 로고
    • The origin of the autophagosomal membrane
    • Tooze SA, Yoshimori T. 2010. The origin of the autophagosomal membrane. Nat. Cell Biol. 12:831-35
    • (2010) Nat. Cell Biol , vol.12 , pp. 831-835
    • Tooze, S.A.1    Yoshimori, T.2
  • 122
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
    • Tsukada M, Ohsumi Y. 1993. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 333:169-74
    • (1993) FEBS Lett , vol.333 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 123
    • 84896909604 scopus 로고    scopus 로고
    • Detection ofWIPI1 mRNA as an indicator of autophagosome formation
    • Tsuyuki S, Takabayashi M, Kawazu M, Kudo K, Watanabe A, et al. 2014. Detection ofWIPI1 mRNA as an indicator of autophagosome formation. Autophagy 10:497-513
    • (2014) Autophagy , vol.10 , pp. 497-513
    • Tsuyuki, S.1    Takabayashi, M.2    Kawazu, M.3    Kudo, K.4    Watanabe, A.5
  • 125
    • 78651164698 scopus 로고
    • Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue
    • Vaughan M, Berger JE, Steinberg D. 1964. Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue. J. Biol. Chem. 239:401-9
    • (1964) J. Biol. Chem , vol.239 , pp. 401-409
    • Vaughan, M.1    Berger, J.E.2    Steinberg, D.3
  • 126
    • 84905981861 scopus 로고    scopus 로고
    • A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast
    • Wang CW, Miao YH, Chang YS. 2014. A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast. J. Cell Biol. 206:357-66
    • (2014) J. Cell Biol , vol.206 , pp. 357-366
    • Wang, C.W.1    Miao, Y.H.2    Chang, Y.S.3
  • 127
    • 77954230819 scopus 로고    scopus 로고
    • Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress
    • Wang Y, Singh R, Xiang Y, Czaja MJ. 2010. Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology 52:266-77
    • (2010) Hepatology , vol.52 , pp. 266-277
    • Wang, Y.1    Singh, R.2    Xiang, Y.3    Czaja, M.J.4
  • 129
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. 2008. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30:678-88
    • (2008) Mol. Cell , vol.30 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 130
    • 84921298083 scopus 로고    scopus 로고
    • Autophagy mediates nonselective RNA degradation in starving yeast
    • Welter E, Elazar Z. 2015. Autophagy mediates nonselective RNA degradation in starving yeast. EMBO J. 34:131-33
    • (2015) EMBO J , vol.34 , pp. 131-133
    • Welter, E.1    Elazar, Z.2
  • 131
    • 0026627736 scopus 로고
    • The lipolysis/esterification cycle of hepatic triacylglycerol Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas
    • Wiggins D, Gibbons GF. 1992. The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas. Biochem. J. 284(Part 2):457-62
    • (1992) Biochem. J , vol.284 , pp. 457-462
    • Wiggins, D.1    Gibbons, G.F.2
  • 132
    • 79960804104 scopus 로고    scopus 로고
    • Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
    • Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, et al. 2011. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333:228-33
    • (2011) Science , vol.333 , pp. 228-233
    • Wild, P.1    Farhan, H.2    McEwan, D.G.3    Wagner, S.4    Rogov, V.V.5
  • 134
    • 84869005229 scopus 로고    scopus 로고
    • The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism
    • Xiong X, Tao R, DePinho RA, Dong XC. 2012. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J. Biol. Chem. 287:39107-14
    • (2012) J. Biol. Chem , vol.287 , pp. 39107-39114
    • Xiong, X.1    Tao, R.2    Depinho, R.A.3    Dong, X.C.4
  • 135
    • 33646017106 scopus 로고    scopus 로고
    • Degradation of perilipin is mediated through ubiquitinationproteasome pathway
    • Xu G, Sztalryd C, Londos C. 2006. Degradation of perilipin is mediated through ubiquitinationproteasome pathway. Biochim. Biophys. Acta 1761:83-90
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 83-90
    • Xu, G.1    Sztalryd, C.2    Londos, C.3
  • 136
    • 30044445455 scopus 로고    scopus 로고
    • Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway
    • Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, et al. 2005. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J. Biol. Chem. 280:42841-47
    • (2005) J. Biol. Chem , vol.280 , pp. 42841-42847
    • Xu, G.1    Sztalryd, C.2    Lu, X.3    Tansey, J.T.4    Gan, J.5
  • 137
    • 84889663497 scopus 로고    scopus 로고
    • Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissuemacrophages independently of classic activation
    • Xu X, Grijalva A, Skowronski A, van Eijk M, Serlie MJ, et al. 2013. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissuemacrophages independently of classic activation. Cell Metab. 18:816-30
    • (2013) Cell Metab , vol.18 , pp. 816-830
    • Xu, X.1    Grijalva, A.2    Skowronski, A.3    Van Eijk, M.4    Serlie, M.J.5
  • 138
    • 84863060663 scopus 로고    scopus 로고
    • Mapping autophagy on to your metabolic radar
    • Yamada E, Singh R. 2012. Mapping autophagy on to your metabolic radar. Diabetes 61:272-80
    • (2012) Diabetes , vol.61 , pp. 272-280
    • Yamada, E.1    Singh, R.2
  • 139
    • 34247237202 scopus 로고    scopus 로고
    • The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation
    • Yamada Y, Suzuki NN, Hanada T, Ichimura Y, Kumeta H, et al. 2007. The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J. Biol. Chem. 282:8036-43
    • (2007) J. Biol. Chem , vol.282 , pp. 8036-8043
    • Yamada, Y.1    Suzuki, N.N.2    Hanada, T.3    Ichimura, Y.4    Kumeta, H.5
  • 140
  • 141
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. 2010. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11:467-78
    • (2010) Cell Metab , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 142
    • 75749135725 scopus 로고    scopus 로고
    • The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
    • Yen WL, Shintani T, Nair U, Cao Y, Richardson BC, et al. 2010. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J. Cell. Biol. 188:101-14
    • (2010) J. Cell. Biol , vol.188 , pp. 101-114
    • Yen, W.L.1    Shintani, T.2    Nair, U.3    Cao, Y.4    Richardson, B.C.5
  • 143
    • 71649112895 scopus 로고    scopus 로고
    • 3D tomography reveals connections between the phagophore and endoplasmic reticulum
    • Yla-Anttila P, Vihinen H, Jokitalo E, Eskelinen EL. 2009. 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 5:1180-85
    • (2009) Autophagy , vol.5 , pp. 1180-1185
    • Yla-Anttila, P.1    Vihinen, H.2    Jokitalo, E.3    Eskelinen, E.L.4
  • 144
    • 33750366092 scopus 로고    scopus 로고
    • Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
    • Young AR, Chan EY, Hu XW, Kochl R, Crawshaw SG, et al. 2006. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J. Cell Sci. 119:3888-900
    • (2006) J. Cell Sci , vol.119 , pp. 3888-3900
    • Young, A.R.1    Chan, E.Y.2    Hu, X.W.3    Kochl, R.4    Crawshaw, S.G.5
  • 145
    • 51349095898 scopus 로고    scopus 로고
    • Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
    • Zhang C, Cuervo AM. 2008. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat. Med. 14:959-65
    • (2008) Nat. Med , vol.14 , pp. 959-965
    • Zhang, C.1    Cuervo, A.M.2
  • 146
    • 84900344034 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance
    • Zhou J, Farah BL, Sinha RA,Wu Y, Singh BK, et al. 2014. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLOS ONE 9:e87161
    • (2014) PLOS ONE , vol.9 , pp. e87161
    • Zhou, J.1    Farah, B.L.2    Sinha, R.A.3    Wu, Y.4    Singh, B.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.