The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

Molecular Cell

Volumn 60, Issue 1, 2015, Pages 7-20

  Heo, Jin Mi ^a   Ordureau, Alban ^a   Paulo, Joao A ^a   Rinehart, Jesse ^b   Harper, J Wade ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NDP52 PROTEIN; OPTN PROTEIN; PARKIN; PINK1 PROTEIN; PROTEIN; SQSTM1 PROTEIN; TBK1 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; NUCLEAR DOT PROTEIN 52, HUMAN; NUCLEAR PROTEIN; OPTN PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PTEN-INDUCED PUTATIVE KINASE; SEQUESTOSOME 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN; TBK1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR IIIA; UBIQUITIN PROTEIN LIGASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPHAGY; FEEDBACK SYSTEM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOPHAGY; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; UBIQUITINATION; HELA CELL LINE; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; PROCEDURES; PROTEOMICS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; HELA CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; SEQUESTOSOME-1 PROTEIN; TRANSCRIPTION FACTOR TFIIIA; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84951930787     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.08.016     Document Type: Article

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