-
1
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
X. Qu, J. Yu, G. Bhagat, N. Furuya, H. Hibshoosh, and A. Troxel et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene J Clin Invest 112 2003 1809 1820
-
(2003)
J Clin Invest
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
-
2
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
A. Takamura, M. Komatsu, T. Hara, A. Sakamoto, C. Kishi, and S. Waguri et al. Autophagy-deficient mice develop multiple liver tumors Genes Dev 25 2011 795 800
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
-
3
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
M. Komatsu, S. Waguri, T. Ueno, J. Iwata, S. Murata, and I. Tanida et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice J Cell Biol 169 2005 425 434
-
(2005)
J Cell Biol
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
-
4
-
-
77953366801
-
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
-
A. Lau, X.J. Wang, F. Zhao, N.F. Villeneuve, T. Wu, and T. Jiang et al. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62 Mol Cell Biol 30 2010 3275 3285
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3275-3285
-
-
Lau, A.1
Wang, X.J.2
Zhao, F.3
Villeneuve, N.F.4
Wu, T.5
Jiang, T.6
-
5
-
-
77954599053
-
P62/SQSTM1 is a target gene for transcription factor NRF2 and Creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
A. Jain, T. Lamark, E. Sjottem, K.B. Larsen, J.A. Awuh, and A. Overvatn et al. P62/SQSTM1 is a target gene for transcription factor NRF2 and Creates a positive feedback loop by inducing antioxidant response element-driven gene transcription J Biol Chem 285 2010 22576 22591
-
(2010)
J Biol Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjottem, E.3
Larsen, K.B.4
Awuh, J.A.5
Overvatn, A.6
-
6
-
-
53049103308
-
Structural basis for sorting mechanism of p62 in selective autophagy
-
Y. Ichimura, T. Kumanomidou, Y.S. Sou, T. Mizushima, J. Ezaki, and T. Ueno et al. Structural basis for sorting mechanism of p62 in selective autophagy J Biol Chem 283 2008 22847 22857
-
(2008)
J Biol Chem
, vol.283
, pp. 22847-22857
-
-
Ichimura, Y.1
Kumanomidou, T.2
Sou, Y.S.3
Mizushima, T.4
Ezaki, J.5
Ueno, T.6
-
7
-
-
84864346121
-
Fibrosis-dependent mechanisms of hepatocarcinogenesis
-
D.Y. Zhang, and S.L. Friedman Fibrosis-dependent mechanisms of hepatocarcinogenesis Hepatology 56 2012 769 775
-
(2012)
Hepatology
, vol.56
, pp. 769-775
-
-
Zhang, D.Y.1
Friedman, S.L.2
-
9
-
-
73449140168
-
Molecular pathogenesis of liver fibrosis
-
D.A. Brenner Molecular pathogenesis of liver fibrosis Trans Am Clin Climatol Assoc 120 2009 361 368
-
(2009)
Trans Am Clin Climatol Assoc
, vol.120
, pp. 361-368
-
-
Brenner, D.A.1
-
10
-
-
81355161371
-
A role for autophagy during hepatic stellate cell activation
-
L.F. Thoen, E.L. Guimaraes, L. Dolle, I. Mannaerts, M. Najimi, and E. Sokal et al. A role for autophagy during hepatic stellate cell activation J Hepatol 55 2011 1353 1360
-
(2011)
J Hepatol
, vol.55
, pp. 1353-1360
-
-
Thoen, L.F.1
Guimaraes, E.L.2
Dolle, L.3
Mannaerts, I.4
Najimi, M.5
Sokal, E.6
-
11
-
-
84859444880
-
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
-
V. Hernandez-Gea, Z. Ghiassi-Nejad, R. Rozenfeld, R. Gordon, M.I. Fiel, and Z. Yue et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues Gastroenterology 142 2012 938 946
-
(2012)
Gastroenterology
, vol.142
, pp. 938-946
-
-
Hernandez-Gea, V.1
Ghiassi-Nejad, Z.2
Rozenfeld, R.3
Gordon, R.4
Fiel, M.I.5
Yue, Z.6
-
12
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
T. Hara, K. Nakamura, M. Matsui, A. Yamamoto, Y. Nakahara, and R. Suzuki-Migishima et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Nature 441 2006 885 889
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
-
13
-
-
84155194923
-
Activation of autophagy protects against acetaminophen-induced hepatotoxicity
-
H.M. Ni, A. Bockus, N. Boggess, H. Jaeschke, and W.X. Ding Activation of autophagy protects against acetaminophen-induced hepatotoxicity Hepatology 55 2011 222 232
-
(2011)
Hepatology
, vol.55
, pp. 222-232
-
-
Ni, H.M.1
Bockus, A.2
Boggess, N.3
Jaeschke, H.4
Ding, W.X.5
-
14
-
-
0030451213
-
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
K. Chan, R. Lu, J.C. Chang, and Y.W. Kan NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development Proc Natl Acad Sci U S A 93 1996 13943 13948
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
15
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, and Y. Ichimura et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat Cell Biol 12 2010 213 223
-
(2010)
Nat Cell Biol
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
Ichimura, Y.6
-
16
-
-
84865287281
-
Keap1 degradation by autophagy for the maintenance of redox homeostasis
-
K. Taguchi, N. Fujikawa, M. Komatsu, T. Ishii, M. Unno, and T. Akaike et al. Keap1 degradation by autophagy for the maintenance of redox homeostasis Proc Natl Acad Sci U S A 109 2012 13561 13566
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 13561-13566
-
-
Taguchi, K.1
Fujikawa, N.2
Komatsu, M.3
Ishii, T.4
Unno, M.5
Akaike, T.6
-
17
-
-
79955492012
-
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
-
Y. Inami, S. Waguri, A. Sakamoto, T. Kouno, K. Nakada, and O. Hino et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells J Cell Biol 193 2011 275 284
-
(2011)
J Cell Biol
, vol.193
, pp. 275-284
-
-
Inami, Y.1
Waguri, S.2
Sakamoto, A.3
Kouno, T.4
Nakada, K.5
Hino, O.6
-
18
-
-
84861466718
-
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury
-
H.M. Ni, N. Boggess, M.R. McGill, M. Lebofsky, P. Borude, and U. Apte et al. Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury Toxicol Sci 127 2012 438 450
-
(2012)
Toxicol Sci
, vol.127
, pp. 438-450
-
-
Ni, H.M.1
Boggess, N.2
McGill, M.R.3
Lebofsky, M.4
Borude, P.5
Apte, U.6
-
19
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Z. Jin, Y. Li, R. Pitti, D. Lawrence, V.C. Pham, and J.R. Lill et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling Cell 137 2009 721 735
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
Li, Y.2
Pitti, R.3
Lawrence, D.4
Pham, V.C.5
Lill, J.R.6
-
20
-
-
79960325950
-
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes
-
J.A. Pan, E. Ullman, Z. Dou, and W.X. Zong Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes Mol Cell Biol 31 2011 3158 3170
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3158-3170
-
-
Pan, J.A.1
Ullman, E.2
Dou, Z.3
Zong, W.X.4
-
21
-
-
79960324454
-
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury
-
E. Ullman, J.A. Pan, and W.X. Zong Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury Mol Cell Biol 31 2011 2902 2919
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2902-2919
-
-
Ullman, E.1
Pan, J.A.2
Zong, W.X.3
-
22
-
-
84859480341
-
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
-
M.M. Young, Y. Takahashi, O. Khan, S. Park, T. Hori, and J. Yun et al. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis J Biol Chem 287 2012 12455 12468
-
(2012)
J Biol Chem
, vol.287
, pp. 12455-12468
-
-
Young, M.M.1
Takahashi, Y.2
Khan, O.3
Park, S.4
Hori, T.5
Yun, J.6
-
23
-
-
79952139698
-
Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
-
K. Fujita, D. Maeda, Q. Xiao, and S.M. Srinivasula Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation Proc Natl Acad Sci U S A 108 2011 1427 1432
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 1427-1432
-
-
Fujita, K.1
Maeda, D.2
Xiao, Q.3
Srinivasula, S.M.4
-
24
-
-
84880274453
-
Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation
-
M. Amir, E. Zhao, L. Fontana, H. Rosenberg, K. Tanaka, and G. Gao et al. Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation Cell Death Differ 20 2013 878 887
-
(2013)
Cell Death Differ
, vol.20
, pp. 878-887
-
-
Amir, M.1
Zhao, E.2
Fontana, L.3
Rosenberg, H.4
Tanaka, K.5
Gao, G.6
-
25
-
-
84859509946
-
Autophagy promotes intracellular degradation of type i collagen induced by transforming growth factor (TGF)-beta1
-
S.I. Kim, H.J. Na, Y. Ding, Z. Wang, S.J. Lee, and M.E. Choi Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1 J Biol Chem 2012
-
(2012)
J Biol Chem
-
-
Kim, S.I.1
Na, H.J.2
Ding, Y.3
Wang, Z.4
Lee, S.J.5
Choi, M.E.6
-
26
-
-
84859509946
-
Autophagy promotes intracellular degradation of type i collagen induced by transforming growth factor (TGF)-beta1
-
S.I. Kim, H.J. Na, Y. Ding, Z. Wang, S.J. Lee, and M.E. Choi Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1 J Biol Chem 287 2012 11677 11688
-
(2012)
J Biol Chem
, vol.287
, pp. 11677-11688
-
-
Kim, S.I.1
Na, H.J.2
Ding, Y.3
Wang, Z.4
Lee, S.J.5
Choi, M.E.6
-
27
-
-
70350532016
-
Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways
-
K.R. Bridle, C. Popa, M.L. Morgan, A.L. Sobbe, A.D. Clouston, and L.M. Fletcher et al. Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways Liver Transpl 15 2009 1315 1324
-
(2009)
Liver Transpl
, vol.15
, pp. 1315-1324
-
-
Bridle, K.R.1
Popa, C.2
Morgan, M.L.3
Sobbe, A.L.4
Clouston, A.D.5
Fletcher, L.M.6
-
28
-
-
77954597127
-
An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis
-
T. Hidvegi, M. Ewing, P. Hale, C. Dippold, C. Beckett, and C. Kemp et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis Science 329 2010 229 232
-
(2010)
Science
, vol.329
, pp. 229-232
-
-
Hidvegi, T.1
Ewing, M.2
Hale, P.3
Dippold, C.4
Beckett, C.5
Kemp, C.6
-
29
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
K. Degenhardt, R. Mathew, B. Beaudoin, K. Bray, D. Anderson, and G. Chen et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell 10 2006 51 64
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
-
30
-
-
63549121490
-
NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
-
J.D. Hayes, and M. McMahon NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer Trends Biochem Sci 34 2009 176 188
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
31
-
-
79960060305
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
G.M. DeNicola, F.A. Karreth, T.J. Humpton, A. Gopinathan, C. Wei, and K. Frese et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Nature 475 2011 106 109
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
Denicola, G.M.1
Karreth, F.A.2
Humpton, T.J.3
Gopinathan, A.4
Wei, C.5
Frese, K.6
-
32
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
A. Lau, N.F. Villeneuve, Z. Sun, P.K. Wong, and D.D. Zhang Dual roles of Nrf2 in cancer Pharmacol Res 58 2008 262 270
-
(2008)
Pharmacol Res
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
|