Clinical potential of oligonucleotide-based therapeutics in the respiratory system

Pharmacology and Therapeutics

Volumn 169, Issue , 2017, Pages 83-103

  Moschos, Sterghios A ^a,c   Usher, Louise ^a   Lindsay, Mark A ^b  

^a UNIVERSITY OF WESTMINSTER   (United Kingdom)

^b University of Bath   (United Kingdom)

^c NORTHUMBRIA UNIVERSITY   (United Kingdom)

Author keywords

Delivery; miRNA; Oligonucleotide therapeutics; PNA; PPMO; siRNA

Indexed keywords

ALTAIR; ANTIASTHMATIC AGENT; ANTISENSE OLIGONUCLEOTIDE; ASVASIRAN; CHEMOKINE RECEPTOR CCR3; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5 RECEPTOR; MICRORNA; OLIGONUCLEOTIDE; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ANATOMICAL CONCEPTS; ASTHMA; BIOLOGICAL ACTIVITY; CLINICAL PHARMACOLOGY; DRUG MECHANISM; DRUG TARGETING; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; LUNG DISEASE; NONHUMAN; PHARMACEUTICAL CARE; PHASE 2 CLINICAL TRIAL (TOPIC); PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PROTEIN TARGETING; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RESPIRATORY SYSTEM; REVIEW; RNA INTERFERENCE; RNAI THERAPEUTICS; ANIMAL; DRUG DESIGN; GENETICS; LUNG DISEASES; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOPHYSIOLOGY; RNA SPLICING;

ANIMALS; DRUG DESIGN; HUMANS; LUNG DISEASES; MOLECULAR TARGETED THERAPY; OLIGONUCLEOTIDES; RNA; RNA INTERFERENCE; RNA SPLICING; RNA, UNTRANSLATED;

EID: 84993940278     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2016.10.009     Document Type: Review

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