Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides

Nano Letters

Volumn 15, Issue 7, 2015, Pages 4364-4373

  Ezzat, Kariem ^a   Aoki, Yoshitsugu ^a,i   Koo, Taeyoung ^a,b,c   McClorey, Graham ^a   Benner, Leif ^a   Coenen Stass, Anna ^a   O'Donovan, Liz ^d   Lehto, Taavi ^e   Garcia Guerra, Antonio ^a   Nordin, Joel ^e   Saleh, Amer F ^d   Behlke, Mark ^a   Morris, John ^a   Goyenvalle, Aurelie ^f   Dugovic, Branislav ^g   Leumann, Christian ^g   Gordon, Siamon ^h   Gait, Michael J ^d   El Andaloussi, Samir ^a,e   Wood, Matthew Ja ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Institute for Basic Science   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e KAROLINSKA INSTITUTE   (Sweden)

^f LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^g UNIVERSITY OF BERN   (Switzerland)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Antisense oligonucleotides; delivery; nanoparticles; scavenger receptors; self assembly; uptake mechanism

Indexed keywords

BINS; BIOMIMETICS; GENE THERAPY; MOBILE SECURITY; NANOPARTICLES; OLIGONUCLEOTIDES; SURFACE PLASMON RESONANCE;

ANTISENSE OLIGONUCLEOTIDES; CHEMICALLY MODIFIED; COMPETITIVE INHIBITION; DELIVERY; DUCHENNE MUSCULAR DYSTROPHIES; LOW CONCENTRATIONS; SCAVENGER RECEPTOR; UPTAKE MECHANISM;

SELF ASSEMBLY;

ANTISENSE OLIGONUCLEOTIDE; MICELLE; NANOPARTICLE; SCAVENGER RECEPTOR A;

ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; EXON; GENE THERAPY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MICELLE; MOUSE; MUSCULAR DYSTROPHY, DUCHENNE; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; CELL LINE; EXONS; GENETIC THERAPY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICELLES; MUSCULAR DYSTROPHY, DUCHENNE; NANOPARTICLES; OLIGONUCLEOTIDES, ANTISENSE; SCAVENGER RECEPTORS, CLASS A;

EID: 84936818363     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/acs.nanolett.5b00490     Document Type: Article

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