Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 16, 2012, Pages 6235-6240

  Augagneur, Yoann ^a   Wesolowski, Donna ^b   Tae, Hyun Seop ^b   Altman, Sidney ^b   Mamoun, Choukri Ben ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Nuclease resistance; RNase P

Indexed keywords

MESSENGER RNA; MORPHOLINO OLIGONUCLEOTIDE; PLASMODIUM FALCIPARUM GYRASE MRNA; RIBONUCLEASE P; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME INHIBITION; EPIFLUORESCENCE MICROSCOPY; ERYTHROCYTE; IN VITRO STUDY; LIFE CYCLE STAGE; NONHUMAN; PARASITE DEVELOPMENT; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RNA SEQUENCE; SCHIZONT; TROPHOZOITE;

AMINO ACID SEQUENCE; BASE SEQUENCE; DNA GYRASE; ERYTHROCYTES; FLUORESCEIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; MORPHOLINOS; PEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA CLEAVAGE; RNA, MESSENGER;

EID: 84860004871     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203516109     Document Type: Article

References (43)

1. Anonymous (2010) World Malaria Report (World Health Organization, Geneva).
2. Murray CJ, et al. (2012) Global malaria mortality between 1980 and 2010: A systematic analysis. Lancet 379:413-431.
3. Singh B, et al. (2004) A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 363:1017-1024. (Pubitemid 38410774)
4. Kolev NG, Tschudi C, Ullu E (2011) RNA interference in protozoan parasites: Achievements and challenges. Eukaryot Cell 10:1156-1163.
5. Ullu E, Tschudi C, Chakraborty T (2004) RNA interference in protozoan parasites. Cell Microbiol 6:509-519. (Pubitemid 38618662)
6. El Bissati K, et al. (2006) The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum. Proc Natl Acad Sci USA 103:9286-9291. (Pubitemid 43902570)
7. Armstrong CM, Goldberg DE (2007) An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods 4:1007-1009. (Pubitemid 350201770)
8. Meissner M, et al. (2005) Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators. Proc Natl Acad Sci USA 102:2980-2985. (Pubitemid 40299902)
9. Muralidharan V, Oksman A, Iwamoto M, Wandless TJ, Goldberg DE (2011) Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci USA 108:4411-4416.
10. Russo I, Oksman A, Vaupel B, Goldberg DE (2009) A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci USA 106:1554-1559.
11. Dvorin JD, et al. (2010) A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science 328:910-912.
12. Farrell A, et al. (2012) A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science 335:218-221.
13. Guerrier-Takada C, Altman S (2000) Inactivation of gene expression using ribonuclease P and external guide sequences. Methods Enzymol 313:442-456. (Pubitemid 29506434)
14. Guerrier-Takada C, Salavati R, Altman S (1997) Phenotypic conversion of drug-resistant bacteria to drug sensitivity. Proc Natl Acad Sci USA 94:8468-8472. (Pubitemid 27335062)
15. Lundblad EW, Altman S (2010) Inhibition of gene expression by RNase P. New Biotechnol 27:212-221.
16. Shen N, et al. (2009) Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci USA 106:8163-8168.
17. Wesolowski D, et al. (2011) Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. Proc Natl Acad Sci USA 108:16582-16587.
18. Dar MA, Sharma A, Mondal N, Dhar SK (2007) Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: Unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit. Eukaryot Cell 6:398-412. (Pubitemid 46492328)
19. Cirak S, et al. (2011) Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: An open-label, phase 2, dose-escalation study. Lancet 378: 595-605.
20. Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL (2007) Antisense peptidephosphorodiamidate morpholino oligomer conjugate: Dose-response in mice infected with Escherichia coli. J Antimicrob Chemother 59:66-73. (Pubitemid 46017902)
21. Warren TK, et al. (2010) Advanced antisense therapies for postexposure protection against lethal filovirus infections. Nat Med 16:991-994.
22. Guerrier-Takada C, Li Y, Altman S (1995) Artificial regulation of gene expression in Escherichia coli by RNase P. Proc Natl Acad Sci USA 92:11115-11119.
23. Ko JH, Izadjoo M, Altman S (2008) Inhibition of expression of virulence genes of Yersinia pestis in Escherichia coli by external guide sequences and RNase P. RNA 14: 1656-1662.
24. Liu F, Altman S (1995) Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli. Genes Dev 9:471-480.
25. McKinney JS, Zhang H, Kubori T, Galán JE, Altman S (2004) Disruption of type III secretion in Salmonella enterica serovar Typhimurium by external guide sequences. Nucleic Acids Res 32:848-854. (Pubitemid 38263079)
26. Plehn-Dujowich D, Altman S (1998) Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P. Proc Natl Acad Sci USA 95:7327-7332. (Pubitemid 28293251)
27. Trang P, Lee J, Kilani AF, Kim J, Liu F (2001) Effective inhibition of herpes simplex virus 1 gene expression and growth by engineered RNase P ribozyme. Nucleic Acids Res 29: 5071-5078. (Pubitemid 34065424)
28. Kirk K, Saliba KJ (2007) Targeting nutrient uptake mechanisms in Plasmodium. Curr Drug Targets 8:75-88. (Pubitemid 46043899)
29. Saliba KJ, Kirk K (2001) Nutrient acquisition by intracellular apicomplexan parasites: Staying in for dinner. Int J Parasitol 31:1321-1330. (Pubitemid 32868712)
30. Kirk K, Martin RE, Bröer S, Howitt SM, Saliba KJ (2005) Plasmodium permeomics: Membrane transport proteins in the malaria parasite. Curr Top Microbiol Immunol 295:325-356. (Pubitemid 41236521)
31. Martin RE, Ginsburg H, Kirk K (2009) Membrane transport proteins of the malaria parasite. Mol Microbiol 74:519-528.
32. Martin RE, Henry RI, Abbey JL, Clements JD, Kirk K (2005) The 'permeome' of the malaria parasite: An overview of the membrane transport proteins of Plasmodium falciparum. Genome Biol 6:R26.
33. Kirk K (2001) Membrane transport in the malaria-infected erythrocyte. Physiol Rev 81: 495-537.
34. Anonymous; malERA Consultative Group on Drugs (2011) A research agenda for malaria eradication: Drugs. PLoS Med 8:e1000402.
35. Joet T, Eckstein-Ludwig U, Morin C, Krishna S (2003) Validation of the hexose transporter of Plasmodium falciparum as a novel drug target. Proc Natl Acad Sci USA 100: 7476-7479. (Pubitemid 36759994)
36. Joët T, Krishna S (2004) The hexose transporter of Plasmodium falciparum is a worthy drug target. Acta Trop 89:371-374.
37. Slavic K, et al. (2010) Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality. Mol Microbiol 75: 1402-1413.
38. Witola WH, et al. (2008) Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylasephosphoethanolamine-methyltransferase pathway and severe growth and survival defects. J Biol Chem 283:27636-27643.
39. Crowther GJ, et al. (2010) Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS Negl Trop Dis 4:e804.
40. Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193:673-675.
41. Johnson JD, et al. (2007) Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening. Antimicrob Agents Chemother 51:1926-1933. (Pubitemid 46903075)
42. Kyes S, Pinches R, Newbold C (2000) A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum. Mol Biochem Parasitol 105:311-315. (Pubitemid 30067771)
43. Ferreira ID, Rosário VE, Cravo PV (2006) Real-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparum. Malar J 5:1.