An unconventional role for miRNA: Let-7 activates Toll-like receptor 7 and causes neurodegeneration

Nature Neuroscience

Volumn 15, Issue 6, 2012, Pages 827-835

  Lehmann, Sabrina M ^a   Krüger, Christina ^a   Park, Boyoun ^b   Derkow, Katja ^a   Rosenberger, Karen ^a   Baumgart, Jan ^c   Trimbuch, Thorsten ^a   Eom, Gina ^a   Hinz, Michael ^d   Kaul, David ^a   Habbel, Piet ^a   Kälin, Roland ^a   Franzoni, Eleonora ^a   Rybak, Agnieszka ^d   Nguyen, Duong ^a   Veh, Rüdiger ^a   Ninnemann, Olaf ^a   Peters, Oliver ^a   Nitsch, Robert ^c   Heppner, Frank L ^a   Golenbock, Douglas ^e   Schott, Eckart ^a   Ploegh, Hidde L ^f   Wulczyn, F Gregory ^a   Lehnardt, Seija ^a   more..

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Yonsei University   (South Korea)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; MICRORNA; MICRORNA LET 7; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; MACROPHAGE; MALE; MICROGLIA; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BRAIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; MICROSCOPY, CONFOCAL; NERVE DEGENERATION; NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7;

EID: 84861577379     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3113     Document Type: Article

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