Morpholino antisense oligomers: Design, preparation, and properties

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 187-195

  Summerton, James ^a   Weller, Dwight ^a  

^a Antivirals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MORPHOLINE DERIVATIVE; NUCLEASE;

ARTICLE; DRUG ACTIVITY; DRUG COST; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFICACY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENE REPRESSION; PRIORITY JOURNAL; RNA BINDING; RNA SEQUENCE;

EID: 0030862707     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.187     Document Type: Article

References (5)

1. ANTIVIRALS Inc. Technical Report 3 (1993). Comparative studies of efficacy and specificity of translation inhibition in reticulocyte lysates. Antisense Res. Dev. 3, following p. 306.
2. BELIKOVA, A., ZARYTOVA, V., and GRINEVA, N. (1967). Synthesis of ribonucleosides and diribonucleoside phosphates containing 2-chloroethylamine and nitrogen mustard residues. Tetrahedron Lett. 7, 3557-3562.
3. BONHAM, M., BROWN, S., BOYD, A., BROWN, P., BRUCKENSTEIN, D., HANVEY, J., THOMSON, S., PIPE, A., HASSMAN, F., BISI, J., FROEHLER, B., MATTEUCCI, M., WAGNER, R., NOBLE, S., and BABISS, L. (1995). An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers. Nucleic Acids Res. 23, 1197-1203.
4. CAZENAVE, C., LOREAU, N., THUONG, N., TOULME, J., and HELEN, C. (1987). Enzymatic amplification of translation inhibition of rabbit beta-globin mRNA mediated by antimessenger oligodeoxynucleotides covalently linked to intercalating agents. Nucleic Acids Res. 15, 4717-4736.
5. ZAMECNIK, P., and STEPHENSON, M. (1978). Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 75, 280-284.