Allergen-induced increases in IL-5 receptor α-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects: A novel marker of progenitor cell commitment towards eosinophilic differentiation

Journal of Clinical Investigation

Volumn 100, Issue 10, 1997, Pages 2466-2475

  Sehmi, Roma ^a   Wood, Lorna J ^a   Watson, Rick ^a   Foley, Ronan ^a   Hamid, Qutayba ^b   O'Byrne, Paul M ^a   Denburg, Judah A ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Asthma; CD34; Hemopoiesis; IL 5 receptor

Indexed keywords

ALLERGEN; CD34 ANTIGEN; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5 RECEPTOR; RECEPTOR SUBUNIT;

ADULT; ALLERGY; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; BONE MARROW CELL; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIA; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

EID: 0030831869     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119789     Document Type: Article

References (52)

1. Bousquet, J., P. Chanez, Y.J. Lacoste, G. Barnéon, N. Chavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F.B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
2. Beasley, R., W.R. Roche, J.A. Roberts, and S.T. Holgate. 1989. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Respir. Dis. 139:806-817.
3. Azzawi, M., B. Bradley, P.K. Jeffery, A.J. Frew, A.J. Wardlaw, G. Knowles, B. Assoufi, J.V. Collins, S.R. Durham, and A.B. Kay. 1990. Identificatin of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic, asthma. Am. Rev. Respir. Dis. 142:1407-1413.
4. Hamid, Q., M. Azzawi, S. Ying, R. Moqbel, A.J. Wardlaw, C.J. Corrigan, B. Bradley, S.R. Durham, J.V. Collins, P.K. Jeffery, et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87:1541-1546.
5. Denburg, J.A., S. Telizyn, A. Belda, J. Dolovich, and J. Bienenstock. 1985. Increased numbers of circulating basophil progenitors in atopic patients. J. Allergy Clin. Immunol. 76:466-472.
6. Gibson, P.G., J. Dolovich, A. Girgis-Gabardo, M.M. Morris, M. Anderson, F.E. Hargreave, and J.A. Denburg. 1990. The inflammatory response in asthma exacerbation: changes in circulating eosinophils, basophils and the ir progenitors. Clin. Exp. Allergy. 20:661-668.
7. Otsuka, H., J. Dolovich, A.D. Befus, J. Bienenstock, and J.A. Denburg. 1986. Peripheral blood basophils, basophil progenitors and nasal metachromatic cells in allergic rhinitis. Am. Rev. Respir. Dis. 136:710-717.
8. Linden, M., C. Svensson, M. Andersson, L. Greiff, E. Andersson, J.A. Denburg, J. Seidegard, and C.G.A. Persson. 1994. Increased numbers of circulating leukocyte progenitors in patients with allergic rhinitis during natural allergen exposure. Am. J. Respir. Crit. Care Med. 149:A602(Abstr.).
9. Gibson, P.G., P.J. Manning, P.M. O'Byrne, A. Girgis-Gabardo, J. Dolovich, J.A. Denburg, and F.E. Hargreave. 1991. Allergen induced asthmatic responses. Relationship between increased airway responsiveness and increases in circulating eosinophils, basophils and their progenitors. Am. Rev. Respir. Dis. 143:331-335.
10. Woolley, M.J., J.A. Denburg, R. Ellis, M. Dahlback, and P.M. O'Byrne. 1994. Allergen induced changes in bone marrow progenitors and airways responsiveness in dogs and the effect of inhaled budesonide on these parameters. Am. J. Respir. Cell. Mol. Biol. 11:600-606.
11. Civin, C., T. Trischman, M.J. Fackler, I. Bernstein, H. Buhring, L. Campos, M.F. Greaves, M. Kamoun, D. Katz, P. Lansdorp, et al. 1989. Leukocyte typing. In Leukocyte Typing IV. W. Knapp, editor. Oxford University Press, Oxford. 818-825.
12. Sutherland, D.R., and A. Keating. 1992. The CD34 antigen: structure, biology and potential clinical applications. J. Hemother. 1:115-129.
13. + hemopoietic progenitor cells in atopic subjects. Am. J. Respir. Cell Mol. Biol. 15:645-654.
14. Coligan, J.E., A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober. 1991. Antibody detection and preparation. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons, Inc., New York. 2.1-2.13.
15. Morris, J.F., A. Koski, and L.C. Johnson. 1997. Spirometer standards for healthy non-smoking adults. Am. Rev. Respir. Dis. 103:57-67.
16. Cockcroft, D.W. 1996. Measurement of airway responsiveness to inhaled histamine or methacholine; method of continuous aerosol generation and tidal breathing inhalation. In Airway Responsiveness: Measurement and Interpretation. F.E. Hargreave and A.J. Woolcock, editors. Astra Pharmaceutical, Canada, Limited, Mississauga, Canada. 22-28.
17. O'Byrne, P.M., J. Dolovich, and F.E. Hargreave. 1987. Late asthmatic response. Am. Rev. Respir. Dis. 136:740-756.
18. Popov, T.A., R. Gottschalk, R. Kolendowicz, J. Dolovich, J. Powers, and F.E. Hargreave. 1994. The evaluation of cell dispersion method of sputum examination. Clin. Exp. Allergy. 24:778-783.
19. Coligan, J.E., A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober. 1991. Cytokines and their cellular receptors. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons, Inc. New York. 6.1-6.22.
20. Sehmi, R., O. Cromwell, A.J. Wardlaw, R. Moqbel, and A.B. Kay. 1993. Interleukin-8 is a chemoattractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects. Clin. Exp. Allergy. 23: 1027-1036.
21. Denburg, J.A., M. Richardson, S. Telizyn, and J. Bienenstock. 1983. Basophil/mast cell precursors in human peripheral blood. Blood. 61:775-780.
22. + cells in peripheral and cord blood by flow cytometry. Exp. Hematol. (Charlottesv.). 22:1003-1010.
23. + cells expressing the alpha-subunit of IL-5 receptors following allergen challenge in dual responder asthmatics. J. Allergy Clin. Immunol. 99:S272. (Abstr.)
24. + cell determination by flow cytometry: international society of hematotherapy and graft engineering. J. Hematother. 5:213-226.
25. Borowitz, M.J., L. Guenther, K.E. Shults, and G.T. Stelzer. 1993. Immunophenotyping of acute leukemia by flow cytometric analysis: use of CD45 and right-angle light scatter to gate on leukemic blasts in three-color analysis. Hematopathol. 100:534-540.
26. Hamid, Q., J. Barkans, Q. Meng, S. Ying, J.S. Abrams, A.B. Kay, and R. Moqbel. 1992. Human eosinophils synthesize and secrete interleukin-6, in vitro. Blood. 806:1496-1501.
27. + cells and leukemic cell lines. J. Allergy Clin. Immunol. 96:1083-1099.
28. Lopez, A.F., M.J. Elliott. J. Woodcock, and M.A. Vadas. 1992. GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cell. Immunol. Today. 13:495-500.
29. De Monchy, J.G., H.F. Kaufman, P. Venge, G.H. Koëter, H.M. Jansen, and H.J. Sluiter. 1985. Bronchoalveolar eosinophilia during allergen induced late asthmatic reactions. Am. Rev. Respir. Dis. 426:373-376.
30. Denbura, J.A., S. Telizyn, A. Belda, H. Messner, B. Lim, N. Jamal, S.J. Ackerman, G.J. Gleich, and J. Bienenstock. 1985. Heterogeneity of human peripheral blood eosinophil-type colonies: evidence of a common basophil-eosinophil progenitor. Blood. 66:312-318.
31. Clutterbuck, E.J., E.M.A. Herst, and C.J. Sanderson. 1989. Human interleukin-5 (IL-5) regulates the production of eosinophils in human hone mar-row cultures: comparisons and interaction with IL-1, IL-3, IL-6 and GM-CSF. Blood. 73:1504-1512.
32. Dent, L.A., M. Strath, A.L. Mellor, and C.J. Sanderson. 1990. Eosinophilia in mice expressing interleukin-5. J. Exp. Med. 172:1425-1431.
33. Nagai, H., N. Yamaguchi, N. Inagaki, N. Tsuruoka, Y. Hitoshi, and K. Takatsu. 1993. Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice. Life Sci. 53:PL243-PL247.
34. Kung T., D.M. Stelts, J.A. Zurcher, G.K. Adams III, R.W. Egan, W. Kreutner, A.S. Watnick, H. Jones, and R.W. Chapman. 1995. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an IL-5 antibody. Am. J. Respir. Cell Mol. Biol. 13:360-365.
35. Chand, R.L., B.W. Seymour. S. Hudak, J. Jackson, and D. Rennick. 1992. Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach. Eur. J. Pharmacol. 211:121-123.
36. Gulbenkian, A.R., R.W. Egan, X. Fernandez, H. Jones, W. Kreutner, T. Kung, F. Payvandi, L. Sullivan, J.A. Zurcher, and A.S. Watnick. 1992. Interleukin-5 modulates eosinophil accumulation in guinea pig lung. Am. Rev. Respir. Dis. 146:263-265.
37. Van Oosterhout, A.J.M., I. Van Ark, G. Folkerts, H.L. Van der Linde, H.F.J. Savelkoul, K.C.P. Verheyen, and F.P. Nijkamp. 1995. Antibody to interleukin-5 inhibits virus-induced airways hyperresponsiveness to histamine in guinea pigs. Am. J. Respir. Crit. Care Med. 151:177-183.
38. Mauser, P.J., A.M. Pitman, X. Fernandez, S.K. Foran, G.K. Adams III, W. Kreutner, R.W. Egan, and R.W. Chapman. 1995. Effects of antibody to interleukin-5 in a monkey model of asthma. Am. J. Repir. Crit. Care Med. 152: 467-472.
39. Egan, R.W., D. Athwahl, C. Chou, S. Emtage, C. Jehn, T.T. Kung, P.J. Mauser, N.J. Murgolo, and M.W. Bodmer. 1995. Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5. Int. Arch. Allergy Immunol. 107:321-322.
40. Ema, H., T. Suda, K. Nagayoshi, Y. Miura, C.I. Civin, and H. Nakauchi. 1990. Target cells for granulocyte macrophage colony-stimulating factor, interleukin-3, and interleukin-5 in the differentiation pathways of neutrophils and eosinophils. Blood. 76:1956-1961(Abstr.).
41. Murata, Y., S. Takaki, M. Migita, Y. Kikuchi, A. Tominaga, and K. Takatsu. 1992. Molecular cloning and expression of the human interleukin-5 receptor. J. Exp. Med. 175:341-351.
42. Tavernier, J., R. Devos, S. Cornelius, T. Tuypens, J. Van der Heyden, W. Fiers, and G. Plaetnick. 1991. A human high affinity interleukin-5 receptor (IL-5R) is composed of an IL-5 specific α-chain and a β-chain shared with a receptor for GM-CSF. Cell. 66:1175-1184.
43. Takaki, S., Y. Murata, T. Kitamura, A. Miyajima, A. Tominaga, and K. Takatsu. 1993. Reconstitution of the functional receptors for murine and human interleukin 5. J. Exp. Med. 177:1523-1529.
44. Takagi, M., H. Kanazawa, M. Shiiba, and K. Takatsu. 1994. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor a chain and its function in IL-5-mediated growth signal transduction. Mol. Cell. Biol. 14:7404-7413.
45. Wood, L.J., M.D. Inman, R.M. Watson, R. Foley, J.A. Denburg, and P.M. O'Byrne. 1997. Inhaled allergen-induced changes in bone marrow eosinophil/basophil progenitors in mild asthmatic subjects. J. Allergy Clin. Immunol. 99:A1485(Abstr.).
46. Inman, M.D., J.A. Denburg, R. Ellis, M. Dahlback, and P.M. O'Byrne. 1996. Allergen-induced increase in bone marrow progenitors in airway hyperresponsive dogs: regulation by a serum hemopoietic factor. Am. J. Respir. Cell. Mol. Biol. 15:305-311.
47. Strath, M., L.A. Dent, and C.J. Sanderson. 1992. Infection of IL-5 transgenic mice with Mesocestoides corti induces very high levels of IL-5 but depressed production of eosinophils. Exp. Hematol. 20:229-234.
48. + cells by IL-5 and other growth factors. Cell. Immunol. 160:50-57.
49. Chihara, J., J. Plumas, V. Gruart, J. Tavernier, L. Prin, A. Capron, and M. Capron. 1990. Characterization of a receptor for interleukin 5 on human eosinophils: variable expression and induction by granulocyte macrophage colony stimulating factor. J. Exp. Med. 172:1347-1351.
50. Jacobson, S.E.W., F.W. Ruscetti, A.B. Roberts, and J.R. Keller. 1993. TGF-β is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-β1 and TGF-β3. J. Immunol. 151:4534-4544.
51. Paul, C.C., S. Mahrer, M. Tolbert, B.L. Elbert, I. Wong, S.J. Ackerman, and M.A. Baumann. 1995. Changing the differentiation program of hematopoietic cells: retinoic acid-induced shift of eosinophil-committed cells to neutrophils. Blood. 86:3737-3744.
52. Gratas, C., M.L. Menot, C. Dresch, and C. Chomienne. 1993. Retinoic acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal hone marrow. Leukemia (Baltimore). 7:1156-1162.