Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: Insights into substrate requirements by the human RISC Ago2 enzyme

Nucleic Acids Research

Volumn 35, Issue 19, 2007, Pages 6424-6438

  Li, Feng ^a   Pallan, Pradeep S ^a   Maier, Martin A ^b   Rajeev, Kallanthottathil G ^b   Mathieu, Steven I ^c   Kreutz, Christoph ^d   Fan, Yupeng ^b   Sanghvi, Jayodita ^b   Micura, Ronald ^d   Rozners, Eriks ^c   Manoharan, Muthiah ^b   Egli, Martin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ENDONUCLEASE; FLUORINE; GUANINE; LUCIFERASE; MESSENGER RNA; NUCLEOTIDE DERIVATIVE; OLIGORIBONUCLEOTIDE; PROTEIN; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BASE MISPAIRING; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG STABILITY; ENZYME SUBSTRATE; GENE CONTROL; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR STABILITY; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; RNA INTERFERENCE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

BASE PAIR MISMATCH; BASE PAIRING; CRYSTALLOGRAPHY, X-RAY; EUKARYOTIC INITIATION FACTOR-2; FLUOROBENZENES; HELA CELLS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEOTIDES; OLIGORIBONUCLEOTIDES; OSMOTIC PRESSURE; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 36148961231     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm664     Document Type: Article

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