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Volumn 277, Issue 2, 1996, Pages 923-937

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; ISIS 3082; ISIS 8005; ISIS 9044; ISIS 9045; ISIS 9046; ISIS 9047; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

EID: 12644302203     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (233)

References (41)
  • 1
    • 0025743216 scopus 로고
    • Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice
    • AGRAWAL, S., TEMSAMANI, J. AND TANG, J. Y.: Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. U.S.A. 88: 7595-7599, 1991.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 7595-7599
    • Agrawal, S.1    Temsamani, J.2    Tang, J.Y.3
  • 3
    • 0026606239 scopus 로고
    • Advances in the synthesis of oligonucleotides by the phosphoramidite approach
    • BEAUCAGE, S. L. AND IYER, R. P.: Advances in the synthesis of oligonucleotides by the phosphoramidite approach. Tetrahedron 48: 2223-2311, 1992.
    • (1992) Tetrahedron , vol.48 , pp. 2223-2311
    • Beaucage, S.L.1    Iyer, R.P.2
  • 4
    • 0028248197 scopus 로고
    • Regulation of endothelial cell adhesion molecule expression with antisense oligonucleotides
    • ed. by J. T. August, M. W. Anders, F. Murad and J. T. Coyle, Academic Press, New York
    • BENNETT, C. F. AND CROOKE, S. T.: Regulation of endothelial cell adhesion molecule expression with antisense oligonucleotides. In Advances in Pharmacology, Vol. 28, ed. by J. T. August, M. W. Anders, F. Murad and J. T. Coyle, p. 1, Academic Press, New York, 1994.
    • (1994) Advances in Pharmacology , vol.28 , pp. 1
    • Bennett, C.F.1    Crooke, S.T.2
  • 5
    • 0025346998 scopus 로고
    • Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid
    • CAMPBELL, J. M., BACON, T. A. AND WICKSTROM, E.: Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid. J. Biochem. Biophy. Methods 20: 259-267, 1990.
    • (1990) J. Biochem. Biophy. Methods , vol.20 , pp. 259-267
    • Campbell, J.M.1    Bacon, T.A.2    Wickstrom, E.3
  • 6
    • 0003098462 scopus 로고
    • Medicinal chemistry strategies for antisense research
    • ed. by S. T. Crooke and B. Lebleu, CRC Press, Inc., Boca Raton
    • COOK, P. D.: Medicinal chemistry strategies for antisense research. In Antisense Research and Applications, ed. by S. T. Crooke and B. Lebleu, p. 149, CRC Press, Inc., Boca Raton, 1993.
    • (1993) Antisense Research and Applications , pp. 149
    • Cook, P.D.1
  • 7
    • 0027182233 scopus 로고
    • Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey
    • CORNISH, K G., IVERSEN, P., SMITH, L., ARNESON, M. AND BAYEVER, E.: Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey. Pharmacol. Commun. 3: 239-247, 1993.
    • (1993) Pharmacol. Commun. , vol.3 , pp. 239-247
    • Cornish, K.G.1    Iversen, P.2    Smith, L.3    Arneson, M.4    Bayever, E.5
  • 9
    • 0028183175 scopus 로고
    • Pharmacokinetics of a 14C-labeled phosphorothioate oligonucleotide Isis 2105 after intravenous administration to rats
    • COSSUM, P. A., TRUONG, L., OWENS, S. R., MARKHAM, P. N., SHEA, J. P. AND CROOKE, S. T.: Pharmacokinetics of a 14C-labeled phosphorothioate oligonucleotide Isis 2105 after intravenous administration to rats. J. Pharmacol. Exp. Ther. 267: 89-94, 1994.
    • (1994) J. Pharmacol. Exp. Ther. , vol.267 , pp. 89-94
    • Cossum, P.A.1    Truong, L.2    Owens, S.R.3    Markham, P.N.4    Shea, J.P.5    Crooke, S.T.6
  • 10
    • 0026356572 scopus 로고
    • In vitro toxicology and pharmacokinetics of antisense oligonucleotides
    • CROOSE, R. M.: In vitro toxicology and pharmacokinetics of antisense oligonucleotides. Anti-Cancer Drug Design 6: 609-646, 1991.
    • (1991) Anti-Cancer Drug Design , vol.6 , pp. 609-646
    • Croose, R.M.1
  • 11
    • 0002442281 scopus 로고
    • In vitro and in vivo toxicology of first generation analogs
    • ed. by S. T. Crooke and B. Lebleu, CRC Press, Boca Raton
    • CROOKE, R. M.: In vitro and in vivo toxicology of first generation analogs. In Antisense Research and Applications, ed. by S. T. Crooke and B. Lebleu, p. 427, CRC Press, Boca Raton, 1993.
    • (1993) Antisense Research and Applications , pp. 427
    • Crooke, R.M.1
  • 13
    • 0001675653 scopus 로고
    • Oligonucleotide therapeutics
    • ed. by M. E. Wolff, J. Wiley and Sons, New York
    • CROOKE, S. T.: Oligonucleotide therapeutics. In Burger's Medicinal Chemistry and Drug Discovery, Vol. 1, ed. by M. E. Wolff, p. 863, J. Wiley and Sons, New York, 1995b.
    • (1995) Burger's Medicinal Chemistry and Drug Discovery , vol.1 , pp. 863
    • Crooke, S.T.1
  • 14
    • 0028856820 scopus 로고
    • In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides
    • CROOKE, R. M., GRAHAM, M. J., COOKE, M. E. AND CROOKE, S. T.: In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. J. Pharmacol. Exp. Ther. 275: 462-673, 1995.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 462-673
    • Crooke, R.M.1    Graham, M.J.2    Cooke, M.E.3    Crooke, S.T.4
  • 16
    • 0029077840 scopus 로고
    • Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity
    • CUMMINS, L. L., OWENS, S. R., RISEN, L. N., LESNIK, E. A., FREIER, S. N., MCGEE, D., GUINOSSO, C. J., COOK, P. D.: Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res. 23: 2019-2024, 1995.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 2019-2024
    • Cummins, L.L.1    Owens, S.R.2    Risen, L.N.3    Lesnik, E.A.4    Freier, S.N.5    Mcgee, D.6    Guinosso, C.J.7    Cook, P.D.8
  • 17
    • 0025738773 scopus 로고
    • Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution
    • DE SMIDT, P. C., LE DOAN, T., DE FALCO, S. AND VAN BERKEL, T. J. C.: Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution. Nucleic Acids Res. 19: 4695-4700, 1991.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 4695-4700
    • De Smidt, P.C.1    Le Doan, T.2    De Falco, S.3    Van Berkel, T.J.C.4
  • 18
    • 0020744244 scopus 로고
    • Solvent effects on the dynamics of (dG-dC)3
    • FREIER, S. M., ALBERGO, D. D. AND TURNER, D. H.: Solvent effects on the dynamics of (dG-dC)3. Biopolymers 22: 1107-1131, 1983.
    • (1983) Biopolymers , vol.22 , pp. 1107-1131
    • Freier, S.M.1    Albergo, D.D.2    Turner, D.H.3
  • 19
    • 0026573769 scopus 로고
    • Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology
    • GAO, W. Y., HAN, F.-S., STORM, C., EGAN, W., CHENG, Y-C.: Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: Implications for antisense technology. Mol Pharmacol. 41: 223-229, 1991.
    • (1991) Mol Pharmacol. , vol.41 , pp. 223-229
    • Gao, W.Y.1    Han, F.-S.2    Storm, C.3    Egan, W.4    Cheng, Y.-C.5
  • 20
    • 0028596461 scopus 로고
    • Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey
    • GALBRAITH, W. M., HOBSON, W. C., GICLAS, P. C., SCHECHTER, P. J. AND AGRAWAL, S.: Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey. Antisense Res. Devel. 4: 201-207, 1994.
    • (1994) Antisense Res. Devel. , vol.4 , pp. 201-207
    • Galbraith, W.M.1    Hobson, W.C.2    Giclas, P.C.3    Schechter, P.J.4    Agrawal, S.5
  • 22
    • 0000876636 scopus 로고
    • Measurement of macromolecular binding using electrospray mass spectrometry. Determination of dissociation constants for oligonucleotide:serum albumin complexes
    • GREIG, M. J., GAUS, H. J., CUMMINS, L. L., SASMOR, H. AND GRIFFEY, R. H.: Measurement of macromolecular binding using electrospray mass spectrometry. Determination of dissociation constants for oligonucleotide:serum albumin complexes. J. Am. Chem. Soc. 117: 10765-10766, 1995.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 10765-10766
    • Greig, M.J.1    Gaus, H.J.2    Cummins, L.L.3    Sasmor, H.4    Griffey, R.H.5
  • 23
    • 0029194414 scopus 로고
    • Utility of organic bases for improved electrospray mass spectroscopy of oligonucleotides
    • GREIG, M. J AND GRIFFEY, R. H.: Utility of organic bases for improved electrospray mass spectroscopy of oligonucleotides. Rapid Commun. Mass Spectromet. 9: 97-102, 1995.
    • (1995) Rapid Commun. Mass Spectromet. , vol.9 , pp. 97-102
    • Greig, M.J.1    Griffey, R.H.2
  • 24
    • 0024352634 scopus 로고
    • Measurement of translational motion by pulse-gradient spin-echo nuclear magnetic resonance
    • HANER, R. L. AND SCHLIECH, T.: Measurement of translational motion by pulse-gradient spin-echo nuclear magnetic resonance. Methods Enzyme 176: 418-446, 1989.
    • (1989) Methods Enzyme , vol.176 , pp. 418-446
    • Haner, R.L.1    Schliech, T.2
  • 25
    • 0026048056 scopus 로고
    • Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection
    • HOKE, G. D., DRAPER, K., FREIER, S. M., GONZALEZ, C., DRIVER, V. B., ZOUNES, M. C. AND ECKER, D. J.: Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res. 19: 5743-5748, 1991.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 5743-5748
    • Hoke, G.D.1    Draper, K.2    Freier, S.M.3    Gonzalez, C.4    Driver, V.B.5    Zounes, M.C.6    Ecker, D.J.7
  • 26
    • 0026335873 scopus 로고
    • In vivo studies with phosphorothioate oligonucleotides: Pharmacokinetic prologue
    • IVERSEN, P.: In vivo studies with phosphorothioate oligonucleotides: Pharmacokinetic prologue. Anti-Cancer Drug Design 6: 531-538, 1991.
    • (1991) Anti-Cancer Drug Design , vol.6 , pp. 531-538
    • Iversen, P.1
  • 27
    • 0027473513 scopus 로고
    • Modification of antisense phosphodiester oligodeoxynucleotides by a 5′ cholesterol moiety increases cellular association and improves efficacy
    • KRIEG, A. M., TONKINSON, J., MATSON, S., ZHAO, Q., SAXON, M., ZHANG, L.-M., BHANJA, U., YAKUBOV, L. AND STEIN, C. A.: Modification of antisense phosphodiester oligodeoxynucleotides by a 5′ cholesterol moiety increases cellular association and improves efficacy. Proc. Natl. Acad. Sci. U.S.A. 90: 1048-1052, 1993.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 1048-1052
    • Krieg, A.M.1    Tonkinson, J.2    Matson, S.3    Zhao, Q.4    Saxon, M.5    Zhang, L.-M.6    Bhanja, U.7    Yakubov, L.8    Stein, C.A.9
  • 28
    • 0029044539 scopus 로고
    • 2′-O- and 3′-O-pyrimidine aminotether-containing oligonucleotides: Synthesis and conjugation chemistry
    • MANOHARAN, M., TIVEL, K. L., ANDRADE, L. K. AND COOK, P. D.: 2′-O- and 3′-O-pyrimidine aminotether-containing oligonucleotides: Synthesis and conjugation chemistry. Tetrahedron Lett. 36: 3647-3650, 1995a.
    • (1995) Tetrahedron Lett. , vol.36 , pp. 3647-3650
    • Manoharan, M.1    Tivel, K.L.2    Andrade, L.K.3    Cook, P.D.4
  • 30
    • 0026774939 scopus 로고
    • Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides
    • MONIA, B. P., JOHNSTON, J. F., ECKER, D. J., ZOUNES, M. A., LIMA, W. F. AND FREIER, S. M.: Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides. J. Biol. Chem 267: 19954-19962, 1992.
    • (1992) J. Biol. Chem , vol.267 , pp. 19954-19962
    • Monia, B.P.1    Johnston, J.F.2    Ecker, D.J.3    Zounes, M.A.4    Lima, W.F.5    Freier, S.M.6
  • 31
    • 0001014648 scopus 로고
    • Cellular internalization of oligodeoxynucleotides
    • ed. by S. T. Crooke and B. Lebleu, CRC Press, Boca Raton
    • NECKERS, L. M.: Cellular internalization of oligodeoxynucleotides. In Antisense Research and Applications, ed. by S. T. Crooke and B. Lebleu, p. 451, CRC Press, Boca Raton, 1993.
    • (1993) Antisense Research and Applications , pp. 451
    • Neckers, L.M.1
  • 32
    • 0024284762 scopus 로고
    • 65 binding mode. Cation and anion effects and polynucleotide specificity
    • 65 binding mode. Cation and anion effects and polynucleotide specificity. Biochemistry 27: 456-471, 1988.
    • (1988) Biochemistry , vol.27 , pp. 456-471
    • Overman, L.B.1    Bujalowski, W.2    Lohman, T.M.3
  • 33
    • 0027954331 scopus 로고
    • Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus
    • PISETSKY, D. S. AND REICH, C. F.: Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. Life Sci. 54: 101-107, 1993.
    • (1993) Life Sci. , vol.54 , pp. 101-107
    • Pisetsky, D.S.1    Reich, C.F.2
  • 35
    • 0028241377 scopus 로고
    • Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I.: Comparison of a phosphodiester and a phosphorothioate
    • SANDS, H., GOREY-FERET, L. J., COCUZZA, A. J., HOBBS, F. W., CHIDESTER, D., AND TRAINOR, G. L.: Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I.: Comparison of a phosphodiester and a phosphorothioate. Mol. Pharmacol. 45: 932-943, 1994.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 932-943
    • Sands, H.1    Gorey-Feret, L.J.2    Cocuzza, A.J.3    Hobbs, F.W.4    Chidester, D.5    Trainor, G.L.6
  • 36
    • 0004171793 scopus 로고
    • Towards second-generation synthetic backbones for antisense oligonucleosides
    • ed. by C. K. Chu and D. C. Baker, Plenum Press, New York
    • SANGHVI, Y. S. AND COOK, P. D.: Towards second-generation synthetic backbones for antisense oligonucleosides. In Nucleosides and Nucleotides as Antitumor and Antiviral Agents, ed. by C. K. Chu and D. C. Baker, p. 311-324, Plenum Press, New York, 1993.
    • (1993) Nucleosides and Nucleotides As Antitumor and Antiviral Agents , pp. 311-324
    • Sanghvi, Y.S.1    Cook, P.D.2
  • 37
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents - Is the bullet really magic?
    • Wash. DC
    • STEIN, C. A. AND CHENG, Y.-C.: Antisense oligonucleotides as therapeutic agents - Is the bullet really magic? Science (Wash. DC) 261: 1004-1012, 1993.
    • (1993) Science , vol.261 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.-C.2
  • 38
    • 0027987972 scopus 로고
    • Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities
    • STEPKOWSKI, S. M., TU, Y., CONDON, T. P. AND BENNETT, C. F.: Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities. J. Immunol. 10: 5336-5346, 1994.
    • (1994) J. Immunol. , vol.10 , pp. 5336-5346
    • Stepkowski, S.M.1    Tu, Y.2    Condon, T.P.3    Bennett, C.F.4
  • 39
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • WAGNER, R. W.: Gene inhibition using antisense oligodeoxynucleotides. Nature (Lond.) 372: 333-335, 1994.
    • (1994) Nature (Lond.) , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 40
    • 0022780091 scopus 로고
    • Oligodeoxynucleotide stability in subcellular extracts and culture media
    • WICKSTROM, E.: Oligodeoxynucleotide stability in subcellular extracts and culture media. J Biochem. Biophys. Methods 13: 97-102, 1986.
    • (1986) J Biochem. Biophys. Methods , vol.13 , pp. 97-102
    • Wickstrom, E.1


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