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Volumn 4, Issue 9, 2015, Pages e252-

siRNA versus miRNA as therapeutics for gene silencing

Author keywords

Cancer therapy; Gene silencing; MicroRNA; RNA interference; Small interfering RNA

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; ATELOCOLLAGEN; CHITOSAN; DENDRIMER; HYALURONIC ACID; LIPOPLEX; LOCKED NUCLEIC ACID; MICRORNA; MICROSPHERE; POLYAMIDOAMINE; SMALL INTERFERING RNA; UNTRANSLATED RNA; VIRUS VECTOR;

EID: 84954441161     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2015.23     Document Type: Review
Times cited : (802)

References (218)
  • 2
    • 84877120847 scopus 로고    scopus 로고
    • First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
    • Tabernero, J, Shapiro, GI, LoRusso, PM, Cervantes, A, Schwartz, GK, Weiss, GJ et al. (2013). First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov 3: 406-417.
    • (2013) Cancer Discov , vol.3 , pp. 406-417
    • Tabernero, J.1    Shapiro, G.I.2    LoRusso, P.M.3    Cervantes, A.4    Schwartz, G.K.5    Weiss, G.J.6
  • 3
    • 84919724347 scopus 로고    scopus 로고
    • First-inhuman phase I study of the liposomal RNA interference therapeutic atu027 in patients with advanced solid tumors
    • Schultheis, B, Strumberg, D, Santel, A, Vank, C, Gebhardt, F, Keil, O et al. (2014). First-inhuman phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors. J Clin Oncol 32: 4141-4148.
    • (2014) J Clin Oncol , vol.32 , pp. 4141-4148
    • Schultheis, B.1    Strumberg, D.2    Santel, A.3    Vank, C.4    Gebhardt, F.5    Keil, O.6
  • 4
    • 83255192141 scopus 로고    scopus 로고
    • Developing therapeutic microRNAs for cancer
    • Bader, AG, Brown, D, Stoudemire, J and Lammers, P (2011). Developing therapeutic microRNAs for cancer. Gene Ther 18: 1121-1126.
    • (2011) Gene Ther , vol.18 , pp. 1121-1126
    • Bader, A.G.1    Brown, D.2    Stoudemire, J.3    Lammers, P.4
  • 5
    • 77952688315 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
    • DeVincenzo, J, Lambkin-Williams, R, Wilkinson, T, Cehelsky, J, Nochur, S, Walsh, E et al. (2010). A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci USA 107: 8800-8805.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8800-8805
    • DeVincenzo, J.1    Lambkin-Williams, R.2    Wilkinson, T.3    Cehelsky, J.4    Nochur, S.5    Walsh, E.6
  • 6
    • 84867068265 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes
    • Chandra, PK, Kundu, AK, Hazari, S, Chandra, S, Bao, L, Ooms, T et al. (2012). Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes. Mol Ther 20: 1724-1736.
    • (2012) Mol Ther , vol.20 , pp. 1724-1736
    • Chandra, P.K.1    Kundu, A.K.2    Hazari, S.3    Chandra, S.4    Bao, L.5    Ooms, T.6
  • 7
    • 84924503116 scopus 로고    scopus 로고
    • MiR-122 decreases HCV entry into hepatocytes through binding to the 3'UTR of OCLN mRNA
    • Sendi, H, Mehrab-Mohseni, M, Foureau, DM, Ghosh, S, Walling, TL, Steuerwald, N et al. (2015). MiR-122 decreases HCV entry into hepatocytes through binding to the 3'UTR of OCLN mRNA. Liver Int 35: 1315-1323.
    • (2015) Liver Int , vol.35 , pp. 1315-1323
    • Sendi, H.1    Mehrab-Mohseni, M.2    Foureau, D.M.3    Ghosh, S.4    Walling, T.L.5    Steuerwald, N.6
  • 8
    • 84867642276 scopus 로고    scopus 로고
    • RNAi-based nanomedicines for targeted personalized therapy
    • Daka, A and Peer, D (2012). RNAi-based nanomedicines for targeted personalized therapy. Adv Drug Deliv Rev 64: 1508-1521.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1508-1521
    • Daka, A.1    Peer, D.2
  • 9
    • 33645500266 scopus 로고    scopus 로고
    • Progress towards in vivo use of siRNAs
    • Behlke, MA (2006). Progress towards in vivo use of siRNAs. Mol Ther 13: 644-670.
    • (2006) Mol Ther , vol.13 , pp. 644-670
    • Behlke, M.A.1
  • 10
    • 84856751210 scopus 로고    scopus 로고
    • Developing microRNA therapeutics
    • van Rooij, E, Purcell, AL and Levin, AA (2012). Developing microRNA therapeutics. Circ Res 110: 496-507.
    • (2012) Circ Res , vol.110 , pp. 496-507
    • Van Rooij, E.1    Purcell, A.L.2    Levin, A.A.3
  • 11
    • 77956901498 scopus 로고    scopus 로고
    • The promise of microRNA replacement therapy
    • Bader, AG, Brown, D and Winkler, M (2010). The promise of microRNA replacement therapy. Cancer Res 70: 7027-7030.
    • (2010) Cancer Res , vol.70 , pp. 7027-7030
    • Bader, A.G.1    Brown, D.2    Winkler, M.3
  • 12
    • 33645135862 scopus 로고    scopus 로고
    • Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease?
    • Weiler, J, Hunziker, J and Hall, J (2006). Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther 13: 496-502.
    • (2006) Gene Ther , vol.13 , pp. 496-502
    • Weiler, J.1    Hunziker, J.2    Hall, J.3
  • 13
    • 83255186696 scopus 로고    scopus 로고
    • MicroRNA therapeutics
    • Broderick, JA and Zamore, PD (2011). MicroRNA therapeutics. Gene Ther 18: 1104-1110.
    • (2011) Gene Ther , vol.18 , pp. 1104-1110
    • Broderick, J.A.1    Zamore, P.D.2
  • 14
    • 84903717510 scopus 로고    scopus 로고
    • Development of microRNA therapeutics is coming of age
    • van Rooij, E and Kauppinen, S (2014). Development of microRNA therapeutics is coming of age. EMBO Mol Med 6: 851-864.
    • (2014) EMBO Mol Med , vol.6 , pp. 851-864
    • Van Rooij, E.1    Kauppinen, S.2
  • 15
    • 84893909299 scopus 로고    scopus 로고
    • Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies
    • Deng, Y, Wang, CC, Choy, KW, Du, Q, Chen, J, Wang, Q et al. (2014). Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies. Gene 538: 217-227.
    • (2014) Gene , vol.538 , pp. 217-227
    • Deng, Y.1    Wang, C.C.2    Choy, K.W.3    Du, Q.4    Chen, J.5    Wang, Q.6
  • 17
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • Fire, A, Xu, S, Montgomery, MK, Kostas, SA, Driver, SE and Mello, CC (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 18
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, SM, Harborth, J, Lendeckel, W, Yalcin, A, Weber, K and Tuschl, T (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 20
    • 34548129595 scopus 로고    scopus 로고
    • The response of mammalian cells to double-stranded RNA
    • Gantier, MP and Williams, BR (2007). The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev 18: 363-371.
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 363-371
    • Gantier, M.P.1    Williams, B.R.2
  • 21
    • 26044469804 scopus 로고    scopus 로고
    • Silence of the transcripts: RNA interference in medicine
    • Barik, S (2005). Silence of the transcripts: RNA interference in medicine. J Mol Med (Berl) 83: 764-773.
    • (2005) J Mol Med (Berl) , vol.83 , pp. 764-773
    • Barik, S.1
  • 23
    • 0038419800 scopus 로고    scopus 로고
    • Induction of an interferon response by RNAi vectors in mammalian cells
    • Bridge, AJ, Pebernard, S, Ducraux, A, Nicoulaz, AL and Iggo, R (2003). Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34: 263-264.
    • (2003) Nat Genet , vol.34 , pp. 263-264
    • Bridge, A.J.1    Pebernard, S.2    Ducraux, A.3    Nicoulaz, A.L.4    Iggo, R.5
  • 25
    • 33847036990 scopus 로고    scopus 로고
    • Strategies for silencing human disease using RNA interference
    • Kim, DH and Rossi, JJ (2007). Strategies for silencing human disease using RNA interference. Nat Rev Genet 8: 173-184.
    • (2007) Nat Rev Genet , vol.8 , pp. 173-184
    • Kim, D.H.1    Rossi, J.J.2
  • 27
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson, BL and McCray, PB Jr (2011). Current prospects for RNA interference-based therapies. Nat Rev Genet 12: 329-340.
    • (2011) Nat Rev Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray, P.B.2
  • 28
    • 0027751663 scopus 로고
    • The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, RC, Feinbaum, RL and Ambros, V (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 29
    • 84904985459 scopus 로고    scopus 로고
    • Regulation of microRNA biogenesis
    • Ha, M and Kim, VN (2014). Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15: 509-524.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 509-524
    • Ha, M.1    Kim, V.N.2
  • 30
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir, SM, Lendeckel, W and Tuschl, T (2001). RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15: 188-200.
    • (2001) Genes Dev , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 31
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez, MA, Liu, J, Hannon, GJ and Parker, R (2006). Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20: 515-524.
    • (2006) Genes Dev , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 32
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, DP (2009). MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 33
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim, LP, Lau, NC, Garrett-Engele, P, Grimson, A, Schelter, JM, Castle, J et al. (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773.
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6
  • 34
    • 77955475953 scopus 로고    scopus 로고
    • Expanding the microRNA targeting code: Functional sites with centered pairing
    • Shin, C, Nam, JW, Farh, KK, Chiang, HR, Shkumatava, A and Bartel, DP (2010). Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell 38: 789-802.
    • (2010) Mol Cell , vol.38 , pp. 789-802
    • Shin, C.1    Nam, J.W.2    Farh, K.K.3    Chiang, H.R.4    Shkumatava, A.5    Bartel, D.P.6
  • 35
    • 84857955708 scopus 로고    scopus 로고
    • An alternative mode of microRNA target recognition
    • Chi, SW, Hannon, GJ and Darnell, RB (2012). An alternative mode of microRNA target recognition. Nat Struct Mol Biol 19: 321-327.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 321-327
    • Chi, S.W.1    Hannon, G.J.2    Darnell, R.B.3
  • 36
    • 78751477191 scopus 로고    scopus 로고
    • Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
    • Huntzinger, E and Izaurralde, E (2011). Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12: 99-110.
    • (2011) Nat Rev Genet , vol.12 , pp. 99-110
    • Huntzinger, E.1    Izaurralde, E.2
  • 39
    • 84881225585 scopus 로고    scopus 로고
    • Integration of RNAi and small molecule screens to identify targets for drug development
    • Drosopoulos, K and Linardopoulos, S (2013). Integration of RNAi and small molecule screens to identify targets for drug development. Methods Mol Biol 986: 97-104.
    • (2013) Methods Mol Biol , vol.986 , pp. 97-104
    • Drosopoulos, K.1    Linardopoulos, S.2
  • 40
    • 84905122848 scopus 로고    scopus 로고
    • MicroRNAs in cancer: Biomarkers, functions and therapy
    • Hayes, J, Peruzzi, PP and Lawler, S (2014). MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med 20: 460-469.
    • (2014) Trends Mol Med , vol.20 , pp. 460-469
    • Hayes, J.1    Peruzzi, P.P.2    Lawler, S.3
  • 41
    • 78449296513 scopus 로고    scopus 로고
    • Designing highly active siRNAs for therapeutic applications
    • Walton, SP, Wu, M, Gredell, JA and Chan, C (2010). Designing highly active siRNAs for therapeutic applications. FEBS J 277: 4806-4813.
    • (2010) FEBS J , vol.277 , pp. 4806-4813
    • Walton, S.P.1    Wu, M.2    Gredell, J.A.3    Chan, C.4
  • 44
    • 63449124025 scopus 로고    scopus 로고
    • Increased potency and longevity of gene silencing using validated dicer substrates
    • Hefner, E, Clark, K, Whitman, C, Behlke, MA, Rose, SD, Peek, AS et al. (2008). Increased potency and longevity of gene silencing using validated Dicer substrates. J Biomol Tech 19: 231-237.
    • (2008) J Biomol Tech , vol.19 , pp. 231-237
    • Hefner, E.1    Clark, K.2    Whitman, C.3    Behlke, M.A.4    Rose, S.D.5    Peek, A.S.6
  • 45
    • 78650885450 scopus 로고    scopus 로고
    • Development of a software tool and criteria evaluation for efficient design of small interfering RNA
    • Chaudhary, A, Srivastava, S and Garg, S (2011). Development of a software tool and criteria evaluation for efficient design of small interfering RNA. Biochem Biophys Res Commun 404: 313-320.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 313-320
    • Chaudhary, A.1    Srivastava, S.2    Garg, S.3
  • 46
    • 84905588593 scopus 로고    scopus 로고
    • Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens
    • Zhong, R, Kim, J, Kim, HS, Kim, M, Lum, L, Levine, B et al. (2014). Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens. Nucleic Acids Res 42: 8214-8222.
    • (2014) Nucleic Acids Res , vol.42 , pp. 8214-8222
    • Zhong, R.1    Kim, J.2    Kim, H.S.3    Kim, M.4    Lum, L.5    Levine, B.6
  • 47
    • 84879414849 scopus 로고    scopus 로고
    • Argonaute proteins: Functional insights and emerging roles
    • Meister, G (2013). Argonaute proteins: functional insights and emerging roles. Nat Rev Genet 14: 447-459.
    • (2013) Nat Rev Genet , vol.14 , pp. 447-459
    • Meister, G.1
  • 48
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A, Reynolds, A and Jayasena, SD (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell 115: 209-216.
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 49
    • 2342626647 scopus 로고    scopus 로고
    • The RNA-induced silencing complex is a mg2+-dependent endonuclease
    • Schwarz, DS, Tomari, Y and Zamore, PD (2004). The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol 14: 787-791.
    • (2004) Curr Biol , vol.14 , pp. 787-791
    • Schwarz, D.S.1    Tomari, Y.2    Zamore, P.D.3
  • 52
    • 84881236735 scopus 로고    scopus 로고
    • SiRNA design principles and off-target effects
    • Petri, S and Meister, G (2013). siRNA design principles and off-target effects. Methods Mol Biol 986: 59-71.
    • (2013) Methods Mol Biol , vol.986 , pp. 59-71
    • Petri, S.1    Meister, G.2
  • 55
    • 33746907851 scopus 로고    scopus 로고
    • SiRNA efficiency: Structure or sequence-that is the question
    • Kurreck, J (2006). siRNA efficiency: structure or sequence-that is the question. J Biomed Biotechnol 2006: 83757.
    • (2006) J Biomed Biotechnol , vol.2006
    • Kurreck, J.1
  • 58
    • 58749086586 scopus 로고    scopus 로고
    • Thermodynamic stability and watson-crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
    • Ui-Tei, K, Naito, Y, Nishi, K, Juni, A and Saigo, K (2008). Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect. Nucleic Acids Res 36: 7100-7109.
    • (2008) Nucleic Acids Res , vol.36 , pp. 7100-7109
    • Ui-Tei, K.1    Naito, Y.2    Nishi, K.3    Juni, A.4    Saigo, K.5
  • 60
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    • Jackson, AL, Burchard, J, Schelter, J, Chau, BN, Cleary, M, Lim, L et al. (2006). Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 12: 1179-1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6
  • 61
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson, AL and Linsley, PS (2010). Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 9: 57-67.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 62
    • 10744219688 scopus 로고    scopus 로고
    • Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
    • Scacheri, PC, Rozenblatt-Rosen, O, Caplen, NJ, Wolfsberg, TG, Umayam, L, Lee, JC et al. (2004). Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci USA 101: 1892-1897.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1892-1897
    • Scacheri, P.C.1    Rozenblatt-Rosen, O.2    Caplen, N.J.3    Wolfsberg, T.G.4    Umayam, L.5    Lee, J.C.6
  • 63
    • 0142173075 scopus 로고    scopus 로고
    • Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
    • Saxena, S, Jónsson, ZO and Dutta, A (2003). Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 278: 44312-44319.
    • (2003) J Biol Chem , vol.278 , pp. 44312-44319
    • Saxena, S.1    Jónsson, Z.O.2    Dutta, A.3
  • 65
    • 2442641279 scopus 로고    scopus 로고
    • Many commonly used siRNAs risk off-target activity
    • Snøve, O Jr and Holen, T (2004). Many commonly used siRNAs risk off-target activity. Biochem Biophys Res Commun 319: 256-263.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 256-263
    • Snøve, O.1    Holen, T.2
  • 67
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm, D, Streetz, KL, Jopling, CL, Storm, TA, Pandey, K, Davis, CR et al. (2006). Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441: 537-541.
    • (2006) Nature , vol.441 , pp. 537-541
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3    Storm, T.A.4    Pandey, K.5    Davis, C.R.6
  • 68
    • 34247873185 scopus 로고    scopus 로고
    • Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
    • Kittler, R, Surendranath, V, Heninger, AK, Slabicki, M, Theis, M, Putz, G et al. (2007). Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies. Nat Methods 4: 337-344.
    • (2007) Nat Methods , vol.4 , pp. 337-344
    • Kittler, R.1    Surendranath, V.2    Heninger, A.K.3    Slabicki, M.4    Theis, M.5    Putz, G.6
  • 69
    • 78651293534 scopus 로고    scopus 로고
    • MiRBase: Integrating microRNA annotation and deep-sequencing data
    • Kozomara, A and Griffiths-Jones, S (2011). miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39(Database issue): D152-D157.
    • (2011) Nucleic Acids Res , vol.39 , Issue.DATABASE ISSUE , pp. D152-D157
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 70
    • 84934439082 scopus 로고    scopus 로고
    • Designing functional siRNA with reduced off-target effects
    • Naito, Y and Ui-Tei, K (2013). Designing functional siRNA with reduced off-target effects. Methods Mol Biol 942: 57-68.
    • (2013) Methods Mol Biol , vol.942 , pp. 57-68
    • Naito, Y.1    Ui-Tei, K.2
  • 71
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, AD, Sood, V, Shaw, JR, Fang, D, McClintock, K and MacLachlan, I (2005). Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462.
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 73
  • 74
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil, F, Hemmi, H, Hochrein, H, Ampenberger, F, Kirschning, C, Akira, S et al. (2004). Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6
  • 75
    • 68949213101 scopus 로고    scopus 로고
    • Sequence determinants of innate immune activation by short interfering RNAs
    • Goodchild, A, Nopper, N, King, A, Doan, T, Tanudji, M, Arndt, GM et al. (2009). Sequence determinants of innate immune activation by short interfering RNAs. BMC Immunol 10: 40.
    • (2009) BMC Immunol , vol.10 , pp. 40
    • Goodchild, A.1    Nopper, N.2    King, A.3    Doan, T.4    Tanudji, M.5    Arndt, G.M.6
  • 76
    • 84934435856 scopus 로고    scopus 로고
    • Engineering small interfering RNAs by strategic chemical modification
    • Bramsen, JB and Kjems, J (2013). Engineering small interfering RNAs by strategic chemical modification. Methods Mol Biol 942: 87-109.
    • (2013) Methods Mol Biol , vol.942 , pp. 87-109
    • Bramsen, J.B.1    Kjems, J.2
  • 77
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
    • Iorio, MV and Croce, CM (2012). MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 4: 143-159.
    • (2012) EMBO Mol Med , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 78
    • 84869013206 scopus 로고    scopus 로고
    • Synthetic pre-miRNA-based shRNA as potent RNAi triggers
    • Terasawa, K, Shimizu, K and Tsujimoto, G (2011). Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers. J Nucleic Acids 2011: 131579.
    • (2011) J Nucleic Acids , vol.2011
    • Terasawa, K.1    Shimizu, K.2    Tsujimoto, G.3
  • 80
    • 84874589695 scopus 로고    scopus 로고
    • A new role for microRNAs, as ligands of toll-like receptors
    • Fabbri, M, Paone, A, Calore, F, Galli, R and Croce, CM (2013). A new role for microRNAs, as ligands of Toll-like receptors. RNA Biol 10: 169-174.
    • (2013) RNA Biol , vol.10 , pp. 169-174
    • Fabbri, M.1    Paone, A.2    Calore, F.3    Galli, R.4    Croce, C.M.5
  • 82
    • 52049090811 scopus 로고    scopus 로고
    • Chemically modified siRNA: Tools and applications
    • Watts, JK, Deleavey, GF and Damha, MJ (2008). Chemically modified siRNA: tools and applications. Drug Discov Today 13: 842-855.
    • (2008) Drug Discov Today , vol.13 , pp. 842-855
    • Watts, J.K.1    Deleavey, G.F.2    Damha, M.J.3
  • 84
    • 56249145105 scopus 로고    scopus 로고
    • Structure of the guide-strand-containing argonaute silencing complex
    • Wang, Y, Sheng, G, Juranek, S, Tuschl, T and Patel, DJ (2008). Structure of the guide-strand-containing argonaute silencing complex. Nature 456: 209-213.
    • (2008) Nature , vol.456 , pp. 209-213
    • Wang, Y.1    Sheng, G.2    Juranek, S.3    Tuschl, T.4    Patel, D.J.5
  • 85
    • 66349108231 scopus 로고    scopus 로고
    • A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
    • Bramsen, JB, Laursen, MB, Nielsen, AF, Hansen, TB, Bus, C, Langkjaer, N et al. (2009). A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res 37: 2867-2881.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2867-2881
    • Bramsen, J.B.1    Laursen, M.B.2    Nielsen, A.F.3    Hansen, T.B.4    Bus, C.5    Langkjaer, N.6
  • 86
    • 0041331496 scopus 로고    scopus 로고
    • SiRNA function in RNAi: A chemical modification analysis
    • Chiu, YL and Rana, TM (2003). siRNA function in RNAi: a chemical modification analysis. RNA 9: 1034-1048.
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.L.1    Rana, T.M.2
  • 87
    • 13944261143 scopus 로고    scopus 로고
    • Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA
    • Allerson, CR, Sioufi, N, Jarres, R, Prakash, TP, Naik, N, Berdeja, A et al. (2005). Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA. J Med Chem 48: 901-904.
    • (2005) J Med Chem , vol.48 , pp. 901-904
    • Allerson, C.R.1    Sioufi, N.2    Jarres, R.3    Prakash, T.P.4    Naik, N.5    Berdeja, A.6
  • 88
    • 21244497878 scopus 로고    scopus 로고
    • Positional effect of chemical modifications on short interference RNA activity in mammalian cells
    • Prakash, TP, Allerson, CR, Dande, P, Vickers, TA, Sioufi, N, Jarres, R et al. (2005). Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J Med Chem 48: 4247-4253.
    • (2005) J Med Chem , vol.48 , pp. 4247-4253
    • Prakash, T.P.1    Allerson, C.R.2    Dande, P.3    Vickers, T.A.4    Sioufi, N.5    Jarres, R.6
  • 89
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a siRNA
    • Amarzguioui, M, Holen, T, Babaie, E and Prydz, H (2003). Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res 31: 589-595.
    • (2003) Nucleic Acids Res , vol.31 , pp. 589-595
    • Amarzguioui, M.1    Holen, T.2    Babaie, E.3    Prydz, H.4
  • 90
    • 38049058354 scopus 로고    scopus 로고
    • Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference
    • Odadzic, D, Bramsen, JB, Smicius, R, Bus, C, Kjems, J and Engels, JW (2008). Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference. Bioorg Med Chem 16: 518-529.
    • (2008) Bioorg Med Chem , vol.16 , pp. 518-529
    • Odadzic, D.1    Bramsen, J.B.2    Smicius, R.3    Bus, C.4    Kjems, J.5    Engels, J.W.6
  • 91
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge, AD, Bola, G, Lee, AC and MacLachlan, I (2006). Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 13: 494-505.
    • (2006) Mol Ther , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    MacLachlan, I.4
  • 92
    • 33751511117 scopus 로고    scopus 로고
    • Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects
    • Cekaite, L, Furset, G, Hovig, E and Sioud, M (2007). Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects. J Mol Biol 365: 90-108.
    • (2007) J Mol Biol , vol.365 , pp. 90-108
    • Cekaite, L.1    Furset, G.2    Hovig, E.3    Sioud, M.4
  • 93
    • 77953543643 scopus 로고    scopus 로고
    • Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist
    • Hamm, S, Latz, E, Hangel, D, Müller, T, Yu, P, Golenbock, D et al. (2010). Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 215: 559-569.
    • (2010) Immunobiology , vol.215 , pp. 559-569
    • Hamm, S.1    Latz, E.2    Hangel, D.3    Müller, T.4    Yu, P.5    Golenbock, D.6
  • 94
    • 77949676231 scopus 로고    scopus 로고
    • Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications
    • Veedu, RN and Wengel, J (2010). Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. Chem Biodivers 7: 536-542.
    • (2010) Chem Biodivers , vol.7 , pp. 536-542
    • Veedu, R.N.1    Wengel, J.2
  • 95
    • 13744250159 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
    • Elmén, J, Thonberg, H, Ljungberg, K, Frieden, M, Westergaard, M, Xu, Y et al. (2005). Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res 33: 439-447.
    • (2005) Nucleic Acids Res , vol.33 , pp. 439-447
    • Elmén, J.1    Thonberg, H.2    Ljungberg, K.3    Frieden, M.4    Westergaard, M.5    Xu, Y.6
  • 96
    • 34147180058 scopus 로고    scopus 로고
    • Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
    • Mook, OR, Baas, F, de Wissel, MB and Fluiter, K (2007). Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol Cancer Ther 6: 833-843.
    • (2007) Mol Cancer Ther , vol.6 , pp. 833-843
    • Mook, O.R.1    Baas, F.2    De Wissel, M.B.3    Fluiter, K.4
  • 97
    • 0038385504 scopus 로고    scopus 로고
    • RNA interference in mammalian cells by chemically-modified RNA
    • Braasch, DA, Jensen, S, Liu, Y, Kaur, K, Arar, K, White, MA et al. (2003). RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 42: 7967-7975.
    • (2003) Biochemistry , vol.42 , pp. 7967-7975
    • Braasch, D.A.1    Jensen, S.2    Liu, Y.3    Kaur, K.4    Arar, K.5    White, M.A.6
  • 98
    • 0038578021 scopus 로고    scopus 로고
    • Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA
    • Grünweller, A, Wyszko, E, Bieber, B, Jahnel, R, Erdmann, VA and Kurreck, J (2003). Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res 31: 3185-3193.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3185-3193
    • Grünweller, A.1    Wyszko, E.2    Bieber, B.3    Jahnel, R.4    Erdmann, V.A.5    Kurreck, J.6
  • 99
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung, V, Guenthner-Biller, M, Bourquin, C, Ablasser, A, Schlee, M, Uematsu, S et al. (2005). Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11: 263-270.
    • (2005) Nat Med , vol.11 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3    Ablasser, A.4    Schlee, M.5    Uematsu, S.6
  • 100
    • 77952329345 scopus 로고    scopus 로고
    • Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo
    • Laursen, MB, Pakula, MM, Gao, S, Fluiter, K, Mook, OR, Baas, F et al. (2010). Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Mol Biosyst 6: 862-870.
    • (2010) Mol Biosyst , vol.6 , pp. 862-870
    • Laursen, M.B.1    Pakula, M.M.2    Gao, S.3    Fluiter, K.4    Mook, O.R.5    Baas, F.6
  • 101
    • 79953144826 scopus 로고    scopus 로고
    • Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
    • Vaish, N, Chen, F, Seth, S, Fosnaugh, K, Liu, Y, Adami, R et al. (2011). Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs. Nucleic Acids Res 39: 1823-1832.
    • (2011) Nucleic Acids Res , vol.39 , pp. 1823-1832
    • Vaish, N.1    Chen, F.2    Seth, S.3    Fosnaugh, K.4    Liu, Y.5    Adami, R.6
  • 102
    • 0025346998 scopus 로고
    • Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid
    • Campbell, JM, Bacon, TA and Wickstrom, E (1990). Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid. J Biochem Biophys Methods 20: 259-267.
    • (1990) J Biochem Biophys Methods , vol.20 , pp. 259-267
    • Campbell, J.M.1    Bacon, T.A.2    Wickstrom, E.3
  • 103
    • 84915763945 scopus 로고    scopus 로고
    • Phosphorothioates, essential components of therapeutic oligonucleotides
    • Eckstein, F (2014). Phosphorothioates, essential components of therapeutic oligonucleotides. Nucleic Acid Ther 24: 374-387.
    • (2014) Nucleic Acid Ther , vol.24 , pp. 374-387
    • Eckstein, F.1
  • 106
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • Choung, S, Kim, YJ, Kim, S, Park, HO and Choi, YC (2006). Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem Biophys Res Commun 342: 919-927.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 919-927
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H.O.4    Choi, Y.C.5
  • 107
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek, J, Akinc, A, Bramlage, B, Charisse, K, Constien, R, Donoghue, M et al. (2004). Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432: 173-178.
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3    Charisse, K.4    Constien, R.5    Donoghue, M.6
  • 108
    • 84924597592 scopus 로고    scopus 로고
    • Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs
    • Jahns, H, Roos, M, Imig, J, Baumann, F, Wang, Y, Gilmour, R et al. (2015). Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs. Nat Commun 6: 6317.
    • (2015) Nat Commun , vol.6 , pp. 6317
    • Jahns, H.1    Roos, M.2    Imig, J.3    Baumann, F.4    Wang, Y.5    Gilmour, R.6
  • 111
    • 77956650867 scopus 로고    scopus 로고
    • Viral vector-mediated RNA interference
    • Couto, LB and High, KA (2010). Viral vector-mediated RNA interference. Curr Opin Pharmacol 10: 534-542.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 534-542
    • Couto, L.B.1    High, K.A.2
  • 112
    • 84857785246 scopus 로고    scopus 로고
    • Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia
    • Kasar, S, Salerno, E, Yuan, Y, Underbayev, C, Vollenweider, D, Laurindo, MF et al. (2012). Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. Genes Immun 13: 109-119.
    • (2012) Genes Immun , vol.13 , pp. 109-119
    • Kasar, S.1    Salerno, E.2    Yuan, Y.3    Underbayev, C.4    Vollenweider, D.5    Laurindo, M.F.6
  • 114
    • 77953642976 scopus 로고    scopus 로고
    • Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies
    • Liu, YP, Vink, MA, Westerink, JT, Ramirez de Arellano, E, Konstantinova, P, Ter Brake, O et al. (2010). Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies. RNA 16: 1328-1339.
    • (2010) RNA , vol.16 , pp. 1328-1339
    • Liu, Y.P.1    Vink, M.A.2    Westerink, J.T.3    Ramirez De Arellano, E.4    Konstantinova, P.5    Ter Brake, O.6
  • 115
    • 84881367251 scopus 로고    scopus 로고
    • Adenovirus vector-mediated RNA interference for the inhibition of human parvovirus B19 replication
    • Brandt, MR, Kirste, AG, Pozzuto, T, Schubert, S, Kandolf, R, Fechner, H et al. (2013). Adenovirus vector-mediated RNA interference for the inhibition of human parvovirus B19 replication. Virus Res 176: 155-160.
    • (2013) Virus Res , vol.176 , pp. 155-160
    • Brandt, M.R.1    Kirste, A.G.2    Pozzuto, T.3    Schubert, S.4    Kandolf, R.5    Fechner, H.6
  • 116
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - Micrornas with a role in cancer
    • Esquela-Kerscher, A and Slack, FJ (2006). Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 117
    • 84878546600 scopus 로고    scopus 로고
    • Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model
    • Lou, W, Chen, Q, Ma, L, Liu, J, Yang, Z, Shen, J et al. (2013). Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model. J Mol Med (Berl) 91: 715-725.
    • (2013) J Mol Med (Berl) , vol.91 , pp. 715-725
    • Lou, W.1    Chen, Q.2    Ma, L.3    Liu, J.4    Yang, Z.5    Shen, J.6
  • 118
    • 84897570851 scopus 로고    scopus 로고
    • Recombinant AAV as a platform for translating the therapeutic potential of RNA interference
    • Borel, F, Kay, MA and Mueller, C (2014). Recombinant AAV as a platform for translating the therapeutic potential of RNA interference. Mol Ther 22: 692-701.
    • (2014) Mol Ther , vol.22 , pp. 692-701
    • Borel, F.1    Kay, M.A.2    Mueller, C.3
  • 119
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota, J, Chivukula, RR, O'Donnell, KA, Wentzel, EA, Montgomery, CL, Hwang, HW et al. (2009). Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137: 1005-1017.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O'Donnell, K.A.3    Wentzel, E.A.4    Montgomery, C.L.5    Hwang, H.W.6
  • 120
    • 84901195245 scopus 로고    scopus 로고
    • Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of huntington's disease
    • Stanek, LM, Sardi, SP, Mastis, B, Richards, AR, Treleaven, CM, Taksir, T et al. (2014). Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease. Hum Gene Ther 25: 461-474.
    • (2014) Hum Gene Ther , vol.25 , pp. 461-474
    • Stanek, L.M.1    Sardi, S.P.2    Mastis, B.3    Richards, A.R.4    Treleaven, C.M.5    Taksir, T.6
  • 122
    • 33645451483 scopus 로고    scopus 로고
    • Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
    • Baum, C, Kustikova, O, Modlich, U, Li, Z and Fehse, B (2006). Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum Gene Ther 17: 253-263.
    • (2006) Hum Gene Ther , vol.17 , pp. 253-263
    • Baum, C.1    Kustikova, O.2    Modlich, U.3    Li, Z.4    Fehse, B.5
  • 123
    • 73449123732 scopus 로고    scopus 로고
    • State-of-the-art lentiviral vectors for research use: Risk assessment and biosafety recommendations
    • Pauwels, K, Gijsbers, R, Toelen, J, Schambach, A, Willard-Gallo, K, Verheust, C et al. (2009). State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations. Curr Gene Ther 9: 459-474.
    • (2009) Curr Gene Ther , vol.9 , pp. 459-474
    • Pauwels, K.1    Gijsbers, R.2    Toelen, J.3    Schambach, A.4    Willard-Gallo, K.5    Verheust, C.6
  • 124
    • 67349204836 scopus 로고    scopus 로고
    • Biological gene delivery vehicles: Beyond viral vectors
    • Seow, Y and Wood, MJ (2009). Biological gene delivery vehicles: beyond viral vectors. Mol Ther 17: 767-777.
    • (2009) Mol Ther , vol.17 , pp. 767-777
    • Seow, Y.1    Wood, M.J.2
  • 125
    • 84937144547 scopus 로고    scopus 로고
    • Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics
    • Movahedi, F, Hu, RG, Becker, DL and Xu, C (2015). Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics. Nanomedicine 11: 1575-1584.
    • (2015) Nanomedicine , vol.11 , pp. 1575-1584
    • Movahedi, F.1    Hu, R.G.2    Becker, D.L.3    Xu, C.4
  • 126
    • 84900301713 scopus 로고    scopus 로고
    • Preclinical development of siRNA therapeutics: Towards the match between fundamental science and engineered systems
    • Videira, M, Arranja, A, Rafael, D and Gaspar, R (2014). Preclinical development of siRNA therapeutics: towards the match between fundamental science and engineered systems. Nanomedicine 10: 689-702.
    • (2014) Nanomedicine , vol.10 , pp. 689-702
    • Videira, M.1    Arranja, A.2    Rafael, D.3    Gaspar, R.4
  • 128
    • 33746438424 scopus 로고    scopus 로고
    • Toxicity of cationic lipids and cationic polymers in gene delivery
    • Lv, H, Zhang, S, Wang, B, Cui, S and Yan, J (2006). Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 114: 100-109.
    • (2006) J Control Release , vol.114 , pp. 100-109
    • Lv, H.1    Zhang, S.2    Wang, B.3    Cui, S.4    Yan, J.5
  • 129
    • 84910011032 scopus 로고    scopus 로고
    • Recent developments in nucleic acid delivery with polyethylenimines
    • Neuberg, P and Kichler, A (2014). Recent developments in nucleic acid delivery with polyethylenimines. Adv Genet 88: 263-288.
    • (2014) Adv Genet , vol.88 , pp. 263-288
    • Neuberg, P.1    Kichler, A.2
  • 131
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein, B, Werth, S, Abuharbeid, S, Czubayko, F and Aigner, A (2005). RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 12: 461-466.
    • (2005) Gene Ther , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 133
    • 84889077122 scopus 로고    scopus 로고
    • Poly(amidoamine) dendrimer complexes as a platform for gene delivery
    • Shcharbin, D, Shakhbazau, A and Bryszewska, M (2013). Poly(amidoamine) dendrimer complexes as a platform for gene delivery. Expert Opin Drug Deliv 10: 1687-1698.
    • (2013) Expert Opin Drug Deliv , vol.10 , pp. 1687-1698
    • Shcharbin, D.1    Shakhbazau, A.2    Bryszewska, M.3
  • 134
    • 84897426837 scopus 로고    scopus 로고
    • Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target akt with the clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer
    • Kala, S, Mak, AS, Liu, X, Posocco, P, Pricl, S, Peng, L et al. (2014). Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target Akt with the clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer. J Med Chem 57: 2634-2642.
    • (2014) J Med Chem , vol.57 , pp. 2634-2642
    • Kala, S.1    Mak, A.S.2    Liu, X.3    Posocco, P.4    Pricl, S.5    Peng, L.6
  • 135
    • 84896514799 scopus 로고    scopus 로고
    • Arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo
    • Liu, C, Liu, X, Rocchi, P, Qu, F, Iovanna, JL and Peng, L (2014). Arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo. Bioconjug Chem 25: 521-532.
    • (2014) Bioconjug Chem , vol.25 , pp. 521-532
    • Liu, C.1    Liu, X.2    Rocchi, P.3    Qu, F.4    Iovanna, J.L.5    Peng, L.6
  • 136
    • 84874728069 scopus 로고    scopus 로고
    • Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells
    • Liu, X, Li, G, Su, Z, Jiang, Z, Chen, L, Wang, J et al. (2013). Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells. Oncol Rep 29: 1387-1394.
    • (2013) Oncol Rep , vol.29 , pp. 1387-1394
    • Liu, X.1    Li, G.2    Su, Z.3    Jiang, Z.4    Chen, L.5    Wang, J.6
  • 137
    • 84888089856 scopus 로고    scopus 로고
    • Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: An optimal delivery of siRNA and anticancer drug
    • Shah, V, Taratula, O, Garbuzenko, OB, Taratula, OR, Rodriguez-Rodriguez, L and Minko, T (2013). Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and anticancer drug. Clin Cancer Res 19: 6193-6204.
    • (2013) Clin Cancer Res , vol.19 , pp. 6193-6204
    • Shah, V.1    Taratula, O.2    Garbuzenko, O.B.3    Taratula, O.R.4    Rodriguez-Rodriguez, L.5    Minko, T.6
  • 138
    • 84893711078 scopus 로고    scopus 로고
    • Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma
    • Siu, KS, Chen, D, Zheng, X, Zhang, X, Johnston, N, Liu, Y et al. (2014). Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma. Biomaterials 35: 3435-3442.
    • (2014) Biomaterials , vol.35 , pp. 3435-3442
    • Siu, K.S.1    Chen, D.2    Zheng, X.3    Zhang, X.4    Johnston, N.5    Liu, Y.6
  • 139
    • 84862808036 scopus 로고    scopus 로고
    • Cationic polyurethanes-short branch PEI-mediated delivery of mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
    • Chiou, GY, Cherng, JY, Hsu, HS, Wang, ML, Tsai, CM, Lu, KH et al. (2012). Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma. J Control Release 159: 240-250.
    • (2012) J Control Release , vol.159 , pp. 240-250
    • Chiou, G.Y.1    Cherng, J.Y.2    Hsu, H.S.3    Wang, M.L.4    Tsai, C.M.5    Lu, K.H.6
  • 140
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI
    • Yang, YP, Chien, Y, Chiou, GY, Cherng, JY, Wang, ML, Lo, WL et al. (2012). Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. Biomaterials 33: 1462-1476.
    • (2012) Biomaterials , vol.33 , pp. 1462-1476
    • Yang, Y.P.1    Chien, Y.2    Chiou, G.Y.3    Cherng, J.Y.4    Wang, M.L.5    Lo, W.L.6
  • 141
    • 84918586982 scopus 로고    scopus 로고
    • Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance
    • Yhee, JY, Song, S, Lee, SJ, Park, SG, Kim, KS, Kim, MG et al. (2015). Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance. J Control Release 198: 1-9.
    • (2015) J Control Release , vol.198 , pp. 1-9
    • Yhee, J.Y.1    Song, S.2    Lee, S.J.3    Park, S.G.4    Kim, K.S.5    Kim, M.G.6
  • 142
    • 84896793649 scopus 로고    scopus 로고
    • Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer
    • Deng, X, Cao, M, Zhang, J, Hu, K, Yin, Z, Zhou, Z et al. (2014). Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer. Biomaterials 35: 4333-4344.
    • (2014) Biomaterials , vol.35 , pp. 4333-4344
    • Deng, X.1    Cao, M.2    Zhang, J.3    Hu, K.4    Yin, Z.5    Zhou, Z.6
  • 143
    • 84964284460 scopus 로고    scopus 로고
    • Atelocollagen-mediated intravenous siRNA delivery specific to tumor tissues orthotopically xenografted in prostates of nude mice and its anticancer effects
    • Yuan, Y, Makita, N, Cao, D, Mihara, K, Kadomatsu, K and Takei, Y (2015). Atelocollagen-mediated intravenous siRNA delivery specific to tumor tissues orthotopically xenografted in prostates of nude mice and its anticancer effects. Nucleic Acid Ther 25: 85-94.
    • (2015) Nucleic Acid Ther , vol.25 , pp. 85-94
    • Yuan, Y.1    Makita, N.2    Cao, D.3    Mihara, K.4    Kadomatsu, K.5    Takei, Y.6
  • 144
    • 84878063536 scopus 로고    scopus 로고
    • Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function
    • Kawakami, E, Kawai, N, Kinouchi, N, Mori, H, Ohsawa, Y, Ishimaru, N et al. (2013). Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function. PLoS One 8: e64719.
    • (2013) PLoS One , vol.8
    • Kawakami, E.1    Kawai, N.2    Kinouchi, N.3    Mori, H.4    Ohsawa, Y.5    Ishimaru, N.6
  • 145
    • 74149083873 scopus 로고    scopus 로고
    • Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes
    • Takeshita, F, Patrawala, L, Osaki, M, Takahashi, RU, Yamamoto, Y, Kosaka, N et al. (2010). Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther 18: 181-187.
    • (2010) Mol Ther , vol.18 , pp. 181-187
    • Takeshita, F.1    Patrawala, L.2    Osaki, M.3    Takahashi, R.U.4    Yamamoto, Y.5    Kosaka, N.6
  • 146
    • 10444279209 scopus 로고    scopus 로고
    • Cyclodextrin-based pharmaceutics: Past, present and future
    • Davis, ME and Brewster, ME (2004). Cyclodextrin-based pharmaceutics: past, present and future. Nat Rev Drug Discov 3: 1023-1035.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1023-1035
    • Davis, M.E.1    Brewster, M.E.2
  • 147
    • 39549120024 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
    • Bartlett, DW and Davis, ME (2008). Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. Biotechnol Bioeng 99: 975-985.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 975-985
    • Bartlett, D.W.1    Davis, M.E.2
  • 148
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic ewing's sarcoma
    • Hu-Lieskovan, S, Heidel, JD, Bartlett, DW, Davis, ME and Triche, TJ (2005). Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 65: 8984-8992.
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3    Davis, M.E.4    Triche, T.J.5
  • 149
    • 39649104546 scopus 로고    scopus 로고
    • Anti-tumor effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice
    • Murata, N, Takashima, Y, Toyoshima, K, Yamamoto, M and Okada, H (2008). Anti-tumor effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice. J Control Release 126: 246-254.
    • (2008) J Control Release , vol.126 , pp. 246-254
    • Murata, N.1    Takashima, Y.2    Toyoshima, K.3    Yamamoto, M.4    Okada, H.5
  • 150
    • 84865514367 scopus 로고    scopus 로고
    • Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation
    • Mountziaris, PM, Tzouanas, SN, Sing, DC, Kramer, PR, Kasper, FK and Mikos, AG (2012). Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation. Acta Biomater 8: 3552-3560.
    • (2012) Acta Biomater , vol.8 , pp. 3552-3560
    • Mountziaris, P.M.1    Tzouanas, S.N.2    Sing, D.C.3    Kramer, P.R.4    Kasper, F.K.5    Mikos, A.G.6
  • 151
    • 84893660789 scopus 로고    scopus 로고
    • Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting S TAT 3 in lung cancer, in vitro and in vivo
    • Das, J, Das, S, Paul, A, Samadder, A, Bhattacharyya, SS and Khuda-Bukhsh, AR (2014). Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting S TAT 3 in lung cancer, in vitro and in vivo. Toxicol Lett 225: 454-466.
    • (2014) Toxicol Lett , vol.225 , pp. 454-466
    • Das, J.1    Das, S.2    Paul, A.3    Samadder, A.4    Bhattacharyya, S.S.5    Khuda-Bukhsh, A.R.6
  • 152
    • 84866738641 scopus 로고    scopus 로고
    • Silica-based nanoparticles for biomedical applications
    • Bitar, A, Ahmad, NM, Fessi, H and Elaissari, A (2012). Silica-based nanoparticles for biomedical applications. Drug Discov Today 17: 1147-1154.
    • (2012) Drug Discov Today , vol.17 , pp. 1147-1154
    • Bitar, A.1    Ahmad, N.M.2    Fessi, H.3    Elaissari, A.4
  • 153
    • 84893434483 scopus 로고    scopus 로고
    • Adsorption and release of siRNA from porous silica
    • Steinbacher, JL and Landry, CC (2014). Adsorption and release of siRNA from porous silica. Langmuir 30: 4396-4405.
    • (2014) Langmuir , vol.30 , pp. 4396-4405
    • Steinbacher, J.L.1    Landry, C.C.2
  • 154
    • 84928137606 scopus 로고    scopus 로고
    • Highly effective antiangiogenesis via magnetic mesoporous silica-based siRNA vehicle targeting the VEGF gene for orthotopic ovarian cancer therapy
    • Chen, Y, Wang, X, Liu, T, Zhang, DS, Wang, Y, Gu, H et al. (2015). Highly effective antiangiogenesis via magnetic mesoporous silica-based siRNA vehicle targeting the VEGF gene for orthotopic ovarian cancer therapy. Int J Nanomedicine 10: 2579-2594.
    • (2015) Int J Nanomedicine , vol.10 , pp. 2579-2594
    • Chen, Y.1    Wang, X.2    Liu, T.3    Zhang, D.S.4    Wang, Y.5    Gu, H.6
  • 155
    • 84861473531 scopus 로고    scopus 로고
    • Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles
    • Tivnan, A, Orr, WS, Gubala, V, Nooney, R, Williams, DE, McDonagh, C et al. (2012). Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS One 7: e38129.
    • (2012) PLoS One , vol.7
    • Tivnan, A.1    Orr, W.S.2    Gubala, V.3    Nooney, R.4    Williams, D.E.5    McDonagh, C.6
  • 156
    • 84908093790 scopus 로고    scopus 로고
    • Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier
    • Chen, Y, Gu, H, Zhang, DS, Li, F, Liu, T and Xia, W (2014). Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. Biomaterials 35: 10058-10069.
    • (2014) Biomaterials , vol.35 , pp. 10058-10069
    • Chen, Y.1    Gu, H.2    Zhang, D.S.3    Li, F.4    Liu, T.5    Xia, W.6
  • 158
    • 72949119713 scopus 로고    scopus 로고
    • Lipidic systems for in vivo siRNA delivery
    • Wu, SY and McMillan, NA (2009). Lipidic systems for in vivo siRNA delivery. AAPS J 11: 639-652.
    • (2009) AAPS J , vol.11 , pp. 639-652
    • Wu, S.Y.1    McMillan, N.A.2
  • 159
    • 84900501023 scopus 로고    scopus 로고
    • Endosomal escape pathways for non-viral nucleic acid delivery systems
    • Ceresa B (Ed.) InTech
    • Liang, W and Lam, JKW. Endosomal escape pathways for non-viral nucleic acid delivery systems. In: Ceresa B (Ed.). Molecular Regulation of Endocytosis. InTech, 2012. pp. 429-456.
    • (2012) Molecular Regulation of Endocytosis , pp. 429-456
    • Liang, W.1    Lam, J.K.W.2
  • 161
    • 84859839124 scopus 로고    scopus 로고
    • Vitamin E TPGS as a molecular biomaterial for drug delivery
    • Zhang, Z, Tan, S and Feng, SS (2012). Vitamin E TPGS as a molecular biomaterial for drug delivery. Biomaterials 33: 4889-4906.
    • (2012) Biomaterials , vol.33 , pp. 4889-4906
    • Zhang, Z.1    Tan, S.2    Feng, S.S.3
  • 162
    • 84874032148 scopus 로고    scopus 로고
    • Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy
    • Kenjo, E, Asai, T, Yonenaga, N, Ando, H, Ishii, T, Hatanaka, K et al. (2013). Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy. Biol Pharm Bull 36: 287-291.
    • (2013) Biol Pharm Bull , vol.36 , pp. 287-291
    • Kenjo, E.1    Asai, T.2    Yonenaga, N.3    Ando, H.4    Ishii, T.5    Hatanaka, K.6
  • 163
    • 84898479092 scopus 로고    scopus 로고
    • Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas
    • Yang, ZZ, Li, JQ, Wang, ZZ, Dong, DW and Qi, XR (2014). Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas. Biomaterials 35: 5226-5239.
    • (2014) Biomaterials , vol.35 , pp. 5226-5239
    • Yang, Z.Z.1    Li, J.Q.2    Wang, Z.Z.3    Dong, D.W.4    Qi, X.R.5
  • 164
    • 84859269808 scopus 로고    scopus 로고
    • Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design
    • Buyens, K, De Smedt, SC, Braeckmans, K, Demeester, J, Peeters, L, van Grunsven, LA et al. (2012). Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design. J Control Release 158: 362-370.
    • (2012) J Control Release , vol.158 , pp. 362-370
    • Buyens, K.1    De Smedt, S.C.2    Braeckmans, K.3    Demeester, J.4    Peeters, L.5    Van Grunsven, L.A.6
  • 165
    • 84907226801 scopus 로고    scopus 로고
    • Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression
    • Shi, S, Han, L, Deng, L, Zhang, Y, Shen, H, Gong, T et al. (2014). Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. J Control Release 194: 228-237.
    • (2014) J Control Release , vol.194 , pp. 228-237
    • Shi, S.1    Han, L.2    Deng, L.3    Zhang, Y.4    Shen, H.5    Gong, T.6
  • 167
    • 77956269093 scopus 로고    scopus 로고
    • Nanoparticles modified with tumortargeting scFv deliver siRNA and miRNA for cancer therapy
    • Chen, Y, Zhu, X, Zhang, X, Liu, B and Huang, L (2010). Nanoparticles modified with tumortargeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther 18: 1650-1656.
    • (2010) Mol Ther , vol.18 , pp. 1650-1656
    • Chen, Y.1    Zhu, X.2    Zhang, X.3    Liu, B.4    Huang, L.5
  • 168
    • 52049121804 scopus 로고    scopus 로고
    • An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor
    • Chono, S, Li, SD, Conwell, CC and Huang, L (2008). An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. J Control Release 131: 64-69.
    • (2008) J Control Release , vol.131 , pp. 64-69
    • Chono, S.1    Li, S.D.2    Conwell, C.C.3    Huang, L.4
  • 169
    • 67349104195 scopus 로고    scopus 로고
    • The influence of size, lipid composition and bilayer fluidity of cationic liposomes on the transfection efficiency of nanolipoplexes
    • Ramezani, M, Khoshhamdam, M, Dehshahri, A and Malaekeh-Nikouei, B (2009). The influence of size, lipid composition and bilayer fluidity of cationic liposomes on the transfection efficiency of nanolipoplexes. Colloids Surf B Biointerfaces 72: 1-5.
    • (2009) Colloids Surf B Biointerfaces , vol.72 , pp. 1-5
    • Ramezani, M.1    Khoshhamdam, M.2    Dehshahri, A.3    Malaekeh-Nikouei, B.4
  • 170
    • 77954386915 scopus 로고    scopus 로고
    • Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery
    • Schäfer, J, Höbel, S, Bakowsky, U and Aigner, A (2010). Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery. Biomaterials 31: 6892-6900.
    • (2010) Biomaterials , vol.31 , pp. 6892-6900
    • Schäfer, J.1    Höbel, S.2    Bakowsky, U.3    Aigner, A.4
  • 171
    • 72149101228 scopus 로고    scopus 로고
    • The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine
    • Alshamsan, A, Hamdy, S, Samuel, J, El-Kadi, AO, Lavasanifar, A and Uludaʇ, H (2010). The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine. Biomaterials 31: 1420-1428.
    • (2010) Biomaterials , vol.31 , pp. 1420-1428
    • Alshamsan, A.1    Hamdy, S.2    Samuel, J.3    El-Kadi, A.O.4    Lavasanifar, A.5    Uludaʇ, H.6
  • 172
    • 84864140974 scopus 로고    scopus 로고
    • Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression
    • Jang, YL, Yun, UJ, Lee, MS, Kim, MG, Son, S, Lee, K et al. (2012). Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression. Int J Pharm 434: 488-493.
    • (2012) Int J Pharm , vol.434 , pp. 488-493
    • Jang, Y.L.1    Yun, U.J.2    Lee, M.S.3    Kim, M.G.4    Son, S.5    Lee, K.6
  • 173
    • 84902551474 scopus 로고    scopus 로고
    • Cardiac RNAi therapy using RAGE siRNA/deoxycholic acid-modified polyethylenimine complexes for myocardial infarction
    • Hong, J, Ku, SH, Lee, MS, Jeong, JH, Mok, H, Choi, D et al. (2014). Cardiac RNAi therapy using RAGE siRNA/deoxycholic acid-modified polyethylenimine complexes for myocardial infarction. Biomaterials 35: 7562-7573.
    • (2014) Biomaterials , vol.35 , pp. 7562-7573
    • Hong, J.1    Ku, S.H.2    Lee, M.S.3    Jeong, J.H.4    Mok, H.5    Choi, D.6
  • 174
    • 33947302736 scopus 로고    scopus 로고
    • Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy
    • Kim, WJ, Chang, CW, Lee, M and Kim, SW (2007). Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy. J Control Release 118: 357-363.
    • (2007) J Control Release , vol.118 , pp. 357-363
    • Kim, W.J.1    Chang, C.W.2    Lee, M.3    Kim, S.W.4
  • 176
    • 84856440598 scopus 로고    scopus 로고
    • MicroRNAs in neurodegenerative diseases and their therapeutic potential
    • Junn, E and Mouradian, MM (2012). MicroRNAs in neurodegenerative diseases and their therapeutic potential. Pharmacol Ther 133: 142-150.
    • (2012) Pharmacol Ther , vol.133 , pp. 142-150
    • Junn, E.1    Mouradian, M.M.2
  • 177
    • 34250167627 scopus 로고    scopus 로고
    • MicroRNA gets down to business
    • Mack, GS (2007). MicroRNA gets down to business. Nat Biotechnol 25: 631-638.
    • (2007) Nat Biotechnol , vol.25 , pp. 631-638
    • Mack, G.S.1
  • 178
    • 84904883854 scopus 로고    scopus 로고
    • Development of RNA interference-based therapeutics and application of multi-target small interfering RNAs
    • Li, T, Wu, M, Zhu, YY, Chen, J and Chen, L (2014). Development of RNA interference-based therapeutics and application of multi-target small interfering RNAs. Nucleic Acid Ther 24: 302-312.
    • (2014) Nucleic Acid Ther , vol.24 , pp. 302-312
    • Li, T.1    Wu, M.2    Zhu, Y.Y.3    Chen, J.4    Chen, L.5
  • 179
    • 84906048507 scopus 로고    scopus 로고
    • An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis
    • Obici, L and Merlini, G (2014). An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis. Expert Opin Investig Drugs 23: 1239-1251.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1239-1251
    • Obici, L.1    Merlini, G.2
  • 180
    • 84937764228 scopus 로고    scopus 로고
    • An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
    • Sehgal, A, Barros, S, Ivanciu, L, Cooley, B, Qin, J, Racie, T et al. (2015). An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nat Med 21: 492-497.
    • (2015) Nat Med , vol.21 , pp. 492-497
    • Sehgal, A.1    Barros, S.2    Ivanciu, L.3    Cooley, B.4    Qin, J.5    Racie, T.6
  • 181
    • 2942615282 scopus 로고    scopus 로고
    • Polo-like kinases and the orchestration of cell division
    • Barr, FA, Silljé, HH and Nigg, EA (2004). Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5: 429-440.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 429-440
    • Barr, F.A.1    Silljé, H.H.2    Nigg, E.A.3
  • 182
    • 0038624074 scopus 로고    scopus 로고
    • Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
    • Liu, X and Erikson, RL (2003). Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci USA 100: 5789-5794.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5789-5794
    • Liu, X.1    Erikson, R.L.2
  • 183
    • 33745823841 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibitors and future drug design
    • Shao, J, Zhou, B, Chu, B and Yen, Y (2006). Ribonucleotide reductase inhibitors and future drug design. Curr Cancer Drug Targets 6: 409-431.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 409-431
    • Shao, J.1    Zhou, B.2    Chu, B.3    Yen, Y.4
  • 184
    • 34247493628 scopus 로고    scopus 로고
    • Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo
    • Heidel, JD, Liu, JY, Yen, Y, Zhou, B, Heale, BS, Rossi, JJ et al. (2007). Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo. Clin Cancer Res 13: 2207-2215.
    • (2007) Clin Cancer Res , vol.13 , pp. 2207-2215
    • Heidel, J.D.1    Liu, J.Y.2    Yen, Y.3    Zhou, B.4    Heale, B.S.5    Rossi, J.J.6
  • 185
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis, ME, Zuckerman, JE, Choi, CH, Seligson, D, Tolcher, A, Alabi, CA et al. (2010). Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464: 1067-1070.
    • (2010) Nature , vol.464 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.3    Seligson, D.4    Tolcher, A.5    Alabi, C.A.6
  • 186
    • 84905670761 scopus 로고    scopus 로고
    • Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA
    • Zuckerman, JE, Gritli, I, Tolcher, A, Heidel, JD, Lim, D, Morgan, R et al. (2014). Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA. Proc Natl Acad Sci USA 111: 11449-11454.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 11449-11454
    • Zuckerman, J.E.1    Gritli, I.2    Tolcher, A.3    Heidel, J.D.4    Lim, D.5    Morgan, R.6
  • 187
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin, DJ and Ellis, LM (2005). Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 188
    • 22244459880 scopus 로고    scopus 로고
    • Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
    • Tao, W, South, VJ, Zhang, Y, Davide, JP, Farrell, L, Kohl, NE et al. (2005). Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage. Cancer Cell 8: 49-59.
    • (2005) Cancer Cell , vol.8 , pp. 49-59
    • Tao, W.1    South, V.J.2    Zhang, Y.3    Davide, J.P.4    Farrell, L.5    Kohl, N.E.6
  • 189
    • 78349299473 scopus 로고    scopus 로고
    • Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models
    • Santel, A, Aleku, M, Röder, N, Möpert, K, Durieux, B, Janke, O et al. (2010). Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models. Clin Cancer Res 16: 5469-5480.
    • (2010) Clin Cancer Res , vol.16 , pp. 5469-5480
    • Santel, A.1    Aleku, M.2    Röder, N.3    Möpert, K.4    Durieux, B.5    Janke, O.6
  • 190
    • 57149086661 scopus 로고    scopus 로고
    • Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression
    • Aleku, M, Schulz, P, Keil, O, Santel, A, Schaeper, U, Dieckhoff, B et al. (2008). Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression. Cancer Res 68: 9788-9798.
    • (2008) Cancer Res , vol.68 , pp. 9788-9798
    • Aleku, M.1    Schulz, P.2    Keil, O.3    Santel, A.4    Schaeper, U.5    Dieckhoff, B.6
  • 191
    • 20844438509 scopus 로고    scopus 로고
    • PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase
    • Leenders, F, Möpert, K, Schmiedeknecht, A, Santel, A, Czauderna, F, Aleku, M et al. (2004). PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. EMBO J 23: 3303-3313.
    • (2004) EMBO J , vol.23 , pp. 3303-3313
    • Leenders, F.1    Möpert, K.2    Schmiedeknecht, A.3    Santel, A.4    Czauderna, F.5    Aleku, M.6
  • 193
    • 84885065624 scopus 로고    scopus 로고
    • First microRNA mimic enters clinic
    • Bouchie, A (2013). First microRNA mimic enters clinic. Nat Biotechnol 31: 577.
    • (2013) Nat Biotechnol , vol.31 , pp. 577
    • Bouchie, A.1
  • 194
    • 84869219338 scopus 로고    scopus 로고
    • MiR-34 - A microRNA replacement therapy is headed to the clinic
    • Bader, AG (2012). miR-34 - a microRNA replacement therapy is headed to the clinic. Front Genet 3: 120.
    • (2012) Front Genet , vol.3 , pp. 120
    • Bader, A.G.1
  • 195
    • 74249084440 scopus 로고    scopus 로고
    • MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives
    • Aqeilan, RI, Calin, GA and Croce, CM (2010). miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ 17: 215-220.
    • (2010) Cell Death Differ , vol.17 , pp. 215-220
    • Aqeilan, R.I.1    Calin, G.A.2    Croce, C.M.3
  • 196
    • 84885113592 scopus 로고    scopus 로고
    • Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy
    • Guzman-Aranguez, A, Loma, P and Pintor, J (2013). Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy. Br J Pharmacol 170: 730-747.
    • (2013) Br J Pharmacol , vol.170 , pp. 730-747
    • Guzman-Aranguez, A.1    Loma, P.2    Pintor, J.3
  • 197
    • 59849100498 scopus 로고    scopus 로고
    • MicroRNA expression in the eyes and their significance in relation to functions
    • Xu, S (2009). microRNA expression in the eyes and their significance in relation to functions. Prog Retin Eye Res 28: 87-116.
    • (2009) Prog Retin Eye Res , vol.28 , pp. 87-116
    • Xu, S.1
  • 198
    • 84858438407 scopus 로고    scopus 로고
    • Pulmonary delivery of therapeutic siRNA
    • Lam, JK, Liang, W and Chan, HK (2012). Pulmonary delivery of therapeutic siRNA. Adv Drug Deliv Rev 64: 1-15.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1-15
    • Lam, J.K.1    Liang, W.2    Chan, H.K.3
  • 199
    • 79951849229 scopus 로고    scopus 로고
    • RNA interference therapy in lung transplant patients infected with respiratory syncytial virus
    • Zamora, MR, Budev, M, Rolfe, M, Gottlieb, J, Humar, A, Devincenzo, J et al. (2011). RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. Am J Respir Crit Care Med 183: 531-538.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 531-538
    • Zamora, M.R.1    Budev, M.2    Rolfe, M.3    Gottlieb, J.4    Humar, A.5    Devincenzo, J.6
  • 200
    • 85176818989 scopus 로고    scopus 로고
    • Dry powder formulation of plasmid DNA and siRNA for inhalation
    • in press
    • Chow, MYT and Lam, JKW. Dry powder formulation of plasmid DNA and siRNA for inhalation. Current Pharmaceutical Design, in press.
    • Current Pharmaceutical Design
    • Chow, M.Y.T.1    Lam, J.K.W.2
  • 201
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: A potential new class of pharmaceutical drugs
    • Bumcrot, D, Manoharan, M, Koteliansky, V and Sah, DW (2006). RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2: 711-719.
    • (2006) Nat Chem Biol , vol.2 , pp. 711-719
    • Bumcrot, D.1    Manoharan, M.2    Koteliansky, V.3    Sah, D.W.4
  • 202
    • 38149060952 scopus 로고    scopus 로고
    • Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice
    • Lively, TN, Kossen, K, Balhorn, A, Koya, T, Zinnen, S, Takeda, K et al. (2008). Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice. J Allergy Clin Immunol 121: 88-94.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 88-94
    • Lively, T.N.1    Kossen, K.2    Balhorn, A.3    Koya, T.4    Zinnen, S.5    Takeda, K.6
  • 203
    • 84863512583 scopus 로고    scopus 로고
    • Pretreatment with interleukin-6 small interfering RNA can improve the survival rate of polymicrobial cecal ligation and puncture mice by down regulating interleukin-6 production
    • Mostafa Anower, AK, Shim, JA, Choi, B and Sohn, S (2012). Pretreatment with interleukin-6 small interfering RNA can improve the survival rate of polymicrobial cecal ligation and puncture mice by down regulating interleukin-6 production. Eur J Pharmacol 688: 76-83.
    • (2012) Eur J Pharmacol , vol.688 , pp. 76-83
    • Mostafa Anower, A.K.1    Shim, J.A.2    Choi, B.3    Sohn, S.4
  • 204
    • 79960963683 scopus 로고    scopus 로고
    • MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma
    • Ibrahim, AF, Weirauch, U, Thomas, M, Grünweller, A, Hartmann, RK and Aigner, A (2011). MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 71: 5214-5224.
    • (2011) Cancer Res , vol.71 , pp. 5214-5224
    • Ibrahim, A.F.1    Weirauch, U.2    Thomas, M.3    Grünweller, A.4    Hartmann, R.K.5    Aigner, A.6
  • 205
    • 84877730567 scopus 로고    scopus 로고
    • Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo
    • Lin, D, Cheng, Q, Jiang, Q, Huang, Y, Yang, Z, Han, S et al. (2013). Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo. Nanoscale 5: 4291-4301.
    • (2013) Nanoscale , vol.5 , pp. 4291-4301
    • Lin, D.1    Cheng, Q.2    Jiang, Q.3    Huang, Y.4    Yang, Z.5    Han, S.6
  • 206
    • 84878559366 scopus 로고    scopus 로고
    • Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes
    • Shim, G, Choi, HW, Lee, S, Choi, J, Yu, YH, Park, DE et al. (2013). Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes. Mol Ther 21: 816-824.
    • (2013) Mol Ther , vol.21 , pp. 816-824
    • Shim, G.1    Choi, H.W.2    Lee, S.3    Choi, J.4    Yu, Y.H.5    Park, D.E.6
  • 207
    • 84905444179 scopus 로고    scopus 로고
    • Improvement of doxorubicin efficacy using liposomal anti-polo-like kinase 1 siRNA in human renal cell carcinomas
    • Sakurai, Y, Hatakeyama, H, Akita, H and Harashima, H (2014). Improvement of doxorubicin efficacy using liposomal anti-polo-like kinase 1 siRNA in human renal cell carcinomas. Mol Pharm 11: 2713-2719.
    • (2014) Mol Pharm , vol.11 , pp. 2713-2719
    • Sakurai, Y.1    Hatakeyama, H.2    Akita, H.3    Harashima, H.4
  • 208
    • 77952550515 scopus 로고    scopus 로고
    • Role of anti-oncomirs miR-143 and -145 in human colorectal tumors
    • Akao, Y, Nakagawa, Y, Hirata, I, Iio, A, Itoh, T, Kojima, K et al. (2010). Role of anti-oncomirs miR-143 and -145 in human colorectal tumors. Cancer Gene Ther 17: 398-408.
    • (2010) Cancer Gene Ther , vol.17 , pp. 398-408
    • Akao, Y.1    Nakagawa, Y.2    Hirata, I.3    Iio, A.4    Itoh, T.5    Kojima, K.6
  • 209
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang, P, Wiggins, JF, Daige, CL, Cho, C, Omotola, M, Brown, D et al. (2011). Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 19: 1116-1122.
    • (2011) Mol Ther , vol.19 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3    Cho, C.4    Omotola, M.5    Brown, D.6
  • 210
    • 33645720317 scopus 로고    scopus 로고
    • Postexposure protection of Guinea Pigs against a lethal ebola virus challenge is conferred by RNA interference
    • Geisbert, TW, Hensley, LE, Kagan, E, Yu, EZ, Geisbert, JB, Daddario-DiCaprio, K et al. (2006). Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference. J Infect Dis 193: 1650-1657.
    • (2006) J Infect Dis , vol.193 , pp. 1650-1657
    • Geisbert, T.W.1    Hensley, L.E.2    Kagan, E.3    Yu, E.Z.4    Geisbert, J.B.5    Daddario-DiCaprio, K.6
  • 211
    • 84875740719 scopus 로고    scopus 로고
    • Systemic delivery of microRNA-34a for cancer stem cell therapy
    • Shi, S, Han, L, Gong, T, Zhang, Z and Sun, X (2013). Systemic delivery of microRNA-34a for cancer stem cell therapy. Angew Chem Int Ed Engl 52: 3901-3905.
    • (2013) Angew Chem Int Ed Engl , vol.52 , pp. 3901-3905
    • Shi, S.1    Han, L.2    Gong, T.3    Zhang, Z.4    Sun, X.5
  • 212
    • 38749136602 scopus 로고    scopus 로고
    • Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
    • DeVincenzo, J, Cehelsky, JE, Alvarez, R, Elbashir, S, Harborth, J, Toudjarska, I et al. (2008). Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res 77: 225-231.
    • (2008) Antiviral Res , vol.77 , pp. 225-231
    • DeVincenzo, J.1    Cehelsky, J.E.2    Alvarez, R.3    Elbashir, S.4    Harborth, J.5    Toudjarska, I.6
  • 213
    • 84864855385 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients
    • Nguyen, QD, Schachar, RA, Nduaka, CI, Sperling, M, Basile, AS, Klamerus, KJ et al.; PF-04523655 Study Group. (2012). Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients. Eye (Lond) 26: 1099-1105.
    • (2012) Eye (Lond) , vol.26 , pp. 1099-1105
    • Nguyen, Q.D.1    Schachar, R.A.2    Nduaka, C.I.3    Sperling, M.4    Basile, A.S.5    Klamerus, K.J.6
  • 214
    • 84865678868 scopus 로고    scopus 로고
    • Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET study)
    • Nguyen, QD, Schachar, RA, Nduaka, CI, Sperling, M, Klamerus, KJ, Chi-Burris, K et al.; MONET Clinical Study Group. (2012). Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study). Ophthalmology 119: 1867-1873.
    • (2012) Ophthalmology , vol.119 , pp. 1867-1873
    • Nguyen, Q.D.1    Schachar, R.A.2    Nduaka, C.I.3    Sperling, M.4    Klamerus, K.J.5    Chi-Burris, K.6
  • 215
    • 84872175978 scopus 로고    scopus 로고
    • Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)
    • Nguyen, QD, Schachar, RA, Nduaka, CI, Sperling, M, Basile, AS, Klamerus, KJ et al.; DEGAS Clinical Study Group. (2012). Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study). Invest Ophthalmol Vis Sci 53: 7666-7674.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 7666-7674
    • Nguyen, Q.D.1    Schachar, R.A.2    Nduaka, C.I.3    Sperling, M.4    Basile, A.S.5    Klamerus, K.J.6
  • 216
    • 84892741671 scopus 로고    scopus 로고
    • Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial
    • Fitzgerald, K, Frank-Kamenetsky, M, Shulga-Morskaya, S, Liebow, A, Bettencourt, BR, Sutherland, JE et al. (2014). Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet 383: 60-68.
    • (2014) Lancet , vol.383 , pp. 60-68
    • Fitzgerald, K.1    Frank-Kamenetsky, M.2    Shulga-Morskaya, S.3    Liebow, A.4    Bettencourt, B.R.5    Sutherland, J.E.6
  • 217


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