A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

Nature Immunology

Volumn 11, Issue 12, 2010, Pages 1085-1092

  Au Yeung, Byron B ^a   Levin, Susan E ^a,b   Zhang, Chao ^a   Hsu, Lih Yun ^a   Cheng, Debra A ^a   Killeen, Nigel ^a   Shokat, Kevan M ^a   Weiss, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; INTEGRIN; PROTEIN KINASE ZAP 70; RAP1 PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CATALYSIS; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BIOCATALYSIS; CELL PROLIFERATION; CELL SEPARATION; ENZYME INHIBITORS; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; PYRAZOLES; PYRIMIDINES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 78449287872     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1955     Document Type: Article

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