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Volumn 6, Issue 303, 2013, Pages

Diacylglycerol kinase ζ limits the generation of natural regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE ZETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

EID: 84889263101     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2004411     Document Type: Article
Times cited : (37)

References (68)
  • 1
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • S. Z. Josefowicz, L. F. Lu, A. Y. Rudensky, Regulatory T cells: Mechanisms of differentiation and function. Annu. Rev. Immunol. 30, 531-564 (2012).
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 2
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • S. Sakaguchi, T. Yamaguchi, T. Nomura, M. Ono, Regulatory T cells and immune tolerance. Cell 133, 775-787 (2008).
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 5
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • J. M. Kim, J. P. Rasmussen, A. Y. Rudensky, Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191-197 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 7
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Int. J. Immunol. 155, 1151-1164 (1995).
    • (1995) Int. J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 8
    • 33847647528 scopus 로고    scopus 로고
    • Regulatory T cells and cancer
    • H. Y. Wang, R. F. Wang, Regulatory T cells and cancer. Curr. Opin. Immunol. 19, 217-223 (2007).
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 217-223
    • Wang, H.Y.1    Wang, R.F.2
  • 9
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Y. Belkaid, B. T. Rouse, Natural regulatory T cells in infectious disease. Nat. Immunol. 6, 353-360 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 10
    • 84859316999 scopus 로고    scopus 로고
    • + regulatory T cells, immune stimulation and host defence against infection
    • + regulatory T cells, immune stimulation and host defence against infection. Immunology 136, 1-10 (2012).
    • (2012) Immunology , vol.136 , pp. 1-10
    • Rowe, J.H.1    Ertelt, J.M.2    Way, S.S.3
  • 14
    • 79953070839 scopus 로고    scopus 로고
    • Becoming self-aware: The thymic education of regulatory T cells
    • C. W. Lio, C. S. Hsieh, Becoming self-aware: The thymic education of regulatory T cells. Curr. Opin. Immunol. 23, 213-219 (2011).
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 213-219
    • Lio, C.W.1    Hsieh, C.S.2
  • 15
    • 84857771151 scopus 로고    scopus 로고
    • T-cell receptor affinity in thymic development
    • A. E. Moran, K. A. Hogquist, T-cell receptor affinity in thymic development. Immunology 135, 261-267 (2012).
    • (2012) Immunology , vol.135 , pp. 261-267
    • Moran, A.E.1    Hogquist, K.A.2
  • 16
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • I. Apostolou, A. Sarukhan, L. Klein, H. von Boehmer, Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 17
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • B. Knoechel, J. Lohr, E. Kahn, J. A. Bluestone, A. K. Abbas, Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202, 1375-1386 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 20
    • 0036568942 scopus 로고    scopus 로고
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168, 4399-4405 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 4399-4405
    • Kawahata, K.1    Misaki, Y.2    Yamauchi, M.3    Tsunekawa, S.4    Setoguchi, K.5    Miyazaki, J.6    Yamamoto, K.7
  • 21
    • 84866524744 scopus 로고    scopus 로고
    • A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self
    • H. M. Lee, J. L. Bautista, J. Scott-Browne, J. F. Mohan, C. S. Hsieh, A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity 37, 475-486 (2012).
    • (2012) Immunity , vol.37 , pp. 475-486
    • Lee, H.M.1    Bautista, J.L.2    Scott-Browne, J.3    Mohan, J.F.4    Hsieh, C.S.5
  • 22
    • 0034093737 scopus 로고    scopus 로고
    • Signal transduction by the TCR for antigen
    • L. P. Kane, J. Lin, A. Weiss, Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12, 242-249 (2000).
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 242-249
    • Kane, L.P.1    Lin, J.2    Weiss, A.3
  • 25
    • 0037163130 scopus 로고    scopus 로고
    • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase ζ
    • X. P. Zhong, E. A. Hainey, B. A. Olenchock, H. Zhao, M. K. Topham, G. A. Koretzky, Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase ζ. J. Biol. Chem. 277, 31089-31098 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 31089-31098
    • Zhong, X.P.1    Hainey, E.A.2    Olenchock, B.A.3    Zhao, H.4    Topham, M.K.5    Koretzky, G.A.6
  • 28
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • A. E. Moran, K. L. Holzapfel, Y. Xing, N. R. Cunningham, J. S. Maltzman, J. Punt, K. A. Hogquist, T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208, 1279-1289 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 30
    • 34548724573 scopus 로고    scopus 로고
    • Transcriptional analysis of clonal deletion in vivo
    • T. A. Baldwin, K. A. Hogquist, Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179, 837-844 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 837-844
    • Baldwin, T.A.1    Hogquist, K.A.2
  • 31
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • C. W. Lio, C. S. Hsieh, A two-step process for thymic regulatory T cell development. Immunity 28, 100-111 (2008).
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 32
    • 0031054632 scopus 로고    scopus 로고
    • Negative selection in the thymus includes semimature T cells
    • H. Kishimoto, J. Sprent, Negative selection in the thymus includes semimature T cells. J. Exp. Med. 185, 263-271 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 263-271
    • Kishimoto, H.1    Sprent, J.2
  • 33
    • 35448967862 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling in regulatory T cell development and homeostasis
    • M. A. Burchill, J. Yang, K. B. Vang, M. A. Farrar, Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol. Lett. 114, 1-8 (2007).
    • (2007) Immunol. Lett. , vol.114 , pp. 1-8
    • Burchill, M.A.1    Yang, J.2    Vang, K.B.3    Farrar, M.A.4
  • 34
    • 67649844269 scopus 로고    scopus 로고
    • Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control
    • G. Wirnsberger, F. Mair, L. Klein, Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control. Proc. Natl. Acad. Sci. U.S.A. 106, 10278-10283 (2009).
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 10278-10283
    • Wirnsberger, G.1    Mair, F.2    Klein, L.3
  • 35
    • 77952767221 scopus 로고    scopus 로고
    • Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development
    • K. B. Vang, J. Yang, A. J. Pagan, L. X. Li, J. Wang, J. M. Green, A. A. Beg, M. A. Farrar, Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J. Immunol. 184, 4074-4077 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 4074-4077
    • Vang, K.B.1    Yang, J.2    Pagan, A.J.3    Li, L.X.4    Wang, J.5    Green, J.M.6    Beg, A.A.7    Farrar, M.A.8
  • 37
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • X. Tai, M. Cowan, L. Feigenbaum, A. Singer, CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6, 152-162 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 38
    • 78751701753 scopus 로고    scopus 로고
    • NF-κB family of transcription factors: Biochemical players of CD28 co-stimulation
    • L. Tuosto, NF-κB family of transcription factors: Biochemical players of CD28 co-stimulation. Immunol. Lett. 135, 1-9 (2011).
    • (2011) Immunol. Lett. , vol.135 , pp. 1-9
    • Tuosto, L.1
  • 42
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-κB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • M. Long, S. G. Park, I. Strickland, M. S. Hayden, S. Ghosh, Nuclear factor-κB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31, 921-931 (2009).
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 44
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Y. Zheng, S. Josefowicz, A. Chaudhry, X. P. Peng, K. Forbush, A. Y. Rudensky, Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808-812 (2010).
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 45
    • 79961170194 scopus 로고    scopus 로고
    • Regulation of NF-κB induction by TCR/CD28
    • J. Cheng, A. Montecalvo, L. P. Kane, Regulation of NF-κB induction by TCR/CD28. Immunol. Res. 50, 113-117 (2011).
    • (2011) Immunol. Res. , vol.50 , pp. 113-117
    • Cheng, J.1    Montecalvo, A.2    Kane, L.P.3
  • 46
    • 0036905264 scopus 로고    scopus 로고
    • Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters
    • N. Brose, C. Rosenmund, Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters. J. Cell Sci. 115, 4399-4411 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 4399-4411
    • Brose, N.1    Rosenmund, C.2
  • 48
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • T. R. Malek, I. Castro, Interleukin-2 receptor signaling: At the interface between tolerance and immunity. Immunity 33, 153-165 (2010).
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 50
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • J. D. Fontenot, J. L. Dooley, A. G. Farr, A. Y. Rudensky, Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 51
    • 0037124339 scopus 로고    scopus 로고
    • The basis for TCR-mediated regulation of the IL-2 receptor α chain gene: Role of widely separated regulatory elements
    • H. P. Kim, W. J. Leonard, The basis for TCR-mediated regulation of the IL-2 receptor α chain gene: Role of widely separated regulatory elements. EMBO J. 21, 3051-3059 (2002).
    • (2002) EMBO J. , vol.21 , pp. 3051-3059
    • Kim, H.P.1    Leonard, W.J.2
  • 52
    • 0026665460 scopus 로고
    • κB site-dependent activation of the interleukin-2 receptor α-chain gene promoter by human c-Rel
    • T. H. Tan, G. P. Huang, A. Sica, P. Ghosh, H. A. Young, D. L. Longo, N. R. Rice, κB site-dependent activation of the interleukin-2 receptor α-chain gene promoter by human c-Rel. Mol. Cell. Biol. 12, 4067-4075 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 4067-4075
    • Tan, T.H.1    Huang, G.P.2    Sica, A.3    Ghosh, P.4    Young, H.A.5    Longo, D.L.6    Rice, N.R.7
  • 53
    • 33750219508 scopus 로고    scopus 로고
    • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
    • H. P. Kim, J. Imbert, W. J. Leonard, Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev. 17, 349-366 (2006).
    • (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 349-366
    • Kim, H.P.1    Imbert, J.2    Leonard, W.J.3
  • 54
    • 0028889159 scopus 로고
    • Regulation of cell-type-specific interleukin-2 receptor α-chain gene expression: Potential role of physical interactions between Elf-1, HMG-I(Y), and NF-κB family proteins
    • S. John, R. B. Reeves, J. X. Lin, R. Child, J. M. Leiden, C. B. Thompson, W. J. Leonard, Regulation of cell-type-specific interleukin-2 receptor α-chain gene expression: Potential role of physical interactions between Elf-1, HMG-I(Y), and NF-κB family proteins. Mol. Cell. Biol. 15, 1786-1796 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1786-1796
    • John, S.1    Reeves, R.B.2    Lin, J.X.3    Child, R.4    Leiden, J.M.5    Thompson, C.B.6    Leonard, W.J.7
  • 57
    • 8944230662 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability
    • T. Tanaka, M. Kurokawa, K. Ueki, K. Tanaka, Y. Imai, K. Mitani, K. Okazaki, N. Sagata, Y. Yazaki, Y. Shibata, T. Kadowaki, H. Hirai, The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability. Mol. Cell. Biol. 16, 3967-3979 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3967-3979
    • Tanaka, T.1    Kurokawa, M.2    Ueki, K.3    Tanaka, K.4    Imai, Y.5    Mitani, K.6    Okazaki, K.7    Sagata, N.8    Yazaki, Y.9    Shibata, Y.10    Kadowaki, T.11    Hirai, H.12
  • 59
    • 70350451993 scopus 로고    scopus 로고
    • Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
    • D. Rudra, T. Egawa, M. M. Chong, P. Treuting, D. R. Littman, A. Y. Rudensky, Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat. Immunol. 10, 1170-1177 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 1170-1177
    • Rudra, D.1    Egawa, T.2    Chong, M.M.3    Treuting, P.4    Littman, D.R.5    Rudensky, A.Y.6
  • 60
    • 79954618943 scopus 로고    scopus 로고
    • Negative regulation of mTOR activation by diacylglycerol kinases
    • B. K. Gorentla, C. K. Wan, X. P. Zhong, Negative regulation of mTOR activation by diacylglycerol kinases. Blood 117, 4022-4031 (2011).
    • (2011) Blood , vol.117 , pp. 4022-4031
    • Gorentla, B.K.1    Wan, C.K.2    Zhong, X.P.3
  • 63
    • 49249109489 scopus 로고    scopus 로고
    • Diacylglycerol kinases in immune cell function and self-tolerance
    • X. P. Zhong, R. Guo, H. Zhou, C. Liu, C. K. Wan, Diacylglycerol kinases in immune cell function and self-tolerance. Immunol. Rev. 224, 249-264 (2008).
    • (2008) Immunol. Rev. , vol.224 , pp. 249-264
    • Zhong, X.P.1    Guo, R.2    Zhou, H.3    Liu, C.4    Wan, C.K.5
  • 64
    • 0029658306 scopus 로고    scopus 로고
    • vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells
    • vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 184, 1161-1166 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 1161-1166
    • Tuosto, L.1    Michel, F.2    Acuto, O.3
  • 66
    • 0042707589 scopus 로고    scopus 로고
    • Membrane translocation of protein kinase Cθ during T lymphocyte activation requires phospholipase C-γ-generated diacylglycerol
    • E. Díaz-Flores, M. Siliceo, A. C. Martínez, I. Mérida, Membrane translocation of protein kinase Cθ during T lymphocyte activation requires phospholipase C-γ-generated diacylglycerol. J. Biol. Chem. 278, 29208-29215 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 29208-29215
    • Díaz-Flores, E.1    Siliceo, M.2    Martínez, A.C.3    Mérida, I.4
  • 67
    • 0033023431 scopus 로고    scopus 로고
    • c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
    • H. C. Liou, Z. Jin, J. Tumang, S. Andjelic, K. A. Smith, M. L. Liou, c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int. Immunol. 11, 361-371 (1999).
    • (1999) Int. Immunol. , vol.11 , pp. 361-371
    • Liou, H.C.1    Jin, Z.2    Tumang, J.3    Andjelic, S.4    Smith, K.A.5    Liou, M.L.6
  • 68
    • 77956645610 scopus 로고    scopus 로고
    • Independent and cooperative roles of adaptor molecules in proximal signaling during FcεRI-mediated mast cell activation
    • T. Kambayashi, M. Okumura, R. G. Baker, C. J. Hsu, T. Baumgart, W. Zhang, G. A. Koretzky, Independent and cooperative roles of adaptor molecules in proximal signaling during FcεRI-mediated mast cell activation. Mol. Cell. Biol. 30, 4188-4196 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4188-4196
    • Kambayashi, T.1    Okumura, M.2    Baker, R.G.3    Hsu, C.J.4    Baumgart, T.5    Zhang, W.6    Koretzky, G.A.7


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